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| 1 | Targeting collagen expression in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is a leading cause of liver disease and liver-related deaths globally,particularly in developed nations.Liver fibrosis is a consequence of ALD and other chronic liver insults,which can progress to cirrhosis and hepatocellular carcinoma if left un-treated.Liver fibrosis is characterized by accumulation of excess extracellular matrix components,including typeⅠcollagen,which disrupts liver microcirculation and leads to injury.To date,there is no therapy for the treatment of liver fibrosis;thus treatments that either prevent the accumulation of typeⅠcollagen or hasten its degradation are desirable.The focus of this review is to examine the regulation of typeⅠcollagen in fibrogenic cells of the liver and to discuss current advances in therapeutics to eliminate excessive collagen deposition. | Kyle J Thompson Iain H McKillop Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 7 |
| 2 | Sequence and the developmental and tissue-specific regulation of the first complete vitellogenin messenger RNA from ticks responsible for heme sequestration显示文摘 | Deborah M. Thompson Sayed M.S. Khalil Laura A. Jeffers Daniel E. Sonenshine Robert D. Mitchell Christopher J. Osgood R. Michael Roe | 2007 | Insect Biochemistry and Molecular Biology2007，，4： | 1 |
| 3 | Effects of feeding practical diets containing various protein levels on growth, survival, body composition, and processing traits of australian red claw crayfish (cherax quadricarinatus) and on pond water quality显示文摘 | Thompson Kenneth R Muzinic Laura A Engler Linda S | 2004 | Aquaculture Research2004，35，： | 1 |
| 4 | A Required third-year medical student palliative care curriculum impacts knowledge and attitudes显示文摘 | Laura J Morrison B Thompson M | 2012 | J Palliative Med2012，15，7： | 1 |
| 5 | Are health-related quality-of-life and self-rated health associated with mortality? Insights from Translating Research Into Action for Diabetes (TRIAD)显示文摘 | Laura N. McEwen Catherine Kim Mary N. Haan Debashis Ghosh Paula M. Lantz Theodore J. Thompson William H. Herman | 2009 | Primary Care Diabetes2009，，1： | 1 |
| 6 | The impact of zero-valent iron nanoparticles on a river water bacterial community显示文摘 | Robert J. Barnes Christopher J. van der Gast Olga Riba Laura E. Lehtovirta James I. Prosser Peter J. Dobson Ian P. Thompson | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 7 | Progressive familial intrahepatic cholestasis—farnesoid X receptor deficiency due to NR1H4 mutation:A case report显示文摘BACKGROUND Functioning farnesoid X receptor(FXR;encoded by NR1H4)is key to normal bile acid homeostasis.Biallelic mutations in NR1H4 are reported in a few children with intrahepatic cholestasis.We describe a boy with progressive familial intrahepatic cholestasis and homozygous mutation in NR1H4.CASE SUMMARY A boy had severe neonatal cholestasis with moderate hypercholanemia and persistently elevated alpha-fetoprotein.Despite medical treatment,coagulopathy was uncontrollable,prompting liver transplantation at age 8 mo with incidental splenectomy.The patient experienced catch-up growth with good liver function and did not develop allograft steatosis.However,1 year after transplant,he died from an acute infection,considered secondary to immunosuppression and asplenia.A homozygous protein-truncating mutation,c.547C>T,p.(Arg183Ter),was subsequently identified in NR1H4,and both parents were shown to be heterozygous carriers.Absence of FXR and of bile salt export pump expression was confirmed by immunostaining of explanted liver.CONCLUSION Severe cholestasis with persistently high alpha-fetoprotein and modest elevation of serum bile acid levels may suggest FXR deficiency.Some patients with FXR deficiency may not develop allograft steatosis and may respond well to liver transplantation. | Piotr Czubkowski Richard J Thompson Irena Jankowska A S Knisely Milton Finegold Pamela Parsons Joanna Cielecka-Kuszyk Sandra Strautnieks Joanna Pawłowska Laura N Bull | 2021 | World Journal of Clinical Cases2021，9，15： | 1 |
| 8 | Primacy Effects in Justice Judgments: Testing Predictions from Fairness Heuristic Theory显示文摘 | E.Allan Lind Laura Kray Leigh Thompson | 2001 | Organizational Behavior and Human Decision Processes2001，，2： | 1 |
| 9 | Axillary Reverse Mapping (ARM): A New Concept to Identify and Enhance Lymphatic Preservation显示文摘 | Margaret Thompson MD Soheila Korourian MD Ronda Henry-Tillman MD Laura Adkins MAP Sheilah Mumford MA Kent C. Westbrook MD V Suzanne Klimberg MD | 2007 | Annals of Surgical Oncology2007，，6： | 1 |
