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| 1 | Expressions of PCNA,p53,p21^(WAF-1)and cell proliferation in fetal esophageal epithelia:Comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal cancer in Henan,North China显示文摘AIM: To characterize the expression of p53, p21WAF-1 and proliferation-cell-nuclear-antigen (PCNA) in fetal esophageal epithelia and to determine the role of these genes in proliferation of fetal and adult esophageal epithelial cells. METHODS: Immunohistochemical avdin-biotin peroxidase complex (ABC) method was applied to 31 cases of fetal esophageal specimens and 194 cases of adult esophageal specimens to detect the expression of p53, p21WAF-1 and PCNA in fetal and adult esophageal epithelia. RESISTS: Both the PCNA positive immunostaining cell number and PCNA positive immunostaining rate in fetal esophageal epithelia (5064-239) were significantly higher than those in adults, induding normal epithelia (2004-113) and epithelia with basal cell hyperplasia (BCH) (2864-150) (P<0.05, ttest). However, the number of PCNA positive immunostaining cells in adult esophageal dysplasia (7194-389) and squamous cell cardnoma (SCC) (12614-545) was apparently higher than that in fetal esophageal epithelia (5064-239) (P<0.05, tbest). The positive immunostaining rabe of P53 was 10 % (3/31) in fetal esophageal epithelia, which was significantly lower than that in adult normal esophageal epithelia (50 %), adult epithelia with basal cell hyperplasia (62 %), dysplasia (73 %) and squamous cell carcinoma (86 %) (P<0.05, Fisher''s exact test). No p21WAF-l positive immunostaining cells were observed in fetal esophageal epithelia. However, p21w^l positive immunost^ining cells wereobserved in adult esophagus with 39 % (11/28) in normal, 38% (14/37) in BCH, 27 % (3/11) in DYS and 14 % (1/7) in SCC. CONCLUSION: PCNA could act as an indicator accurately reflecting the high proliferation status of fetal esophageal epithelium, p53 may play an important role in growth and differentiation of fetal esophageal epithelium, p21WAF-1 may have no physiological function in development of fetal esophageal epithelium. | YingXing YuNing Li-QiangRu Li-DongWang | 2003 | World Journal of Gastroenterology2003，9，7： | 4 |
| 2 | The electrical conductivity of eclogite in Tibet and its geophysical implications显示文摘西藏的 eclogite 的电的传导性在 10 的一个频率范围以内用阻抗光谱学在 1.53.5 GPa 的压力和 500803 K 的温度被调查 < 啜 class= “ a-plus-plus ” > 1 10 6 Hz。eclogite 的电的传导性与增加温度增加(它能被 Arrhenius 方程接近) ,并且被压力微弱地影响。在每个测试压力,电的传导性是弱在 650 K 下面并且更强烈的温度依赖者在 650 K 上面的温度依赖者。计算激活精力和体积是 | GUO YingXing WANG DuoJun SHI YaoLin ZHOU YongSheng DONG YongSheng LI Cai | 2014 | Science China Earth Sciences2014，57，9： | 2 |
| 3 | Electrical conductivities of two granite samples in southern Tibet and their geophysical implications显示文摘There are clear differences in the electrical conductivities of the crustal granites of the Qinghai-Tibet Plateau.Because these granites are among the major rock types on the Qinghai-Tibet Plateau, it is very important to detect the electrical conductivity of granites under high temperatures and pressures to study the electrical conductivity structure of this area. Using impedance spectroscopy at a frequency range of 10.1–106 Hz, the electrical conductivity of the muscovite-granite collected from Yadong was investigated at a confining pressure of 1.0 GPa and temperatures ranging from 577 to 996 K, while the electrical conductivity of the biotite-granite collected from Lhasa was investigated at a pressure of 1.0 GPa and temperatures ranging from587 to 1382 K. The calculated activation enthalpies of the Yadong muscovite-granite sample is 0.92 eV in the low-temperature range(577–919 K) and 2.16 eV in the high-temperature range(919–996 K). The activation enthalpies of the Lhasa biotite-granite sample is 0.48 eV in the low-temperature range(587–990 K) and 2.06 eV in the high-temperature range(990–1382 K). The change in the activation enthalpies of the granites at different temperature ranges may be associated with the dehydration of the two samples. The electrical conductivities of the granite samples obtained in the laboratory using impedance spectroscopy correspond well with field observations conducted near the sampling points, both in terms of the actual conductivity values and the observed variations between the low-temperature and high-temperature regimes. This correlation of laboratory and field conductivities indicates that the conductivities of the crustal rocks in the two regions closely correspond to granite conductivities.We calculated the electrical conductivities of muscovite-granite and biotite-granite samples using the effective medium and HS boundary models. When applied to the crustal rocks of southern Tibet, the results of the geophysical conductivity profiles lie within the range of laboratory data. Thus, the electrical characteristics of the crustal rocks underlying the southern Qinghai-Tibet Plateau can largely be attributed to granites, with the large changes to high conductivities at increasing depths resulting from the dehydration of crustal rocks with granitic compositions. | GUO YingXing WANG DuoJun ZHOU YongSheng LIU ZaiYang YU YingJie LI DanYang ZHANG DongNing ZHU AiYu | 2017 | Science China Earth Sciences2017，60，8： | 2 |
