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| 1 | AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men显示文摘瞄准:第一次评估 Y 染色体的频率,并且讨论 AZF 删除的临床的意义微删除和在摩洛哥的人的 AZFc 区域的部分删除的出现。方法:我们屏蔽了 Y 染色体微删除和不肥沃的人的一个连续的组的 AZFc 区域的部分删除(n = 149 ) 并且控制(100 个肥沃的人, 76 个 normospermic 人) 。AZFa, AZFb, AZFc 和 AZFc 区域的部分删除被聚合酶链反应(PCR ) 根据确定的协议分析。结果:在为微删除屏蔽的 127 个不肥沃的人之中,四个题目被发现有微删除:二 AZFc 删除和二 AZFb+AZFc 删除。所有删除仅仅在 azoospermic 题目被发现(4/48, 8.33%) 。全面 AZFc 删除频率是低的(4/127, 3.15%) 。AZF 微删除没在 oligoasthenoteratozoospermia (燕麦) 或控制被观察。AZFc (gr/gr ) 的部分删除总共部分 AZFc 删除(gr/gr ) 在控制组被发现的 149 个不肥沃的人(4.70%) 中的 7 个和 7 的被观察(7/176, 3.98%) 。另外,二 b2/b3 删除在二个 azoospermic 题目被识别(2/149, 1.34%) 然而并非在控制组。结论:我们的结果建议 Y 染色体 AZF 微删除的频率与严重 spermatogenic 失败在个人被提高并且 gr/gr 删除没与 spermatogenic 失败被联系。 | Laila Imken Brahim El Houate Abdelaziz Chafik Halima Nahili Redouane Boulouiz Omar Abidi Elbakkay Chadli Noureddine Louanjli Abdelouhab Elfath Mohammed Hassar Ken McElreavey Abdelhamid Barakat Hassan Rouba | 2007 | Asian Journal of Andrology2007，9，5： | 22 |
| 2 | Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection显示文摘AIM: To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection. METHODS: One hundred and fifty-four patients with chronic HCV infection were included in this study; 124 patients were non-cirrhotic, and 30 were cirrhotic. The following measurements were obtained in all patients: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, prothrombin time and concentration, complete blood count, hepatitis B surface antigen (HBsAg), HCVAb, HCV-RNA by quantitative polymerase chain reaction, abdominal ultrasound and ultrasonic-guided liver biopsy. The following ratios, scores and indices were calculated and compared with the results of the histopathological examination: AST/ALT ratio (AAR), age platelet index (API), AST to platelet ratio index (APRI), cirrhosis discriminating score (CDS), Pohl score, G teborg University Cirrhosis Index (GUCI). RESULTS: AAR, APRI, API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5%, 79.2%, 76.6% and 80.5%, respectively); P values were: < 0.01, < 0.05, < 0.001 and < 0.001, respectively. Among the studied parameters, AAR and GUCI gave the highest diagnostic accuracy (80.5%) with cutoff values of 1.2 and 1.5, respectively. APRI, API and GUCI were significantly correlated with the stage of fibrosis (P < 0.001) and the grade of activity (P < 0.001, < 0.001 and < 0.005, respectively), while CDS only correlated significantly with the stage of fibrosis (P < 0.001) and not with the degree of activity (P > 0.05). In addition, we found significant correlations for the AAR, APRI, API, GUCI and Pohl score between the non-cirrhotic (F0, F1, F2, F3) and cirrhotic (F4) groups (P values: < 0.001, < 0.05, < 0.001, < 0.001 and < 0.005, respectively; CDS did not demonstrate significant correlation (P > 0.05). CONCLUSION: The use of AAR, APRI, API, GUCI and Pohl score measurements may decrease the need for liver biopsies in diagnosing cirrhosis, especially in Egypt, where resources are limited. | Shawky Abdelhamid Fouad Serag Esmat Dalia Omran Laila Rashid Mohamed H Kobaisi | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 3 | Effects of food quality on trade-offs among growth, immunity and survival in the greater wax moth Galleria mellonella显示文摘对在任何给定的环境的一个个人可得到的资源是有限的,并且特点反映的生活历史上的变化到竞争生活的这些资源的微分分配工作食物的营养的质量具有在在这研究的这些生活历史决定的特别重要性,我们在生长之中测试了交易,在幼虫在我们发现生长快速的高、平均的营养的质量的节食喂了的3组更大的蜡蛾(街郎 mellonella )的免疫和弱免疫(是由封装反应测量了)在高精力的食物组的幼虫,它更长拿了在食物上发展平均营养不管多么的质量,封装反应在这是更强壮的幼虫在低精力的食物组更长种了,并且有的组我们观察了的最强壮的封装反应在低精力的食物的幼虫的最高的幸存率组织,当最高的死亡率在高精力的食物组被观察时,在身体质量和封装反应的力量之间的重要否定关联仅仅在仅仅在这研究的结果帮助建立关系的最高的增长率揭示在生长和免疫之间的重要竞争的高精力的食物组被发现在食物,它的营养的价值和G. mellonella 幼虫的生活历史特点的类型之间。 | Indrikis Krams Sanita Kecko Katariina Kangassalo Fhionna R. Moore Eriks Jankevics Inna Inashkina Tatjana Krama Vilnis Lietuvietis Laila Meija Markus J. Rantala | 2015 | Insect Science2015，22，3： | 5 |
