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| 1 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 2 | Knockdown of survivin expression by siRNAs enhances chemosensitivity of prostate cancer cells and attenuates its tumorigenicity显示文摘Survivin, apoptosis 家庭蛋白质的禁止者的一个成员,为肿瘤房间生存能力在肿瘤房间和它的重要角色由于它的选择表示在癌症成为了一个吸引人的治疗学的目标。这里,我们在前列腺癌症房间显示出那基于向量的小介入 RNA (siRNAs ) silenced survivin 表情,导致显著地减少了房间增长并且提高了 apoptosis,并且增加了前列腺癌症房间(PC-3 ) 的敏感到导致 apoptosis 代理人, platinol。而且,有表示 siRNA 向量的 PC-3 房间 transfected 在 vivo 在裸体老鼠异种皮移植显示出更低的肿瘤形成。这些结果证明由 siRNA 的 survivin 表示的抑制稀释了前列腺癌症房间的恶意的显型,并且可以为雄激素无关的前列腺癌症的基因治疗提供一条新奇途径。 | Jianjun Shen Jiayun Liu Yin Long Yinye Miao Mingquan Su Qing Zhang Hua Han Xiaoke Hao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 19 |
| 3 | Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1显示文摘Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple hepatic diseases. However, the exact molecular mechanisms of action and the direct protein targets of celastrol in the treatment of liver fibrosis remain largely elusive. Here, we discover that celastrol exerts anti-fibrotic effects via promoting the production of reactive oxygen species(ROS) and inducing ferroptosis in activated hepatic stellate cells(HSCs). By using activity-based protein profiling(ABPP) in combination with bio-orthogonal click chemistry reaction and cellular thermal shift assay(CETSA), we show that celastrol directly binds to peroxiredoxins(PRDXs), including PRDX1, PRDX2, PRDX4 and PRDX6,through the active cysteine sites, and inhibits their anti-oxidant activities. Celastrol also targets to heme oxygenase 1(HO-1) and upregulates its expression in activated-HSCs. Knockdown of PRDX1, PRDX2,PRDX4, PRDX6 or HO-1 in HSCs, to varying extent, elevated cellular ROS levels and induced ferroptosis. Taken together, our findings reveal the direct protein targets and molecular mechanisms via which celastrol ameliorates hepatic fibrosis, thus supporting the further development of celastrol as a promising therapeutic agent for liver fibrosis. | Piao Luo Dandan Liu Qian Zhang Fan Yang Yin-Kwan Wong Fei Xia Junzhe Zhang Jiayun Chen Ya Tian Chuanbin Yang Lingyun Dai Han-Ming Shen Jigang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 14 |
| 4 | Field Simulation of Aerosol Transmission of SARS-CoV-2 in a Special Building Layout—Guangdong Province,China,2021显示文摘What is already known on this topic?Aerosol transmission was one route for the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and usually occurred in confined spaces.What is added by this report?Aerosol transmission was found to exist between handshake buildings,i.e.,buildings with extremely close proximity that formed relatively enclosed spaces.Transmission was mainly affected by the airflow layout caused by switching air conditioners on and off as well as opening and closing doors and windows.What are the implications for public health practice?Centralized isolation and home isolation in handshake buildings creates a risk of SARS-CoV-2 aerosol transmission under certain conditions.Attention should be paid to the influence of air distribution layout on aerosol diffusion in isolation wards,and disinfection of isolation venues should be strengthened. | Zhuona Zhang Xia Li Qin Wang Jin Xu Qinqin Jiang Sili Jiang Jiayun Lyu Shiqiang Liu Ling Ye Jun Yuan Wenru Feng Dongqun Xu | 2021 | China CDC weekly2021，3，34： | 8 |
| 5 | Biosynthesis of selenosubtilisin: A novel way to target selenium into the active site of subtilisin显示文摘Glutathione peroxidase (GPx, EC1.11.1.9), an important anti-oxidative selenoenzyme, can catalyze the reduction of harmful hydroperoxides with concomitant glutathione, thereby protecting cells and other biological issues against oxidative damage. It captures considerable interest in redesign of its function for either the mechanism study or the pharmacological development as an antioxidant. In order to de- velop a general strategy for specifically targeting and operating selenium in active sites of enzymes, the catalytically essential residue selenocysteine (Sec) was first successfully bioincorporated into the catalytic center of subtilisin by using an auxotrophic expression