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| 1 | Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis显示文摘Recent studies have revealed that osthole,an active constituent isolated from the fruit of Cnidium monnieri(L.) Cusson,a traditional Chinese medicine,possesses anticancer activity.However,its effect on breast cancer cells so far has not been elucidated clearly.In the present study,we evaluated the effects of osthole on the proliferation,cell cycle and apoptosis of human breast cancer cells MDA-MB 435.We demonstrated that osthole is effective in inhibiting the proliferation of MDA-MB 435 cells,The mitochondrion-mediated apoptotic pathway was involved in apoptosis induced by osthole,as indicated by activation of caspase-9 and caspase-3 followed by PARP degradation.The mechanism underlying its effect on the induction of G1 phase arrest was due to the up-regulation of p53 and p21 and down-regulation of Cdk2 and cyclin D1 expression.Were observed taken together,these findings suggest that the anticancer efficacy of osthole is mediated via induction of cell cycle arrest and apoptosis in human breast cancer cells and osthole may be a potential chemotherapeutic agent against human breast cancer. | Lintao Wang Yanyan Peng Kaikai Shi Haixiao Wang Jianlei Lu Yanli Li Changyan Ma | 2015 | The Journal of Biomedical Research2015，29，2： | 12 |
| 2 | Design and test of soft-pot-tray automatic embedding system for light-economical pot seedling nursery machine显示文摘Most of the commercially-available pot seedling nursery machines are incompatible with soft-pot-trays and are labor-intensive and low in productivity.A soft-pot-tray automatic embedding system was developed in this study to achieve automatic embedding of the soft pot tray into the hard tray following sowing and covering with soil.A control system was constructed using the Arduino program development environment.An embedded-hard-tray automatic lowering mechanism and conveyor-belt-based pot-tray embedding system were designed.Dynamics analysis was conducted to derive an equation to describe the embedding process of the soft pot tray into the embedded hard tray.A prototype of the soft-pot-tray automatic embedding system was manufactured and tested.The analytical equation suggested that a minimum linear velocity of 0.86 m/s was required for a complete embedding process.The experimental results showed that the embedded-hard-tray automatic lowering mechanism was reliable and stable as the tray placement success rate was greater than 99%.The successful tray embedding rate was 100%and the seed exposure rate was less than 1%with a linear velocity of the conveyor belt of 0.92 m/s.The experiment findings agreed well with the analytical results.The proposed soft-pot-tray automatic embedding system satisfied the technical specifications for a light-economical pot seedling nursery machine. | Lintao Chen Xu Ma Cong Wang Hongwei Li Zehua Li Xueshen Chen Tao Chen | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 4 |
| 3 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 4 | The Distribution of Petroleum Resources and Characteristics of Main Petroliferous Basins along the Silk Road Economic Belt and the 21st-Century Maritime Silk Road显示文摘The Silk Road Economic Belt and the 21st-century Maritime Silk Road Initiative,abbreviated as the Belt and Road Initiative,is a primary development strategy of China's future international cooperation.Especially,the energy resource cooperation,including oil and gas resources cooperation,is an important part of this initiative.The Belt and Road has undergone complicated geological evolution,and contains abundant mineral resources such as oil,gas,coal,uranium,iron,copper,gold and manganese ore resources.Among these,Africa holds 7.8% of the world's total proven oil reserves.The oil and gas resources in Africa are relatively concentrated,with an overall low exploration degree and small consumption demand.Nigeria and Libya contain the most abundant oil resources in Africa,accounting for 2.2%and 2.9%of the world's total reserves,respectively.Nigeria and Algeria hold the richest natural gas resources in Africa,occupying 2.8%and 