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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 3 | SHRIMP ages of detrital zircons from the Changcheng System in the Ming Tombs area,Beijing:Constraints on the protolith nature and maximum depositional age of the Mesoproterozoic cover of the North China Craton显示文摘The Mesoproterozoic Changcheng System is widely distributed in the North China Craton. Determining its time of deposition and sources is important to understand the Precambrian crustal evolution of the North China Craton. This paper suggests age distribution patterns for detrital zircons from clastic sediments of the Changcheng System in the Ming Tombs area, Beijing. Samples of feldspar-bearing sandstone (CHc-2) and pure sandstone (CHc-9) were collected from the Changzhougou Formation, which constitutes the basal part of the Changcheng System. Detrital zircons show an age range from 2.35 to 2.60 Ga. However, sample CHc-9 in the upper Changzhougou Formation also contains some zircons with ages of 1.9-1.8 Ga and 2.3-2.1 Ga. The age patterns lead to the following conclusions: (1) Most of the detrital material came from a source area composed predominantly of ~2.5 Ga continental crust of the North China Craton; (2) 1.9-1.8 Ga reflects the age record of Palaeoproterozoic continent-continent collisional event in the North China Craton; and (3) the oldest age for deposition of the Changcheng System is 1.8 Ga. | WAN Yusheng1,2, ZHANG Qiaoda1 & SONG Tianrui1 1. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 2. Beijing SHRIMP Laboratory, Beijing 100037, China Correspondence should be addressed to Wan Yusheng (e-mail: wanyusheng@cags.net.cn) | 2003 | Chinese Science Bulletin2003，48，22： | 60 |
| 4 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 5 | Polycyclic aromatic hydrocarbons in soils of Beijing and Tianjin region: Vertical distribution, correlation with TOC and transport mechanism显示文摘The contents and distribution of 20 polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic hydrocarbons (HAHs) were investigated in 16 soil profiles of Beijing and Tianjin region. Transport of high molecular weight PAHs (HMWPAHs) and the correlation between total organic carbon (TOC) and their concentrations were also discussed. The results indicated that highly contaminated sites were located at urban or wastewater irrigation areas and pollutants mainly accumulated in topsoil (< 40 cm), with a sharp content decrease at the vertical boundary of 30-40 cm. Total PAHs/HAHs concentrations in soils from Tianjin were markedly greater than those from Beijing. Even the contents at bottoms of soil profiles in Tianjin were higher than those in topsoils of Beijing soil profile. HMWPAHs dominated the PAH profiles, exhibiting a uniform distribution of pyrogenic origin between topsoils and deep layers. Furthermore, the percentages of HMWPAHs remained relative constant with the depth of soil profiles, which were consistent with the distribution of particulate matter-associated PAHs in the local atmospheric environments. Therefore, HMWPAHs transport with particulates might be the predominant source found in soil profiles. | HE Fengpeng ZHANG Zhihuan WAN Yunyang LU Song WANG Liang BU Qingwei | 2009 | Journal of Environmental Sciences2009，21，5： | 34 |
| 6 | Adakitic rocks and destruction of the North China Craton:Evidence from experimental petrology and geochemistry显示文摘The general temporal-spatial consistency for the formation of adakitic rocks and lithospheric thinning in northern China provide a window to examine the processes and mechanism for the destruction of the North China Craton.With experimental petrology data,this paper demonstrates that the adakitic rocks in northern China are the products of partial melting of middle-to high-potassic metabasalts at the base of the lower continent crust.Based on the TiO2 solubility model,many adakitic rocks in Dabie,Jiaodong and the northern part of the craton appear to have been saturated with TiO2.This indicates the presence of a Ti-rich accessory phase in their source regions.This phase must be rutile based on the decreasing Nb/La with increasing La/Yb in the adakitic rocks.The adakitic magmas were,thus,derived from a depth of more than 50 km,based on pressures (higher than 1.5 GPa) for the stability of rutile in a metabasalt system.Because present-day crustal thickness is generally only 35 km,we suggest that the destruction of the North China Craton may have led to at least 15 km of thinning or delamination of the crust. | XIONG XiaoLin LIU XingCheng ZHU ZhiMin LI Yuan XIAO Wan Sheng SONG MaoShuang ZHANG Sheng WU JinHua | 2011 | Science China Earth Sciences2011，54，6： | 34 |
