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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Modelling of cells,stacks and sustems based around metal-supported planar IT-SOFC cells with CGO eletrolytes operating at 500~600℃显示文摘 | Leah R T BrTandon N P Aguiar P | | 0，，： | 1 |
| 3 | Multidrug Resistance Proteins\sMRP3,MRP1,and MRP2 in Lung Cancer:Correlation of Protein Levels\swith Drug Response and Messenger RNA Levels显示文摘 | Leah C Barbara G Susan P | 2001 | Clinical Cance\sResearch2001，7，： | 1 |
| 4 | Modelling of cells,stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500 ~ 600 ℃显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | Power Sources2005，145，2： | 1 |
| 5 | Notch 1 overexpres- sion inhibits osteoblastogenesis by suppressing Wnt/be- ta-catenin but not bone morphogenetic protein signaling 显示文摘 | Deregowski V Elisabetta G Leah P | 2006 | J Biol Chem2006，281，10： | 1 |
| 6 | Modeling of ceils, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500-600显示文摘 | Leah R T Brandon N P Aguiar P | 2005 | Journal of Power Sources2005，145，2： | 1 |
| 7 | Was postwar suburbanization 'white flight'? Evidence from the black migration显示文摘 | Leah P B | 2010 | Quarterly Journal of Economics2010，125，1： | 1 |
| 8 | Notch 1 overexpres- sion inhibits osteoblastogenesis by suppressing Wnt/beta- catenin but not bone morphogenetic protein signaling显示文摘 | Valerie D Elisabetta G Leah P | 2006 | J Biol2006，281，10： | 1 |
| 9 | The coexistence of neuropeptides in feline sensory neurons 显示文摘 | CAMERSON A A LEAH J D SNOW P J | 1988 | Neuroscience1988，，27： | 1 |
| 10 | Role of nutrients in skeletal metabolism and pathology in fish-An overview 显示文摘 | Lall S P Leah M Lewis-McCrea | 2007 | Aquaculture2007，267，： | 1 |
| 11 | Multidrug Resistance Proteins MRP3,MRP1,and MRP2 in Lung Cancer:Correlation of Protein Levels with Drug Response and Messenger RNA Levels显示文摘 | Leah C Barbara G Susan P | 2001 | Clinical Cancer Research2001，7，： | 1 |
| 12 | Modelling of cells, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 50-600 ℃ 显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | J Power Sources2005，145，： | 1 |
| 13 | Endothelin-induced increases in Ca^2+ entry mechanisms of vascular contraction are enhanced during high-sah diet 显示文摘 | LEAH S JASON A P MON H S | 2003 | Hypertension2003，41，2： | 1 |
| 14 | Magnetic resonance urography in the evaluation of prenatally diagnosed hydronephrosis and renal dysgenesis显示文摘 | Leah P McMann D Andrew J | 2006 | Urology2006，176，： | 1 |
| 15 | Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill a- dult patients? A systematic review of the literature显示文摘 | Leah G Krikor K Jaime P | 2004 | Nutrition2004，20，10： | 1 |
| 16 | Modelling of cells, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500-600 ℃ 显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | Journal of Power Sources2005，145，2： | 1 |
| 17 | Complexity,pattern,and evolutionary trade-offs in animal aggregation显示文摘 | Julia K P Leah E K | 1999 | Science1999，284，： | 1 |
| 18 | Prediction of finished relaxed dimensions of cotton knits -The starfish project: Part I: introduction and general overview显示文摘 | Heap S A Greenwood P F Leah R D | 1983 | Textile Research Journal1983，，2： | 1 |
| 19 | Modelling of Cells, Stacks and Systems Based Around Metal- Supported Planar IT- SOFC cells with CGO Electrolytes Operating at 500 - 600 C 显示文摘 | Leah R T Brandon N P Aguiar P | 2005 | Journal of Power Sources2005，145，： | 1 |
| 20 | Prediction of finished relaxed dimensions of cotton knits - The starfish project: Part II: shrinkage and the reference state显示文摘 | Heap S A Greenwood P F Leah R D | 1985 | Textile Research Journal1985，，4： | 1 |
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