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| 1 | A Silicon Monoxide Lithium-Ion Battery Anode with Ultrahigh Areal Capacity显示文摘Silicon monoxide(SiO)is an attractive anode material for next-generation lithium-ion batteries for its ultra-high theoretical capacity of 2680 mAh g−1.The studies to date have been limited to electrodes with a rela-tively low mass loading(<3.5 mg cm^(−2)),which has seriously restricted the areal capacity and its potential in practical devices.Maximizing areal capacity with such high-capacity materials is critical for capitalizing their potential in practi-cal technologies.Herein,we report a monolithic three-dimensional(3D)large-sheet holey gra-phene framework/SiO(LHGF/SiO)composite for high-mass-loading electrode.By specifically using large-sheet holey graphene building blocks,we construct LHGF with super-elasticity and exceptional mechanical robustness,which is essential for accommodating the large volume change of SiO and ensuring the structure integrity even at ultrahigh mass loading.Additionally,the 3D porous graphene network structure in LHGF ensures excellent electron and ion transport.By systematically tailoring microstructure design,we show the LHGF/SiO anode with a mass loading of 44 mg cm^(−2)delivers a high areal capacity of 35.4 mAh cm^(−2)at a current of 8.8 mA cm^(−2)and retains a capacity of 10.6 mAh cm^(−2)at 17.6 mA cm^(−2),greatly exceeding those of the state-of-the-art commercial or research devices.Furthermore,we show an LHGF/SiO anode with an ultra-high mass loading of 94 mg cm^(−2)delivers an unprecedented areal capacity up to 140.8 mAh cm^(−2).The achievement of such high areal capacities marks a critical step toward realizing the full potential of high-capacity alloy-type electrode materials in practical lithium-ion batteries. | Jiang Zhong Tao Wang Lei Wang Lele Peng Shubin Fu Meng Zhang Jinhui Cao Xiang Xu Junfei Liang Huilong Fei Xidong Duan Bingan Lu Yiliu Wang Jian Zhu Xiangfeng Duan | 2022 | Nano-Micro Letters2022，14，3： | 4 |
| 2 | Oxygen‑Deficient β‑MnO_(2)@Graphene Oxide Cathode for High‑Rate and Long‑Life Aqueous Zinc Ion Batteries显示文摘Recent years have witnessed a booming interest in grid-scale electrochemical energy storage,where much attention has been paid to the aqueous zinc ion batteries(AZIBs).Among various cathode materials for AZIBs,manganese oxides have risen to prominence due to their high energy density and low cost.However,sluggish reaction kinetics and poor cycling stability dictate against their practical application.Herein,we demonstrate the combined use of defect engineering and interfacial optimization that can simultaneously promote rate capability and cycling stability of MnO_(2) cathodes.β-MnO_(2) with abundant oxygen vacancies(VO)and graphene oxide(GO)wrapping is synthesized,in which VO in the bulk accelerate the charge/discharge kinetics while GO on the surfaces inhibits the Mn dissolution.This electrode shows a sustained reversible capacity of~129.6 mAh g^(−1) even after 2000 cycles at a current rate of 4C,outperforming the state-of-the-art MnO_(2)-based cathodes.The superior performance can be rationalized by the direct interaction between surface VO and the GO coating layer,as well as the regulation of structural evolution ofβ-MnO_(2) during cycling.The combinatorial design scheme in this work offers a practical pathway for obtaining high-rate and long-life cathodes for AZIBs. | Shouxiang Ding Mingzheng Zhang Runzhi Qin Jianjun Fang Hengyu Ren Haocong Yi Lele Liu Wenguang Zhao Yang Li Lu Yao Shunning Li Qinghe Zhao Feng Pan | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 3 | Comparative Study on Analysis and Fitting of Pudong Chicken Growth Curve显示文摘The objective of this paper was to study the growth and development laws of Pudong chicken. The growth curve of Pudong chicken(cock and hen) from 0 to 20 weeks was analyzed and fitted with three models(Gompertz, Logistic and Bertalanffy). It was concluded that the growth curves were appropriately fitted with three models, and fitness degree(R2)in growth data of Pudong