| 7 | How many sutures in the southern Central Asian Orogenic Belt:Insights from East Xinjiang-West Gansu(NW China)?显示文摘How ophiolitic mèlanges can be defined as sutures is controversial with regard to accretionary orogenesis and continental growth.The Chinese Altay,East junggar,Tianshan,and Beishan belts of the southern Central Asian Orogenic Belt(CAOB) in Northwest China,offer a special natural laboratory to resolve this puzzle.In the Chinese Altay,the Erqis unit consists of ophiolitic melanges and coherent assemblages,forming a Paleozoic accretionary complex.At least two ophiolitic melanges(Armantai,and Kelameili) in East Junggar,characterized by imbricated ophiolitic melanges,Nb-enriched basalts,adakitic rocks and volcanic rocks,belong to a Devonian-Carboniferous intra-oceanic island arc with some Paleozoic ophiolites,superimposed by Permian arc volcanism.In the Tianshan,ophiolitic melanges like Kanggurtag,North Tianshan,and South Tianshan occur as part of some Paleozoic accretionary complexes related to amalgamation of arc terranes.In the Beishan there are also several ophiolitic melanges,including the Hongshishan,Xingxingxia-Shibangjing,Hongliuhe-Xichangjing,and Liuyuan ophiolitic units.Most ophiolitic melanges in the study area are characterized by ultramafic,mafic and other components,which are juxtaposed,or even emplaced as lenses and knockers in a matrix of some coherent units.The tectonic settings of various components are different,and some adjacent units in the same melange show contrasting different tectonic settings.The formation ages of these various components are in a wide spectrum,varying from Neoproterozoic to Permian.Therefore we cannot assume that these ophiolitic melanges always form in linear sutures as a result of the closure of specific oceans.Often the ophiolitic components formed either as the substrate of intra-oceanic arcs,or were accreted as lenses or knockers in subduction-accretion complexes.Using published age and paleogeographic constraints,we propose the presence of (1) a major early Paleozoic tectonic boundary that separates the Chinese Altay-East Junggar multiple subduction systems of the southern Siberian active margin from those of the northern Tarim;and (2) a major Permian suture zone that separates the Tianshan-Beishan from the northern active margin of the Tarim Craton.These new observations and interpretations have broad implications for the architecture and crustal growth of central Asia and other ancient orogens as well. | Wenjiao Xiao Chunming Han Wei Liu Bo Wan Ji'en Zhang Songjian Ao Zhiyong Zhang Dongfang Song Zhonghua Tian Jun Luo | 2014 | Geoscience Frontiers2014，5，4： | 31 |
| 8 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 9 | Photovoltaic and Solar Power Forecasting for Smart Grid Energy Management显示文摘Due to the challenge of climate and energy crisis,renewable energy generation including solar generation has experienced significant growth.Increasingly high penetration level of photovoltaic(PV)generation arises in smart grid.Solar power is intermittent and variable,as the solar source at the ground level is highly dependent on cloud cover variability,atmospheric aerosol levels,and other atmosphere parameters.The inherent variability of large-scale solar generation introduces significant challenges to smart grid energy management.Accurate forecasting of solar power/irradiance is critical to secure economic operation of the smart grid.This paper provides a comprehensive review of the theoretical forecasting methodologies for both solar resource and PV power.Applications of solar forecasting in energy management of smart grid are also investigated in detail. | Can Wan Jian Zhao Yonghua Song Zhao Xu Jin Lin Zechun Hu | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 29 |