2.4%of the world's total reserves,respectively.Africa's oil and gas resources are mainly concentrated in Egypt,Sultan and Western Sahara regions in the northern Africa,and the Gulf of Guinea,Niger River and Congo River area in the western Africa.The Russia-Central Asia area holds rich petroleum resources in Russia,Kazakhstan,Turkmenistan and Uzbekistan.The potential oil and gas areas include the West Siberia Basin,East Siberia Basin and sea continental shelf in Russia,the northern and central Caspian Basin in Kazakhstan,the right bank of the Amu-Darya Basin,the East Karakum uplift and the South Caspian Basin in Turkmenistan,and the Amu-Daria Basin,Fergana Basin,Afghan-Tajik Basin and North Ustyurt Basin in Uzbekistan.The Middle East oil and gas resources are mainly distributed in the Zagros foreland basin and Arabian continental margin basin,and the main oil-producing countries include Saudi Arabia,Iran and Iraq.The Asia Pacific region is a new oil and gas consumption center,with rapid growth of oil and gas demand.In 2012,this region consumed about 33.6%of the world's total oil consumption and 18.9%of the world's total natural gas consumption,which has been ranked the world's largest oil and gas consumption center.The oil and gas resources are concentrated in China,Indosinian,Malaysia,Australia and India.The abundant European proven crude oil reserves are in Norway,Britain and Denmark and also rich natural gas resources in Norway,Holland and Britain.Norway and Britain contain about 77.5%of European proven oil reserves,which accounts for only 0.9%of the world's proven reserves.The Europe includes main petroliferous basins of the Voring Basin,Anglo-Dutch Basin,Northwest German Basin,Northeast German-Polish Basin and Carpathian Basin.According to the analysis of source rocks,reservoir rocks,cap rocks and traps for the main petroliferous basins,the potential oil and gas prospecting targets in the Belt and Road are mainly the Zagros Basin and Arabic Platform in the Middle East,the East Barents Sea Basin and the East Siberia Basin in Russia-Central Asia,the Niger Delta Basin,East African rift system and the Australia Northwest Shelf.With the development of oil and gas theory and exploration technology,unconventional petroleum resources will play an increasingly important role in oil and gas industry. | HAO Qingqing ZUO Yinhui LI Lintao CHEN Weijun YI Junjie WU Lei | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 3 |
| 5 | Study on the surface cracking in hot-rolled plates of Fe-23Mn-2Al-V austenitic steel显示文摘The study introduces the chemical composition,mechanical properties,physical properties and production processes of the Fe-23Mn-2Al-V austenitic steel.Investigations were made into the formation of cracks in the hot-rolled Fe-23Mn-2Al-V steel plates,with optical microscopy (OM),scanning electron microscopy (SEM) and energy dispersive spectrum (EDS).The results have shown that intergranular oxidation in the reheating furnace is the main cause of the cracks on the surface of the hot-rolled steel plates.The surface cracking can be largely avoided by controlling the remaining oxygen content in the reheating furnace and improving continuous casting (CC) processes to increase the thickness of fine equiaxed grain layer of the steel slabs. | LIAO Hongjun MAO Zhengdong WANG Lintao ZHU Jun LI Yuan ZHANG Heng | 2011 | Baosteel Technical Research2011，5，1： | 2 |
| 6 | Temperature field analysis and its application in hot continuous rolling of Inconel 718 superalloy显示文摘A coupled thermo-mechanical model containing metal flow and temperature field for calculating temperature variation has been developed on fourteen-pass hot continu-ous rolling of round rod for Inconel 718 alloy using 3D elastic-plastic finite element method(FEM).The temperature of characteristic analysis points in the intermedi-ate cross-section of the workpiece has been simulated at initial temperature ranging from 960 to 1000 °C and initial velocity in range of 0.15-0.55 m·s-1.Based on fi-nite element analysis and microstructural observation in cylindrical hot compression experiments,the appropriate hot continuous rolling technologies have been designed for rod products with different diameters.For a real rolling practice,the simulated surface temperature was examined and is in good agreement with the measured one. | Fengli SUI Liqing CHEN Xianghua LIU Lintao WANG Wei LI | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，2： | 2 |
