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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 3 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 4 | Muein7 and eytokeratin 20 as new diagnostic urinary markers for bladder tumor显示文摘 | Retz M Lehmann JE | 2003 | J Urol2003，169，： | 1 |
| 5 | Effect of UVB radiation emitted from the narrowband TL-01 lamp (311 nm) on the calcitriol synthesis in organotypic cultures of keratinocytes显示文摘 | Lehmann B Knuschke P Meurer M | 2005 | Exp Dermatol2005，14，2： | 1 |
| 6 | Nonmonotonic reasoning,preferential modelsand cumulative logics显示文摘 | KRAUS S LEHMANN D MEGIDOR M | 1990 | Artificial Intelligence1990，44，12： | 1 |
| 7 | Effect of UVB radiation emitted from the narrowband TL-01 lamp(311 nm)on the calcitnol synthesis in organotypic cultures of keratinocytes 显示文摘 | Lehmann B Knuschke P Meurer M | 2005 | Exp Dermatol2005，14，2： | 1 |
| 8 | An all-solid-state optical range camera for 3D real-time imaging with sub-centimeter depth resolution显示文摘 | OGGIER T LEHMANN M KAUFMANN R | 2003 | Proceedings of SPIE2003，5249，： | 1 |
| 9 | Bio-char sequestration in terrestrial ecosystems-a review显示文摘 | Lehmann J Gaunt J Rondon M | 2006 | Mitigation and Adaptation Strategies for Global Change2006，11，2： | 1 |
| 10 | Survey: Interpolation methods in medical image processing 显示文摘 | LEHMANN T M GONNER C SPITZER K | 1999 | IEEE Transactions on Medical Imaging1999，18，11： | 1 |
| 11 | Autonomic imbalance hypothesis and overtraining syndrome 显示文摘 | Lehmann M Foster C Dickhuth H H | 1998 | Med Sci Sports Exercise1998，30，7： | 1 |
| 12 | Engineer ing the root-soil interface via targeted expression of a synthetic phytase gene in trichoblasts显示文摘 | Zimmermann P Zardi G Lehmann M | 2003 | Plant Biotechnol2003，1，： | 1 |
| 13 | Glucose induce beta-cell apoptosis via upregulation of the Fas receptor in human islets显示文摘 | Maedler K Spinas GA Lehmann R Sergeev P Weber M Fontana A | 2001 | Diabetes2001，50，8： | 1 |
| 14 | Laser rapid prototyping of photonic band-gap microstructures显示文摘 | WANKE M LEHMANN O MULLER K | 1997 | Science1997，275，： | 1 |
| 15 | Wing Rotation and the Aerodynamic Basis of Insect Flight显示文摘 | Dickinson M H Lehmann F O Sanjay P S | 1999 | Science1999，，284： | 1 |
| 16 | Science显示文摘 | Wanke M C Lehmann O | 1997 | (275):12841997，，275： | 1 |
| 17 | Limited open reduction and internal fixation of displaced intra-articular fractures of the calcaneum显示文摘 | Weber M Lehmann O Sagesser D | | 0，，12： | 1 |
| 18 | FATE of Soil-AppliedBlack Carbon:Downward Migration,Leaching and Soil Respiration显示文摘 | MAJOR J LEHMANN J RONDON M | 2010 | Global Change Biology2010，16，4： | 1 |
| 19 | Dose dependent alteraton in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate 显示文摘 | Lehmann K P Phillips S Sar M | 2004 | Toxicol Sci2004，81，： | 1 |
| 20 | Biochar effects on soil biota-A review显示文摘 | Lehmann J Riuig M C Thies J | 2011 | Soil Biology and Biochemistry2011，43，9： | 1 |
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