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| 1 | Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis显示文摘Recent studies have revealed that osthole,an active constituent isolated from the fruit of Cnidium monnieri(L.) Cusson,a traditional Chinese medicine,possesses anticancer activity.However,its effect on breast cancer cells so far has not been elucidated clearly.In the present study,we evaluated the effects of osthole on the proliferation,cell cycle and apoptosis of human breast cancer cells MDA-MB 435.We demonstrated that osthole is effective in inhibiting the proliferation of MDA-MB 435 cells,The mitochondrion-mediated apoptotic pathway was involved in apoptosis induced by osthole,as indicated by activation of caspase-9 and caspase-3 followed by PARP degradation.The mechanism underlying its effect on the induction of G1 phase arrest was due to the up-regulation of p53 and p21 and down-regulation of Cdk2 and cyclin D1 expression.Were observed taken together,these findings suggest that the anticancer efficacy of osthole is mediated via induction of cell cycle arrest and apoptosis in human breast cancer cells and osthole may be a potential chemotherapeutic agent against human breast cancer. | Lintao Wang Yanyan Peng Kaikai Shi Haixiao Wang Jianlei Lu Yanli Li Changyan Ma | 2015 | The Journal of Biomedical Research2015，29，2： | 12 |
| 2 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 3 | Structure characteristics and microwave dielectric properties of Pr_(2)(Zr_(1-x)Ti_(x))_(3)(MoO_(4))_(9) solid solution ceramic with a stable temperature coefficient显示文摘Pr_(2)(Zr_(1−x)Ti_(x))_(3)(MoO_(4))_(9)(x=0.1-1.0)ceramics were prepared via a conventional solid-state method,the dependence of crystal structure and bond characteristics on microwave dielectric properties was investigated systemically.The X-ray diffraction patterns indicated that the single-phase Pr_(2)Zr_(3)(MoO_(4))_(9)structure was formed in all the specimens.As the Ti^(4+)content increased,the lattice volume gradually decreased,which was ascribed to the fact that the ionic radius of Ti^(4+)was smaller than that of Zr^(4+).Notably,outstanding microwave dielectric properties withεr of 10.73-16.35,Q·f values of 80,696-18,726 GHz and minorτ_(f) values−14.1-−2.6 ppm/℃were achieved in Pr_(2)(Zr_(1−x)Ti_(x))_(3)(MoO_(4))_(9)ceramics.Theε_(r) increased with the rising x values,which was associated with the increase ofα/Vm values.The decreasing Q·f was affected by the decline of lattice energy of[Zr/TiO_(6)]octahedral.Theτf value was dominated by[Zr/TiO_(6)]octahedral distortion,Mo-O bond energy,bond strength and B-site bond valence.Furthermore,infrared reflection spectra suggested that the properties were mainly caused by the absorption of phonon,and the dielectric loss could be further reduced by optimizing the experimental process. | Huanrong Tian Jinjie Zheng Lintao Liu Haitao Wu Hideo Kimura Yizhong Lu Zhenxing Yue | 2022 | Journal of Materials Science & Technology2022，，21： | 3 |
| 4 | Mining Representative Subset Based on Fuzzy Clustering显示文摘Two new concepts-fuzzy mutuality and average fuzzy entropy are presented. Then based on these concepts,a new algo-rithm-RSMA(representative subset mining algorithm) is pro-posed,which can abstract representative subset from massive data. To accelerate the speed of producing representative subset,an improved algorithm-ARSMA(accelerated representative subset mining algorithm) is advanced,which adopt combining putting forward with backward strategies. In this way,the performance of the algorithm is improved. Finally we make experiments on real datasets and evaluate the representative subset. The experiment shows that ARSMA algorithm is more excellent than RandomPick algorithm either on effectiveness or efficiency. | ZHOU Hongfang FENG Boqin LU Lintao | 2007 | Wuhan University Journal of Natural Sciences2007，12，5： | 1 |
