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| 1 | Integrated modeling environment and a preliminary application on the Heihe River Basin, China显示文摘Environmental and water issues are essentially complex interdisciplinary problems. Multiple models from different disciplines are usually integrated to solve those problems. Integrated modeling environment is an effective technical approach to model integration. Although a number of modeling environments worldwide are available, they cannot meet current challenges faced. Their old-fashion designs and original development purposes constrain their possible applications to the domain of hydrologic or land surface modeling. One of the challenges is that we intend to link knowledge database or ontology system to the modeling environment in order to make the modeling support more intelligent and powerful. In this paper, we designed and implemented an integrated modeling environment (HIME) for hydrological and land surface modeling purpose in a much extendable, efficient and easy use manner. With such design, a physical process was implemented as a module, or component. A new model can be generated in an intuitive way by linking module icons together and establishing their relationships. Following an introduction to the overall architecture, the designs for module linkage and data transfer between modules are described in details. Using XML based meta-information, modules in either source codes or binary form can be utilized by the environment. As a demonstration, with the help of HIME, we replaced the evaporation module of TOPMODEL with the evapotranspiration module from the Noah land surface model which explicitly accounts for vegetation transpiration. This example showed the effectiveness and efficiency of the modeling environment on model integration. | NAN ZhuoTong SHU LeLe ZHAO YanBo LI Xin DING YongJian | 2011 | Science China(Technological Sciences)2011，54，8： | 8 |
| 2 | Malware Detection Algorithm Based on the Attention Mechanism and ResNet显示文摘The cost of misclassifying a malware program as normal is often higher than that of misclassifying a normal program as malware.Therefore,how to improve the detection accuracy of malware programs is a very important problem.This paper proposes a deep learning malware program detection algorithm based on attention mechanism.Word2Vec model is used to map the Application programming interface(API)into word vectors,and all word vectors of each sample are arranged into a matrix with the same size.On this basis,residual network is used to extract features of samples.The features are input into the attention mechanism to learn the similarity between samples.Then,the features are weighted with the similarity to obtain the new features with better robustness.The new features and the original features are added element by element to obtain the sample features more suitable for classification.Finally,samples are classified by classifier.Experiments show that the classification effect of the proposed method is better than that of the traditional machine learning method. | WANG Lele WANG Binqiang ZHAO Peipei LIU Ruyi LIU Jiangang MIAO Qiguang | 2020 | Chinese Journal of Electronics2020，29，6： | 5 |
| 3 | DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells显示文摘superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests. | Wenting Xue Zhenghan Di Ya Zhao Aiping Zhang Lele Li | 2019 | Chinese Chemical Letters2019，30，4： | 4 |
| 4 | Oxygen‑Deficient β‑MnO_(2)@Graphene Oxide Cathode for High‑Rate and Long‑Life Aqueous Zinc Ion Batteries显示文摘Recent years have witnessed a booming interest in grid-scale electrochemical energy storage,where much attention has been paid to the aqueous zinc ion batteries(AZIBs).Among various cathode materials for AZIBs,manganese oxides have risen to prominence due to their high energy density and low cost.However,sluggish reaction kinetics and poor cycling stability dictate against their practical application.Herein,we demonstrate the combined use of defect engineering and interfacial optimization that can simultaneously promote rate capability and cycling stability of MnO_(2) cathodes.