chicken were all above 0.992. The Bertalanffy model was the most effective with the highest R2 for cock(R2=0.995) and hen(R2=0.999), respectively. With further analysis of fitted parameters for Logistic model of cock, 0-3 weeks' fitted values were significantly greater than measured values and 4-8 weeks ' fitted values were lower than measured values. Compared with Logistic model, the values calculated by Gompertz model and Bertalanffy model were more coincident with the practical measuring values. For hens, 0-3 weeks ' fitted values of Logistic model were significantly greater than measured values and 0-2 weeks ' fitted values of Gompertz model were slightly greater than measured values, while the values calculated by Bertalanffy model best matched the observed val-ues from actual measure. The results showed that Bertalanffy model used to estimate the growth weight of Pudong chicken was the best while Logis-tic model was the worst. So the fitness and analysis of growth curves of Pudong chicken are valid, which may be adopted to predict growth and de-velopment laws of Pudong chicken and provide reliable data for precise feeding and breeding. | Lu Xuelin Zhao Lele Li Hejun Xu Dong Wu Haomin Xu Weibin | 2018 | Animal Husbandry and Feed Science2018，10，3： | 1 |
| 4 | Geology, Pb Isotope Geochemistry and Ore Genesis of the Liziyuan Gold Deposit, West Qinling Orogen, Central China显示文摘The Liziyuan gold deposit, situated on the south side of the Shangdan suture zone, West Qinling Orogen, occurs in metamorphic volcanic rocks(greenschist facies) of the early Paleozoic Liziyuan Group and in Indosinian Tianzishan monzogranite. Orebodies in the Liziyuan gold field are controlled by the ductile-brittle shear zone, and by thrusting nappe faults related to the Indosinian orogeny. In detail, this paper analyzed the geological characteristics of the Liziyuan gold field, and the Pb isotopes of the Lziyuan host rocks, granitoids(Tianzishan monzogranite and Jiancaowan syenite porphyry), sulfides, and auriferous quartz veins by multiple-collector inductively coupled plasma mass spectrometry(MC-ICPMS). In addition, previous data on the sulfur, hydrogen, and oxygen isotopes were employed to discuss the possible sources of the ore-forming fluids and materials, and to further understand the tectonic setting of the Liziyuan gold deposit. The sulfides and their host rocks(Lziyuan Group), Tianzishan monzogranite and Jiancaowan syenite porphyry, and auriferous quartz veins have similar Pb isotopic compositions.Zartman's plumbotectonic model diagram shows that most of the data for the deposit fall near the orogenic Pb evolutionary curve or within the area between the orogenic and mantle Pb evolutionary curves. In the△β-△γ diagram, which genetically classifies the lead isotopes, most of the data fall within the range of the subduction-zone lead mixed with upper crust and mantle. This indicates that a complex source of the ore lead formed in the orogenic environment. The δ^(34)S values of the sulfides range from 3.90 to 8.50‰(average6.80‰), with a pronounced mode at 5.00‰-8.00‰. These values are consistent with that of orogenic gold deposits worldwide, indicating that the sulfur sourced mainly from reduced metamorphic fluids. The isotopic hydrogen and oxygen compositions support a predominantly metamorphic origin of the oreforming fluids, with possible mixing of minor magmatic fluids, but the late stage was dominated by meteoric water. The characteristics of the Liziyuan gold deposit formed in the Indosinian orogenic environment of the Qinling Orogen are consistent with those of orogenic gold deposits found worldwide. | DING Lele ZHU Laimin YUAN Honglin LU Rukui XIONG Xiao YANG Tao | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 1 |