| 4 | Photopic negative response in diagnosis of glaucoma:an experimental study in glaucomatous rabbit model显示文摘AIM: To determine whether the photopic negative response(Ph NR) elicited by transient white flash on white background is characterizing for glaucoma model in rabbits.METHODS: Glaucoma was induced in twelve rabbits by subconjunctival injection of 0.05 m L of betamethasone in right eyes(each 1 m L contain betamethasone dipropionate5 mg and betamethasone sodium phosphate 2 mg).The intraocular pressure(IOP), electroretinogram(ERG) and visual evoked potential(VEP) were measured successively prior and on the 3, 7d, two weeks and four weeks postglaucoma induction. After four weeks, the animals were sacrificed and the globes were histopathologically examined.RESULTS: The IOP increased significantly after one week(P =0.0001), then it gradually returned to the control level. In ERG examination, the means of a and b wave amplitude and latency were not affected significantly.Ph NR amplitude decreased significantly within one week(P =0.0001), but its latency was not affected significantly(P =0.132). The means of VEP latency and amplitude were significantly affected after two weeks and four weeks of glaucoma induction(P =0.0001 and 0.02,respectively). The histopathologic examination of the globes showed reduced number of cells in the retinal ganglion cell layer with multiple vacuoles in the retinal nerve fibre layer.There was significant positive correlation between ganglion cell layer cells and Ph NR amplitude( r =0.8, P =0.002).CONCLUSION: The rise in IOP resulted in irreversible changes or incomplete recovery of VEP and Ph NR amplitude. Both Ph NR and VEP represented good additional tools in early diagnosis of glaucoma. | Amal A.El Gohary Laila Hassan M.Elshazly | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 5 |
| 5 | Purification and Characterization of Glyceraldehyde-3-phosphate Dehydrogenase from European Pilchard Sardina pilchardus显示文摘NAD^+ 依赖的 cytosolic glyceralehyde-3-phosphate 脱氢酶(GAPDH;EC 1.2.1.12 ) 从欧洲沙丁鱼 Sardina 沙丁鱼的骨胳的肌肉被净化我们和它的物理化学、运动的性质被调查。纯化方法由二个步骤组成了,铵硫酸盐分别由蓝 Sepharose CL-6B 层析列在后面,导致比活和约 25% 的最后的收益的近似 78 褶层增加。为 NAD^+ 和 D-glyceraldehyde-3-phosphate 的 Michaelis (K_m ) 分别地是 92.0 妈妈和 73.4 妈妈。净化的酶的最大的速度(V_( 最大)) 被估计是 37.6 U/mg。在试金条件下面,最佳 pH 和温度是 8.0 和 30 ° C。净化的酶的分子的重量是钠 dodecyl sulfate-polyacrylamide 凝胶电泳决定的 37 kDa。产出 154 kDa 的分子的重量的非使中毒的 polyacrylamide 胶化建议酶是 homotetramer。对净化的酶的 Polyclonal 抗体被用来由蛋白质印迹分析在不同沙丁鱼纸巾认出酶。等电点,在 polyacrylamide 平板胶化由一个等电位的集中系统获得了,揭示了一仅仅 GAPDH isoform (pI 7.9 ) 。 | Tarik BAIBAI Laila OUKHATFAR Adnane MOUTAOUAKKIL Abdelaziz SOUKRI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 5 |
| 6 | Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats’ critical-sized mandibular defects显示文摘BACKGROUND Critically sized bone defects represent a significant challenge to orthopaedic surgeons worldwide.These defects generally result from severe trauma or resection of a whole large tumour.Autologous bone grafts are the current gold standard for the reconstruction of such defects.However,due to increased patient morbidity and the need for a second operative site,other lines of treatment should be introduced.To find alternative unconventional therapies to manage such defects,bone tissue engineering using a combination of suitable bioactive factors,cells,and biocompatible scaffolds offers a promising new approach for bone regeneration.AIM To evaluate the healing capacity of platelet-rich fibrin(PRF)membranes seeded with allogeneic mesenchymal bone marrow-derived stem cells(BMSCs)on critically sized mandibular defects in a rat