β-MnO_(2) with abundant oxygen vacancies(VO)and graphene oxide(GO)wrapping is synthesized,in which VO in the bulk accelerate the charge/discharge kinetics while GO on the surfaces inhibits the Mn dissolution.This electrode shows a sustained reversible capacity of~129.6 mAh g^(−1) even after 2000 cycles at a current rate of 4C,outperforming the state-of-the-art MnO_(2)-based cathodes.The superior performance can be rationalized by the direct interaction between surface VO and the GO coating layer,as well as the regulation of structural evolution ofβ-MnO_(2) during cycling.The combinatorial design scheme in this work offers a practical pathway for obtaining high-rate and long-life cathodes for AZIBs. | Shouxiang Ding Mingzheng Zhang Runzhi Qin Jianjun Fang Hengyu Ren Haocong Yi Lele Liu Wenguang Zhao Yang Li Lu Yao Shunning Li Qinghe Zhao Feng Pan | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 5 | Development of a Label-Free Colorimetric Aptasensor with Rationally Utilized Aptamer for Rapid Detection of Okadaic Acid显示文摘Okadaic acid(OA)is a typical marine toxin with strong toxicity causing diarrheic shellfish poisoning(DSP).Aptamers show great advantages in toxin detection and attract increasing attentions in the field of food analysis.In this study,a label-free col-orimetric aptasensor was constructed for visual and rapid detection of OA in shellfish.To exploit the binding capability of the anti-OA aptamer,the inherent molecular recognition mechanism of aptamer and OA was studied,based on molecular docking,fluorescent assay,and biolayer interferometry.Consistent results showed that the stem-loop near the 3’terminal of the aptamer exhibit dominate binding capacity.Based on the revealed recognition information,the aptamer was thus rationally utilized and combined with AuNPs and cationic polymer polydiallyl dimethyl ammonium chloride(PDDA)for the development of the label-free colorimetric aptasensor,in which the 3’terminal was thoroughly exposed to OA.The aptasensor provided robust performance with a linear detection range of 100-1200 nmol L-1,a limit of detection of 41.30 nmol L-1,recovery rates of 91.6%-106.2%,as well as a high selectivity towards OA in shellfish samples.The whole detection process can be completed within 1 h.To our best knowledge,this is the first time that the anti-OA aptamer was thoroughly studied,and a label-free colorimetric aptasensor was rationally designed in this way.This study not only provides a rapid detection method for highly sensitive and specific detection of OA,but also serves as a reference for the design of efficient aptasensors in the future. | YAN Xiaochen QI Xiaoyan ZHAO Yinglin LI Ling MA Rui WANG Lele WANG Sai MAO Xiangzhao | 2022 | Journal of Ocean University of China2022，21，2： | 2 |
| 6 | Synthesis of Environmentally Friendly Magnesium Linoleate Detergent显示文摘This paper mainly covers a method for preparing a highly alkaline magnesium linoleate solution with a total base number(TBN) value of 328 mg KOH/g using linoleic acid as the biodegradable raw material, which can substitute for traditional lubricant detergents as an environmentally friendly detergent. Reaction conditions, including the molar ratio of magnesium oxide to linoleic acid, the molar ratio of methanol to magnesium oxide, the carbonation temperature, the molar ratio of water to magnesium oxide, the flow rate of CO2 gas and the duration for injection of CO2 to magnesium oxide system, were optimized. | Wang Yonglei Li Haiyun Fang Hongxia Ni Zhifei Zhao Lele | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 2 |
| 7 | A smart DNA nanodevice for ATP-activatable bioimaging and photodynamic therapy显示文摘Rational design of activatable photosensitizers for controlled generation of singlet oxygen remains a challenge for precise photodynamic therapy(PDT).Herein,we present an aptamer-based nanodevice for adenosine 5′-triphosphate(ATP)-activatable bioimaging and PDT.The nanodevice is constructed by modifying ATP-responsive duplex DNA units and polyethylene glycol on the surface of a gold nanoparticle(AuNP)through the thiolate-Au chemistry.The DNA units were designed by the hybridization of the ATP aptamer strand with a methylene blue(MB)-modified complementary DNA(cDNA).The close proximity of MB to the surface of AuNP results in the low photodynamic activity of MB(OFF state).Once internalized into cancer cells,the ATP-binding induced conformation switch of aptamer strand leads to the release of the MB-bearing DNA strand from AuNPs,resulting in the activatable generation of singlet oxygen under light irradiation(ON state).We demonstrate that the DNA nanodevice represents a promising platform for ATP-responsive bioimaging and specific PDT in vitro and in vivo.This work highlights a potential way for specific tumor diagnosis and therapy. | Bei Liu Rui Ma Jian Zhao Yuliang Zhao Lele Li | 2020 | Science China Chemistry2020，63，10： | 1 |