| 10 | When Work - family Benefits are not Enough : The Influence of Work - family Culture on Benefit Utilization, Organizational Attachment, and Work - family Conflict 显示文摘 | Thompson Cynthia A Beauvais Laura L Lyness Karen S | 1999 | Journal of Vocational Behavior1999，54，3： | 1 |
| 11 | VPS33B mutation with ichthyosis, cholestasis, and renal dysfunction but without arthrogryposis: Incomplete ARC syndrome phenotype显示文摘 | Laura N. Bull Venus Mahmoodi Alastair J. Baker Rosamond Jones Sandra S. Strautnieks Richard J. Thompson A.S. Knisely | 2006 | The Journal of Pediatrics2006，，2： | 1 |
| 12 | 玩具业中重金属的等离子体发射光谱分析显示文摘 | LEE Davidowski ZOE Grosser LAURA Thompson | 2009 | 岩矿测试2009，28，2： | 1 |
| 13 | Defining the clinical course of multiple sclerosis: The 2013 revisions显示文摘 | Fred D. Lublin Stephen C. Reingold Jeffrey A. Cohen Gary R. Cutter Per Soelberg S?rensen Alan J. Thompson Jerry S. Wolinsky Laura J. Balcer Brenda Banwell Frederik Barkhof Bruce Bebo Peter A. Calabresi Michel Clanet Giancarlo Comi Robert J. Fox Mark S. Fr | 2014 | Neurology2014，，3： | 1 |
| 14 | Penile mass formation after neglected penile fracture:Surgical management with pericardial graft reinforcement显示文摘Background:Penile fracture is defined as the rupture of the tunica albuginea of the corpora cavernosa while in an erect state,during mostly intercourse or masturbation.Diagnosis of such condition is mainly clinical,while on the other hand,seeking medical attention is often delayed,and treatment options depend upon the time of presentation.Methods:This case report details a patient who developed a penile cystic fibro-hematoma lesion,2 months after a neglected penile fracture.After proper assessment including detailed history,physical exam and a penile doppler ultrasound,patient was elected for surgery.Results:The patient underwent surgical removal of the mass,correction of the curvature,and reinforcement of the weakened tunica albuginea with a pericardium graft.Postoperative course was uneventful.At follow-up,he reported normal erectile function with resolved penile curvature.Conclusion:This highlights the importance of seeking prompt medical attention for suspected penile fractures to avoid potential long-term complications. | Laura Thompson Kareim Khalafalla Run Wang | 2023 | UroPrecision2023，1，1： | 0 |
| 15 | Age-related impairment of esophagogastric junction relaxation and bolus flow time显示文摘AIM To investigate the functional effects of abnormal esophagogastric(EGJ) measurements in asymptomatic healthy volunteers over eighty years of age. METHODS Data from 30 young controls(11 M, mean age 37 ± 11 years) and 15 aged subjects(9 M, 85 ± 4 years) were compared for novel metrics of EGJ-function: EGJcontractile integral(EGJ-CI), 'total' EGJ-CI and bolus flow time(BFT). Data were acquired using a 3.2 mm, 25 pressure(1 cm spacing) and 12 impedance segment(2 cm) solid-state catheter(Unisensor and MMS SolarGI system) across the EGJ. Five swallows each of 5 m L liquid(L) and viscous(V) bolus were analyzed. Mean values were compared using Student's t test for normally distributed data or Mann Whitney U-test when non-normally distributed. A P value < 0.05 was considered significant.RESULTS EGJ-CI at rest was similar for older subjects compared to controls. 'Total' EGJ-CI, measured during liquid swallowing, was increased in older individuals when compared to young controls(O 39 ± 7 mm Hg.cm vs C 18 ± 3 mm Hg.cm; P = 0.006). For both liquid and viscous bolus consistencies, IRP4 was increased(L: 11.9 ± 2.3 mm Hg vs 5.9 ± 1.0 mm Hg, P = 0.019 and V: 14.3 ± 2.4 mm Hg vs 7.3 ± 0.8 mm Hg; P = 0.02) and BFT was reduced(L: 1.7 ± 0.3 s vs 3.8 ± 0.2 s and V: 1.9 ± 0.3 s vs 3.8 ± 0.2 s; P < 0.001 for both) in older subjects, when compared to young. A matrix of bolus flow and presence above the EGJ indicated reductions in bolus flow at the EGJ occurred due to both impaired bolus transport through the esophageal body(i.e., the bolus never reached the EGJ) and increased flow resistance at the EGJ(i.e., the bolus retained just above the EGJ).CONCLUSION Bolus flow through the EGJ is reduced in asymptomatic older individuals. Both ineffective esophageal bolus transport and increased EGJ resistance contribute to impaired bolus flow. | Charles Cock Laura K Besanko Carly M Burgstad Alison Thompson Stamatiki Kritas Richard Heddle Robert JL Fraser Taher I Omari | 2017 | World Journal of Gastroenterology2017，23，15： | 0 |
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