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| 1 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 2 | A new nor-sesquiterpene lactone from Ainsliaea fulvioides显示文摘新 nor-sesquiterpene 内酯 ainsliatone A (1 ) 从 Ainsliaea fulvioides 的天线部分被孤立。它的结构被分光镜的方法和单个水晶的 X 光检查衍射分析的基础建立。 | Yan Wang Ming Lu Xu Hui Zi Jin Jian Jun Fu Xiao Jia Hu Jiang Jiang Qin Shi Kai Yan Yun Heng Shen Wei Dong Zhang | 2009 | Chinese Chemical Letters2009，20，5： | 2 |
| 3 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 4 | Nurse Staffing Levels Make a Difference on Patient Outcomes: A Multisite Study in Chinese Hospitals显示文摘 | Xiao‐wen Zhu Li‐ming You Jing Zheng Ke Liu Jin‐bo Fang Shu‐xiao Hou Min‐min Lu Ai‐li Lv Wei‐guang Ma Hong‐hong Wang Zi‐jing Wu Li‐feng Zhang | 2012 | Journal of Nursing Scholarship2012，，3： | 1 |
| 5 | BjDHNs Confer Heavy-metal Tolerance in Plants显示文摘 | Jin Xu Yu Xiu Zhang Wei Wei Lu Han Zi Qiu Guan Zi Wang Tuan Yao Chai | 2008 | Molecular Biotechnology2008，，2： | 1 |
| 6 | BjDHNs Confer Heavy-metal Tolerance in Plants显示文摘 | Jin Xu Yu Xiu Zhang Wei Wei Lu Han Zi Qiu Guan Zi Wang Tuan Yao Chai | 2008 | Molecular Biotechnology2008，，2： | 1 |
| 7 | CERS2 Suppresses Tumor Cell Invasion and is Associated with Decreased V‐ATPase and MMP‐2/MMP‐9 Activities in Breast Cancer显示文摘 | Shao‐hua Fan Yan‐yan Wang Jun Lu Yuan‐lin Zheng Dong‐mei Wu Zi‐feng Zhang Qun Shan Bin Hu Meng‐qiu Li Wei Cheng | 2015 | J. Cell. Biochem2015，，： | 1 |
| 8 | Neuronal apoptosis and neurofilament protein expression in the lateral geniculate body of cats following acute optic nerve injuries显示文摘BACKGROUND: The visual pathway have 6 parts, involving optic nerve, optic chiasm, optic tract, lateral geniculate body, optic radiation and cortical striatum area. Corresponding changes may be found in these 6 parts following optic nerve injury. At present, studies mainly focus on optic nerve and retina, but studies on lateral geniculate body are few. OBJECTIVE: To prepare models of acute optic nerve injury for observing the changes of neurons in lateral geniculate body, expression of neurofilament protein at different time after injury and cell apoptosis under the optical microscope, and for investigating the changes of neurons in lateral geniculate body following acute optic nerve injury. DESIGN: Completely randomized grouping design, controlled animal experiment. SETTING: Department of Neurosurgery, General Hospital of Ji’nan Military Area Command of Chinese PLA. MATERIALS: Twenty-eight adult healthy cats of either gender and common grade, weighing from 2.0 to 3.5 kg, were provided by the Animal Experimental Center of Fudan University. The involved cats were divided into 2 groups according to table of random digit: normal control group (n =3) and model group (n = 25). Injury 6 hours, 1, 3, 7 and 14 days five time points were set in model group for later observation, 5 cats at each time point. TUNEL kit (Bohringer-Mannheim company)and NF200& Mr 68 000 mouse monoclonal antibody (NeoMarkers Company)were used in this experiment. METHODS: This experiment was carried out in the Department of Neurosurgery, General Hospital of Ji’nan Military Area Command of Chinese PLA between June 2004 and June 2005. ① The cats of model group were developed into cat models of acute intracranial optic nerve injury as follows: The anesthetized cats were placed in lateral position. By imitating operation to human, pterion approach was used. An incision was made at the joint line between outer canthus and tragus, and deepened along cranial base until white optic nerve via optic nerve pore and further to brain tissue. Optic nerve about 3 mm was liberated and occluded by noninvasive vascular clamp for 20 s. After removal of noninvasive vascular clamp, the area compressed by optic nerve was hollowed and narrowed, but non-fractured. Skull was closed when haemorrhage was not found. Bilateral pupillary size, direct and indirect light reflect were observed. Operative side pupil was enlarged as compared with opposite side, direct light reflect disappeared and indirect light reflect existed, which indicated that the models were successful. Animals of control group were not modeled .