system. The studies of the catalytic activity and the steady-state kinetics demonstrated that selenosubtilisin is an excellent GPx-like bio- catalyst. In comparison with the chemically modified method, biosynthesis exhibits obvious advan- tages: Sec could be site-directly incorporated into active sites of enzymes to overcome the non-speci- ficity generated by chemical modification. This study provides an important strategy for specifically targeting and operating selenium in the active site of an enzyme. | LI Jing LIU XiaoMan JI YueTong QI ZhenHui GE Yan XU JiaYun LIU JunQiu LUO GuiMin SHEN JiaCong | 2008 | Chinese Science Bulletin2008，53，16： | 3 |
| 6 | Decreased expression of GLUT4 in male CG- IUGR rats may play a vital role in their increased susceptibility to diabetes mellitus in adulthood显示文摘 | Chang Duan Min Liu Haiyan Xu Weiwei Tang Jiayun Liu Lamei Hou Lijuan Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 3 |
| 7 | 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs显示文摘Hepatic stellate cells(HSCs)are essential drivers of fibrogenesis.Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis.18beta-glycyrrhetinic acid(18b-GA)is a natural compound that exists widely in herbal medicines,such as Glycyrrhiza uralensis Fisch,which is used for treating multiple liver diseases,especially in Asia.In the present study,we demonstrated that 18b-GA decreased hepatic fibrosis by inducing the apoptosis in activated HSCs.18b-GA inhibited the expression of a-smooth muscle actin and collagen type Ⅰ alpha-1.Using a chemoproteomic approach derived from activity-based protein profiling,together with cellular thermal shift assay and surface plasmon resonance,we found that 18b-GA covalently targeted peroxiredoxin 1(PRDX1)and peroxiredoxin 2(PRDX2)proteins via binding to active cysteine residues and thereby inhibited their enzymatic activities.18b-GA induced the elevation of reactive oxygen species(ROS),resulting in the apoptosis of activated HSCs.PRDX1 knockdown also led to ROS-mediated apoptosis in activated HSCs.Collectively,our findings revealed the target proteins and molecular mechanisms of 18b-GA in ameliorating hepatic fibrosis,highlighting the future development of 18b-GA as a novel therapeutic drug for hepatic fibrosis. | Qian Zhang Piao Luo Liuhai Zheng Jiayun Chen Junzhe Zhang Huan Tang Dandan Liu Xueling He Qiaoli Shi Liwei Gu Jiahao Li Qiuyan Guo Chuanbin Yang Yin Kwan Wong Fei Xia Jigang Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 3 |
| 8 | A Self-Powered Nanogenerator for the Electrical Protection of Integrated Circuits from Trace Amounts of Liquid显示文摘With the increase in the use of electronic devices in many different environments,a need has arisen for an easily implemented method for the rapid,sensitive detection of liquids in the vicinity of electronic components.In this work,a high-performance power generator that combines carbon nanoparticles and TiO2 nanowires has been fabricated by sequential electrophoretic deposition(EPD).The opencircuit voltage and short-circuit current of a single generator are found to exceed 0.7 V and 100μA when 6μL of water was applied.The generator is also found to have a stable and reproducible response to other liquids.An output voltage of 0.3 V was obtained after 244,876,931,and 184μs,on exposure of the generator to 6μL of water,ethanol,acetone,and methanol,respectively.The fast response time and high sensitivity to liquids show that the device has great potential for the detection of small quantities of liquid.In addition,the simple easily implemented sequential EPD method ensures the high mechanical strength of the device.This compact,reliable device provides a new method for the sensitive,rapid detection of extraneous liquids before they can impact the performance of electronic circuits,particularly those on printed circuit board. | Zhuang Hui Ming Xiao Daozhi Shen Jiayun Feng Peng Peng Yangai Liu Walter WDuley YNorman Zhou | 2020 | Nano-Micro Letters2020，12，1： | 2 |
