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| 1 | Signal structure of the Chinese Area Positioning System显示文摘Proper signal structure is very important in the navigation, positioning, and time services of a satellite navigation system. In this paper, the carrier wave characteristics, ranging code functions, BOC modulation, navigation data rate, the error-correcting methods, and signal channel resource allocation are discussed in terms of the technical characteristics of the transforming satellite navigation system and the resources of communication satellites. The results show that dual-frequency of C band in the Chinese Area Positioning System (CAPS), compound ranging code, a combination of the coarse code and precise code, BOC modulation, separate-channel transmission of different users are compatible with the satellite navigation system at present. The experiments show that the current signal structure can meet the demand of CAPS. | LU XiaoChun WU HaiTao BIAN YuJing HUA Yu | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 9 |
| 2 | The role of BRCA1 in DNA damage response显示文摘BRCA1 is a well-established tumor suppressor gene,which is frequently mutated in familial breast and ovarian cancers.The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability,including DNA damage-induced cell cycle checkpoint activation,DNA damage repair,protein ubiquitination,chromatin remodeling,as well as transcriptional regulation and apoptosis.In this review,we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response,including DNA damage-induced cell cycle checkpoint activation and DNA damage repair. | Jiaxue Wu Lin-Yu Lu Xiaochun Yu | 2010 | Protein & Cell2010，1，2： | 9 |
| 3 | Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin显示文摘Biomimetic nanocarriers are emerging as efficient vehicles to facilitate dietary absorption of biomacromolecules. In this study, two vitamins, thiamine and niacin, are employed to decorate liposomes loaded with insulin, thus facilitating oral absorption via vitamin ligand–receptor interactions. Both vitamins are conjugated with stearamine, which works to anchor the ligands to the surface of liposomes.Liposomes prepared under optimum conditions have a mean particle size of 125–150 nm and an insulin entrapment efficiency of approximately 30%–36%. Encapsulation into liposomes helps to stabilize insulin due to improved resistance against enzymatic disruption, with 60% and 80% of the insulin left after 4 h when incubated in simulated gastric and intestinal fluids, respectively, whereas non-encapsulated insulin is broken down completely at 0.5 h. Preservation of insulin bioactivity against preparative stresses is validated by intra-peritoneal injection of insulin after release from various liposomes using the surfactant Triton X-100. In a diabetic rat model chemically induced by streptozotocin, both thiamine-and niacindecorated liposomes showed a comparable and sustained mild hypoglycemic effect. The superiority of decorated liposomes over conventional liposomes highlights the contribution of vitamin ligands. It is concluded that decoration of liposomes with thiamine or niacin facilitates interactions with gastrointestinal vitamin receptors and thereby facilitates oral absorption of insulin-loaded liposomes. | Haisheng He Yi Lu Jianping Qi Weili Zhao Xiaochun Dong Wei Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 8 |
| 4 | Time synchronization and carrier frequency control of CAPS navigation signals generated on the ground显示文摘The Chinese Area Positioning System (CAPS) works without atomic clocks on the satellite, and the CAPS navigation signals transmitted on the ground may achieve the same effect as that with high-performance atomic clocks on the satellite. The primary means of achieving that effect is through the time synchronization and carrier frequency control of the CAPS navigation signals generated on the ground. In this paper the synchronization requirements of different time signals are analyzed by the formation of navigation signals, and the theories and methods of the time synchronization of the CAPS navigation signals generated on the ground are also introduced. According to the conditions of the high-precision satellite velocitymeasurement signal source, the carrier frequency and its chains of the navigation signals are constructed. CAPS velocity measurement is realized by the expected deviation of real time control to the carrier frequency, and the precision degree of this method is also analyzed. The experimental results show that the time synchronization precision of CAPS generating signals is about 0.3 ns and the precision of the velocity measurement signal source is about 4 cm/s. This proves that the theories and methods of the generating time synchronization and carrier frequency control are workable. | WU HaiTao BIAN YuJing LU XiaoChun LI XiaoHui WANG DanNi | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 8 |