② The animals in the control group and model group were sacrificed before and 6 hours, 1, 3, 7 and 14 days after modeling respectively. Lateral geniculate body sample was taken and performed haematoxylin & eosin staining. Immunohistochemical staining showed lateral geniculate body neurofilament protein expression, and a comparison of immunohistochemial staining results was made between experimental group and control group. Terminal deoxynucleo-tidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) was used to label apoptotic cells in lateral geniculate body. MAIN OUTCOME MEASURES: Neuronal morphological change, neurofilament protein expression and cell apoptosis in lateral geniculate body following acute optic nerve injury. RESULTS: Twenty-eight involved cats entered the final analysis. ① Histological observation results: In the control group, cell processes were obviously found, which were few or shortening in the model group. ② Neuronal neurofilament protein expression: Cells in lateral geniculate body in the control group and at 6 hours after injury presented clear strip-shaped staining, and those at 7 and 14 days presented irregular distribution without layers and obviously decreasing staining intensity. The positive rate of neurofilament protein in lateral geniculate body in control group and 6 hours, 1, 3, 7 and 14 days after injury was (10.22±0.42)%,(10.03±0.24)%,(9.94±0.14)%,(9.98±0.22)%,(8.18±0.34)% and (6.37±0.18)%, respectively. Positive rate of neurofilament protein in control group, at 6 hours, 1 or 3 days after injury was significantly different from that at 7 days after injury (P < 0.05); Positive rate of neurofilament protein in control group, at 6 hours, 1, 3 or 7 days after injury was significantly different from that at 14 days after injury (P < 0.05). It indicated that neuronal injury in lateral geniculate body was not obvious within short term after optic nerve injury, but obvious at 7 days after injury and progressively aggravated until at 14 days after injury. ③ Neuronal apoptosis: TUNEL staining showed that neuronal apoptosis in lateral geniculate body appeared at 7 days after injury, and a lot of neuronal apoptosis in lateral geniculate body was found at 14 days after injury. It indicated that neuronal injury in lateral geniculate body was related to apoptosis. CONCLUSION: In short term after optic nerve injury (within 7 days), nerve injury of lateral geniculate body is not obvious, then, it will aggravate with the elongation of injury time. The occurrence of neuronal injury of lateral geniculate body is related to the apoptosis of nerve cells. | Feng Yu Shao ji Yuan Gang Sui Rong wei Zhang Zi sheng Liu Pei gang Lu | 2007 | Neural Regeneration Research2007，2，10： | 1 |
| 9 | PALACE HERITAGE IN STAMPS显示文摘In addition to their usual function,stamps can awaken long-lost memories of manysocietal factors,including the development of a country.Stamps are only small objects,but they can reflect elements of a country's entire history,culture,science,technology and economy.Palace Heritage in Stamps:Special Exhibition of Stamps is currently showing at the Palace Museum.Co-sponsored by China Post,China Philately and Chinaau.com.cn,the exhibition kicked off at the Forbidden City on May 18 and willcontinue until July 18. | Wang Wei Brad Green Zi Lu | 2021 | Beijing2021，，28： | 0 |
| 10 | ETERNAL LEGACY显示文摘To salute the ICOM-CC 19th Triennial Conference being held in Bejing,the exhibition Pursuing Eternity:ConservationofMuseum Collections in China opened at the Capital Museum on May 18,which also served as a major activity for International Museum Day in China.The exhibition will last until August 17,and is co-sponsored by the Nation Cultural Heritage Administration. | Wang Wei Brad Green Zi Lu | 2021 | Beijing2021，，29： | 0 |
| 11 | ART ON BRICKS显示文摘In ancient China,brick reliefs were moulded or carved portraits or patternscommonlyfoundon bricks.Brick reliefs were created by craftspeople with their extraordinary imaginations,and were typically themed around real societal elements.These works of art shed light ll aspects of ancient Chinese spiritual and material thinking.Highlights of this type of art are the unearthed artefacts from Hexi Corridor-a narrow passage stretching from the hillsides of Wushaolin near Lanzhou to Yumenguan at the border of Gansu and Xinjiang.Hexi Corridor,which was an active part of the ancient Silk Road,boasts profound history and culture. | Wang Wei Zi Lu | 2021 | Beijing2021，，23： | 0 |
| 12 | The Pathogenic Characteristics of the Initial Three Mpox Cases in Hunan Province, China显示文摘Mpox virus (MPXV) belongs to the family Poxviridae,subfamily Chordopoxvirinae,and genus Orthopoxvirus,which also includes Variola virus(VARV),Cowpox virus (CPXV),and Vaccinia virus(VACV).Clinical symptoms of mpox are similar to smallpox but are relatively milder^([1]).MPXV was first isolated from crab-eating monkeys in the tropical rainforests of Africa in 1958^([2]).The first human case of MPXV infection was reported in the Congo in1970^([3]).Following the eradication of smallpox in1977,mpox has emerged as one of the prominent viral members of the Poxviridae family,significantly impacting public health^([4]),mainly prevalent in Central and West Africa.Starting from May 2022. | LIU Rong Jiao XIANG Xing Yu HE Zi Xiang SUN Qian Lai LIU Fu Qiang ZHOU Shuai Feng HUANG Yi Wei LI Fang Cai HUANG Chao Yang WANG Juan HE Fang Ling OU Xin Hua LI Shi Kang LU Yu Ying ZHANG Fan CAI Liang MA Hai Ling ZHAN Zhi Fei | 2023 | Biomedical and Environmental Sciences2023，36，12： | 0 |