| 5 | The Jidong Eye Cohort Study:objectives,design,and baseline characteristics显示文摘Background:To describe the objective,design and baseline characteristics of the Jidong Eye Cohort Study(JECS),a community-based cohort in China based on etiology,imaging and biomarkers.The JECS will clarify the pathogenesis of visual impairment and status of ocular indicators in the occurrence and progression of cardiocerebrovascular and neurological diseases.Methods:Between August 2019 and January 2020,the JECS recruited consecutive participants aged 18 years and older from the Jidong communities in China.The demographic and clinical characteristics were collected by trained site personnel via face-to-face interviews.The relevant biological samples were also collected.The participants underwent comprehensive ophthalmic examination,such as retinal photography and optical coherence tomography(OCT)angiography.The following outcomes were measured annually:ocular vascular abnormality,optic nerve degeneration,cardiovascular diseases(CVD)and neurological diseases.The study will be performed until 2024.Results:Among 3377 participants,the average age was 45.0±12.5 years and 1809(53.6%)were women.Hypertension occurred in 825 individuals(25.0%),diabetes in 258(7.7%),hyperglycemia in 474(14.2%),and a CVD history in 100(3.0%).The mean best-corrected visual acuity was 0.1 logMAR in the recruited subjects.The average OCT signal index was 8.2±1.2.Additionally,the mean vessel densities for the entire measured area were 46.4%and 50.8%for the superficial and deep vascular complex,respectively.Mean area and perimeter of foveal avascular zone was 0.3 mm2 and 2.3 mm.Conclusions:The JECS is a large community-based prospective cohort in North China.Rich data collected from this study will provide the opportunity to identify risk factors,imaging,and biomarkers of visual impairment(either ocular vascular anomalies or optic nerve degeneration)and to evaluate their associations with CVD and neurological diseases. | Kai Yang Lele Cui Guoyun Zhang Xianwei Wang Xiaoxuan Zhu Yunfan Xiao Binbin Su Daiyu Song Xinyao Zhang Yang Zheng Fan Lu Jia Qu Ming Li | 2020 | Eye and Vision2020，7，1： | 0 |
| 6 | Prediction of fracture and dilatancy in granite using acoustic emission signal cloud显示文摘The invisibility of fracture network evolution in the rock under triaxial compression seriously restricts the correlation modeling between dilatancy behavior and fracture interconnectivity.The key to solving such a challenge is strongly dependent on the accurate modeling of the spatial correlation in fracture network,which could be indirectly re-constructed by the acoustic emission(AE)signal cloud.Considering the interaction of local fractures,a cube cluster approach is established to describe the spatial correlation.The evolutional cube clusters effectively present the geometric characteristics induced by the increasing dilatancy of fracture.Two descriptors(i.e.three-axis length sum and pore fraction)are introduced to correlate cluster model with dilatancy behavior.Most fitting results support the linear correlation between two descriptors and volumetric strain,which verifies the sensitiveness of the cube cluster model to dilatancy.More importantly,by the statistical analysis of cluster structure,the cluster model shows the potential of calculating fracture angle.Moreover,a comparison between dilatancybased damage and porosity-based damage is made not to prove the best but provide an AE-based prediction of local damage evolution.Finally,four classical models for calculating fracture angle are compared.The deviations prove the huge difficulty of describing the development of the fracture network uniquely dependent on a fracture angle.The proximity of measured angle and cluster-based angle supports the effectiveness of predication by the cube cluster approach. | Dongjie Xue Lan Lu Lie Gao Lele Lu Cheng Chen | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，5： | 0 |