| 10 | Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis显示文摘瞄准: 进行系统的评论和元分析估计关于支持的血发行量和搬迁的血壅滞(PBCRBS ) 可得到的当前的证据为有尖锐 intracerebral 出血(ICH ) 的中国病人的治疗。 | Hui-qin LI Jing-jing WEI Wan XIA Ji-huang LI Ai-ju LIU Su-bing YIN Chert WANG Liang SONG Yan WANG Guo-qing ZHENG Ji-ping FAN | 2015 | Acta Pharmacologica Sinica2015，36，6： | 23 |
| 11 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 12 | Ratios of T-helper 2 Cells to T-helper 1 Cells and Cytokine Levels in Patients with Hepatitis B显示文摘 | Ming-Hui Li Dan Zhang Lu Zhang Xiao-Jing Qu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Hong-Xiao Hao Wen-Hao Hua Shu-Jing Song Gang Wan Shun-Ai Liu Yao Xie | 2017 | Chinese Medical Journal2017，，15： | 21 |
| 13 | Anatomy of composition and nature of plate convergence: Insights for alternative thoughts for terminal India-Eurasia collision显示文摘The pattern and timing of collision between India and Eurasia have long been a major concern of the international community. However, no consensus has been reached hitherto. To explore and resolve the disagreements in the Himalayan study,in this paper we begin with the methodology and basic principles for the anatomy of composition and nature of convergent margins,then followed by an effort to conduct a similar anatomy for the India-Eurasia collision. One of the most common patterns of plate convergence involves a passive continental margin, an active continental margin and intra-oceanic basins together with accreted terranes in between. The ultimate configuration and location of the terminal suture zone are controlled by the basal surface of the accretionary wedge, which may show fairly complex morphology with Z-shape and fluctuant geometry. One plausible method to determine the terminal suture zone is to dissect the compositions and structures of active continental margins. It requires a focus on various tectonic elements belonging to the upper plate, such as accretionary wedges, high-pressure(HP)-ultra-high-pressure(UHP) metamorphic rocks, Barrovian-type metamorphic rocks and basement nappes, together with superimposed forearc basins.Such geological records can define the extreme limits and the intervening surface separating active margin from the passive one,thus offering a general sketch for the surface trace of the terminal suture zone often with a cryptic feature. Furthermore, the occurrence of the cryptic suture zone in depth may be constrained by geophysical data, which, in combination with outcrop studies of HP-UHP metamorphic rocks, enables us to outline the terminal suture zone. The southern part of the Himalayan orogen records complicated temporal and spatial features, which are hard to be fully explained by the classic 'two-plate-one-ocean' template,therefore re-anatomy of the compositions and nature for this region is necessitated. Taking advantage of the methodology and basic principles of plate convergence anatomy and synthesizing previous studies together with our recent research, we may gain new insights into the evolution of the Himalayan orogeny.(1) The Yarlung-Zangbo ophiolite is composed of multiple tectonic units rather than a single terminal suture zone, and a group of different tectonic units were juxtaposed against each other in the backstop of the Gangdese forearc.(2) The Tethyan Himalayan Sequence(THS) contains mélanges with typical block-in-matrix structures, uniform southwards paleocurrents and age spectra of detrital zircons typical of Eurasia continent. All of these facts indicate that the THS belonged to Eurasia plate before the terminal collision, emplaced in the forearc of the Gangdese arc.