| 8 | Telomeraseimmortalized human mammary stern/progenitor cells with ability to self-renew and differentiate显示文摘 | Zhao X Malhotra GK Lele SM | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 9 | A reversible Br2/Br-redox couple in the aqueous phase as a high-performance catholyte for alkali-ion batteries显示文摘 | Zhao Yu Ding Yu Song Jie Peng Lele Goodenough John B Yu Guihua | 2014 | Energy&Environmental Science2014，7，6： | 1 |
| 10 | Comparative Study on Analysis and Fitting of Pudong Chicken Growth Curve显示文摘The objective of this paper was to study the growth and development laws of Pudong chicken. The growth curve of Pudong chicken(cock and hen) from 0 to 20 weeks was analyzed and fitted with three models(Gompertz, Logistic and Bertalanffy). It was concluded that the growth curves were appropriately fitted with three models, and fitness degree(R2)in growth data of Pudong chicken were all above 0.992. The Bertalanffy model was the most effective with the highest R2 for cock(R2=0.995) and hen(R2=0.999), respectively. With further analysis of fitted parameters for Logistic model of cock, 0-3 weeks' fitted values were significantly greater than measured values and 4-8 weeks ' fitted values were lower than measured values. Compared with Logistic model, the values calculated by Gompertz model and Bertalanffy model were more coincident with the practical measuring values. For hens, 0-3 weeks ' fitted values of Logistic model were significantly greater than measured values and 0-2 weeks ' fitted values of Gompertz model were slightly greater than measured values, while the values calculated by Bertalanffy model best matched the observed val-ues from actual measure. The results showed that Bertalanffy model used to estimate the growth weight of Pudong chicken was the best while Logis-tic model was the worst. So the fitness and analysis of growth curves of Pudong chicken are valid, which may be adopted to predict growth and de-velopment laws of Pudong chicken and provide reliable data for precise feeding and breeding. | Lu Xuelin Zhao Lele Li Hejun Xu Dong Wu Haomin Xu Weibin | 2018 | Animal Husbandry and Feed Science2018，10，3： | 1 |
| 11 | Preparation of immobilized glucose oxidase and its application in improving breadmaking quality of commercial wheat flour显示文摘 | Lele Tang Ruijin Yang Xiao Hua Chaohua Yu Wenbin Zhang Wei Zhao | 2014 | Food Chemistry2014，，： | 1 |
| 12 | Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation显示文摘Cilia are cellular protrusions containing nine microtubule(MT)doublets and function to propel cell movement or extracellular liquid flow through beating or sense environmental stimuli through signal transductions.Cilia require the central pair(CP)apparatus,consisting of two CP MTs covered with projections of CP proteins,for planar strokes.How the CP MTs of such‘9+2’cilia are constructed,however,remains unknown.Here we identify Spef1,an evolutionarily conserved microtubule-bundling protein,as a core CP MT regulator in mammalian cilia.Spef1 was selectively expressed in mammalian cells with 9+2 cilia and specifically localized along the CP.Its depletion in multiciliated mouse ependymal cells by RNAi completely abolished the CP MTs and markedly attenuated ciliary localizations of CP proteins such as Hydin and Spag6,resulting in rotational beat of the ependymal cilia.Spef1,which binds to MTs through its N-terminal calponin.homologous domain,formed homodimers through its C-terminal coiled coil region to bundle and stabilize MTs.Disruption of either the MT-binding or the dimerization activity abolished the ability of exogenous Spef1 to restore the structure and functions of the CP apparatus.We propose that Spefl bundles and stabilizes central MTs to enable the assembly and functions of the CP apparatus. | Jianqun Zheng Hao Liu Lei Zhu Yawen Chen Huijie Zhao Wei Zhang Fan Li Lele Xie Xiumin Yan Xueliang Zhu | 2019 | Journal of Molecular Cell Biology2019，11，1： | 1 |
| 13 | Heat-inducible SlWRKY3 confers thermotolerance by activating the SlGRXS1 gene cluster in tomato显示文摘High temperature stress is one of the major environmental factors that affect the growth and development of plants. Although WRKY transcription factors play a critical role in stress responses, there are few studies on the regulation of heat stress by WRKY transcription factors,especially in tomato. Here, we identified a group I WRKY transcription factor, SlWRKY3, involved in thermotolerance in tomato. First, SlWRKY3 was induced and upregulated under heat stress. Accordingly, overexpression of SlWRKY3 led to an increase, whereas knock-out of SlWRKY3 resulted in decreased tolerance to heat stress. Overexpression of SlWRKY3 accumulated less reactive oxygen