| 5 | Security Analysis of Secret Image Sharing显示文摘Differently from pure data encryption,secret image sharing(SIS)mainly focuses on image protection through generating a secret image into n shadow images(shares)distributed to n associated participants.The secret image can be reconstructed by collecting sufficient shadow images.In recent years,many SIS schemes are proposed,among which Shamir’s polynomial-based SIS scheme and visual secret sharing(VSS)also called visual cryptography scheme(VCS)are the primary branches.However,as the basic research issues,the security analysis and security level classification of SIS are rarely discussed.In this paper,based on the study of image feature and typical SIS schemes,four security levels are classified as well as the security of typical SIS schemes are analyzed.Furthermore,experiments are conducted to evaluate the efficiency of our analysis by employing illustrations and evaluation metrics. | Xuehu Yan Yuliang Lu Lintao Liu Song Wan Wanmeng Ding Hanlin Liu | 2017 | 国际计算机前沿大会会议论文集2017，，1： | 0 |
| 6 | From Barren To Flourishing显示文摘A county in north China shakes off poverty by tapping into its potential There’s a well-known saying in Fuping County in Baoding,north China’s Hebei Province,'Ninety percent of Fuping’s land is mountains,5 percent water and 5 percent arable land.' It is an apt way of describing the mountainous region.The total amount of arable land in the county is 219,000 mu(14,600 hectares),far from enough for the county’s population | Yu Lintao Lu Yan | 2017 | Beijing Review2017，60，42： | 0 |
| 7 | Clarity Corresponding to Contrast in Visual Cryptography显示文摘The visual quality of the recovered secret image is usually evaluated by contrast in visual cryptography (VC). Precisely, the reconstructed secret image can be recognized as the original secret image when contrast is greater than zero. It is important for the user to know the clarity of the revealed secret image corresponding to different contrast values. In this paper, the clarity corresponding to contrast is investigated through conducting subjective evaluation scores and objective evaluation indexes, which can be extended to general applications. | Xuehu Yan Yuliang Lu Hui Huang Lintao Liu Song Wan | 2016 | 国际计算机前沿大会会议论文集2016，，1： | 0 |
| 8 | Rituximab in Combination with CHOP, an Effective and Well-tolerated Salvage Regimen for Diffuse Large B-Cell Lymphoma显示文摘OBJECTIVE To evaluate the clinical effect of the R-CHOP regimen (rituximab in combination with cyclophosphamide, epirubicin, vincristine and prednisone) in treating refractory or relapsed diffuse large B-cell lymphoma (DLBCL), as a salvage therapy for DLBCL. METHODS Eighteen patients with refractory or relapsed DLBCL who were treated with the R-CHOP regimen from 2001 to 2006 in hospitals in Jilin Province were analyzed retrospectively. The response rate, change of serum lactate dehydrogenase (LDH), time to progression (TTP) and toxicity were observed. RESULTS The R-CHOP regimen can achieve a higher response rate, decrease serum LDH to a larger extent and obtain longer TTP than a con- ventional secondary regimen. The main adverse effects were similar to con- ventional chemotherapy. CONCLUSION The R-CHOP regimen is one of the most effective sec- ondary therapies for DLBCL. | Yong Guan Zhenxia Lu Butong Sun Lintao Bi Pengyu Zhang | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 0 |
| 9 | Identification of Factors Influencing Radiotherapy Errors during Radiation Treatments Using Quality Management Tools显示文摘Objective:To investigate factors that may cause radiotherapy errors during radiation treatments using quality management tools.Methods:The Delphi method was used to sort out the factors that cause radiotherapy errors which were then clasified by the Kaiser model.Results:In the first round of brainstorming,33 types of influencing factors were put forward,which were further reduced to 19 through the Delphi method.The recruited factors were,then,divided into four types by the Kaiser model,radiotherapyspecific factors with the mean weight of 49.49%,patient-related factors with the mean weight of 42.27%,therapist-related factors with the mean weight of 35.64% and hardware-related factors with the mean weight of 19.72%.Conclusion:Delphi plus Kaiser may be a promising method for predicting factors that may cause radiotherapy errors,which is worthy of further research. | Li Lintao Lucia Clara Orlandini Wang Xianliang Fan Ming Lu Shun Kang Shengwei Zhang Dekang Heng Li | 2022 | 肿瘤预防与治疗2022，35，1： | 0 |