| 5 | Initial analysis for characterizing and mitigating the pseudorange biases of BeiDou navigation satellite system显示文摘Pseudorange bias has become a practical obstacle in the field of high-precision global navigation satellite system(GNSS)applications,which greatly restricts the further development of high-precision applications.Unfortunately,no studies have been conducted on the pseudorange biases of the BeiDou navigation satellite system(BDS).To mitigate the effects of pseudorange biases on the BDS performance to the greatest extent possible,the origin of such BDS pseudorange biases are first thoroughly illustrated,based upon which the dependency of the biases on the receiver configurations are studied in detail.Owing to the limitations regarding the parameter re-settings for hardware receivers,software receiver technology was used to achieve the ergodicity of the receiver parameters,such as the correlator spacing and front-end bandwidth,using high-fidelity signal observations collected by a 40-m-high gain dish antenna at Haoping Observatory.Based on this,the pseudorange biases of the BDS B1I and B3I signals and their dependency on different correlator spacings and front-end bandwidths were adequately provided.Finally,herein,the suggested settings of the correlator spacing and front-end bandwidth for BDS receivers are in detail proposed for the first time.As a result,the pseudorange biases of the BDS signals will be less than 20 cm,reaching even under 10 cm,under this condition.This study will provide special attention to GNSS pseudorange biases,and will significantly promote a clear definition of the appropriate receiver parameter settings in the interface control documents of BDS and other individual satellite systems. | Chengyan He Xiaochun Lu Ji Guo Chengeng Su Wei Wang Meng Wang | 2020 | Satellite Navigation2020，1，1： | 7 |
| 6 | FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis显示文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy. | Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai | 2022 | Bone Research2022，10，4： | 5 |
| 7 | Effects of three needling manipulations of the right-side Zusanli(ST 36) on brain using functional magnetic resonance imaging显示文摘OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with needles.METHODS: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture manipulations.RESULTS: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left caudate.Twirling activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifting-thrusting were the strongest, especially in the limbic system,followed by twirling plus lifting-thrusting; twirling alone was the weakest.CONCLUSION: Three methods of needling manipulations similarly activated areas associated with the somatosensory system, vision, cognition, and emotional regulation. This may have significant implications for acupuncture in clinical practice. | Lu Fengyan Gao Junhong Wang Yuanyuan Dai Qiufu Bao Yan Hong Yang Zhang Guolei Xin Juanjuan Zhao Yuxue Wu Shuyang Chen Yuanyuan Li Xiaojiao Fang Jiliang Yu Xiaochun | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 5 |
| 8 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 9 | Permeation into but not across the cornea:Bioimaging of intact nanoemulsions and nanosuspensions using aggregation-caused quenching probes显示文摘Nanoemulsions(NEs) and nanosuspensions(NSs) show great potential in enhancing the ocular bioavailability of therapeutics through topical delivery. However, transocular fate of intact NEs and NSs is still inconclusive. In this study, an aggregation-caused quenching fluorescent probe is used to track precorneal retention and transocular transportation of intact NEs and NSs, while coumarin 6 is used to mimick the cargo. NEs show superior precorneal retention to NSs. Both the two types of nanocarriers can permeate into but not across the cornea. The smaller NEs(100 nm) permeate better into the cornea than the bigger ones(210 nm). Nanocarriers in the cornea serves as depots. The released cargo molecules can penetrate across the cornea and diffuse into the lens. Moreover, the conjunctiva-scleral route may be potential to deliver drugs to the back of the eye, In conclusion, the study provides useful tools and information in the field of transocular transportation of nanoparticles. | Dailei Liu Bo Wan Jianping Qi Xiaochun Dong Weili Zhao Wei Wu Yikang Dai Yi Lu Zhongjian Chen | 2018 | Chinese Chemical Letters2018，29，12： | 4 |