model.METHODS Sixty-three Sprague Dawley rats were subjected to bilateral bone defects of critical size in the mandibles created by a 5-mm diameter trephine bur.Rats were allocated to three equal groups of 21 rats each.Group I bone defects were irrigated with normal saline and designed as negative controls.Defects of group II were grafted with PRF membranes and served as positive controls,while defects of group III were grafted with PRF membranes seeded with allogeneic BMSCs.Seven rats from each group were killed at 1,2 and 4 wk.The mandibles were dissected and prepared for routine haematoxylin and eosin(HE)staining,Masson's trichrome staining and CD68 immunohistochemical staining.RESULTS Four weeks postoperatively,the percentage area of newly formed bone was significantly higher in group III(0.88±0.02)than in groups I(0.02±0.00)and II(0.60±0.02).The amount of granulation tissue formation was lower in group III(0.12±0.02)than in groups I(0.20±0.02)and II(0.40±0.02).The number of inflammatory cells was lower in group III(0.29±0.03)than in groups I(4.82±0.08)and II(3.09±0.07).CONCLUSION Bone regenerative quality of critically sized mandibular bone defects in rats was better promoted by PRF membranes seeded with BMSCs than with PRF membranes alone. | Muhammad A Awadeen Fouad A Al-Belasy Laila E Ameen Mohamad E Helal Mohammed E Grawish | 2020 | World Journal of Stem Cells2020，12，1： | 4 |
| 7 | Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats显示文摘瞄准:估计他我在勃起组织 ofsildenafil 的 oxygenase-1 (HO-1 ) 活动对待柠檬酸盐的老鼠。方法:192 只 Sprague-Dawley 雄的老鼠,划分了成四个相等的组,被调查。组织 1,控制组,收到的常规动物食物;由胃内试管组织 2 收到的 sildenafil 柠檬酸盐;组 3 收到的 sildenafiland 惊讶禁止者(锌原卟啉, ZnPP ) ;并且组 4 收到了 sildenafil 和氮的 oxidesynthase (NOS ) 禁止者 L-nitroarginine 甲基酉旨(L 名字) 。从每个组的 12 只老鼠在 0.5 h, 1 h, 2 h 和药管理的 3 h 以后被打死。然后,在勃起组织的 HO-1 活动, cGMP 层次和 NOSenzymatic 活动被估计。结果:在勃起组织, HO-1activity, NOS 酶的活动和 cGMP,集中在整个实验与另外的组相比增加了显著地对待 insildenafil 的老鼠。收到任何一个 HOor NOS 禁止者的老鼠在这些参数显示出重要减少。酶的活动表明了的 HO-1 勃起组织活动和 NOS 与 cGMP 层次的积极重要关联(r =0.646, r = 0.612 分别地;P <
0.001 ) 。结论:在勃起组织的 PDE_5 禁止者 sildenafilcitrate 的行动部分通过在 HO-1 和 NOS 活动之间的相互依赖的关系被调停。 | M. Talaat Abdel Aziz M. Farid Al-Asmar Taymour Mostafa Hazem Atta Laila Rashed Dina Sabry Shedeed Ashour Ahmed T. Abdel Aziz | 2007 | Asian Journal of Andrology2007，9，3： | 4 |
| 8 | Pillararene-based supramolecular systems for theranostics and bioapplications显示文摘As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and biology.Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results.Owing to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional biomaterials.On one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of drugs.On the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability.In this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,etc.By introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are described.Future challenges and directions of this field are also outlined. | Huangtianzhi Zhu Qi Li Laila E.Khalil-Cruz Niveen M.Khashab Guocan Yu Feihe Huang | 2021 | Science China Chemistry2021，64，5： | 4 |
| 9 | Gas chromatography-mass spectrometry analysis of different organic crude extracts from the local medicinal plant of Thymus vulgaris L显示文摘Objective:To isolate and analyze the chemical composition in different crude extracts of from the leaves of locally grown of Thymus vulgaris L(T.vulgaris)by gas chromatography-mass spectrometry(GC-MS).Methods:The shade dried leaves powder was extracted with methanol by using Soxhlet extractor.Methanol crude extracts of T.vulgaris and the derived fractions of hexane,chloroform,ethyl acetate and butanol were obtained.Results:Qualitative analyses of various organic crude extracts of T.vulgaris by using GC-MS showed that there were different types of high and