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| 1 | Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis显示文摘NF-κ 的受体使活跃之物; B (等级) 和 immunoreceptor 包含适配器的基于酷氨酸的激活主题(ITAM ) 是涉及调整改变的骨破折形成和骨头的必要因素。这里,我们识别早导致雌激素的基因(EEIG1 ) 1 作为一篇小说评价身体上与等级并且进一步交往的可诱导的蛋白质与 Gab2 联系的 ligand (RANKL ) , PLCγ 2 并且在 RANKL 刺激之上的 Tec/Btk kinases。EEIG1 断然调整导致 RANKL 的骨破折形成,由于它便于刺激 RANKL 的 PLCγ 的能力可能; 2 phosphorylation 和 NFATc1 正式就职。另外,设计堵住 RANK-EEIG1 相互作用的禁止的肽由减少骨破折形成禁止了导致 RANKL 的骨头破坏。一起,我们的结果作为一篇小说识别 EEIG1 评价控制调停等级的骨破折形成的发信号的部件,并且建议那指向的 EEIG1 可能为病理学的骨头再吞的处理代表新治疗学的策略。 | Han Kyoung Choi Hye Ri Kang Eutteum Jung Tae Eon Kim Jing Jing Lin Soo Young Lee | 2013 | Cell Research2013，23，4： | 4 |
| 2 | MRI of magnetically labeled mesenchymal stem cells in hepatic failure model显示文摘AIM:To track intravascularly transplanted mesenchymal stem cells (MSCs) labeled with superparamagnetic iron oxide (SPIO) by using magnetic resonance imaging (MRI) in an experimental rabbit model of hepatic failure.METHODS:Human MSCs labeled with FDA-approved SPIO particles (Feridex) were transplanted via the mes-enteric vein into rabbits (n=16) with carbon tetrachloride-induced hepatic failure.Magnetic resonance (MR) examinations were performed with a 3.0 T clinical scanner immediately before and 2 h and 1,3,and 7 d after transplantation.Signal intensity (SI) changes on T2weighted MRI were measured,and correlation between MR findings and histomorphologic findings was also investigated.RESULTS:SI on T2-weighted MRI decreased significantly in the liver 2 h after injection of human MSCs and returned gradually to the levels found before injection in 7 d.Changes in SI in the liver at 2 h,1,3,and 7 d were 41.87% ± 9.63%,10.42% ± 4.3%,5.12% ± 1.9%,3.75% ± 1.2%,respectively (P < 0.001).Histologic analyses confirmed the presence of MSCs in the liver,localized mainly in the sinusoids in early period (2 h and 1 d) and concentrated to the border zone in late period (3 and 7 d).The number of iron-positive cells in the liver at 2 h and on 1,3 and 7 d after transplantation was 29.2 ± 4.8,10.1 ± 3.7,6.7 ± 2.2,and 5.8 ± 2.1,respectively (P=0.013).CONCLUSION:Intravascularly injected SPIO-labeled MSCs in an experimental rabbit model of hepatic failure can be detected and followed with MRI. | Kyu Ri Son Se Young Chung Hyo-Cheol Kim Hoe Suk Kim Seung Hong Choi Jeong Min Lee Woo Kyung Moon | 2010 | World Journal of Gastroenterology2010，16，44： | 4 |
| 3 | Safe drug treatment and procedure for herpes zoster in pregnancy:a case report显示文摘To the Editor:A first infection of varicella-zoster virus(VZV)during pregnancy can cause serious systemic disease to both mother and the fetus.Despite this maternal herpes zoster(HZ)does not increase fetal mortality,and the transmission of varicella-zoster virus to the fetus rarely occurs.Although HZ infection has a minimal effect on the fetus,maternal HZ can cause significant complications for the mother. | Ji Yeong Kim You Ri Ko Sung Eun Sim Sua Oh Mi Hyeon Lee Hue Jung Park | 2020 | Chinese Medical Journal2020，，16： | 2 |
| 4 | Comparison of Endoscopic Papillary Balloon Dilation and Sphincterotomy in Young Patients with CBD Stones and Gallstones显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Ji Su Ha Tae Hoon Lee Sang-Woo Cha Young Deok Cho Sang-Heum Park Sun-Joo Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 2 |
| 5 | Papillary balloon dilation is not itself a cause of post‐endoscopic retrograde cholangiopancreatography pancreatitis; results of anterograde and retrograde papillary balloon dilation显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park Sun‐Joo Kim | 2013 | J Gastroenterol Hepatol2013，，8： | 2 |
| 6 | Recombinant human fibroblast growth factor-2 promotes nerve regeneration and functional recovery after mental nerve crush injury显示文摘Several studies have shown that fibroblast growth factor-2(FGF2) can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the effect of recombinant human FGF-2(rh FGF2) treatment on damaged mental nerves. The mental nerves of 6-week-old male Sprague-Dawley rats were crush-injured for 1 minute and then treated with 10 or 50 μg/m L rh FGF2 or PBS in crush injury area with a mini Osmotic pump. Sensory test using von Frey filaments at 1 week revealed the presence of sensory degeneration based on decreased gap score and increased difference score. However, at 2 weeks, the gap score and difference score were significantly rebounded in the mental nerve crush group treated with 10 μg/m L rh FGF2. Interestingly, treatment with 10 μg/m L rh FGF had a more obviously positive effect on the gap score than treatment with 50 μg/m L rh FGF2. In addition, retrograde neuronal tracing with Dil revealed a significant increase in nerve regeneration in the trigeminal ganglion at 2 and 4 weeks in the rh FGF2 groups(10 μg/m L and 50 μg/m L) than in the PBS group. The 10 μg/m L rh FGF2 group also showed an obviously robust regeneration in axon density in the mental nerve at 4 weeks. Our results demonstrate that 10 μg/m L rh FGF induces mental nerve regeneration and sensory recovery after mental nerve crush injury. | Sung Ho Lee Wei-Peng Jin Na Ri Seo Kang-Mi Pang Bongju Kim Soung-Min Kim Jong-Ho Lee | 2017 | Neural Regeneration Research2017，12，4： | 2 |
