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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | ^(40)Ar-^(39)Ar thermochronology of two ductile shear zones from Yiwulüshan,West Liaoning Region: Age constraints on the Mesozoic tectonic events显示文摘Two ductile shear zones trending EW and NNE respectively not only controlled the tectonic framework of the northern North China, but also constrained the geody-namic background for gold mineralization in this region. Field observations and microstructural analyses reveal that the EW trending ductile shear zones are mainly contributed to dextral compressional deformation resulting from top-to-the-southeast oblique thrust shearing, whereas the NNE trending ones are genetically related to sinistral strike-slip and extensional faulting. One sample from the former yielded an 40Ar-39Ar plateau age of (219±4) Ma (Bi) and two samples from the latter gave 40Ar-39Ar plateau ages of (116± 2) Ma (Bi) and (127±3) Ma (Bi). These ages provide constraints on the top-to-the-southeast oblique thrusting event occurring in Late Triassic and the sinistral extensional and strike-slip faulting event which occurred in Early Cretaceous. | ZHANG Xiaohui, LI Tiesheng & PU ZhipingResearch Center of Mineral Resources Exploration, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 51 | 2002 | Chinese Science Bulletin2002，47，13： | 24 |
| 4 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 5 | Barometric altimetry system as virtual constellation applied in CAPS显示文摘This work describes the barometric altimetry as virtual constellation applied to the Chinese Area Positioning System (CAPS), which uses the transponders of communication satellites to transfer navigation messages to users. Barometric altimetry depends on the relationship of air pressure varying with altitude in the Earth’s atmosphere. Once the air pressure at a location is measured the site altitude can be found. This method is able to enhance and improve the availability of three-dimensional positioning. The difficulty is that the relation between barometric pressure and altitude is variable in different areas and under various weather conditions. Hence, in order to obtain higher accuracy, we need to acquire the real-time air pressure corresponding to an altimetric region’s reference height. On the other hand, the altimetry method will be applied to satellite navigation system, but the greatest difficulty lies in how to get the real-time air pressure value at the reference height in the broad areas overlaid by satellite navigation. We propose an innovational method to solve this problem. It is to collect the real-time air pressures and temperatures of the 1860 known-altitude weather observatories over China and around via satellite communication and to carry out time extrapolation forecast uniformly. To reduce data quantity, we first partition the data and encode them and then broadcast these information via navigation message to CAPS users’ receivers. Upon the interpolations being done in receivers, the reference air pressure and temperature at the receiver’s nearby place is derived. Lastly, combing with the receiver-observed real air pressure and temperature, the site’s altitude can be determined. The work is presented in the following aspects: the calculation principle, formulae, data collection, encoding, prediction, interpolation method, navigation message transmission together with errors causes and analyses. The advantages and shortcomings of the technique are discussed at the end. | AI GuoXiang SHENG PeiXuan DU JinLin ZHENG YongGuang CAI XianDe WU HaiTao HU YongHui HUA Yu LI XiaoHui | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 22 |
| 6 | Self-monitoring of blood glucose in type 2 diabetic patients in China:current status and influential factors显示文摘 | Yuan Li Guo Xiaohui Xiong Zhenzhen Lou Qingqing Shen Li Zhao Fang Sun Zilin Li Jianwei | 2014 | Chinese Medical Journal2014，，2： | 21 |
| 7 | ^(40)Ar-^(39)Ar ages of the Louzidian-Dachengzi ductile shear zone near Chifeng,Inner Mongolia and their tectonic significance显示文摘The Louzidian normal fault occurs as the eastern detachment fault of the Kalaqin metamorphic core complex. Field observations and microstructural analyses reveal that the Louzidian-Dachengzi ductile shear zone developed in its lower-plate was genetically related to sinistral strike-slips and extensional faulting. Two samples from this ductile shear zone yield 40Ar-39Ar plateau ages of 133 Ma (Bi) and 126 Ma (Kp), which are concordant with their isochron ages. The plateau age of 133 Ma (Bi) records the formation age of the ductile shear zone. The inconsistent relationship between the earlier strike-slip ductile shear zone and the later normal fault makes the Kalaqin Quasi-metamorphic core complex distinctive from Cordil-leran nietamorphic core complex. These ages provide important geochronological data for putting constraints on the formation age and genesis of such ductile shear zones. | ZHANG Xiaohui, LI Tiesheng, PU Zhiping & WANG HuiResearch Center for Mineral Resources Exploration, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, G | 2002 | Chinese Science Bulletin2002，47，15： | 21 |
