|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 3 | C_2H_4-O_2混合气体直接起爆的临界能量显示文摘主要基于化学动力学和Ng模型,对C2H4-O2混合气体的爆轰胞格尺寸进行预测;结合Lee表面积能量模型,预测物质在不同初始压力和化学当量比的条件下,直接起爆引起球面爆轰的临界起爆能量。直接起爆实验主要采用高压电点火提供起爆能量,起爆能量通过放电过程中电流的输出信号确定。结果表明,理论预测与实验值较吻合。首先,通过化学动力学计算得出ZND模型的爆轰参数,利用Ng模型得出爆轰胞格尺寸与ZND诱导区长度之间的比例因数A在不同初始压力与当量比的条件下分别为:A=43.815(1+p1/p0)-0.123 71和A=8.531exp(φ/3.135)+28.644,在此基础上对爆轰胞格尺寸进行定量预测。胞格尺寸的理论预测与实验结果吻合。其次,把爆轰胞格尺寸作为中间特征参数并结合Lee的表面积能量模型,提出可以预测临界起爆能量的定量模型,并得出C2H4-O2混合气体直接起爆的临界起爆能量与初始压力和化学当量比的参量拟合关系分别为Ec=0.332(p1/p0)-2.017和Ec=exp[3.951(φ-1.401)2-1.9]。 | 张博 Lee J H S 白春华 | 2012 | 爆炸与冲击2012，32，2： | 7 |
| 4 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 5 | 实施新生儿复苏项目减少中国新生儿出生窒息死亡显示文摘中国作为增速领先的世界经济力量不断向前发展,妇幼健康状况取得了显著的成效。5岁以下儿童死亡率的降低提前实现了千年发展目标,但是新生儿死亡所占比例仍较高。在相对较高的新生儿死亡率背后,存在农村地区的地理环境不利于提供医疗服务、医疗机构的医疗条件存在差异、基层医务人员技术能力较低等因素。为了解决新生儿死亡问题,尤其是减少新生儿出生窒息的发生率和死亡率,在过去十年间,主要的相关各方已经着手在中国实施新生儿复苏项目。这些努力在临床保健方面已经显现成效,而且在未来会进一步发挥作用,从而改善儿童的长期健康结局。 | 薛艳萍 Xu T Niermeyer S Lee H | 2017 | 中国妇幼卫生杂志2017，8，3： | 5 |
| 6 | Similarity measure application to fault detection of flight system显示文摘差错察觉技术与类似措施被介绍。常规类似措施的特征基于模糊数字被讨论。在距离措施的帮助下,类似措施明确地被构造。设计基于距离的类似措施对包括非凸的模糊会员功能的一般模糊会员功能适用,而模糊基于数字的类似措施有限制计算一般模糊会员功能的类似。到一般模糊会员结构的建议类似措施的适用性被识别定义证明。为了决定,指责飞行系统的察觉,试验性的数据(投球的时刻系数和电梯系数) 被转变成模糊会员函数。基于距离的类似措施被用于获得的模糊会员功能,和类似计算,分析与差错和正常操作系数被获得。 | KIM J H LEE S H 王洪梅 | 2009 | Journal of Central South University2009，16，5： | 5 |
| 7 | 高浓度氩气稀释对C2H2-2.5O2气体直接起爆临界能量影响的实验研究显示文摘采用高压电点火进行直接起爆,通过放电过程中电流的输出信号确定起爆能量,实验测定了C2H2-2.5O2气体和加入摩尔浓度为70%氩气的C2H2-2.5O2混合气体直接起爆的临界起爆能量,研究了高浓度氩气稀释对C2H2-2.5O2混合物临界起爆能量的影响。实验测得的混合物临界起爆能量实验值与Lee等人的表面积能量理论值基本吻合。研究表明:C2H2-2.5O2气体和加入摩尔浓度为70%氩气的C2H2-2.5O2混合气体的临界起爆能量均依赖于初始压力,并呈反相关指数关系;在相同实验条件下,高浓度氩气稀释极大提高了混合气体直接起爆的临界起爆能量。分析认为,由于临界起爆能量正比于诱导区长度的3次方,因此在相同初始压力下,高浓度氩气的稀释增加了C2H2-2.5O2混合气体爆轰诱导区长度,并最终导致其临界起爆能量的显著上升。 | 张博 Lee John H S 白春华 | 2012 | 高压物理学报2012，26，1： | 5 |
| 8 | Clinical update on the management of pseudopapillary tumor of pancreas显示文摘Solid pseudopapillary neoplasm(SPN) is a rare tumor with malignant potential which is generally located in the tail of pancreas.The prevalence of SPN has increased with widespread use of cross sectional imaging.SPN is often misdiagnosed due to nonspecific clinical presentation and accurate diagnosis is essential for optimal management.Endoscopic ultrasound-FNA with immunohistochemistry can help in preoperative diagnosis.Surgery is the treatment of choice and a successful R0 resection is curative.Overall,SPN has a good prognosis.This review article focuses on pathogenesis,diagnosis and management of SPN. | Gandhi Lanke Faisal S Ali Jeffrey H Lee | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 5 |
| 9 | Antibiotic Resistance and Heavy Metals Tolerance in Gram-Negative Bacteria from Diseased American Bullfrog (Rana catesbeiana) Cultured in Malaysia显示文摘A total of 140 bacterial isolates have been successfully isolated from various organs of diseased American bullfrog (Rana catesbeiana) cultured in Malaysia. The most frequently isolated bacteria was Edwardsiella spp. (46 isolates) followed by Aeromonas spp. (33 isolates), Flavobacterium spp. (31 isolates), and Vibrio spp. (30 isolates). Majority of the bacterial isolates were found sensitive to furazolidone (85.0%), chloramphenicol (85.0%), oxolinic acid (90.0%), florfenicol (95.0%), and flumequine (97.5%). On the other hand, most of the bacterial isolates were resistant to oleandomycin (77.5%) and lincomycin (87.5%). Nitrofurantoin and flumequine can be inhibited the growth of all of Vibrio spp. whereas all isolates of Edwardsiella spp. were found sensitive to florfenicol and flumequine. Multiple antibiotic resistance (MAR) index were in range of 0.30-0.40, indicating that bacterial isolates from cultured bullfrogs may have received high risk exposure to the tested antibiotics. In addition, 90-100% of the isolates were resistant to copper, cadmium, and chromium. These results provided insight information on tolerance level of bacterial isolates from cultured bullfrogs to 21 antibiotics as well as heavy metals. | M Najiah S W Lee W Wendy L W Tee M Nadirah S H Faizah | 2009 | Agricultural Sciences in China2009，8，10： | 4 |