low molecular weight compounds.Most of the isolated and identified compounds by GC-MS in the crude extracts are basically biologically important.Further,the T.vulgaris leaf possessed certain characteristics that can be ascribed to cultivation on a domestic plantation.The crude extracts were prepared from the powder leaves of T.vulgaris for respective compounds can be chosen on the basis of above GC-MS analysis.Conclusions:All the major compounds were identified and characterized by spectroscopic method in different organic crude extracts of T.vulgaris are biologically active molecules.Thus the identification of a good number of compounds in various crude extracts of T.vulgaris might have some ecological role. | Laila Salim Al Hashmi Mohammad Amzad Hossain Afaf Mohammed Weli Qasim Al-Riyami Jamal Nasser Al-Sabahi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 4 |
| 10 | THE MIRROR-NEURON SYSTEM显示文摘 | Giacomo Rizzolatti Laila Craighero | 2004 | Annual Review of Neuroscience2004，，： | 3 |
| 11 | Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats显示文摘Objective:To evaluate the effect of mesenchymal stem cells(MSCs)in rats with anti-Thy 1,1nephritis.Methods:Female albino rats were divided into three groups,control group,anti-Thy 1,1group and treatment with i.v.MSCs group.MSCs were derived from bone marrow of male albino rats,Y—chromosome gene was detected by polymerase chain reaction in the kidney.Serum urea and creatinine were estimated for all groups.Kidney of all studied groups was examined histologically and histochemically(total carbohydrates and total proteins).DNA fragmentation and expression ofα-SMA were delected.Results:Kidney of animals injected with anti-Thy 1,1showed inflammatory leucocytic infiltration,hypertrophied glomeruli,tubular necrosis and congestion in the renal blood vessels.The kidney tissue also showed reduction of carbohydrates and total proteins together with increase in apoptosis and in expression ofα-SMA.Moreover,the levels of urea and creatinine were elevated.Treating animals with MSCs revealed that kidney tissue displayed an improvement in the histological and histochemical changes.Apoptosis andα-SMA expression were decreased,and the levels of urea and creatinine decreased.Conclusions:The obtained results demonstrated the potential of MSCs to ameliorate the structure and function of the kidney in rats with anti-Thy 1,1 nephritis possibly through the release of paracrine growth factor(s). | Saber Sakr Laila Rashed Waheba Zarouk Rania El-Shamy | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，3： | 3 |
| 12 | Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats显示文摘AIM: To examine the possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats. METHODS: Female rats were fed a standard diet and received a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception. In study 1, neonatal rats were randomly subjected to blood tests to investigate autism. In study 2, the 1st group was fed by the mother after an injection of interferon-γ (IFN-γ) and administration of gliadin. The pups in the 2nd group were prevented from accessing maternal milk, injected IFN-γ, administered gliadin, and hand-fed human colostrum. The normal littermates fed by the table mothers were injected with physiological saline and served as normal controls in this study.RESULTS: The protein concentration was higher in group 2 than in group 1 in the duodenum (161.6 ± 9 and 135.4 ± 7 mg/g of tissue, respectively, P < 0.01). A significant increase (P < 0.001) in body weight was detected in human colostrum-treated pups on post natal day (PND) 7 and 21 vs suckling pups in group 1. A delay in eye opening was noticed in the treated rats in group 1 on PND 13 compared with the control group and