(3) The Greater Himalayan Crystalline Complex(GHC) and Lesser Himalayan Sequence(LHS) comprise complex components including eclogites emplaced into the GHC and the upper part of the LHS. Judging from the fact that HP-UHP metamorphic rocks are exhumed and emplaced in the upper plate, the GHC and the upper part of the LHS where eclogite occur should be assigned to the upper plate, lying above the terminal subduction zone surface. It is the very surface along which the continuous subduction of the India subcontinent occurred, therefore acting as the terminal, cryptic suture. From the suture further southward, the bulk rock associations of the LHS and Sub-Himalayan Sequence(Siwalik) show little affinity of mélange, probably belonging to the foreland system of the India plate. By the anatomy of tectonic features of all the tectonic units in the Himalayan orogen as well as the ages of the subduction-accretion related deformation, we conclude that the terminal India-Eurasia collision occurred after 14 Ma, the timing of the metamorphism of the eclogites emplaced into the upper plate. The development of rifts stretching in N-S direction in Tibet and tectonic events with the transition from sinistral to dextral movements in shear zones, such as the Ailaoshan fault in East Tibet, can coordinately reflect the scale and geodynamic influence of the India-Eurasia convergence zone.By conducting a detailed anatomy of the southern Himalayas, we propose a new model for the final collision-accretion of the Himalayan orogeny. Our study indicates that the anatomy of structures, composition, and tectonic nature is the key to a better understanding of orogenic belts, which may apply to all the orogenic belts around the world. We also point out that several important issues regarding the detailed anatomy of the structures, compositions and tectonic nature of the Himalayan orogeny in future. | XIAO WenJiao AO SongJian YANG Lei HAN ChunMing WAN Bo ZHANG Ji'En ZHANG ZhiYong LI Rui CHEN ZhenYu SONG ShuaiHua | 2017 | Science China Earth Sciences2017，60，6： | 20 |
| 14 | Potential Toxicological and Cardiopulmonary Effects of PM2,5 Exposure and Related Mortality:Findings of Recent Studies Published during 2003-2013显示文摘INTRODUCTION Air pollution has become a serious environmental issue owing to its diverse harmful effects on the physical and biological environment.According to the Environmental Protection Agency(EPA)and the World Health Organization(WHO)[1-2],air pollution affects millions of people worldwide.Hundreds of thousands of deaths each year and a range of diseases, | Mohammed O.A.Mohammed SONG Wei Wei MA Wan Li LI Wen Long LI Yi Fan Afed Ullah Khan Mohammed A.E.M.Ibrahim Osman Adam Maarouf Alshebli A Ahmed John J.Ambuchi | 2016 | Biomedical and Environmental Sciences2016，29，1： | 16 |
| 15 | Accretionary processes and metallogenesis of the Central Asian Orogenic Belt:Advances and perspectives显示文摘As one of the largest Phanerozoic orogens in the world,the Central Asian Orogenic Belt(CAOB)is a natural laboratory for studies of continental dynamics and metallogenesis.This paper summarizes the research progresses of the accretionary processes and metallogenesis of the CAOB since the Peopled Republic of China was founded,and puts forward the prospect for future research.During the early period(1950s-1970s),several geological theories were applied to explain the geological evolution of Central Asia.In the early period of China's reform and opening-up,the plate tectonics theory was applied to explain the evolution of the northern Xinjiang and Xingmeng regions,and the opinion of subduction-collision between Siberian Kazakhstan and China-North Korea-Tarim plates was proposed.The idea of the Solonker-Yanbian suture zone was established.In the 1990s,the study of the CAOB entered a period of rapid development.One school of scholars including geologists from the former Soviet Union proposed a multi-block collision model for the assemblage of the CAOB.In contrast,another school of scholars,led by a Turkish geologist,Celal Sengor,proposed that the Altaids was formed through the growth and strike-slip duplicates of a single island arc,and pointed out that the Altaids is a special type of collisional orogen.During this period,Chinese geologists carried out a lot of pioneering researches on ophiolites and high-pressure metamorphic rocks in northern China,and confirmed the main suture zones accordingly.In 1999,the concept of'Central Asian metallogenic domain'was proposed,and it became one of the three major