| 4 | Transarterial chemoembolization in combination with programmed death-1/programmed cell death-ligand 1 immunotherapy for hepatocellular显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies worldwide.With the development of systemic therapies,several studies are currently underway,especially those related to the use of programmed death-1/programmed cell death-ligand 1(PD-1/PD-L1)immunotherapy.Moreover,studies on transarterial che-moembolization(TACE)and PD-1/PD-L1 immunotherapy have demonstrated some interesting outcomes.This article reviewed the current clinical evidence on the combination of TACE and PD-1/PD-L1 immunotherapy.Overall,our review summarized that a favorable survival time could be achieved using this combination in most patients.However,complications such as hyperprogression should be taken seriously,and the underlying mechanisms need to be explored. | Jingxin Yan Manjun Deng Shunyu Kong Ting Li Zhenwu Lei Lushun Zhang Yutong Zhuang Xin He Huanwei Wang Haining Fan Yingxing Guo | 2022 | iLIVER2022，1，4： | 2 |
| 5 | Influence of mantle convection to the crustal movement pattern in the northeastern margin of the Tibetan Plateau based on numerical simulation显示文摘Based on the recent observations about the movement and rheological structure of the lithosphere and deformation pattern of the crust, we developed a three-dimensional finite element model for the northeastern margin of the Tibetan Plateau.The model considered the impacts of both external and internal conditions, including mantle convection, gravitational potential energy and block interactions. We compared the simulated surface movement rates to the observed GPS velocities, and the results revealed that crustal movement gradually decreased toward the edge of the plateau. The factors controlling this pattern are the interactions of adjacent blocks, gravitational potential energy of the plateau, and also mantle convection as well. Additionally,according to the observation that there was an apparent difference between the horizontal movement rate of the lithosphere and convective velocity of the underlying mantle, and also based on the results of seismic anisotropy studies that suggest different strengths and deformation regimes of the lithosphere in different tectonic blocks, we proposed that the impact of mantle convection on the lithosphere may have varied in space, and introduced a parameter named mantle convection intensity factor in numerical simulations. Our simulation results show consistent surface movement rates with GPS observations, which further supports the viewpoint of seismic anisotropy studies, i.e., the degree of coupling between the crust and mantle varies significantly among different blocks. | Aiyu ZHU Dongning ZHANG Tao ZHU Yingxing GUO | 2018 | Science China Earth Sciences2018，61，11： | 1 |
| 6 | Does index futures trading reduce volatility in the Chinese stock market? A panel data evaluation approach显示文摘 | Chen Haiqiang Han Qian Li Yingxing | 2013 | Journal of Futures Markets2013，33，12： | 1 |
| 7 | Efficacy and complications of transarterial chemoembolization alone or in combination with different protocols for hepatocellular carcinoma: A Bayesian network meta-analysis of randomized controlled trials显示文摘Background and aims:Transarterial chemoembolization(TACE)is the standard treatment for most intermediate-toadvanced stage hepatocellular carcinoma.With the ongoing development of interventional therapies,TACE in combination with different protocols is being explored.A network meta-analysis to collect recent evidence in this field is required.Methods:We searched PubMed,Web of Science,Cochrane Central Register of Controlled Trials,Embase,Chinese National Knowledge Infrastructure database,Cochrane Library,and Wanfang database from their inception to May 2022 for randomized controlled trials(RCTs)that reported TACE in combination with different protocols for hepatocellular carcinoma.Results:In total,67 RCTs assessing eight combination treatments were included.The quality of primary outcomes was from moderate to low.The Bayesian network meta-analysis confirmed that TACE combined with iodine-125 seed implantation had the highest probability of 1-year survival rate and TACE combined with sorafenib had the highest probability of 2-year survival rate.TACE alone had the highest probability of incidence of fever,TACE combined with sorafenib had the highest probability of incidence of pain and TACE combined with percutaneous ethanol injection had the highest probability of incidence of nausea and vomiting.Conclusion:This Bayesian network meta-analysis found that TACE combined with iodine-125 seed and TACE combined with sorafenib may benefit patients in terms of 1-year survival and 2-year survival,respectively.To confirm this conclusion,high-quality and well-designed RCTs with a larger sample size are needed. | Jingxin Yan Manjun Deng Ting Li Changhao Dong Minglan Wang Shunyu Kong Yingxing Guo Haining Fan | 2023 | iLIVER2023，2，2： | 1 |