group 2. Administration of a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception resulted in significantly reduced calcium and vitamin D levels in study 1 compared with the control groups (P < 0.001). However, human colostrum uptake inhibited increases in the level of transglutaminase antibody in autistic pups with coeliac disease. CONCLUSION: The effects of early-life nutrition and human colostrum on the functional maturation of the duodenal villi in autistic rats with coeliac disease that might limit or prevent the coeliac risk with autism. | Manar E Selim Laila Y Al-Ayadhi | 2013 | World Journal of Gastroenterology2013，19，21： | 3 |
| 13 | Effect of the Si/Al ratio of HZSM-5 zeolite on the production of dimethyl ether before and after ultrasonication显示文摘A series of as-synthesized HZSM-5 zeolites with different Si/Al ratios(25,90,120,240 and 400)were post-treated by ultrasonication for an optimum time of 60 min.The morphology,acidity and textural properties of HZSM-5 were characterized with XRD,SEM,N_2 adsorption and NH3-TPD techniques.The catalytic performance was evaluated by dehydration of methanol to dimethyl ether(DME),which is a promising gaseous automotive fuel in future.It was found that the Si/Al ratio of HZSM-5 had considerable impacts on its catalytic performance for dehydration of methanol to DME.Its activity increased with decreasing Si/Al ratio from 400 to 25.Ultrasonication of HZSM-5 could significantly improve its catalytic performance. | Sameh M.K.Aboul-Fotouh Laila I.Ali Mona A.Naghmash Noha A.K.Aboul-Gheit | 2017 | 燃料化学学报2017，45，5： | 3 |
| 14 | Short‐term evaluation of autologous transplantation of bone marrow–derived mesenchymal stem cells in patients with cirrhosis: Egyptian study显示文摘 | Mona A. Amin Dina Sabry Laila A. Rashed Wael M. Aref Mohamed Ahmed el‐Ghobary Marwa Salah Farhan Hany Ahmed Fouad Youssef Abdel‐Aziz Youssef | 2013 | Clin Transplant2013，，4： | 2 |
| 15 | Dental pulp stem cells stimulate neuronal differentiation of PC12 cells显示文摘Dental pulp stem cells(DPSCs) secrete neurotrophic factors which may play an important therapeutic role in neural development, maintenance and repair. To test this hypothesis, DPSCs-conditioned medium(DPSCs-CM) was collected from 72 hours serum-free DPSCs cultures. The impact of DPSCs-derived factors on PC12 survival, growth, migration and differentiation was investigated. PC12 cells were treated with nerve growth factor(NGF), DPSCs-CM or co-cultured with DPSCs using Transwell inserts for 8 days. The number of surviving cells with neurite outgrowths and the length of neurites were measured by image analysis. Immunocytochemical staining was used to evaluate the expression of neuronal markers NeuN, microtubule associated protein 2(MAP-2) and cytoskeletal marker βIII-tubulin. Gene expression levels of axonal growth-associated protein 43 and synaptic protein Synapsin-I, NeuN, MAP-2 and βIII-tubulin were analysed by quantitative polymerase chain reaction(qRT-PCR). DPSCs-CM was analysed for the neurotrophic factors(NGF, brain-derived neurotrophic factor [BDNF], neurotrophin-3, and glial cell-derived neurotrophic factor [GDNF]) by specific ELISAs. Specific neutralizing antibodies against the detected neurotrophic factors were used to study their exact role on PC12 neuronal survival and neurite outgrowth extension. DPSCs-CM significantly promoted cell survival and induced the neurite outgrowth confirmed by NeuN, MAP-2 and βIII-tubulin immunostaining. Furthermore, DPSCsCM was significantly more effective in stimulating PC12 neurite outgrowths than live DPSCs/PC12 co-cultures over the time studied. The morphology of induced PC12 cells in DPSCs-CM was similar to NGF positive controls;however, DPSCs-CM stimulation of cell survival was