metallogenic domains in the world.Since the 21st century,given the importance for understanding continental accretion and metallogenic mechanism,the CAOB has become the international academic forefront.China has laid out a series of scientific research projects in Central Asia.A large number of important scientific research achievements have been spawned,including the tectonic attribution of micro-continents,timing and tectonic settings of ophiolites,magmatic arcs,identification and anatomy of accretionary wedges,regional metamorphism-deformation,(ultra)high-pressure metamorphism,ridge subduction plume-plate interaction archipelagic paleogeography and spatio-temporal framework of multiple accretionary orogeny,continental growth accretionary metallogenesis,structural superposition and transformation etc.These achievements have made important international influences.There still exist the following aspects that need further study:(1)Early evolution history and subduction initiation of the Paleo-Asian Ocean;(2)The accretionary mechanism of the extroversion Paleo-Asian Ocean;(3)The properties of the mantle of the Paleo-Asian Ocean and their spatiotemporal distribution;(4)The interaction between the Paleo-Asian Ocean and the Tethys Ocean;(5)Phanerozoic continental growth mechanism and its global comparison;(6)Accretionary metallogenic mechanism of the Central Asian metallogenic domain;and(7)Continental transformation mechanism. | Wenjiao XIAO Dongfang SONG Brian FWINDLEY Jiliang LI Chunming HAN Bo WAN Ji'en ZHANG Songjian AO Zhiyong ZHANG | 2020 | Science China Earth Sciences2020，63，3： | 16 |
| 16 | Geophysical-Geological Interpretation and Deep-Seated Gold Deposit Prospecting in Sanshandong-Jiaojia Area, Eastern Shandong Province, China显示文摘Integrated gravitational, electrical-magnetic surveys and data processing carried out in the Sanshandao-Jiaojia area, Eastern Shandong Province, northeast China, aim to illuminate the geological characteristics of this shallow-covered area and delineate deep-seated gold prospecting targets. In this region, altogether 12 faults exert critical control on distribution of three types of Early Precambrian metamorphic rock series, i.e. those in the metamorphic rock area, in the granitic rock area underlying the metamorphic rock, and in the remnant metamorphic rock area in granites, respectively. Additionally, the faults have major effects on distribution of four Mesozoic Linglong rock bodies of granite, i.e. the Cangshang, Liangguo, Zhuqiao-Miaojia and Jincheng granites. The Sanshandao and Jiaojia Faults are two well-known regional ore-controlling faults; they have opposite dip direction, and intersect at a depth of 4500 m. Fracture alteration zones have striking geophysical differences relative to the surrounding county rocks. The two faults extend down along dip direction in a gentle wave form, and appear at some steps with different dips. These steps comprise favorable gold prospecting areas, consistent with a step metallogenic model. Six deep-seated gold-prospecting targets are delineated, i.e. Jincheng-Qianchenjia, Xiaoxizhuang-Zhaoxian, Xiyou-Wujiazhuangzi, Xiangyangling-Xinlicun, Panjiawuzi and Miaojia-Pinglidian. | SONG Mingchun WAN Guopu CAO Chunguo HE Chunyan | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 15 |
| 17 | Co-transplantation of neural stem cells and Schwann cells within poly (L-lactic-co-glycolic acid) scaffolds facilitates axonal regeneration in hemisected rat spinal cord显示文摘 | XIA Lei WAN Hong HAO Shu-yu LI De-zhi CHEN Gang GAO Chuan-chuan LI Jun-hua YANG Fei WANG Shen-guo LIU Song | 2013 | Chinese Medical Journal2013，，5： | 15 |