| 13 | Numerical Analysis of the Erosion Mechanism inside the Tube Sockets of Main Steam Thermometers in a Coal-Fired Power Plant显示文摘Leakage occurring in the tube sockets of the main steam thermometers can seriously threaten the safe operation of coal-fired power plants.Here,assuming a 300 MW unit as a relevant testbed,this problem is investigated numerically through solution of the equations of fluid-dynamics in synergy with the mathematical treatment of relevant statistics.The results indicate that the steam can form a large-scale spiral flow inside the tube socket and continuously scour the inner wall.In the model with the protective casing setting angle of 60°,the average tangential fluid velocity can reach up to 4.8 m/s,which is about twice higher than that in the model with the protective casing setting angle of 0°.The wake disturbance generated by the flow around the thermo-sensitive body leads to differences in the fluid motion inside the tube sockets between the upstream and downstream thermometers.These differences are affected by the distance between the thermometers,the setting angle of protective casing,and other factors.The pressure of the main steam inside the tube socket for a R3 thermometer,located outside the curved pipeline,is about 1756 Pa higher than that of the L3 thermometer located outside the straight pipeline,indicating that the secondary flow generated in the curved pipeline is able to provide stronger energy for the large-scale spiral flow inside the tube socket.On the basis of these findings,an improvement scheme for the installation of long-itudinal ribs in the tube sockets is proposed.The simulation results show that the average tangential velocity of the fluid within the near-wall area of tube sockets decreases by more than 90%,which should be enough to effectively alleviate the damage to the inner wall caused by high-pressure fluid or particles. | Yukun Lv Fan Yang Zi’an Wei Quan Lu | 2023 | Fluid Dynamics & Materials Processing2023，19，2： | 0 |
| 14 | SHINING THE BRILLIANT LIGHT OF TRUTH显示文摘0n July 8,a special exhibition onTheCommunistManifesto openedattheNational Museum of Classics.The exhibition is sponsored by the National Library of China and the Publication Department of the Communist Party of China(CPC)Zhejiang Provincial Committee.The exhibition presents 423 publications and documents in 55 languages,including 306 editions of the famed work The Communist Manifesto.These include early editions of the manifesto printed in various languages.The exhibition helps visitors better understand the background and process of the birth of the manifesto,as wellas its major theoretical contributions.The exhibition also covers how the important work was translated and disseminated throughout the world. | Wang Wei Brad Green Zi Lu | 2021 | Beijing2021，，31： | 0 |
| 15 | How will telomeric complex be further contributed to our longevity?—The potential novel biomarkers of telomere complex counteracting both aging and cancer显示文摘With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase,and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models(Garcia-Cao et al.,2006;Jaskelioff et al.,2011),we are convinced that targeting telomeres based on telomerase will be a potential approach to conquer both aging and cancer and the idea of longevity seems to be no more mysterious.More interestingly,emerging evidences from clinical research reveal that other telomeric factors,like specifi c telomeric binding proteins and nonspecific telomere associated proteins also show crucial importance in aging and oncogenesis.This stems from their roles in the stability of telomere structure and in the inhibition of DNA damage response at telomeres.Uncapping these proteins from chromosome ends leads to dramatic telomere loss and telomere dysfunction which is more abrupt than those induced by telomerase inactivation.Abnormal expression of these factors results in developmental failure,aging and even oncogenesis evidenced by several experimental models and clinical cases,indicating telomere specifi c proteins and its associated proteins have complimentary roles to telomerase in telomere protection and controlling cellular fate.Thus,these telomeric factors might be potential clinical biomarkers for early detection or even therapeutic targets of aging and cancer.Future studies to elucidate how these proteins function in telomere protection might benefit patients suffering aging or cancer who are not sensitive to telomerase mediation. | Yiming Lu Bohua Wei Tao Zhang Zi Chen Jing Ye | 2013 | Protein & Cell2013，4，8： | 0 |