| 7 | Combination strategies for first-line treatment of patients with unresectable hepatocellular carcinoma:prospect of natural products显示文摘Liver cancer stands as a significant global health concern,contributing substantially to cancer incidence and mortality,particularly in Asian countries[1].Hepatocellular carcinoma(HCC)accounts for approximately 90%of all liver cancer cases and is characterized by a high-risk profile and a generally poor prognosis[2].To address advanced HCC,systemic therapy has been recommended,leading to the approval of a range of treatment regimens in clinical practice.Traditionally,first-line therapy involved the use of multitargeted tyrosine kinase inhibitors(TKIs)such as sorafenib or lenvatinib,while cabozantinib,ramucirumab. | ZHANG Lele LU Jinjian | 2024 | Chinese Journal of Natural Medicines2024，22，1： | 0 |
| 8 | Developing new Mg alloy as potential bone repair material via constructing weak anode nano-lamellar structure显示文摘The mechanics-corrosion and strength-ductility tradeoffs of magnesium(Mg)alloys have limited their applications in fields such as orthopedic implants.Herein,a fine-grain structure consisting of weak anodic nano-lamellar solute-enriched stacking faults(SESFs)with the average thickness of 8 nm and spacing of 16 nm is constructed in an as-extruded Mg96.9Y1.2Ho1.2Zn0.6Zr0.1(at.%)alloy,obtaining a high yield strength(YS)of 370 MPa,an excellent elongation(EL)of 17%,and a low corrosion rate of 0.30 mm y−1(close to that of high-pure Mg)in a uniform corrosion mode.Through scanning Kelvin probe force microscopy(SKPFM),one-dimensional nanostructured SESFs are identified as the weak anode(∼24 mV)for the first time.The excellent corrosion resistance is mainly related to the weak anodic nature of SESFs and their nano-lamellar structure,leading to the more uniform potential distribution to weaken galvanic corrosion and the release of abundant Y^(3+)/Ho^(3+)from SESFs to form a more protective film with an outer Ca_(10)(PO_(4))_(6)(OH)_(2)/Y_(2)O_(3)/Ho_(2)O_(3) layer(thickness percentage of this layer:72.45%).For comparison,the as-cast alloy containing block 18R long period stacking ordered(LPSO)phase and the heat-treated alloy with fine lamellar 18R-LPSO phase(thickness:80 nm,spacing:120 nm)are also studied,and the characteristics of SESFs and 18R-LPSO phase,such as the weak anode nature of the former and the cathode nature of the latter(37-90 mV),are distinguished under the same alloy composition.Ultimately,we put forward the idea of designing Mg alloys with high mechanical and anti-corrosion properties by constructing'homogeneous potential strengthening microstructure',such as the weak anode nano-lamellar SESFs structure. | Jinshu Xie Lele Wang Jinghuai Zhang Liwei Lu Zhi Zhang Yuying He Ruizhi Wu | 2023 | Journal of Magnesium and Alloys2023，11，1： | 0 |
| 9 | Cluster modeling of the short-range correlation of acoustically emitted scattering signals显示文摘As a widely used measurement technique in rock mechanics,spatial correlation modeling of acoustic emission(AE)scattering signals is attracting increasing focus for describing mechanical behavior quantitatively.Unlike the statistical description of the spatial distribution of randomly generated AE signals,spatial correlation modeling is based mainly on short-range correlation considering the interrelationship of adjacent signals.As a new idea from percolation models,the covering strategy is used to build the most representative cube cluster,which corresponds to the critical scale at peak stress.Its modeling process of critical cube cluster depends strongly on the full connection of the main fracture network,and the corresponding cube for coverage is termed the critical cube.The criticality pertains to not only the transition of local-to-whole connection of the fracture network but also the increasing-to-decreasing transition of the deviatoric stress with an obvious stress drop in the brittle failure of granite.Determining a reasonable critical cube guarantees the best observation scale for investigating the failure process.Besides,the topological connection induces the geometric criticality of three descriptors,namely anisotropy,pore fraction,and specific surface area,which are evaluated separately and effectively.The results show that cluster modeling based on the critical cube is effective and has criticality in both topology and geometry,as well as the triaxial behavior.Furthermore,the critical cube length presents a high confidence probability of being correlated to the mineral particle size.Besides,its pore fraction of cube cluster is influenced strongly by the critical cube length and confining pressure. | Dongjie Xue Lele Lu Jie Zhou Lan Lu Yintong Liu | 2021 | International Journal of Coal Science & Technology2021，8，4： | 0 |