| 18 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 19 | Effects of viral infection and microbial diversity on patients with sepsis:A retrospective study based on metagenomic next-generation sequencing显示文摘BACKGROUND: The study aims to investigate the performance of a metagenomic next-generationsequencing (NGS)-based diagnostic technique for the identifi cation of potential bacterial and viral infectionsand eff ects of concomitant viral infection on the survival rate of intensive care unit (ICU) sepsis patients.METHODS: A total of 74 ICU patients with sepsis who were admitted to our institution from February1, 2018 to June 30, 2019 were enrolled. Separate blood samples were collected from patients for bloodcultures and metagenomic NGS when the patients’ body temperature was higher than 38 °C. Patients’demographic data, including gender, age, ICU duration, ICU scores, and laboratory results, were recorded.The correlations between pathogen types and sepsis severity and survival rate were evaluated.RESULTS: NGS produced higher positive results (105 of 118;88.98%) than blood cultures(18 of 118;15.25%) over the whole study period. Concomitant viral infection correlated closelywith sepsis severity and had the negative effect on the survival of patients with sepsis. However,correlation analysis indicated that the bacterial variety did not correlate with the severity of sepsis.CONCLUSIONS: Concurrent viral load correlates closely with the severity of sepsis and thesurvival rate of the ICU sepsis patients. This suggests that prophylactic administration of antiviraldrugs combined with antibiotics may be benefi cial to ICU sepsis patients. | Li-wei Duan Jin-long Qu Jian Wan Yong-hua Xu Yi Shan Li-xue Wu Jin-hao Zheng Wei-wei Jiang Qi-tong Chen Yan Zhu Jian Zhou Wen-bo Yu Lei Pei Xi Song Wen-fang Li Zhao-fen Lin | 2021 | World Journal of Emergency Medicine2021，12，1： | 14 |
| 20 | High-resolution 3D crustal S-wave velocity structure of the MiddleLower Yangtze River Metallogenic Belt and implications for its deep geodynamic setting显示文摘The Middle-Lower Yangtze River Metallogenic Belt(MLYMB) is an important mineral resource region in China.High-resolution crustal models can provide crucial constraints to understand the ore-forming processes and geodynamic setting in this region. Using ambient seismic noise from 107 permanent and 82 portable stations in the MLYMB and the adjacent area,we present a new high-resolution 3D S-wave velocity model of this region. We first extract 5–50 s Rayleigh wave phase velocity dispersion data by calculating ambient noise cross-correlation functions(CFs) and then use the surface wave direct inversion method to invert the mixed path travel times for the 3D S-wave velocity structure. Checkerboard tests show that the horizontal resolution of the 3D S-wave velocity model is approximately 0.5°–1.0° and that the vertical resolution decreases with increasing noise and depth. Our high-resolution 3D S-wave velocity model reveals:(1) AV-shaped high-velocity zone(HVZ) is located in the lower crust and the uppermost mantle in the study region. The western branch of the HVZ passes through the Jianghan Basin,the Qinling-Dabie orogenic belt and the Nanxiang Basin. The eastern branch, which almost completely covers the main body of the MLYMB, is located near the Tanlu Fault. The low-velocity anomalies between the western and eastern branches are located in the area of the Qinling-Dabie orogenic belt.(2) High-velocity uplifts(HVUs) are common in the crust of the MLYMB,especially in the areas near the Tanlu Fault, the Changjiang Fault and the Yangxin-Changzhou Fault. The intensities of the HVUs gradually weaken from west to east. The V-shaped HVZ in the lower crust and uppermost mantle and the HVUs in the middle and lower crust likely represent cooled mantle intrusive rocks. During the Yanshanian period, fault systems formed in the MLYMB due to the convergence between the South China Plate and the North China Plate, the multiple-direction drifting of the PaleoPacific Plate and its subduction beneath the Eurasian Plate. The dehydration of the cold oceanic crust led to partial melting in the upper mantle. Temperature differences caused strong convection of the upper mantle material that underplated the lower crust and rose to near the surface along the deep fault systems. After mixing with the crustal materials, mineralization processes, such as assimilation and fractional crystallization, occurred in the MLYMB. | Song LUO Huajian YAO Qiusheng LI Weitao WANG Kesong WAN Yafeng MENG Bin LIU | 2019 | Science China Earth Sciences2019，62，9： | 13 |
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