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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Miniature gastrointestinal endoscopy: Now and the future显示文摘Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical practice.One method of achieving this has been to reduce the caliber of endoscopic devices.We propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and discussed.The progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are described.The opportunities presented by these technologies are set out in a clinical context,as are their current limitations.Many of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient acceptability.This must be balanced with the costs of new technologies and recognition of device specific challenges.Perspectives on future application are also considered and the efforts being made to bring new innovations to a clinical platform are outlined.Current devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and screening.Newer technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant. | John J McGoran Mark E McAlindon Prasad G Iyer Eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells 显示文摘 | Lovat PE Corazzari M Goranov B | 2004 | Ann NY Acad Sci2004，1028，6： | 1 |
| 4 | Amyloidosis and the liver显示文摘 | Gillmore J D Lovat L B Hawkins P N | | 0，，1： | 1 |
| 5 | Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis显示文摘 | Anna L Paterson Maria O’Donovan Elena Provenzano Liam J Murray Helen G Coleman Brian T Johnson Damian T McManus Marco Novelli Laurence B Lovat Rebecca C Fitzgerald | 2013 | J Pathol2013，，1： | 1 |
| 6 | Some remarks on nonlocal elliptic and parabolic problems显示文摘 | CHIPOT M LOVAT B | 1997 | Nonlinear Analysis1997，30，7： | 1 |
| 7 | Optical diagnosis of colorectal polyps using convolutional neural networks显示文摘Colonoscopy remains the gold standard investigation for colorectal cancer screening as it offers the opportunity to both detect and resect pre-malignant and neoplastic polyps.Although technologies for image-enhanced endoscopy are widely available,optical diagnosis has not been incorporated into routine clinical practice,mainly due to significant inter-operator variability.In recent years,there has been a growing number of studies demonstrating the potential of convolutional neural networks(CNN)to enhance optical diagnosis of polyps.Data suggest that the use of CNNs might mitigate the inter-operator variability amongst endoscopists,potentially enabling a“resect and discard”or“leave in”strategy to be adopted in real-time.This would have significant financial benefits for healthcare systems,avoid unnecessary polypectomies of non-neoplastic polyps and improve the efficiency of colonoscopy.Here,we review advances in CNN for the optical diagnosis of colorectal polyps,current limitations and future directions. | Rawen Kader Andreas V Hadjinicolaou Fanourios Georgiades Danail Stoyanov Laurence B Lovat | 2021 | World Journal of Gastroenterology2021，27，35： | 1 |
| 8 | P27( kipl ) functional regulation in human cancer: A potential target for therapeutic designs 显示文摘 | Belletti B Nicoloso MS Schiappacassi M Chimienti E Berton S Lovat F | 2005 | Cancer Res Curt Med Chem2005，12，14： | 1 |
| 9 | A microRNAsignature defines chemoresistance in ovarian cancerthrough modulation of angiogenesis显示文摘 | Vecchione A Belletti B Lovat F | 2013 | Proc Natl AcadSci USA2013，0，24： | 1 |
| 10 | High resolution colonoscopy in a bowel cancer screening program improves polyp detection显示文摘AIM:To compare high resolution colonoscopy(Olympus Lucera) with a megapixel high resolution system(Pentax HiLine) as an in-service evaluation.METHODS:Polyp detection rates and measures of performance were collected for 269 colonoscopy procedures.Five colonoscopists conducted the study over a three month period,as part of the United Kingdom bowel cancer screening program.RESULTS:There were no differences in procedure duration(χ2 P = 0.98),caecal intubation rates(χ2 P = 0.67),or depth of sedation(χ2 P = 0.64).Mild discomfort was more common in the Pentax group(χ2 P = 0.036).Adenoma detection rate was significantly higher in the Pentax group(χ2 test for trend P = 0.01).Most of the extra polyps detected were flat or sessile adenomas.CONCLUSION:Megapixel definition colonoscopes improve adenoma detection without compromising other measures of endoscope performance.Increased polyp detection rates may improve future outcomes in bowel cancer screening programs. | Matthew R Banks Rehan Haidry M Adil Butt Lisa Whitley Judith Stein Louise Langmead Stuart L Bloom Austin O' Bichere Sara McCartney Kalpesh Basherdas Manuel Rodriguez-Justo Laurence B Lovat | 2011 | World Journal of Gastroenterology2011，17，38： | 1 |
| 11 | On the asymptotic behaviour of some problems显示文摘 | CHIPOT M LOVAT B | 1999 | Positivity1999，3，1： | 1 |
| 12 | Role of artificial intelligence in the diagnosis of oesophageal neoplasia:2020 an endoscopic odyssey显示文摘The past decade has seen significant advances in endoscopic imaging and optical enhancements to aid early diagnosis.There is still a treatment gap due to the underdiagnosis of lesions of the oesophagus.Computer aided diagnosis may play an important role in the coming years in providing an adjunct to endoscopists in the early detection and diagnosis of early oesophageal cancers,therefore curative endoscopic therapy can be offered.Research in this area of artificial intelligence is expanding and the future looks promising.In this review article we will review current advances in artificial intelligence in the oesophagus and future directions for development. | Mohamed Hussein Juana González-Bueno Puyal Peter Mountney Laurence B Lovat Rehan Haidry | 2020 | World Journal of Gastroenterology2020，26，38： | 0 |
| 13 | Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia显示文摘Barrett’s oesophagus(BO)is a usually indolent condition that occasionally requires endoscopic therapy.Radiofrequency ablation(RFA)is an effective endoscopic treatment for high grade dysplasia(HGD)and intramucosal cancer in BO.It has a good efficacy,durability and safety profile although complications can occur.Here we describe a case of RFA in a patient with high grade dysplasia.Although the response to treatment was initially very good with the development of neosquamous epithelium,the patient very rapidly developed a squamous cell cancer of the oesophagus confirmed on radiology,histology and immunohistochemistry.Sanger sequencing confirmed that the original HGD and the squamous cell cancer(SCC)were derived from separate clonal origins.The report highlights the fact that SCC of the oesophagus has been noted after endoscopic ablation for BO previously and suggest that ablation of BO may encourage the clonal expansion of cells carrying carcinogenic mutations once a dominant clonal population has been eradicated. | Sebastian S Zeki Rehan Haidry Manuel Justo-Rodriguez Laurence B Lovat Nicholas A Wright Stuart A McDonald | 2014 | World Journal of Gastroenterology2014，20，15： | 0 |
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