| 8 | Quantum poincare section of two-dimensional Hamiltonian in a coherent state representation显示文摘 | Jin Yingxing He Kai fen | 2002 | Chinese Phys Lett2002，19，9： | 1 |
| 9 | Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion显示文摘AIM: To investigate the effect of tetramethylpyrazine (ligustrazine, TMP) on the secretion of exocrine pancreas (and biliary).METHODS: In in vivo study, we investigated the effect of TMP on the secretion of pancreatic-bile juice (PBJ) in rats.Using human pancreatic duct cell line, CAPAN-1, combined with the short-circuit current (ISC) technique we further studied the effect of TMP on the pancreatic anion secretion.RESULTS: Administration of TMP (80 mg/kg, ip) significantly increased the secretion of PBJ (P<0.05), but the pH of PBJ and the secretion of pancreatic protein were not significantly affected. Basolateral addition of TMP produced a dosedependent increase in ISC(EC50=1.56 mmol/L), which contained a fast transient ISC response followed by a slow decay. Apical application of Cl- channel blockers, DPC (1 mmol/L),decreased the response by about 67.1% (P<0.001), whereas amiloride (100 μmol/L), a epithelial sodium channel blockers,had no effect. Removal of extracellular HCO3- abolished TMP-induced increase in ISC by about 74.4 % (P<0.001),but the removal of external Cl- did not. Pretreatment with phosphodiesterase inhibitor, TBMX(0.5 mmol/L), decreased the TMP-induced ISC by 91% (P<0.001).CONCLUSION: TMP could stimulate the secretion of PBJ,especially pancreatic ductal HCO3- secretion via cAvlp or cGMP-dependent pathway. It need further study to investigate the roles of cAMP or cGMP in the effect of TMP on the secretion of exocrine pancreas. | Wen-ChaoZhao Jin-XiaZhu NingTang Yu-LinGou DewiKennethRowlands Yiu-WaChung YingXing Hsiao-ChangChan | 2003 | World Journal of Gastroenterology2003，9，11： | 1 |
| 10 | 显示文摘 | 刘海洋(LiuHY) 胡希明(HuXM) 应晓(YingX) 刘义(LiuY) 黄锦汪(HuangJW) 计亮年(JiLN) | | 无机化学学报0，，： | 1 |
| 11 | Experi- mental behavior of high performance concrete- filled steel tubular columns显示文摘 | YU Qing TAO Zhong WU Yingxing | 2008 | Thin-walled structures2008，46，4： | 1 |
| 12 | 显示文摘 | 刘海洋(LiuHY) 刘兰英(LiuLY) 张雷(ZhangL) 应晓(YingX) 王湘利(WangXL) 江焕峰(JiangHF) 张启光(ZhangQG) | 2007 | 高等学校化学学报2007，28，： | 1 |
| 13 | Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting显示文摘 | Anthony P. Furnary Guangqiang Gao Gary L. Grunkemeier YingXing Wu Kathryn J. Zerr Stephen O. Bookin H.Storm Floten Albert Starr | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，5： | 1 |
| 14 | Highly selective and sensitive fluorescent paper sensor for nitroaromatie ex- plosive detection 显示文摘 | Ma Yingxing Li Hao Peng Shan | 2012 | Anal Chem2012，84，： | 1 |
| 15 | Reasearch on enterprise application integration technology显示文摘 | ZHANG Shensheng ZHOU Xiaojun | 2002 | Computer Integrated Manufacturing System - CIMS2002，8，8： | 1 |
| 16 | Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting显示文摘 | Anthony P. Furnary Guangqiang Gao Gary L. Grunkemeier YingXing Wu Kathryn J. Zerr Stephen O. Bookin H.Storm Floten Albert Starr | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，5： | 1 |
| 17 | Does video-assisted thoracoscopic lobectomy for lung cancer provide improved functional outcomes compared with open lobectomy?显示文摘 | John R. Handy James W. Asaph Emory Charles Douville Gary Y. Ott Gary L. Grunkemeier YingXing Wu | 2010 | European Journal of Cardio-Thoracic Surgery2010，，2： | 1 |
| 18 | Experimental behaviour of high performance concrete-filled steel tubular columns 显示文摘 | Yu Qing Tao Zhong Wu Yingxing | 2008 | Thin-Walled Structures2008，46，4： | 1 |
| 19 | Research progress of resistance breeding to tomato root-knot nematode disease (in Chinese) [ J ]显示文摘 | WangQH GeCH YinGX etal | 2001 | 莱阳农学院学报2001，18，3： | 1 |
| 20 | Association Mapping of Quantitative Trait Loci for Grain Size in Introgression Line Derived from Oryza rufipogon显示文摘Grain size is one of the critical agronomic traits governing grain yield and quality in rice.However,the underlying genetic mechanisms that control grain size in rice are poorly understood.We used an introgression line derived from Zhonghui 8015 and Oryza rufipogon Griff.This introgression line was evaluated under two different environmental conditions to dissect the quantitative trait loci controlling grain size.Genome-wide association study(GWAS)was performed using 28193 SNPs through a general linear model,and 56 significant SNPs on different loci associated with the 4 grain size traits were detected.Cloned genes including GS3 and q GL3 showed substantial effects on grain length and size.Seven new stable loci were identified with pleiotropic effects on grain size.Haplotype,gene expression analyses,combined gene-based associations,and functional annotations permitted the shortlisting of important dominant genes including GS3 and q GL3. | Kashif HUSSAIN ZHANG Yingxing Workie ANLEY Aamir RIAZ Adil ABBAS MdHasanuzzaman RANI WANG Hong SHEN Xihong CAO Liyong CHENG Shihua | 2020 | Rice science2020，27，3： | 0 |
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