| 8 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 9 | Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook显示文摘Traditional Chinese medicine (TCM) is a medical system that has collected and summarized abundant clinical experience over its long history of more than 2000 years. However, the frequent occurrence of TCM-induced adverse reactions has hindered the modernization and internationalization of TCM, while attracting increasing attention from around the world. Unlike chemical drugs and biological agents, the difficulties involved in research on the toxicity and safety of TCM mainly include the complexity of its components and the unpredictability of drug–body interactions. Much of TCM, which has overall therapeutic effects, has the typical mechanisms of multiple components, multiple pathways, and multiple targets. While considering the gradualness and unpredictability of TCM toxicity, the ambiguity of toxicants and safe dosage, and individual differences during long-term TCM administration, we have systematically established key techniques for the toxicity assessment of TCM. These techniques mainly include TCM toxicity discovery in an early phase, based on a combination of drug toxicology genomics and metabolomics;methods to identify dose–toxicity relationships in TCM;and integrated techniques for the exploration of TCM interactions, such as fast-screening tests based on drug-metabolizing enzymes and receptor pathways. In particular, we have developed a new technical system for TCM safety evaluation using molecular toxicology, which has been validated well in research on TCM compatibility contraindication, quality control, and allergen discovery. The application of this key technical platform is introduced here in detail. This application includes model organisms, toxicant biomarkers, a magnetic suspension technique, and the application of network toxicology and computational toxicology in research on the toxicity of Fructus toosendan, Semen cassiae, Polygonum multiflorum, and Fructus psoraleae. | Yue Gao Aihua Liang Xiaohui Fan Limin Hu Feiran Hao Yubo Li | 2019 | Engineering2019，5，1： | 19 |
| 10 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 11 | Renewed profile of the Mesozoic magmatism in Korean Peninsula: Regional correlation and broader implication for cratonic destruction in the North China Craton显示文摘Widespread Mesozoic magmatism occurs in the Korean Peninsula(KP). The status quo is poles apart between the northern and southern parts in characterizing its distribution and nature, with the nearly absence of any related information in North Korea. We have the opportunity to have conducted geological investigations in North Korea and South Korea during the past ten years through international cooperation programs. This led to the revelation of a number of granitoids and related volcanic rocks and thus facilitates the comparison with those in East China and Japan. Mesozoic granitoids in the KP can be divisible into three age groups: the Triassic group with a peak age of ~220 Ma, the Jurassic one of ~190–170 Ma and the late Early Cretaceous one of ~110 Ma. The Triassic intrusions include syenite, calc-alkaline to alkaline granite and minor kimberlite in the Pyeongnam Basin of North Korea. They have been considered to form in post-orogenic settings related to the Central Asian Orogenic Belt(CAOB) or the Dabie-Sulu Orogenic Belt(DSOB). The Jurassic granitoids constitute extensive occurrence in the KP and are termed as the Daebo-period magmatism. They correlate well with coeval counterparts in NE China encompassing the northeastern part of the North China Craton(NCC) and the eastern segment of the CAOB. They commonly consist of biotite or two-mica granites and granodiorites, with some containing small dark diorite enclaves. On one hand, Early Jurassic to early Middle Jurassic magmatic rocks are rare in most areas of the NCC, whilst Middle-Late Jurassic ones are not developed in the KP. On the other hand, both NCC and KP host abundant Cretaceous granites. However, the present data revealed contrasting age peaks, with ~130–125 Ma in the NCC and ~110–105 Ma in the KP. Cretaceous granites in the KP comprise the dominant biotite granites and a few amphibole granites. The former exhibit mildly fractionated REE patterns and zircon εHf(t) values from ?15 to ?25, whereas the latter feature strongly fractionated REE patterns and zircon εHf(t) values from ?10 to ?1. Both granites contain inherited zircons of ~1.8–1.9 or ~2.5 Ga. These geochemical characters testify to their derivation from re-melting distinct protoliths in ancient basement. Another Cretaceous magmatic sub-event has been entitled as the Gyeongsang volcanism, which is composed of bimodal calc-alkaline volcanic rocks of 94–55 Ma and granitic-hypabyssal granitic bodies of 72–70 Ma. Synthesizing the Mesozoic magmatic rocks across the KP, NCC and Japan can lead to the following highlights:(1) All Triassic granites in the NCC, KP and Japan have similar characteristics in petrology, chronology and geochemistry. Therefore, the NCC, KP and Japan tend to share the same tectonic setting during the Triassic, seemingly within the context of Indosinian orogensis.(2) Jurassic to earliest Cretaceous magmatic rocks in the NCC seem to define two episodes: episode A from 175 to 157 Ma and episode B from 157 to 135 Ma. Jurassic magmatic rocks in the KP span in age mainly from 190 to 170 Ma, whereas 160–135 Ma ones are rare. With the exception of ~197 Ma Funatsu granite, Jurassic magmatic rocks are absent in Japan.(3) Cretaceous granites in the KP have a peak age of ~110, ~20 Ma younger than those in the NCC, while Japan is exempt from ~130–100 Ma granites.(4) The spatial-temporal distribution and migratory characteristics of theJurassic-Cretaceous magmatic rocks in Japan, KP, and NE China-North China indicate that the subduction of the Paleo-Pacific plate might not be operative before Late Cretaceous(~130–120 Ma).(5) Late Cretaceous magmatic rocks(~90–60 Ma) occur in the southwestern corner of the KP and also in Japan, coinciding with the metamorphic age of ~90–70 Ma in the Sanbagawa metamorphic belt of Japan. The magmatic-metamorphic rock associations and their spatial distribution demonstrate the affinities of sequentially subduction zone, island arc and back-arc basin from Japan to Korea, arguing for the Pacific plate subduction during Late Cretaceous.(6) This study raises another possibility that the Mesozoic cratonic destruction in the NCC, which mainly occurred during ~150–120 Ma, might not only be due to the subduction of the Paleo-Pacific Plate, but also owe much to the intraplate geodynamic forces triggered by other adjacent continental plates like the Eurasian and Indian plates. | ZHAI MingGuo ZHANG YanBin ZHANG XiaoHui WU Fu Yuan PENG Peng LI Qiu Li HOU QuanLin LI TieSheng ZHAO Lei | 2016 | Science China(Information Sciences)2016，59，12： | 16 |