| 10 | Interactions between ShPP2-1, an F-box family gene, and ACR11A regulate cold toleranee of tomato显示文摘There is a critical need to identify germplasm resources and genes that promote cold tolerance of tomato because global tomato production is threatened by cold stress.We found that the expression of an F-box gene family member named ShPP2-1 from Solanum habrochaites is cold inducible and studied its contribution to cold tolerance.Overexpression of ShPP2-1 in cultivated tomato(AC)reduced cold tolerance by intensifying damage to cell membranes.To explore the underlying molecular mechanism,we conducted a yeast two-hybrid library screen and found that a protein containing ACT domain repeats named ACR11A interacts with PP2-1.Overexpression of SIACR11A in AC enhanced the cold tolerance of seedlings and germinating seeds.Cold tolerance decreased in tomato plants that overexpressed both of these genes.Additionally,we performed seed germination experiments in the cold with 177 tomato accessions and identified two alleles of SlACR11A that differ in one single-nucleotide polymorphism.We found that one of these alleles,SlACR11A G,is significantly enriched in cold-tolerant tomato plants.Taken together,our fi ndings indicate that the combination of low expression levels of PP2-1 and high expression levels of ACR11A can promote cold tolerance.These genes may therefore serve as direct targets for both genetic engineering and improvement projects that aim to enhance the cold tolerance of tomato. | Jianwen Song Lele Shang Shiwei Chen Yongen Lu Yuyang Zhang Bo Ouyang Zhibiao Ye Junhong Zhang | 2021 | Horticulture Research2021，8，1： | 0 |
| 11 | Bimetallic cobalt-nickel coordination polymer electrocatalysts for enhancing oxygen evolution reaction显示文摘Coordination polymers(CPs)have great potential to be used in electrocatalysis owing to their designable compositions and structures.It is highly challenging to apply CPs as electrocatalysts for oxygen evolution reaction(OER)on account of insufficient catalytic efficiency and relatively poor stability of current electrocatalysts.Herein,through a mixed-metal strategy,one-dimensional Co_(x)Ni_(1-x)-HIPA with dual active sites was synthesized and studied for OER electrocatalysts.By changing the metal ratio of CoxNi1-x-HIPA,the OER performance was well regulated.The optimized Co_(1/2)Ni_(1/2)-HIPA exhibited minimum reaction activation energy,and represented an overpotential of 367 m V to reach 10 mA/cm^(2) at 25℃.Moreover,an overpotential of 314 m V at 10 m A/cm^(2) was obtained from Co_(1/2)Ni_(1/2)-HIPA at 55℃.This mixed-metal strategy provides a feasible way for adjusting the electronic states of the electrocatalysts to improve the electrocatalytic OER performance. | Lele Lu Qiang Li Jia Du Wei Shi Peng Cheng | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 12 | Decrease of Matrix Plasticity Promotes Fibroblast Activation in Fibrosis显示文摘This work identified the important role of matrix mechanical plasticity in mediating fibroblast activation.Many existing studies have highlighted the important effects of biochemical cues(e.g.,transforming growth factor-β1)and mechanicalstiffness on fibroblast activation.Our results indicated that self-assembled collagen hydrogels showed high plasticity and in which fibroblasts remain undifferentiated.However,when we decreased the plasticity of collagen hydrogels by increasing covalent crosslinking,fibroblasts showed a significant fibrotic response as reflected by the increasedα-SMA expression.Since the material systems we constructed have low and the same initial modulus,this process is stiffness independent.Although it has been reported that covalently crosslinked hydrogels are more difficult to degrade and matrix degradability has an important impact on