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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | Leydig cell death in rats exposed to bismuth subnitrate显示文摘 | Lars H P Meredin S Erik E | 2003 | Journal of Applied Toxicology2003，23，4： | 1 |
| 4 | Non-point source critical area analysis in the Gisseloe watershed using GIS 显示文摘 | AKE S LARS P | 2003 | Environmental Modelling & Software2003，18，： | 1 |
| 5 | Enhanced auto adhesion of wood fibers using phenol oxidases显示文摘 | Claus F Lars S P Nielsen B R | 1997 | Holzforschung1997，51，3： | 1 |
| 6 | Enhanced auto adhesion of wood fibers using phenol oxidases 显示文摘 | FELBY C LARS S P NIELSEN B R | 1997 | Holzforsehung1997，51，3： | 1 |
| 7 | Trust Breeds trust: How Taxpayers are Treated 显示文摘 | Lars P Feld Bruno S Frey | 2002 | Economics of Governance2002，，3： | 1 |
| 8 | Parameter estimation for fractional dispersion model for rivers显示文摘 | DENG Z Q LARS B VIJAY P S | 2006 | Environmental Fluid Mechanics2006，6，5： | 1 |
| 9 | Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization显示文摘 | Tuva B. Dahl Arne Yndestad Mona Skjelland Erik ?ie Arve Dahl Annika Michelsen Jan K. Dam?s Siv H. Tunheim Thor Ueland Camilla Smith Bj?rn Bendz Serena Tonstad Lars Gullestad Stig S. Fr?land Kirsten Krohg-S?rensen David Russell P?l Aukrust Bente Halvorsen | 2007 | Circulation2007，，8： | 1 |
| 10 | Noninvasive quantification of atherosclerotic lesions:reproducibility of ultrasonographic measurement of arterial wall thickness and plaque size显示文摘 | Jerker P Lars S John W | 1992 | Arteriosclerosis and Thrombosis1992，12，： | 1 |
| 11 | Non-point critical area analysis in the Gisselo watershed using GIS显示文摘 | Ake S Lars P | 2003 | Environmental Modelling & Software2003，18，： | 1 |
| 12 | Detection of Penicillium species in complex food samples using the polymerase chain reaction显示文摘 | Lars H P Pernille S Marianne B | 1997 | International Journal of Food Microbiology1997，35，： | 1 |
| 13 | 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial显示文摘 | Samir R Kapadia Martin B Leon Raj R Makkar E Murat Tuzcu Lars G Svensson Susheel Kodali John G Webb Michael J Mack Pamela S Douglas Vinod H Thourani Vasilis C Babaliaros Howard C Herrmann Wilson Y Szeto Augusto D Pichard Mathew R Williams Gregory P Fontan | 2015 | The Lancet . 2015 (9986)2015，，： | 1 |
| 14 | Full-Scale Co-Fire of Straw and Coal显示文摘 | Lar S P Hanne P N Sφren K | 1996 | Fuel1996，75，13： | 1 |
| 15 | Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization显示文摘 | Tuva B. Dahl Arne Yndestad Mona Skjelland Erik ?ie Arve Dahl Annika Michelsen Jan K. Dam?s Siv H. Tunheim Thor Ueland Camilla Smith Bj?rn Bendz Serena Tonstad Lars Gullestad Stig S. Fr?land Kirsten Krohg-S?rensen David Russell P?l Aukrust Bente Halvorsen | 2007 | Circulation2007，，8： | 1 |
| 16 | Non-point critical area analysis in the Gisselo watershed using GIS 显示文摘 | Ake S Lars P | 2003 | Environmental Modelling & Software2003，18，： | 1 |
| 17 | Landscape composition influences farm management effects on farmland birds in winter: A pan-European approach显示文摘 | Flavia Geiger Geert R. de Snoo Frank Berendse Irene Guerrero Manuel B. Morales Juan J. O?ate S?nke Eggers Tomas P?rt Riccardo Bommarco Jan Bengtsson Lars W. Clement Wolfgang W. Weisser Adam Olszewski Piotr Ceryngier Violetta Hawro Pablo Inchausti Christin | 2010 | Agriculture Ecosystems and Environment2010，，4： | 1 |
| 18 | Discursive biases of the environmental research framework DPSIR 显示文摘 | HANNE S LARS K P DALE R | 2008 | Land Use Policy2008，，25： | 1 |
| 19 | Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy显示文摘 | P?l Aukrust Thor Ueland Egil Lien Klaus Bendtzen Fredrik Müller Arne K Andreassen Ingvild Nord?y Halfdan Aass Terje Espevik Svein Simonsen Stig S Fr?land Lars Gullestad | 1999 | The American Journal of Cardiology1999，，3： | 1 |
| 20 | Prospective randomized neurocognitive and S-100 study of hypothermic circulatory arrest, retrograde brain perfusion, and antegrade brain perfusion for aortic arch operations 显示文摘 | LARS G S EDWARD M N DANA L P | 2001 | Ann Thorac Surg2001，71，5： | 1 |
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