| 7 | Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus显示文摘Dear Editor,Porcine deltacoronavirus(PDCoV)is a novel discovered swine enteric coronavirus which can cause diarrhea and dehydration in pigs,particularly in neonatal piglets(Jung et al.,2016).At present,there are no commercial vaccines available for PDCo V.To control PDCoV transmission and perform antiviral therapy efficiently,a rapid and accurate diagnostic method to detect PDCo V is needed. | Haojie Ren Xiaoguang Yan Lintao Liu Yixuan Zhang Qianqian Li Xiumei Li Hui Hu | 2022 | Virologica Sinica2022，37，2： | 1 |
| 8 | Petroleum Distribution Characteristics of the Americas and the Exploration Prospect Analysis显示文摘The world's present demand for oil and gas is still in a rapid growth period, and traditional oil and gas resources account for more than 60% of the global oil and gas supply. The Americas is the world's second largest production and consumption center of liquid fuel, and is also the world's largest natural gas producer. In 2016, the Americas had 85.3 billion tons of proven oil reserves and 18.7 trillion m^3 of proven natural gas reserves, which account for 35.4% and 10.0% of world's total reserves, respectively. It produced 1267.1 Mt of oil and 1125.4 billion m^3 of natural gas, which account for 28.9% and 31.7% of the world's total production, respectively. The crude oil and natural gas reserves are mainly distributed in the U.S., Canada and Venezuela. The U.S. is the earliest and most successful country in shale gas exploration and development, and its shale gas is concentrated in the southern, central and eastern U.S., including the Marcellcus shale, Barnett shale, Eagle Ford shale, Bakken shale, Fayettevis shale, Haynsvill shale, Woodford shale and Monterey/Santos shale. The potential oil and gas resources in the Americas are mainly concentrated in the anticline and stratigraphic traps in the MiddleUpper Jurassic slope deposition of the North Slope Basin, the Paleozoic Madsion group dolomite and limestone in the Williston Basin, dominant stratigraphic traps and few structural traps in the Western Canada Sedimentary Basin, the Eocene structural-stratigraphic hydrocarbon combination, structuralunconformity traps and structural hydrocarbon combination, and the Upper Miocene stratigraphicstructural hydrocarbon combination in the Maracaibo Basin of Venezuela, the stratigraphic-structural traps and fault horst, tilting faulted blocks and anticlines related to subsalt structure and basement activity in the Campos Basin, the subsalt central low-uplift belt and supra-salt central low-uplift belt in the Santos Basin of Brazil, and the structural-stratigraphic traps in the Neuquen Basin of Argentina. In addition, the breakthrough of seismic subsalt imaging technology makes the subsalt deepwater sea area of eastern Barzil an important oil and gas potential area. | HAO Qingqing LI Lintao ZUO Yinhui CHEN Weijun WU Lei YI Junjie | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 1 |
| 9 | Physical layer security enhanced system with under-sampling spectrum-sparse signals显示文摘The ubiquity of wireless communication systems has resulted in extensive concern regarding their security issues.A practical secure transmission scheme based on under-sampling spectrum-sparse signals is designed.Secure transmission is initialized as the intended receiver transmits a pilot signal for the transmitter,to perform channel sounding and clock synchronization according to the channel reciprocal principle.Then,sampling clock offset compensation and precoding method based on channel state information(CSI)can be conducted at the transmitter's end.Because the intended receiver adopts an under-sampling method based on active aliasing which depends very sensitively on accurate sampling clock and CSI,the eavesdroppers can hardly intercept the signal.Closed form expression of symbol error rate(SER)at the intended receiver's end and secrecy capacity in fading wiretap channel has been derived.Numerical evaluation and simulations are carried out to validate the effectiveness of the proposed strategy. | Li Lintao Liu Yuanan | 2019 | The Journal of China Universities of Posts and Telecommunications2019，26，4： | 1 |