| 10 | The Phytol Phosphorylation Pathway Is Essential for the Biosynthesis of Phylloquinone, which Is Required for Photosystem I Stability in Arabidopsis显示文摘Phytyl-diphosphate,在 tocopherol 和 phylloquinone 生合成作为普通底层提供 phytyl 一半,经由 phytol phosphorylation 源于 de novo isoprenoid 生合成或一条抢救小径。然而,很,很少为 phylloquinone 生合成对 phytyl 一半的角色和起源被知道。自从 VTE6, phytyl 磷酸盐 kinase,是为 phytol phosphorylation 的关键酶,我们描绘了 Arabidopsis vte6 异种在 photosystem 在 phylloquinone 生合成并且 phylloquinone 获得卓见进 phytyl 一半的角色我(希腊语的第二十三个字母) 生物的续生说。VTE6 猛烈异种 vte6-1 和 vte6-2 缺乏可检测的 phylloquinone,而在 VTE6 击倒的变异的 vte6-3 的 phylloquinone 内容是 90% 比那低在里面野类型。在 vte6 异种,希腊语的第二十三个字母功能被损害, PSI 建筑群的累积是有缺点的。希腊语的第二十三个字母核心子单元 PsaA/B 高效地在 vte6-3 被综合并且集合进 PSI 建筑群。然而,在装配希腊语的第二十三个字母建筑群的希腊语的第二十三个字母子单元的降级率比在在 vte6-3 是更快速的野类型。在 vte6-3,希腊语的第二十三个字母是更易受影响的加亮损坏比在里面野类型。我们的结果提供 phytol phosphorylation 小径为 phylloquinone 生合成是必要的,并且那 phylloquinone 为希腊语的第二十三个字母复杂稳定性被要求的第一条基因证据。 | Lei Wang Qingwei Li Aihong Zhang Wen Zhou Rui Jiang Zhipan Yang Huixia Yang Xiaochun Qin Shunhua Ding Qingtao Lu Xiaogang wen Congming Lu | 2017 | Molecular Plant2017，10，1： | 4 |
| 11 | Identification of microRNAs involved in crosstalk between nitrogen, phosphorus and potassium under multiple nutrient deficiency in sorghum显示文摘Nitrogen(N),phosphorus(P),and potassium(K)are important for plant growth and development.MicroRNAs(miRNAs)play important roles in regulating plant response to nutrient(N,P,and K)deficiencies.Several miRNAs have been identified under nutrient deficiency conditions in many plant species.However,the manner in which miRNAs regulate the interaction between NPK signaling pathways under multiple nutrient deficiency remains largely unknown.We systematically compared and identified microRNAs involved in both single and triple NPK nutrient deficiency responses.We identified 32 shoot and 17 root miRNAs differentially expressed under potassium deficiency.Several NP starvation-associated miRNAs including miR169s and miR399s,were also regulated by K deficiency.Several identified miRNAs including miR5565c,miR5564,and miR1432 have not previously been associated with respectively N,P,and K deficiency(−N,−P,and−K).Expression correlation analysis between miRNAs and their predicted targets showed that miR169,miR172,and miR160 displayed expression trends exactly opposite to those of their corresponding predicted targets.Of 550 predicted novel miRNAs,novel_mir_42 was upregulated in shoots under−K but was downregulated under−N and−P.The effects of combined NPK starvation were not a simple addition of the individual stresses on sorghum seedlings.The identified common and specific differentially expressed miRNAs were observed under single and combined NPK deficiencies.These findings will help to further elucidate the functions of microRNAs and their interactions under multiple nutrient deficiency. | Zhenxing Zhu Dan Li Ling Cong Xiaochun Lu | 2021 | The Crop Journal2021，9，2： | 4 |
| 12 | Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route显示文摘Self-microemulsifying drug delivery systems(SMEDDSs)have recently returned to the limelight of academia and industry due to their enormous potential in oral delivery of biomacromolecules.However,information on gastrointestinal lipolysis and trans-epithelial transport of SMEDDS is rare.Aggregation-caused quenching(ACQ)fuorescent probes are utilized to visualize the in vivo behaviors of SMEDDSs,because the released probes during lipolysis are quenched upon contacting water.Two SMEDDSs composed of medium chain triglyceride and different ratios of Tween-80 and PEG-400 are set as models,meanwhile Neoral?was used as a control.The SMEDDS droplets reside in the digestive tract for as long as 24 h and obey frst order kinetic law of lipolysis.The increased chain length of the triglyceride decreases the lipolysis of the SMEDDSs.Ex vivo imaging of main tissues and histological examination confrm the trans-epithelial transportation of the SMEDDS droplets.Approximately 2%-4%of the given SMEDDSs are transported via the lymph route following epithelial uptake,while liver is the main termination.Caco-2 cell lines confrm the cellular uptake and trans-epithelial transport.In conclusion,a fraction of SMEDDSs can survive the lipolysis in the gastrointestinal tract,permeate across the epithelia,translocate via the lymph,and accumulate mainly in the liver. | Fei Xia Zhongjian Chen Quangang Zhu Jianping Qi Xiaochun Dong Weili Zhao Wei Wu Yi Lu | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 4 |