| 10 | A Novel Progressive Secret Image Sharing Method with Better Robustness显示文摘Secret image sharing (SIS) can be utilized to protect a secret image during transmit in the public channels. However, classic SIS schemes, e.g., visual secret sharing (VSS) and polynomial-based scheme, are not suitable for progressive encryption of greyscale images in noisy environment, since they will result in different problems, such as lossy recovery, pixel expansion, complex computation, 'All-or-Nothing'and robustness. In this paper, a novel progressive secret sharing (PSS)method based on the linear congruence equation, namely LCPSS, is proposed to solve these problems. LCPSS is simple designed and easy to realize, but naturally has many great properties, e.g., (k, n) threshold,progressive recovery, lossless recovery, lack of robustness and simple computation. | Lintao Liu Yuliang Lu Xuehu Yan Wanmeng Ding | 2017 | 国际计算机前沿大会会议论文集2017，，2： | 0 |
| 11 | Identification and genetic characterization of bovine hepacivirus in China:A large scale epidemiological study显示文摘Bovine hepacivirus(BovHepV)is a novel virus that was recently discovered in Ghana and Germany in 2015.Until now,this virus has been identified in cattle population worldwide and is classified into subtypes A-G.To fully understand the epidemic situation and genetic characteristic of BovHepV in China,a total of 612 cattle serum samples were collected from 20 farms in seven provinces and municipality in China between 2018 and 2020 and were tested for the presence of BovHepV RNA via semi-nested PCR.The results demonstrated that 49(8.0%)samples were BovHepV RNA-positive.It is noted that BovHepV infection in yak was confirmed for the first time.BovHepV was detected in all the seven provinces,with the positive rate ranging from 3.1%to 13.3%,which indicates a wide geographical distribution pattern of BovHepV in China.Sequencing results revealed that 5'UTR of the 49 field BovHepV strains have a nucleotide similarity of 96.3%-100%between each other and 93.9%-100%with previously reported BovHepV strains.In addition,genetic analysis identified five critical nucleotide sites in 5'UTR to distinguish different subtypes,which was further verified by genomic sequencing and nucleotide similarity analysis.All the 49 Chinese field BovHepV strains were classified into subtype G and this subtype is only determined in cattle in China currently.This study will provide insights for us to better understand the epidemiology and genetic diversity of BovHepV. | Gang Lu Chaoxi Chen Ran Shao Juan Zhang Jinghao Li Siqi Cai Lintao Zhong Zhiying Lai Jiajun Ou Xin Yin Guihong Zhang Shoujun Li | 2022 | Virologica Sinica2022，37，2： | 0 |
| 12 | Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer显示文摘Sonodynamic therapy(SDT)has aroused considerable momentum in cancer therapy due to its abilities of deep penetration,low toxicity,and noninvasion,while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT effect.Here,we developed a 4T1 cancer cell-macrophage hybrid membrane(HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor(HPPH)-loaded albumin nanoparticles(PHNPs).The experimental results proved that the HM-coated biomimetic NPs(PHNPs@HM)could express the characteristic membrane proteins of both cancer cells and macrophages,remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune escaping.Meanwhile,as a novel sonosensitizer,HPPH could generate amount of reactive oxygen species(ROS)under ultrasound(US)irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell apoptosis.This study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency. | Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu Lanlan Liu Ze Chen Hui Ran Qingxia Shi Hong Pan Aiqing Ma Lintao Cai | 2022 | Nano Research2022，15，5： | 0 |
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