| 16 | Growth Behavior of Rubrene Thin Films on Hexagonal Boron Nitride in the Early Stage显示文摘Two-dimensional materials,with an in-plane ordered and dangling-bonding-free surface,are ideal substrates for fabricating high-quality crystalline thin films.Here,we show a systematic study on the growth of a benchmark organic semiconductor,rubrene,on hexagonal boron nitride(h-BN)substrate via physical vapor deposition from the initial amorphous phase to the final crystalline phase;the role of temperature in such transition and the epitaxy relationship between rubrene and h-BN are revealed.With the increase of substrate temperature,the critical thickness of amorphous-crystalline-transition decreases and the morphology of crystalline phase also evolves from porous to terrace-like.When substrate temperature reaches>100℃,the critical thickness reduces to only 0.5 nm and a precise layer-by-layer growth from the very first layer is achieved,which is quite rare for rubrene growing on other substrates.The high ordering can be attributed to the fine epitaxy relationship between rubrene films and the h-BN surface lattice,and this film demonstrates good charge transport ability with a p-type field-effect mobility of>1 cm^(2)·V^(-1)·s^(-1). | Yujia Wei Di Xue Lianlian Ji Jie Lu Qi Wang Xingyu Jiang Yinghui Sun Zi Wang Lizhen Huang Lifeng Chi | 2022 | Chinese Journal of Chemistry2022，40，11： | 0 |
| 17 | Research progress of natural products in treating polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS)is a common metabolic disorder reproductive endocrine disease in puberty and women of childbearing age.At present,metformin is mainly used in clinical to treat PCOS.From recent researches,many natural products,such as flavonoids,alkaloids,cumarins,etc,showed curing effects on PCOS.These have been attracting more and more attention.By searching the researches from database of CNKI,PubMed etc,this paper aims at providing a reference for PCOS drug research and development. | JI Min WANG Wen‑ting WU Ying HUANG Zi‑bao DONG Lin ZHANG Xiao‑po MA Ning LU Wei‑ying | 2023 | Journal of Hainan Medical University2023，29，12： | 0 |
| 18 | Photonic-dispersion neural networks for inverse scattering problems显示文摘Inferring the properties of a scattering objective by analyzing the optical far-field responses within the framework of inverse problems is of great practical significance.However,it still faces major challenges when the parameter range is growing and involves inevitable experimental noises.Here,we propose a solving strategy containing robust neuralnetworks-based algorithms and informative photonic dispersions to overcome such challenges for a sort of inverse scattering problem—reconstructing grating profiles.Using two typical neural networks,forward-mapping type and inverse-mapping type,we reconstruct grating profiles whose geometric features span hundreds of nanometers with nanometric sensitivity and several seconds of time consumption.A forward-mapping neural network with a parameters-to-point architecture especially stands out in generating analytical photonic dispersions accurately,featured by sharp Fano-shaped spectra.Meanwhile,to implement the strategy experimentally,a Fourier-optics-based angle-resolved imaging spectroscopy with an all-fixed light path is developed to measure the dispersions by a single shot,acquiring adequate information.Our forward-mapping algorithm can enable real-time comparisons between robust predictions and experimental data with actual noises,showing an excellent linear correlation(R2>0.982)with the measurements of atomic force microscopy.Our work provides a new strategy for reconstructing grating profiles in inverse scattering problems. | Tongyu Li Ang Chen Lingjie Fan Minjia Zheng Jiajun Wang Guopeng Lu Maoxiong Zhao Xinbin Cheng Wei Li Xiaohan Liu Haiwei Yin Lei Shi Jian Zi | 2021 | Light(Science & Applications)2021，10，10： | 0 |
| 19 | Leukocyte Telomere Length and Lacunar Stroke:A Mendelian Randomization Study显示文摘Lacunar stroke is a cerebral small vessel disease that accounts for nearly 25%of cases of ischemic stroke.As an age-related disease,the incidence of lacunar stroke increases with age.Generally,biological age is equal to chronological age.However,under the influence of a range of chronic diseases and circumstances,the biological age can accelerate,which may contribute to the variation in risk of illness and death between individuals. | DANG Mei Juan LI Tao ZHAO Li Li LI Ye WANG Xiao Ya WU Yu Lun LU Jia Liang LU Zi Wei YANG Yang FENG Yu Xuan WANG He Ying JIAN Ya Ting FAN Song Hua JIANG Yu ZHANG Gui Lian | 2023 | Biomedical and Environmental Sciences2023，36，4： | 0 |
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