| 13 | In vivo dissolution of poorly water-soluble drugs:Proof of concept based on fluorescence bioimaging显示文摘In vitro-in vivo correlation(IVIVC)of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients.Nevertheless,in vivo dissolution profles have never been accurately portrayed.The current practice of IVIVC has to resort to in vivo absorption fractions(Fa).In this proof-of-concept study,in vivo dissolution of a model poorly watersoluble drug fenofbrate(FNB)was investigated by fuorescence bioimaging.FNB crystals were frst labeled by near-infrared fuorophores with aggregation-caused quenching properties.The dyes illuminated FNB crystals but quenched immediately and absolutely once been released into aqueous media,enabling accurate monitoring of residual drug crystals.The linearity established between fuorescence and crystal concentration justifed reliable quantifcation of FNB crystals.In vitro dissolution was frst measured following pharmacopoeia monograph protocols with well-documented IVIVC.The synchronicity between fuorescence and in vitro dissolution of FNB supported using fuorescence as a measure for determination of dissolution.In vitro dissolution correlated well with in vivo dissolution,acquired by either live or ex vivo imaging.The newly established IVIVC was further validated by correlating both in vitro and in vivo dissolution with Faobtained from pharmacokinetic data. | Yinqian Yang Yongjiu Lv Chengying Shen Tingting Shi Haisheng He Jianping Qi Xiaochun Dong Weili Zhao Yi Lu Wei Wu | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 3 |
| 14 | Differential equation dynamical system based assessment model in GNSS interoperability显示文摘With the development of Global Navigation Satellite System (GNSS),the idea of GNSS interoperability is born and has become the focus of study in the field of satellite navigation.The popularity for GNSS to augment the interoperability with the existing ones necessitates the study of the assessment algorithm of this idea.In this paper,an assessment algorithm for interoperability comprehensive benefits based on the differential equation dynamical system is discussed.There are two important aspects in GNSS that interoperability will affect:one is the performance advancement;the other one is the cost of adopting interoperability.While researching the complex relationship between the performance and cost,we found this relationship is similar as what between prey and predator in biomathematics,so the Lotka-Volterra model used to depict the prey-predator relationship is a felicitous tool.After building a differential dynamical model,we analyze the existence and stability of the positive equilibrium in the model.Then a Cost-Effective Function of GNSS is constructed based on the positive equilibrium,which is employed to assess the interoperability,qualitatively and quantitatively.Finally,the paper demonstrates the significance of the model and its application by citing a numerical example. | HAN Tao LU XiaoChun WANG Xue RAO YongNan ZOU DeCai YANG JianFei WU YangYang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 3 |
| 15 | Recover the abnormal positioning,velocity and timing services caused by BDS satellite orbital maneuvers显示文摘The BeiDou Navigation Satellite System(BDS)provides global Positioning,Velocity,And Timing(PVT)services that are widely used in various areas.The BDS satellites frequently need the orbit maneuvers due to various perturbations to keep satellites in their designed positions.During these maneuvers,PVT services may be abnormal if the data from a maneuvering satellite is used.In this paper we developed an approach to recover the abnormal PVT services.By using BDS observations from multiple tracking stations,the orbital errors of a maneuvering satellite can be in real time obtained and corrected,thereby avoiding any influence on the performance of PVT services.The tests show that the average precision of position,velocity and timing services are improved by 0.8 m,0.1 mm/s and 0.16 ns,respectively,using the developed orbital maneuver recovery approach.In addition,the approach can also be used for the orbital maneuver detection and monitoring. | Rui Tu Rui Zhang Pengfei Zhang Junqiang Han Lihong Fan Xiaochun Lu | 2021 | Satellite Navigation2021，2，1： | 3 |
| 16 | Strongly Singular Convo1ution Operators on the Weighted Herz-Type Hardy Spaces | Li Xiaochun Lu Shanzhen Department of Mathematics, Beijing Normal University, Beijing 100875, China | 1998 | Acta Mathematica Sinica,English Series1998，14，1： | 3 |