| 9 | A writable lithium metal ink显示文摘The recent revival of Li metal anodes(LMA)leads to a renewed interest in LMA as the ultimate choice for rechargeable lithium batteries towards high energy density.However,multiple challenges stand in the way of using LMA,of which high reactivity,dendrite growth,the difficulty of fabricating Li thin foils,and the flammability of organic liquid electrolytes are typical.Here,a writable Li metal ink(LMI)prepared by introducing biomass-derived carbon particles into molten Li is presented.Due to the significantly decreased surface tension,LMI is able to directly write on copper foils or other substrates that ultrathin Li foils with a remarkably small thickness(<10μm)can be achieved.The versatility of LMI is further demonstrated in addressing the interface issue between LMA and garnet-type solid-state electrolytes,where directly writing LMI on the garnet offers a perfect contact and enables an extremely low interfacial resistance of 6Ωcm^2,in sharp contrast to 939Ωcm^2 between the pure Li and the garnet.Due to the successful partnership with non-flammable solid-state electrolytes,ink-based technology may have a chance to bring us very close to the use of solid-state lithium metal batteries(SSLMBs)with high safety and high energy density. | Wangyan Wu Jian Duan Jiayun Wen Yuwei Chen Xuyang Liu Liqiang Huang Zhengfeng Wang Shengyuan Deng Yunhui Huang Wei Luo | 2020 | Science China Chemistry2020，63，10： | 2 |
| 10 | Construction of Redox Responsive Vesicles Based on a Supra-Amphiphile for Enzyme Confinement显示文摘 | Tiezheng Pan Huixin Zou Hongcheng Sun Yao Liu Shengda Liu Quan Luo Zeyuan Dong Jiayun Xu Junqiu Liu | 2017 | Chinese Journal of Chemistry2017，35，6： | 2 |
| 11 | Bifunctional flexible electrochromic energy storage devices based on silver nanowire flexible transparent electrodes显示文摘Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(FTEs)materials for the emerging flexible devices.Currently,fabricating FECESD based on AgNWs FTEs is still hindered by their intrinsic poor electrochemical stability.To address this issue,a hybrid AgNWs/Co(OH)_(2)/PEDOT:PSS electrode is proposed.The PEDOT:PSS could not only improve the resistance against electrochemical corrosion of AgNWs,but also work as functional layer to realize the color-changing and energy storage properties.Moreover,the Co(OH)_(2)interlayer further improved the color-changing and energy storage performance.Based on the improvement,we assembled the symmetrical FECESDs.Under the same condition,the areal capacitance(0.8 mF cm^(−2))and coloration efficiency(269.80 cm^(2)C−1)of AgNWs/Co(OH)_(2)/PEDOT:PSS FECESDs were obviously higher than AgNWs/PEDOT:PSS FECESDs.Furthermore,the obtained FECESDs exhibited excellent stability against the mechanical deformation.The areal capacitance remained stable during 1000 times cyclic bending with a 25 mm curvature radius.These results demonstrated the broad application potential of the AgNWs/Co(OH)_(2)/PEDOT:PSS FECESD for the emerging portable and multifunctional electronics. | He Zhang Fangyuan Sun Ge Cao Dongyan Zhou Guofan Zhang Jiayun Feng Shang Wang Fengyu Su Yanqing Tian Yan Jun Liu Yanhong Tian | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
| 12 | Assessment of the apparent activation energies for gas/solid reactions—carbonate decomposition显示文摘The guidelines for assessing the apparent activation energies of gas/solid reactions have been proposed based on the experimental results from literatures. In CO2 free inlet gas flow, CaCO3 decomposition between 950 and 1250 K with thin sample layer could be controlled by the interracial chemical reaction with apparent activation energy E = (215±10) kJ/mol and E = (200±10)kJ/mol at T = 813 to 1020 K, respectively. With relatively thick sample layer between 793 and 1273 K, the CaCO3 decomposition could be controlled by one or more steps involving self-cooling, nucleation, intrinsic diffusion and heat transfer of gases, and E could vary between 147 andl90 kJ/mol. In CO2 containing inlet gas flow (5%-100% of CO2), E was determined to be varied from 949 to 2897 kJ/mol. For SrCO3 and BaCO3 decompositions controlled by the interfacial chemical reaction, E was (213±15) kJ/mol (1000-1350 K) and (305+15) kJ/mol (1260-1400 K), respectively. | Jianhua Liu and Jiayun ZhangMetallurgical Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，2： | 1 |