| 10 | Path Planning and Navigation of Oceanic Autonomous Sailboats and Vessels: A Survey显示文摘Oceanic autonomous surface vehicles(ASVs) are one kind of autonomous marine robots that have advantages of energy saving and is flexible to use. Nowadays, ASVs are playing an important role in marine science, maritime industry, and national defense. It could improve the efficiency of oceanic data collection, ensure marine transportation safety, and protect national security. One of the core challenges for ASVs is how to plan a safe navigation autonomously under the complicated ocean environment. Based on the type of marine vehicles, ASVs could be divided into two categories: autonomous sailboats and autonomous vessels. In this article, we review the challenges and related solutions of ASVs' autonomous navigation, including modeling analysis, path planning and implementation. Finally, we make a summary of all of those in four tables and discuss about the future research directions. | JING Wei LIU Chao LI Ting RAHMAN A B M Mohaimenur XIAN Lintao WANG Xi WANG Yu GUO Zhongwen BRENDA Gumede TENDAI Wachi Kelvin | 2020 | Journal of Ocean University of China2020，19，3： | 1 |
| 11 | Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab显示文摘Despite the successful use of the humanized monoclonal antibody trastuzumab(Herceptin)in the clinical treatment of human epidermal growth factor receptor 2(HER2)-overexpressing breast cancer,the frequently occurring drug resistance remains to be overcome.The regulatory mechanisms of trastuzumab-elicited immune response in the tumor microenvironment remain largely uncharacterized.Here,we found that the nonclassical histocompatibility antigen HLA-G desensitizes breast cancer cells to trastuzumab by binding to the natural killer(NK)cell receptor KIR2DL4.Unless engaged by HLA-G,KIR2DL4 promotes antibody-dependent cell-mediated cytotoxicity and forms a regulatory circuit with the interferon-γ(IFN-γ)production pathway,in which IFN-γ upregulates KIR2DL4 via JAK2/STAT1 signaling,and then KIR2DL4 synergizes with the Fey receptor to increase IFN-γ secretion by NK cells.Trastuzumab treatment of neoplastic and NK cells leads to aberrant cytokine production characterized by excessive tumor growth factor-β(TGF-β)and IFN-γ,which subsequently reinforce HLA-G/KIR2DL4 signaling.In addition,TGF-β and IFN-γ impair the cytotoxicity of NK cells by upregulating PD-L1 on tumor cells and PD-1 on NK cells.Blockade of HLA-G/KIR2DL4 signaling improved the vulnerability of HER2-positive breast cancer to trastuzumab treatment in vivo.These findings provide novel insights into the mechanisms underlying trastuzumab resistance and demonstrate the applicability of combined HLA-G and PD-L1/PD-1 targeting in the treatment of trastuzumab-resistant breast cancer. | Guoxu Zheng Zhangyan Guo Weimiao Li Wenjin Xi Baile Zuo Rui Zhang Weihong Wen An-Gang Yang Lintao Jia | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 12 | AIDA通过内质网相关的蛋白质降解途径选择性下调脂肪合成途径的代谢酶从而减缓肠道脂肪吸收并防止肥胖发生显示文摘文章简介肠道对膳食脂肪吸收的效率是个人是否易患肥胖的主要决定因素之一。然而,目前人们还不清楚脂肪吸收是如何受调控并导致肥胖的。本研究表明,抑制内质网相关的蛋白质降解途径会提高甘油三酯合成途径的数个代谢酶的水平,并促进小肠对脂肪的吸收。 | 罗辉 姜鸣 Guili Lian Qing Liu Meng Shi Terytty Yang Li Lintao Song Jing Ye Ying He Luming Yao Cixiong Zhang Zhi-Zhong Lin Chen-Song Zhang Tong-Jin Zhao Wei-Ping Jia Peng Li 林舒勇 林圣彩 | 2019 | 科学新闻2019，0，2： | 1 |
| 13 | Recent Advances,Problems and Outlooks in Rapeseed(Brassica napus L.)Breeding in China显示文摘As a big rapeseed(Brassica napus L.) producing and consuming country, China provides more and more rapeseed oil year by year. With the development of demand for rapeseed and import of edible oil, rapeseed breeding and production is facing a great challenge. New situation has proposed higher requirements to yield, oil quality and safety, etc. In the review, some aspects about rapeseed breeding in China were reported, including breeding of high-oil content rapeseed, breeding of extremely early-maturing rapeseed, development of mechanization and development of chemical emasculation. Some prospects and expectations were also proposed. | Liang CHAI Haojie Li Benchuan ZHENG Jinfang ZHANG Cheng CUI Jun JIANG Bi ZHANG Liangcai JIANG Lintao WU Jiang KE | 2017 | Agricultural Science & Technology2017，18，12： | 0 |