cell behaviors,no significant changes of fibroblast activation were observed when proteases were broadly inhibited in our experiments.Importantly,the hydrogels we constructed showed similar plastic behaviors under creep and recovery tests compared to native normal and fibrotic tissues.These highlight the importance of matrix plasticity in mimicking the mechanical microenvironment of native fibrotic tissues.Mechanistically,we found that the enhanced fibroblast activation in low plastic matrix is mediated through integrin-actin pathway and nuclear localization of YAP.In high plastic collagen,matrix cannot provide effective resistance to actin contraction because of the rupture of weak crosslinks and the slippage of local fibers.On the contrary,in low plastic collagen,deformation energy can be stored in the network due to the existence of strong covalent crosslinks,thus enabling the build-up of cell traction and the formation of a robust cell-matrix interaction.Experiments of inhibiting or promoting cytoskeletal contractility and CGMD simulation both verified the above points.Our results clarify plasticity changes on the development of fibrotic diseases and highlight plasticity as an important mechanical cue in understanding cell-matrix interactions. | Yuanbo Jia Yanzhong Wang Lele Niu Hang Zhang Jin Tian Dengfeng Gao Xiaohui Zhang Tian Jian Lu Jin Qian Guoyou Huang Feng Xu | 2019 | 医用生物力学2019，34，A01： | 0 |
| 13 | Two-dimensional bimetallic coordination polymers as bifunctional evolved electrocatalysts for enhanced oxygen evolution reaction and urea oxidation reaction显示文摘Two-dimensional coordination polymers(CPs) have aroused tremendous interest as electrocatalysts because the catalytic performance could be fine-tuned by their well-designed coordination layers with highly accessible and active metal sites.However,it remains great challenge for CP-based catalysts to be utilized for electrocatalytic oxidation reactions due to their inefficient activities and low catalytic stabilities.Herein,we applied a mixed-metal strategy to fabricate two-dimensional Co_xNi_(1-x)-CPs with dual active sites for electrocatalytic water and urea oxidation.By metal ratio regulation in the twodimensional layer,an optimized Co_(2/3)Ni_(1/3)-CP exhibits a water oxidation performance with an overpotential of 325 mV at a current density of 10 mA cm^(-2) and a Tafel slope of 86 mV dec^(-1) in alkaline solution for oxygen evolution reaction.Importantly,a lower potential than that of commercial RuO_(2) is observed over20 mA cm^(-2).Co_(2/3)Ni_(1/3)-CP also displays a potential of 1.381 V at 10 mA cm^(-2) for urea oxidation reaction and a Tafel slope of 124 mV dec^(-1).This mixed-metal strategy to maximize synergistic effect of different metal centers may ultimately lead to promising electrocatalysts for small molecule oxidation reaction. | Qiang Li Lele Lu Jingwei Liu Wei Shi Peng Cheng | 2021 | Journal of Energy Chemistry2021，30，12： | 0 |
| 14 | Rational Design of a Near-infrared Fluorescent Material with High Solid-state Efficiency,Aggregation-induced Emission and Live Cell Imaging Property显示文摘Near-infrared(NIR)fluorescent materials with high photoluminescent quantum yields(PLQYs)have wide application prospects.Therefore,we design and synthesize a D-A type NIR organic molecule,TPATHCNE,in which triphenylamine and thiophene are utilized as the donors and fumaronitrile is applied as the acceptor.We systematically investigate its molecular structure and photophysical property.TPATHCNE shows high T_(g) of 110℃ and T_(d) of 385℃ and displays an aggregation-induced emission(AIE)property.A narrow optical bandgap of 1.65 eV is obtained.The non-doped film of TPATHCNE exhibits a high PLQY of 40.3%with an emission peak at 732 nm,which is among the best values of NIR emitters.When TPATHCNE is applied in organic light-emitting diode(OLED),the electroluminescent peak is located at 716 nm with a maximum external quantum efficiency of 0.83%.With the potential in cell imaging,the polystyrene maleic anhydride(PMSA)modified TPATHCNE nanoparticles(NPs)emit strong fluorescence when labeling HeLa cancer cells,suggesting that TPATHCNE can be used as a fluorescent carrier for specific staining or drug delivery for cellular imaging.TPATHCNE NPs fabricated by bovine serum protein(BSA)are cultivated with mononuclear yeast cells,and the intense intracellular red fluorescence indicates that it can be adopted as a specific stain for imaging. | SHANG Anqi ZHAO Lele LI Zhenhua CHENG Zhuang JIN Haixu FENG Zijun CHEN Zhijun ZHANG Haiquan LU Ping | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