| 13 | Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis显示文摘Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by organ dysfunction.Studies on the therapeutic effect and mechanism of immunomodulatory drugs on the sepsis-induced hyperinflammatory or immunosuppression states of various immune cells remain limited.This study aimed to investigate the protective effects and underlying mechanism of artesunate(ART)on the splenic microenvironment of cecal ligation and puncture-induced sepsis model mice using single-cell RNA sequencing(scRNA-seq)and experimental validations.The scRNA-seq analysis revealed that ART inhibited the activation of pro-inflammatory macrophages recruited during sepsis.ART could restore neutrophils’chemotaxis and immune function in the septic spleen.It inhibited the activation of T regulatory cells but promoted the cytotoxic function of natural killer cells during sepsis.ART also promoted the differentiation and activity of splenic B cells in mice with sepsis.These results indicated that ART could alleviate the inflammatory and/or immunosuppressive states of various immune cells involved in sepsis to balance the immune homeostasis within the host.Overall,this study provided a comprehensive investigation of the regulatory effect of ART on the splenic microenvironment in sepsis,thus contributing to the application of ART as adjunctive therapy for the clinical treatment of sepsis. | Jiayun Chen Xueling He Yunmeng Bai Jing Liu Yin Kwan Wong Lulin Xie Qian Zhang Piao Luo Peng Gao Liwei Gu Qiuyan Guo Guangqing Cheng Chen Wang Jigang Wang | 2023 | Journal of Pharmaceutical Analysis2023，13，7： | 1 |
| 14 | Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery 显示文摘 | WEN Weihong LIU Jiayun QIN Weijun | 2007 | Hepatology2007，46，1： | 1 |
| 15 | SIMULATION RESEARCH OF ACTIVE VIBRATION CONTROL FOR ELASTIC MISSILE WITH SWING NOZZLE THRUST VECTOR CONTROL显示文摘Aiming at the deficiencies of notch filters on the aspect of vibration suppression for elastic missile with swing nozzle thrust vector control(SNTVC),an active vibration controller(AVC)is proposed.It is composed of an optimal state feedback controller(OSFC)and an optimal minimal order state observer(OMOSO),which can be respectively designed based on the separation principle.The design rules of these two elements are successively given.Computer simulation results present that AVC can realize strong vibration suppression and good convergence property after disturbing.Moreover,it has simple design and then it is easily implemented in engineering.In addition,the AVC scheme can also resolve the poor system stability to a great extent,which is resulted from the bad static stability of missile body. | XIAODONG LIU YUNJIE WU YONG DENG SEN WANG JIAYUN SONG | 2013 | International Journal of Modeling, Simulation, and Scientific Computing2013，4，4： | 1 |
| 16 | Responses of antioxidant systems and LPO level to benzo (a) pyrene and benzo (k) fluoranthene in the haemolymph of the scallop Chlamys ferrari 显示文摘 | PAN L Q REN Jiayun LIU Jing | 2006 | Environmental Pollu- tion (Barking Essex: 1987)2006，141，3： | 1 |
| 17 | Defect Passivation on Lead-Free CsSnI_(3) Perovskite Nanowires Enables High-Performance Photodetectors with Ultra-High Stability显示文摘In recent years,Pb-free CsSnI_(3) perovskite materials with excellent photoelectric properties as well as low toxicity are attracting much atten-tion in photoelectric devices.However,deep level defects in CsSnI_(3),such as high density of tin vacancies,structural deformation of SnI_(6)−octahedra and oxidation of Sn^(2+)states,are the major challenge to achieve high-performance CsSnI_(3)-based photoelectric devices with good stability.In this work,defect passivation method is adopted to solve the above issues,and the ultra-stable and high-performance CsSnI_(3) nanowires(NWs)photodetectors(PDs)are fabricated via incorporating 1-butyl-2,3-dimethylimidazolium chloride salt(BMIMCl)into perovskites.Through materials analysis and theoretical calculations,BMIM+ions can effectively passivate the Sn-related defects and reduce the dark current of CsSnI_(3) NW PDs.To further reduce the dark current of the devices,the polymethyl methacrylate is introduced,and finally,the dual passivated CsSnI_(3) NWPDs show ultra-high performance with an ultra-low dark current of 2×10^(-11) A,a responsivity of up to 0.237 A W^(−1),a high detectivity of 1.18×10^(12) Jones and a linear dynamic range of 180 dB.Furthermore,the unpackaged devices exhibit ultra-high stability in device performance after 60 days of storage in air(25℃,50% humidity),with the device performance remaining above 90%. | Zheng Gao Hai Zhou Kailian Dong Chen Wang Jiayun Wei Zhe Li Jiashuai Li Yongjie Liu Jiang Zhao Guojia Fang | 2022 | Nano-Micro Letters2022，14，12： | 1 |