significantly higher than what was seen in NGF-treated cultures. The number of surviving PC12 cells treated with DPSCs-CM was markedly reduced by the addition of anti-GDNF, whilst PC12 neurite outgrowth was significantly attenuated by anti-NGF, anti-GDNF and anti-BDNF antibodies. These findings demonstrated that DPSCs were able to promote PC12 survival and differentiation. DPSCs-derived NGF, BDNF and GDNF were involved in the stimulatory action on neurite outgrowth, whereas GDNF also had a significant role in promoting PC12 survival. DPSCs-derived factors may be harnessed as a cell-free therapy for peripheral nerve repair. All experiments were conducted on dead animals that were not sacrificed for the purpose of the study. All the methods were carried out in accordance with Birmingham University guidelines and regulations and the ethical approval is not needed. | Nessma Sultan Laila E.Amin Ahmed R.Zaher Mohammed E.Grawish Ben A.Scheven | 2021 | Neural Regeneration Research2021，16，9： | 2 |
| 16 | Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response显示文摘AIM: To correlate a genetic polymorphism of the low-density lipoprotein(LDL) receptor with antiviral responses in Egyptian chronic hepatitis C virus(HCV) patients.METHODS: Our study included 657 HCV-infected patients with genotype 4 who received interferonbased combination therapy. Patients were divided into two groups based on their response to therapy: 356 were responders, and 301 were non-responders. Patients were compared to 160 healthy controls. All patients and controls underwent a thorough physical examination, measurement of body mass index(BMI) and the following laboratory tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, direct bilirubin, prothrombin time, prothrombin concentration, INR, complete blood count, serum creatinine, fasting blood sugar, HCV antibody, and hepatitis B surface antigen. All HCV patients were further subjected to the following laboratory tests: HCV-RNA using quantitative polymerase chain reaction(PCR), antinuclear antibodies, thyroid-stimulating hormone, an LDL receptor(LDLR) genotype study of LDLR exon8 c.1171G>A and exon-10 c.1413G>A using real-time PCR-based assays, abdominal ultrasonography, ultrasonographic-guided liver biopsy, and histopathological examination of liver biopsies. Correlations of LDL receptor polymorphisms with HAI, METAVIR score, presence of steatosis, and BMI were performed in all cases.RESULTS: There were no statistically significant differences in response rates between the different types of interferon used or LDLR exon10 c.1413G>A. However, there was a significant difference in the frequency of the LDL receptor exon8 c.1171G>A genotype between cases(AA: 25.9%, GA: 22.2%, GG: 51.9%) and controls(AA: 3.8%, GA: 53.1% and GG: 43.1%)(P < 0.001). There was a statistically significant difference in the frequency of the LDLR exon 8C:1171 G>A polymorphism between responders(AA: 3.6%, GA: 15.2%, GG: 81.2%) and nonresponders(AA: 52.2%, GA: 30.6%, GG: 17.2%)(P < 0.001). The G allele of LDL receptor exon8 c.1171G>A predominated in cases and controls over the A allele, and a statistically significant association with response to interferon was observed. The frequency of the LDLR exon8 c.1171G>A allele in non-responders was: A: 67.4% and G: 32.6 vs A: 11.2% and G: 88.8% in responders(P < 0.001). Therefore, carriers of the A allele exhibited a 16.4 times greater risk for nonresponse. There was a significant association between LDL receptors exon8 c.1171G>A and HAI(P < 0.011). There was a significant association between LDL receptors exon8 c.1171G>A and BMI. The mean BMI level was highest in patients carrying the AA genotype(28.7 ± 4.7 kg/m2) followed by the GA genotype(28.1 ± 4.8 kg/m2). The lowest BMI was the GG genotype(26.6 ± 4.3 kg/m2)(P < 0.001). The only significant associations were found between LDL receptors exon8 c.1171G>A and METAVIR score or steatosis(P < 0.001).CONCLUSION: LDL receptor gene polymorphisms play a role in the treatment response of HCV and the modulation of disease progression in Egyptiansinfected with chronic HCV. | Mazen Naga Mona Amin Dina Algendy Ahmed Elbadry May Fawzi Ayman Foda Serag Esmat Dina Sabry Laila Rashed Samia Gabal Manal Kamal | 2015 | World Journal of Gastroenterology2015，21，39： | 2 |