| 10 | 青年人群单纯收缩期或舒张期高血压的心血管病风险显示文摘根据2017年美国心脏病学院/美国心脏协会高血压指南定义,在1级高血压青年人群中,关于单纯收缩期高血压(isolated systolic hypertension,ISH)、单纯舒张期高血压(isolated diastolic hypertension,IDH)或收缩期和舒张期高血压(systolic and diastolic hypertension,SDH)相关的健康预后知之甚少。方法:在全国健康筛查数据库中. | 刘青(译) 刘莉(校) Lee H Yano Y Cho SMJ Park JH Park S Lloyd-Jones DM Kim HC | 2020 | 中华高血压杂志2020，28，8： | 3 |
| 11 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 12 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 13 | Fabrication of SAW Sensor for Detecting Chemical Agent显示文摘SAW sensors using five different types of polymer to detect of chemical agents(DMMP,CH_3CN,CH_2Cl_2,DCP) have been fabricated and its gas response characteristics were extensively investigated.The polymers used as the sensing material are polyisobutylene(PIB),polyepichlorohydrin(PECH),polydimethylsiloxane(PDMS),polyisoprene(PIP)and polybutadiene(PBD).Their thin films were coated on quartz substrate by spin coating technique.Three types of simulants gases,dimethylmethylphosphonate(DMMP),acetonitrile(CH_3CN)and dichloromethane(CH_2Cl_2),dichloropentane(DCP)were used as target gases,instead of the real nerve,blood,choking and vesicant agents.After spin coating of PIB and PECH,the substrates were heated to 65℃with N_2 flow for 1 h to remove the cyclohexane and ethylacetate which was used as solvent. PDMS was heated to 75℃with N_2 flow for 2 h to remove the ethylacetate which was used as solvent.PBD and PIP on the substrate were heated to 60℃with N_2 flow for 1 h to remove the benzen which was used as solvent.The sensing characteristics of the SAW sensors were measured by using E-5061A network analyzer. | J H Lee B S Joo J S Huh D D Lee | 2006 | 稀有金属材料与工程2006，35，A03： | 3 |
| 14 | Fault detection method with PCA and LDA and its application to induction motor显示文摘A feature extraction and fusion algorithm was constructed by combining principal component analysis(PCA) and linear discriminant analysis(LDA) to detect a fault state of the induction motor.After yielding a feature vector with PCA and LDA from current signal that was measured by an experiment,the reference data were used to produce matching values.In a diagnostic step,two matching values that were obtained by PCA and LDA,respectively,were combined by probability model,and a faulted signal was finally diagnosed.As the proposed diagnosis algorithm brings only merits of PCA and LDA into relief,it shows excellent performance under the noisy environment.The simulation was executed under various noisy conditions in order to demonstrate the suitability of the proposed algorithm and showed more excellent performance than the case just using conventional PCA or LDA. | JUNG D Y LEE S M 王洪梅 KIM J H LEE S H | 2010 | Journal of Central South University2010，17，6： | 3 |
| 15 | Antibiotic susceptibility of bacterial strains isolated from patients with various infections 显示文摘 | Lee S H Jeong S H | 2002 | Lett Appl Microbiol2002，34，： | 2 |
| 16 | PID controllers tuning for integrating and unstable processes with time delay显示文摘 | Lee Y H Lee J S | 2002 | Chemical Engineering Science2002，55，4： | 2 |
| 17 | Overcoming Jahn-Teller distortion for spinel Mn phase显示文摘 | Sun Y K Jeon Y S Lee H J | 2000 | Electrochem SolidState Lett2000，3，： | 2 |
| 18 | Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating fact or gene in intramuscular DNA immunization显示文摘 | Cho J H Lee S W Sung Y C | 1999 | Vaccine1999，17，910： | 2 |
| 19 | Optimum placement of fixed and switched capacitors on primary distribution fee-ders显示文摘 | Lee S H Grainger J J | 1981 | IEEE Trans on Power Appratus and Systems1981，100，1： | 2 |
| 20 | Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage-colony stimulating factor gene显示文摘 | Lee S W Cho J H Sung Y C | 1998 | J Virol1998，72，10： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员