| 12 | Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。 | Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu | 2017 | Nano Research2017，10，4： | 16 |
| 13 | 恶性肿瘤骨转移及骨相关疾病临床诊疗中国专家共识(英文)显示文摘Since 1980s, palliative medicine has been an independent educational project. The development of palliative care in China started in the early 1990s. During the last 18 years, we have seen an increasing allocation of resources to palliative care, the establishment of an academic chair in palliative medicine, and more focused interest and awareness of the need for palliative care in the society at large. So the doctors in China have established principles of treatment on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. In order to share our experience with the world, after two years’ preparation, the top-level experts in palliative medicine have written the consensus statement on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. The overview includes not only the achievements in the world, but the hands-on experience in clinic, especially the experience in combination of TCM and Western medicine. We hope that the publication of this consensus statement will contribute to the palliative medicine development in this field, thus bring benefits to the majority of patients. | Shiying Yu Zefei Jiang Li Zhang Xiaohui Niu Lvhua Wang Ning Wu Jianhui Ma | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 15 |
| 14 | Ghost imaging for an axially moving target with an unknown constant speed显示文摘The influence of the axial relative motion between the target and the source on ghost imaging(GI) is investigated.Both the analytical and experimental results show that the transverse resolution of GI is reduced as the deviation of the target’s center position from the optical axis or the axial motion range increases. To overcome the motion blur,we propose a deblurring method based on speckle-resizing and speed retrieval, and we experimentally validate its effectiveness for an axially moving target with an unknown constant speed. The results demonstrated here will be very useful to forward-looking GI remote sensing. | Xiaohui Li Chenjin Deng Mingliang Chen Wenlin Gong Shensheng Han | 2015 | Photonics Research2015，3，4： | 15 |
| 15 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 16 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 17 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 18 | CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy显示文摘CRISPR/Cas9 is a versatile genome-editing tool which is widely used for modifying the genome of both prokaryotic and eukaryotic organisms for basic research and applications. An increasing number of reports have demonstrated that CRISPR/Cas9-mediated genome editing is a powerful technology for gene therapy. Here, we review the recent advances in CRISPR/Cas9-mediated gene therapy in animal models via different strategies and discuss the challenges as well as future prospects. | Xiaohui Zhang Liren Wang Mingyao Liu Dali Li | 2017 | Science China(Life Sciences)2017，60，5： | 12 |
| 19 | Effects of Pulsed Magnetic Field on Microsegregation of Solute Elements in a Ni-Based Single Crystal Superalloy显示文摘The effects of a pulsed magnetic field(PMF) on the microsegregation of solute elements during directional solidification of a Ni-based single crystal superalloy were experimentally investigated,and the results show that the PMF significantly affects the microsegregation of Al,Ti,Co,Mo and W elements in the alloy.However,the distribution behavior differs for both positive and negative segregation elements.With the PMF,the microsegregation of negative segregation elements,Co and W,was restrained effectively,while that of positive segregation elements,Al,Tiand Mo,was aggravated.A segregation model was established to reveal the distribution mechanism of the elements with PMF.It is considered that,under the action of PMF,the jumping of solute atoms from the liquid phase to solid phase is hindered,but the jumping of solute atoms from the solid phase into liquid phase is promoted during solidification.As a result,the effective distribution coefficient of the solute atoms is reduced,which leads to the reduction of microsegregation of negative segregation elements and aggravation of microsegregation of positive segregation elements. | Yingju Li Yuefei Teng Xiaohui Feng Yuansheng Yang | 2017 | Journal of Materials Science & Technology2017，33，1： | 12 |
| 20 | rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study显示文摘Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ever.Here,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated information.Accelerated by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at http://gffzz188fe103f8f1460asxb0b0960906q6kxo.ffgz.tsg.suse.edu.cn/xiaolei-lab/r MVP. | Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li Xiaolei Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
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