| 17 | Nitrogen removal from summer to winter in a field pilot-scale multistage constructed wetland-pond system显示文摘A pilot-scale multistage constructed wetland-pond(MCWP)system with a'pre-ecological oxidation pond,two-stage horizontal subsurface flow constructed wetland(HSCW)and surface flow constructed wetland(SFCW)as the core and postsubmerged plant pond'as the process was used to treat actual polluted river water in the field,and the variation in nitrogen removal from summer to winter was investigated.The results showed that the average total nitrogen(TN)removal efficiency in the MCWP was approximately 40.74%.The significant positive correlation between the daily highest temperature and the TN removal efficiency of the whole system was fitted with a nonlinear curve(R^(2)=0.7192).The TN removal load rate in the HSCWs was 2.7–3.7 times that in the SFCW.The SFCW,which had high-density plants(35 plants/m^(2)),increased the proportion of nitrogen removed by plant harvesting and microbial function.The TN transformed by Iris pseudacorus L.accounted for 54.53%in the SFCW.Furthermore,bacteria completed the nitrogen cycle in the SFCW through a variety of nitrogen removal pathways.This research not only investigated the TN removal performance in an MCWP system but also made it possible to predict the TN removal efficiency according to the daily highest temperature from summer to winter in the field. | Tao Wang Liping Xiao Hongbin Lu Shaoyong Lu Jiaxin Li Xiaochun Guo Xiaoliang Zhao | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 18 | The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing显示文摘p53 is a key transcription factor to regulate gene transcription.However,the molecular mechanism of chromatin-associated p53 on gene transcription remains elusive.Here,using unbiased protein affinity purification,we found that the RNF20/40 complex associated with p53 on the chromatin.Further analyses indicated that p53 mediated the recruitment of the RNF20/40 complex to p53 target gene loci including p21 and PUMA loci and regulated the transcription of p21 and PUMA via the RNF20/40 complex-dependent histone H2B ubiquitination(ubH2B).Lacking the RNF20/40 complex suppressed not only ubH2B but also the generation of the mature mRNA of p21 and PUMA.Moreover,ubH2B was recognized by the ubiquitin-binding motif of pre-mRNA processing splicing factor 8(PRPF8),a subunit in the spliceosome,and PRPF8 was required for the maturation of the mRNA of p21 and PUMA.Our study unveils a novel p53-dependent pathway that regulates mRNA splicing for tumor suppression. | Chen Wu Yaqi Cui Xiuhua Liu Feng Zhang Lin-Yu Lu Xiaochun Yu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 2 |
| 19 | The effects of circadian rhythm on catechin accumulation in tea leaves显示文摘As the major bitter-and astringent-tasting components in tea leaves,catechins play an essential role in determining flavor characteristics and health benefits of tea products.This study analyzed the circadian rhythm effects on the accumulation pattern of catechins in tender leaves of three tea cultivars,'Huangkui'(HK),'Longjing43'(LJ43)and'Fuding Dabaicha'(FD).There were two major factors involved in the catechin regulation in tea plants:genetic background of the cultivar-specific regulation,and temporal effects of the circadian rhythm.Etiolated leaves of'HK'contained lower levels of catechins than'LJ43'and'FD'.The composition of EGCG in total catechins was significantly higher in'LJ43'leaves(65%)when compared with that in'HK'and'FD'(45%).The accumulation of individual catechins increased during the daytime but decreased overnight,especially over the time period of 22:00−02:00.The correlation analysis between catechins and environmental factors indicated catechin accumulation in tea leaves potentially resulted from a combined regulation of light and temperature.These findings provide new insights into our understanding of circadian rhythm regulation on flavor-important secondary metabolites in tea leaves. | Xiaohui Wang Wenfeng Zhu Xin Cheng Zhiqiang Lu Xuyang Liu Xiaochun Wan Chuankui Song Linlin Liu | 2021 | Beverage Plant Research2021，1，1： | 2 |
| 20 | Induction of priming by cold stress via inducible volatile cues in neighboring tea plants^FA显示文摘Plants have evolved sophisticated defense mechanisms to overcome their sessile nature.However,if and how volatiles from cold‐stressed plants can trigger interplant communication is still unknown.Here,we provide the first evidence for interplant communication via inducible volatiles in cold stress.The volatiles,including nerolidol,geraniol,linalool,and methyl salicylate,emitted from cold‐stressed tea plants play key role(s)in priming cold tolerance of their neighbors via a C‐repeatbinding factors‐dependent pathway.The knowledge will help us to understand how plants respond to volatile cues in cold stress and agricultural ecosystems. | Mingyue Zhao Lu Wang Jingming Wang Jieyang Jin Na Zhang Lei Lei Ting Gao Tingting Jing Shangrui Zhang Yi Wu Bin Wu Yunqing Hu Xiaochun Wan Wilfried Schwab Chuankui Song | 2020 | Journal of Integrative Plant Biology2020，62，10： | 2 |
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