| 14 | Probability stopping criterion for analog decoding of LDPC codes显示文摘To detect uncorrectable frames and terminate the decoding procedure early, a probability stopping criterion for iterative analog decoding of low density parity check(LDPC) codes is proposed in this paper. By using probabilities of satisfied checks to detect uncorrectable frames and terminate decoding, the proposed criterion could be applied to analog decoders without much structure modifications. Simulation results show that the proposed criterion can reduce the average number of iterations and achieve a better balance in bit error ratio(BER) performance and decoding complexity than other stopping criteria using extrinsic information. | Zheng Hao Zhang Shuyi Li Lintao Gao Yuan Shao Liwei | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，1： | 0 |
| 15 | Experimental Studies of Radionuclide Imaging of Receptor: CD-IRES2-hSSTR Transgenes显示文摘 | Guoquan Li Jing Wang Lintao Jia Zhe Wang Rui Zhang Angang Yang Jinglan Deng | 2006 | Journal of US-China Medical Science2006，3，3： | 0 |
| 16 | Awakening the oxygen evolution activity of MoS_(2) by oxophilic-metal induced surface reorganization engineering显示文摘Although molybdenum disulfide (MoS_(2))-based materials are generally known as active electrocatalysts for the hydrogen evolution reaction (HER), the inert performance for the oxygen evolution reaction (OER) seriously limits their wide applications in alkaline electrolyzers due to there exists too strong metal-sulfur (M−S) bond in MoS_(2). Herein, by means of surface reorganization engineering of bimetal Al, Co-doped MoS_(2) (devoted as AlCo_(3)-MoS_(2)) through in situ substituting partial oxidation, we successfully significantly activate the OER activity of MoS_(2), which affords a considerably low overpotential of 323 mV at −30 mA cm^(−2), far lower than those of MoS_(2), Al-MoS_(2) and Co-MoS_(2) catalysts. Essentially, the AlCo_(3)-MoS_(2) substrate produces lots of M−O (M=Al, Co and Mo) species with oxygen vacancies, which trigger the surface self-reconstruction of pre-catalysts and simultaneously boost the electrocatalytic OER activity. Moreover, benefiting from the moderate M−O species formed on the surface, the redistribution of surface electron states is induced, thus optimizing the adsorption of OH* and OOH* intermediates on metal oxyhydroxides and awakening the OER activity of MoS_(2). | Xueqin Mu Yang Zhu Xiangyao Gu Shipeng Dai Qixin Mao Lintao Bao Wenxuan Li Suli Liu Jianchun Bao Shichun Mu | 2021 | Journal of Energy Chemistry2021，30，11： | 0 |
| 17 | ULK1/2所构成的信号节点除控制细胞自噬外还控制葡萄糖代谢通路显示文摘在细胞感受到环境中营养物质和生长因子的提供量发生改变后,代谢通路的重编程对于维持此时胞内的稳态是非常重要的过程。ULK1和ULK2是传递外界应激信号至自噬发生的重要整合因子。 | Terytty Yang Li Yu Sun Yu Liang Qing Liu Yuzhe Shi Chen-Song Zhang Cixiong Zhang Lintao Song Pu Zhang Xianzhong Zhang Xiaotong Li Tao Chen Hui-Ying Huang Xiadi He Yi Wang Yu-Qing Wu Shaoxuan Chen Ming Jiang Canhe Chen Changchuan Xie James Y.Yang Yan Lin Shimin Zhao Zhiyun Ye Shu-Yong Lin Daniel Tsun-yee Chiu 林圣彩 | 2017 | 科学新闻2017，19，4： | 0 |
| 18 | Chevrel phase:A review of its crystal structure and electrochemical properties显示文摘Chevrel phase compounds have attracted increasing attention as electrochemical energy storage materials and electro-catalysts.Benefiting from their unique crystal structure,Chevrel phase compounds can not only function as the host structures for reversible intercalation of a broad range of cations,but also exhibit high catalytic activity in electrochemical reduction reactions.Here we provide an overview of recent progress in the development of Chevrel phase materials including new understanding of structural features,synthetic methods,and electro-chemical properties.A brief conclusion and perspectives on the future development of Chevrel phase materials are also provided. | Meng Liu Guocheng Lv Tianming Liu Hao Liu Lingchang Kong Lintao Tian Wenxiu Rao Yuxin Li Libing Liao Juchen Guo | 2023 | Progress in Natural Science:Materials International2023，33，1： | 0 |