| 7 | Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1(G93A)mice and SOD1(G17S and G86S)ALS patients显示文摘Background:MicroRNAs(miRNAs)are endogenous non-coding RNAS that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases.Overexpressed miRNAs play an important role in amyotrophic lateral sclerosis(ALS);however,the pathogenic mechanisms of deregulated miRNAS are still unclear.Methods:We aimed to assess the dysfunction of RNAS or miRNAs in fALS(SOD1 mutations).We compared the RNA-seq of subcellular fractions in NSC-34 WT(hSOD1)and MT(hSOD1(G93A))cells to find altered RNAs or miRNAs.We identified that Hif1a and Mef2c were upregulated,and Mctp1 and Rarb were downregulated in the cytoplasm of NSC-34 MT cells.Results:SOD1 mutations decreased the level of miR-18b-5p.Induced Hif1a which is the target for miR-18b increased Mef2c expression as a transcription factor.Mef2c upregulated miR-206 as a transcription factor.Inhibition of Mctp1 and Rarb,which are targets of miR-206,induced intracellular Ca^2+ levels and reduced cell differentiation,respectively.The miR-18b-5p pathway was also observed in G93A Tg mice,fALS(G86S)patient,and iPSC-derived motor neurons from fALS(G17S)patient.Conclusions:Our data indicate that SOD1 mutation decreases miR-18b-5p,which sequentially regulates Hif1a,Mef2c,miR-206,Mctp1 and Rarb in fALS-linked SOD1 mutation.These results provide new insights into the downregulation of miR-18b-5p-dependent pathogenic mechanisms of ALS. | Ki Yoon Kim Yu Ri Kim Kyung Won Choi Mijung Lee Somyung Lee Wooseok Im Je-Young Shin Jin Young Kim Yoon Ho Hong Manho Kim Jong-ll Kim Jung-Joon Sung | 2020 | Translational Neurodegeneration2020，9，3： | 2 |
| 8 | Chemical and functional components in different parts of rough rice ( Oryza sativa L.) before and after germination显示文摘 | Hyun Young Kim In Guk Hwang Tae Myoung Kim Koan Sik Woo Dong Sik Park Jae Hyun Kim Dae Joong Kim Junsoo Lee Youn Ri Lee Heon Sang Jeong | 2012 | Food Chemistry2012，，1： | 2 |
| 9 | Examination of 1-methylimidazole series ionic liquids in the extraction of flavonoids from Chamaecyparis obtuse leaves using a response surface methodology显示文摘 | Baokun Tang Yu Jin Lee Yu Ri Lee Kyung Ho Row | 2013 | Journal of Chromatography B2013，，： | 2 |
| 10 | Rheological and electtrical properties of polypropylene composites containing functionalized multi-walled carbon nanotubes and comrpatibilizers显示文摘 | Lee Seung H w an Cho Eun Na Ri | | 0，，： | 1 |
| 11 | Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer显示文摘 | Geng Zhang Peijun He Hanson Tan Anuradha Budhu Jochen Gaedcke B. Michael Ghadimi Thomas Ried Harris G. Yfantis Dong H. Lee Anirban Maitra Nader Hanna H. Richard Alexander S. Perwez Hussain | 2013 | Clinical Cancer Research2013，，18： | 1 |
| 12 | Histological study of lumbar intervertebral disc herniation in adolescents 显示文摘 | Lee JY Ernestus RI Schroder R | 2000 | Acta Neurochir (Wien)2000，142，10： | 1 |
| 13 | The venous distension sign: a diagnostic sign of intracranial hypotension at MR imaging of the brain显示文摘 | Farb RI Forghani R Lee SK | 2007 | Am J Neuroradiol2007，28，8： | 1 |
| 14 | Various surgical treat ments of chronic subdural hematoma and outcome in 172 patients: is membraneetomy necessary?显示文摘 | Lee JY Ebel H Ernestus RI | 2004 | Surg Neurol2004，61，6： | 1 |
| 15 | The venous distension sign:a diagnostic sign of intracranial hypotension at MR imaging of the brain显示文摘 | Farb RI Forghani R Lee SK | 2007 | Am J Neuroradiol2007，28，8： | 1 |
| 16 | Various surgical treatment of chronic subdural hematoma and outcome in 172显示文摘 | Lee JY Ebel H Ernestus RI | 2004 | Patients is membranectomy necessary Surg neurol2004，61，6： | 1 |
| 17 | Histological study of lumbar intervertebral disc herniation in adolescents显示文摘 | Lee JY Ernestus RI Schroder R | 2000 | Acta Neurochir2000，142，： | 1 |
| 18 | Various surgical treatments ofchronic subdural hematoma and outcome in 172 patients : is mem-branectomy necessary显示文摘 | Lee JY Ebel H Emestus RI | 2004 | Surg Neurol2004，61，6： | 1 |
| 19 | Histological study of lumbar intervertebral disc herniation in adolescents显示文摘 | Lee JY Ernestus RI Schroder R | 2000 | Acta Neurochir(Wien)2000，142，10： | 1 |
| 20 | The venous distension sign: a diagnostic sign of intracranial hypotension at MR imaging of the brain显示文摘 | Farb RI Forghani R Lee SK | 2007 | AJNR Am J Neuroradiol2007，28，8： | 1 |
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