| 15 | Study on Cognition of Urban Residents on Haze Control and Their Willingness to Pay:A Case Study of Zhengzhou City and Jiaozuo City显示文摘Residents’payment is an important supplement to the government’s urban haze control costs.In this paper,Zhengzhou City and Jiaozuo City of Henan Province were taken as research objects.Through research methods such as data mining,questionnaire survey and model construction,the residents’cognition on haze control,willingness to pay and its influencing factors were deeply studied.Main research results were as below:residents in Zhengzhou and Jiaozuo have improved their awareness and satisfaction with haze control,but the growth rate was slow.In 2014,2018 and 2021,the expected values of willingness to pay for haze control in Zhengzhou were 79.94,85.52 and 47.20 yuan/month respectively,while they were 62.17,57.77 and 46.96 yuan/month in Jiaozuo City.Residents’haze awareness had the most significant effect on the willingness to pay for haze control,and there was positive correlation(P<0.05).Residents’cognition of haze control was the most important factor affecting their willingness to pay for haze control.Residents’income level and air pollution level had a positive effect on residents’willingness to pay,while residents’confidence in the government had a weak impact on their willingness to pay. | Lele DU Xiaoming CHUAI Lu LIU Yanjun HAN Hong WANG Chao FAN | 2022 | Meteorological and Environmental Research2022，13，4： | 0 |
| 16 | Identification of Bulbocodin D and C as novel STAT3 inhibitors and their anticancer activities in lung cancer cells显示文摘Cancer stands as one of the predominant causes of mortality globally, necessitating ongoing efforts to develop innovative therapeutics. Historically, natural products have been foundational in the quest for anticancer agents. Bulbocodin D (BD) and Bulbocodin C (BC), two bibenzyls derived from Pleione bulbocodioides (Franch.) Rolfe, have demonstrated notable in vitro anticancer activity. In human lung cancer A549 cells, the IC50s for BD and BC were 11.63 and 11.71 μmol·L^(−1), respectively. BD triggered apoptosis, as evidenced by an upsurge in Annexin V-positive cells and elevated protein expression of cleaved-PARP in cancer cells. Furthermore, BD and BC markedly inhibited the migratory and invasive potentials of A549 cells. The altered genes identified through RNA-sequencing analysis were integrated into the CMap dataset, suggesting BD’s role as a potential signal transducer and activator of transcription 3 (STAT3) inhibitor. SwissDock and MOE analyses further revealed that both BD and BC exhibited a commendable binding affinity with STAT3. Additionally, a surface plasmon resonance assay confirmed the direct binding affinity between these compounds and STAT3. Notably, treatment with either BD or BC led to a significant reduction in p-STAT3 (Tyr 705) protein levels, regardless of interleukin-6 stimulation in A549 cells. In addition, the extracellular signal-regulated kinase (ERK) was activated after BD or BC treatment. An enhancement in cancer cell mortality was observed upon combined treatment of BD and U0126, the MEK1/2 inhibitor. In conclusion, BD and BC emerge as promising novel STAT3 inhibitors with potential implications in cancer therapy. | HE Xinyu FU Jiarui LYU Wenyu HUANG Muyang MO Jianshan CHENG Yaxin XU Yulian ZHENG Lijun ZHANG Xiaolei QI Lu ZHANG Lele ZHENG Ying HUANG Mingqing NI Lin LU Jinjian | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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