| 17 | Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat显示文摘 | Mokhtar I. Yousef Sahar A.M. Omar Marwa I. El-Guendi Laila A. Abdelmegid | 2010 | Food and Chemical Toxicology2010，，11： | 2 |
| 18 | Joint 2D DOA and Doppler frequency estimation for L-shaped array using compressive sensing显示文摘A joint two-dimensional(2D)direction-of-arrival(DOA)and radial Doppler frequency estimation method for the L-shaped array is proposed in this paper based on the compressive sensing(CS)framework.Revised from the conventional CS-based methods where the joint spatial-temporal parameters are characterized in one large scale matrix,three smaller scale matrices with independent azimuth,elevation and Doppler frequency are introduced adopting a separable observation model.Afterwards,the estimation is achieved by L1-norm minimization and the Bayesian CS algorithm.In addition,under the L-shaped array topology,the azimuth and elevation are separated yet coupled to the same radial Doppler frequency.Hence,the pair matching problem is solved with the aid of the radial Doppler frequency.Finally,numerical simulations corroborate the feasibility and validity of the proposed algorithm. | WANG Shixin ZHAO Yuan LAILA Ibrahim XIONG Ying WANG Jun TANG Bin | 2020 | Journal of Systems Engineering and Electronics2020，31，1： | 2 |
| 19 | Persian medicine non-pharmacological therapies for headache:phlebotomy and wet cupping显示文摘OBJECTIVE: To describe the common causes of headache as well as the different methods of Phlebotomy(Fasd) and wet Cupping(Hijamat) based on Persian Medicine.METHODS: In this study, we searched Google Scholar, Science Direct, Pub Med and Scopus to get any in vitro or clinical evidence of the efficacy and possible mechanisms of phlebotomy or wet cupping on different types of headaches. Also different types of headaches, according to PM, under the title of 'Sodaa'; extracted from famous Persian medical text books with key words including 'Sodaa','Bayze' and 'Shaqiqe'.RESULTS: According to PM, diseases(dystemperament) are created by abnormal alteration in temperament. Temperament is a monolithic quality yielded by interaction between opposing qualities of four elements that are coldness, hotness, dryness and wetness. Headaches are caused by dystemperament(sue-Mizaj) in brain or in total body that are divided into simple and corporal. Common forms of the latter type are Vaporal and Migrant headache(Bokhari and Rihi). Each of these headaches is treated either through phlebotomy or wet cupping.CONCLUSION: In Persian Medicine, Fasd and Hijamat are easy and economical methods for treatment of headache with reasonable results. By describing the precise areas and indications of phlebotomy and wet cupping, this study provides the first step for future clinical trials in this field. | Akramo Sadat Atyabi Fatemeh Nejatbakhsh Hoorie Mohammadi Kenari Fatemeh Eghbalian Mohammad Hos-sein Ayati Laila Shirbeigi | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 2 |
| 20 | Cardiac metallothi-onein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation 显示文摘 | Wang Jian xun Song Ye Laila E | 2006 | Circulation2006，113，： | 1 |
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