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| 1 | STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease显示文摘 | Arian Laurence Shoba Amarnath Jacopo Mariotti Yong Chan Kim Jason Foley Michael Eckhaus John J. O’Shea Daniel H. Fowler | 2012 | Immunity2012，，2： | 1 |
| 2 | Selective regulatory function of Socs3 in the formation of IL-17-secreting T eells 显示文摘 | Zhi Chen Arian Laurence Yuka Kanno | 2006 | PNAS2006，103，21： | 1 |
| 3 | Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation显示文摘 | Laurence Arian Tato Cristina M Davidson Todd S | 2007 | Immunity2007，26，3： | 1 |
| 4 | Signal transduction and Th17 cell differentiation显示文摘 | John J. O’Shea Scott M. Steward-Tharp Arian Laurence Wendy T. Watford Lai Wei Adewole S. Adamson Samuel Fan | 2009 | Microbes and Infection2009，，5： | 1 |
| 5 | Signal transduction pathways and transcriptional regulation in Th17 cell differentiation显示文摘 | Kiyoshi Hirahara kamran Ghoreschi Arian Laurence | 2010 | Cytokine Growth Factor Reviews2010，，21： | 1 |
| 6 | Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis显示文摘 | Lydia Durant Wendy T. Watford Haydeé L. Ramos Arian Laurence Golnaz Vahedi Lai Wei Hayato Takahashi Hong-Wei Sun Yuka Kanno Fiona Powrie John J. O’Shea | 2010 | Immunity2010，，5： | 1 |
| 7 | A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise显示文摘 | Comasia Addolorata Raguso Ursula Kyle Michel Picard Kossovsky Catherine Roynette Ariane Paoloni-Giacobino Didier Hans Laurence Genton Claude Pichard | 2005 | Clinical Nutrition2005，，4： | 1 |
| 8 | ATP6V0d2 mediates leucine-induced mTORCI activation and polarization of macrophages显示文摘Dear Editor, mTORCI, as a center regulatory hub of metabolism, senses the cellular energy status, nutrition and extracellular stimuli and regulates cell growth, differentiation and functions of immune cells (Powell et al., 2012). Lysosomal localization of key signal comp orients is critical for mTORCI activati on: mTORCI activation requires co-localization of activated Rheb and mTORCI to the lysosome membrane (Buerger et al., 2006). Signals in eluding growth factors, cellular stresses and energy levels act on the disruption the formation of tuberous sclerosis complex (TSC) complex, comprised of TSC1, TSC2 and TBC1D7, which leads to the translocation and activation of Rheb on the lysosome membrane (Dibble et al., 2012). In response to nutrient levels, specifically the availability of amino acids and glucose (Efeyan et al., 2013), mTORCI is recruited to the lysosomal surface by Rag GTPases that are heterodimers of RagA or RagC bound to RagB or RagD. Multiple protein complexes have been implicated in regulation of mTORCI upon nutrient sensing including Ragulator, GATOR1, GATOR2, KICSTOR and vacuolar ATPases (Wolfson et al., 2017). Vacuolar ATPases are large multiple-protein complexes that acidify the lysosome and may mediate additional functions independent of their proton pump activity (Nishi and Forgac, 2002). | Pingfei Li Xiaofei Deng Jing Luo Yufei Chen Guoyu Bi Feili Gong Zhengping Wei Na Liu Huabin Li Arian Laurence Xiang-Ping Yang | 2019 | Protein & Cell2019，10，8： | 1 |
| 9 | STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease显示文摘 | Arian Laurence Shoba Amarnath Jacopo Mariotti Yong Chan Kim Jason Foley Michael Eckhaus John J. O’Shea Daniel H. Fowler | 2012 | Immunity2012，，2： | 1 |
| 10 | Nasal inverted papilloma expresses the muscle segment homeobox gene Msx2: possible prognostic implications显示文摘 | Joel Depondt El-Hassan Shabana Francine Walker Laurence Pibouin Frederic Lezot Ariane Berdal | 2008 | Human Pathology2008，，3： | 1 |
| 11 | A variant in IL6ST with a selective IL-11 signaling defect in human and mouse显示文摘The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in IL6 ST(p.R281 Q) in a patient with craniosynostosis and retained deciduous teeth. We characterize the impact of the variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and support these findings using a mouse model with the corresponding genome-edited variant Il6 st p.R279 Q. We show that human GP130 p.R281 Q is associated with selective loss of IL-11 signaling without affecting IL-6, IL-27, OSM, LIF, CT1, CLC, and CNTF signaling. In mice Il6 st p.R279 Q lowers litter size and causes facial synostosis and teeth abnormalities. The effect on IL-11 signaling caused by the GP130 variant shows incomplete penetrance but phenocopies aspects of IL11 RA deficiency in humans and mice. Our data show that a genetic variant in a pleiotropic cytokine receptor can have remarkably selective defects. | Tobias Schwerd Freia Krause Stephen R.F.Twigg Dominik Aschenbrenner Yin-Huai Chen Uwe Borgmeyer Miryam Müller Santiago Manrique Neele Schumacher Steven A.Wall Jonathan Jung Timo Damm Claus-Christian Glüer Jürgen Scheller Stefan Rose-John E.Yvonne Jones Arian Laurence Andrew O.M.Wilkie Dirk Schmidt-Arras Holm H.Uhlig | 2020 | Bone Research2020，8，2： | 0 |
| 12 | DAPK1(death associated protein kinase 1)mediates mTORC1 activation and antiviral activities in CD8^(+)T cells显示文摘Mechanistic target of rapamycin complex 1(mTORCt)regulates CD8^(+)T-cell differentiation and function.Despite the links between PI3K-AKT and mTORCI activation in CD8^(+)T cells,the molecular mechanism underlying mTORCI activation remains undear.Here,we show that both the kinase activity and the death domain of DAPK1 are required for maximal mTOR activation and CD8^(+)T-cell function.We found that TCR-induced activation of calcineurin activates DAPK1,which subsequently interacts with TSC2 via its death domain and phosphorylates TSC2 to mediate mTORCI activation.Furthermore,both the kinase domain and death domain of DAPK1 are required for CD8^(+)T-cell antiviral responses in an LCMV infection model.Together,our data reveal a novel mechanism of mTORCI activation that mediates optimal CD8^(+)T-cell function and antiviral activity. | Zhengping Wei Pingfei Li Ran He Huicheng Liu Na Liu Yu Xia Guoyu Bi Qiuyang Du Minghui Xia Lei Pei Jing Wang Guihua Wang Zhao-Hui Tang Xiang Cheng Huabin Li Zhuoya Li Lilin Ye Arian Laurence Youming Lu Xiang-Ping Yang | 2021 | Cellular & Molecular Immunology2021，18，1： | 0 |
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