| 19 | Optical characteristics and environmental pollutants detection of porous silicon microcavities显示文摘Porous silicon microcavities (PSM) optical crystals consisting of a Fabry-Perot microcavity embedded between two distributed Bragg reflectors have been fabricated by electrochemical etching. Scanning electron microscopy (SEM) clearly depicted their physical sandwich construction. The optical feature of the PSM structure was tuned by varying the anodization parameters. Through proper thermal oxidation and surface chemical modifications, the resulting structures were employed as optical sensors for the detection of environmental pollutants including volatile organic vapors (i.e. acetonitrile, toluene, cyclohexane, chloroform, acetone and ethanol) and interior decoration gases (i.e. toluene, ammonia and formaldehyde). Fourier transform infrared spectroscopy (FTIR) spectra confirmed the effective thermal annealing and surface modification chemistry, and the sensing process was accompanied by recording the modified structures' optical responses when exposed to target analytes. The PSM optical sensors showed good stability, sensitivity and selectivity, implying promising applications in gas sensing and en- vironmental monitoring. | HUANG JianFeng, LI Sha, CHEN QingWei & CAI LinTao CAS Key Laboratory of Health Informatics Shenzhen Key Laboratory of Cancer Nanotechnology Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China | 2011 | Science China Chemistry2011，54，8： | 0 |
| 20 | Deciphering the chemical profile and pharmacological mechanism of Jinlingzi powder(金铃子散)against bile reflux gastritis using ultra-high performance liquid chromatography coupled with Q exactive focus mass spectrometry,network pharmacology,and molecular docking显示文摘OBJECTIVE:To elucidate the chemical profile and the pharmacological mechanism by which Jinlingzi powder(金铃子散,JLZP)treats bile reflux gastritis(BRG).METHODS:A BRG model was established in rats by oral administration of the model solution.JLZP was orally administered for 35 d.Residual gastric rate and tumor necrosis factor(TNF)-α,interleukin(IL)-6,and gastrin levels in the serum were measured,and stomach tissues were collected for histopathological analysis.We used ultra-high performance liquid chromatography coupled with Q Exactive Focus mass spectrometry to identify the chemical ingredients in JLZP.Then,protein-protein interaction and herb-compound-target networks were constructed to screen potential bioactive compounds and targets.Kyoto Encyclopedia of Genes and Genomes pathway analysis was then performed to elucidate the pathway involved in the JLZP-mediated treatment of BRG.After constructing the core compound-target-pathway interaction network,molecular docking was performed to study the binding free energy of core bioactive compounds and two candidate targets[RAC-alpha serine/threonine-protein kinase(AKT1)and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(PIK3CA)].RESULTS:JLZP extracts significantly promoted gastric emptying,regulating the release of cytokines(TNF-αand IL-6)and improving gastrin secretion and mucosal repair.Fifty-six compounds were tentatively characterized in JLZP.Moreover,the network pharmacology and molecular docking results showed that alkaloids and flavonoids might be the bioactive compounds in JLZP that treat BRG.JLZP might improve mucosal repair during BRG progression by modulating the phosphatidylinositol-4,5-bisphosphate 3-kinase-protein kinase B,hypoxia inducible factor-1,mitogen-activated protein kinase,forkhead box O,TNF,and IL-17 signaling pathways.CONCLUSIONS:We elucidated the chemical constituents and the pharmacological mechanism of JLZP in treating BRG and provided a basis for clinical application. | REN Hui ZHAO Lintao GAO Kai YANG Yuanyuan CUI Xiaomin HU Jing CHEN Zhiyong LI Ye | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
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