| 18 | Bioresponsive cisplatin crosslinked albumin hydrogel served for efficient cancer combination therapy显示文摘Combination therapy is one of the potential strategies for tackling complicated tumor treatments like drug resistance.In this work,we have generated a therapeutic cisplatin-crosslinked albumin hydrogel(BC-Gel)that allows the local release of L-Buthionine-sulfoximine(BSO),cisplatin,and glucose oxidase(GOx)with distinct release kinetics.The BC-Gel with favorable biostimuli degradability and injectability could release therapeutic agents in a programmed manner within the tumor microenvironment(TME).The preferentially released BSO significantly suppressed the glutathione(GSH)-related cisplatin resistance and sensitized the tumor cells to cisplatin by inhibiting theγ-glutamylcysteine synthetase.Meanwhile,cisplatin achieved a sequential release and long-term treatment following the bioresponsive gel degradation under the combined action of chloride ions(Cl−)and proteinase in the body.In addition,the overproduced H_(2)O_(2)of GOx-catalyzed glucose oxidation accelerated the depletion of existed GSH within cells and further weakened the cisplatin resistance,achieving enhanced tumor treatment together with a strong cell-killing effect.The above sequential drug release strategy based on the dual GSH depletion effect breaks the balance of the GSH-mediated redox TME and enhances the sensitivity of A549 cells to cisplatin forcefully,and provides a promising way for temporal control of drug release as well as efficient cancer combination therapy. | An Yan Zherui Zhang Jiamei Gu Xiaoran Ding Yongchen Chen Jingjing Du Shu Wei Hongcheng Sun Jiayun Xu Shuangjiang Yu Junqiu Liu | 2023 | Nano Research2023，16，2： | 1 |
| 19 | Construction of Protein Nanowires through Cucurbit[8]uril‐based Highly Specific Host–Guest Interactions: An Approach to the Assembly of Functional Proteins显示文摘 | Chunxi Hou Jiaxi Li Linlu Zhao Wei Zhang Quan Luo Zeyuan Dong Jiayun Xu Junqiu Liu | 2013 | Angew Chem Int Ed2013，，21： | 1 |
| 20 | Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors显示文摘Signal transduction across lipid bilayers is of profound importance in biological processes.In biological systems,natural enzymes mediate biochemical effects by binding to substrates and facilitating the conversion of external signals into physiological responses.Sequential transmission of biological signals from one enzyme to the next promotes signal transduction with feedforward and feedback mechanisms.Reconstructing these processes in an artificial system provides potential applications and offers a new way to understand fundamental biological processes in depth.However,the design of artificial signal transduction systems regulated by artificial enzyme receptors in a predictable and intelligent manner remains a challenge.Herein,benefiting from the polarity-regulated characteristics of Se-containing compounds with artificial glutathione peroxidase(GPx)activity,we constructed an artificial transmembrane signaling receptor with a Se-containing GPx-like recognition head group,a membrane-anchoring group,and a pre-enzyme end group.The artificial supramolecular signal transduction system containing such signal transduction receptors extends the range of signaling systems based on enzyme regulation,which provides a new way to study natural signal processes in cells and artificially regulated biological processes. | Shengda Liu Yunpeng Xing Tengfei Yan Yijia Li Ruizhen Tian Jinxing Hou Jiayun Xu Tingting Wang Junqiu Liu | 2023 | Nano Research2023，16，1： | 0 |
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