species(ROS), whereas knock-out of SlWRKY3 accumulated more ROS under heat stress. This indicated that SlWRKY3 positively regulates heat stress in tomato. In addition,SlWRKY3 activated the expression of a range of abiotic stress-responsive genes involved in ROS scavenging, such as a SlGRXS1 gene cluster.Further analysis showed that SlWRKY3 can bind to the promoters of the SlGRXS1 gene cluster and activate their expression. Collectively, these results imply that SlWRKY3 is a positive regulator of thermotolerance through direct binding to the promoters of the SlGRXS1 gene cluster and activating their expression and ROS scavenging. | Ying Wang Wenxian Gai Liangdan Yuan Lele Shang Fangman Li Zhao Gong Pingfei Ge Yaru Wang Jinbao Tao Xingyu Zhang Haiqiang Dong Yuyang Zhang | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 14 | A Detection Method of Bolts on Axlebox Cover Based on Cascade Deep Convolutional Neural Network显示文摘This paper proposes a cascade deep convolutional neural network to address the loosening detection problem of bolts on axlebox covers.Firstly,an SSD network based on ResNet50 and CBAM module by improving bolt image features is proposed for locating bolts on axlebox covers.And then,theA2-PFN is proposed according to the slender features of the marker lines for extracting more accurate marker lines regions of the bolts.Finally,a rectangular approximationmethod is proposed to regularize themarker line regions asaway tocalculate the angle of themarker line and plot all the angle values into an angle table,according to which the criteria of the angle table can determine whether the bolt with the marker line is in danger of loosening.Meanwhile,our improved algorithm is compared with the pre-improved algorithmin the object localization stage.The results show that our proposed method has a significant improvement in both detection accuracy and detection speed,where ourmAP(IoU=0.75)reaches 0.77 and fps reaches 16.6.And in the saliency detection stage,after qualitative comparison and quantitative comparison,our method significantly outperforms other state-of-the-art methods,where our MAE reaches 0.092,F-measure reaches 0.948 and AUC reaches 0.943.Ultimately,according to the angle table,out of 676 bolt samples,a total of 60 bolts are loose,69 bolts are at risk of loosening,and 547 bolts are tightened. | Ji Wang Liming Li Shubin Zheng Shuguang Zhao Xiaodong Chai Lele Peng Weiwei Qi Qianqian Tong | 2023 | Computer Modeling in Engineering & Sciences2023，，3： | 0 |
| 15 | Simulation and Experiment of Double Grits Interacting Scratch for Optical Glass BK7显示文摘The elastic-plastic transition regime and brittle-ductile transition regime in scratch process for optical glass BK7 were analyzed based on the Hertzian equation and the stress ratio theory which was proposed by Wei. The interacting scratch process for optical glass BK7 with the grit interval distance as the variable was simulated by the ABAQUS software of finite element simulation based on the energy fracture theory. Double grits interacting scratch test for optical glass BK7 was carried out on the DMG ULTRASONIC 70-5 linear, by which the reliability of finite element simulation was verified. The surface morphology of the workpiece was analyzed by scanning electron microscopy(SEM), which showed that the width of groove increased obviously with the increase of scratch depth and the grit interval distance. Results of the width of groove were consistent with the simulation results. The subsurface damage layer was analyzed by the method of HF acid etching, which showed that there was an area of cracks intersecting. The scratching force was measured by the threedimensional dynamometer of KISTLER, which showed that the second scratching force increased with the increase of scratching depth and the grit interval distance. The force in the second scratch was smaller than that in the first time, which was consistent with the Griffith fracture theory. | 张飞虎 李琛 ZHAO Hang LENG Bing REN Lele | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，1： | 0 |
| 16 | Engineering hierarchical metal-organic@metal-DNA heterostructures for combinational tumor treatment显示文摘Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks(MOFs)is important for various biomedical applications,yet remains a challenge.Herein,a simple and general approach to load DNA on the surface of MOFs is developed via one-pot self-assembly of DNA and FeII ions on nanoscale MOFs,resulting in hierarchical core-shell nanostructures of metal-organic@metal-DNA coordination polymers.The strategy enables assembly of DNA molecules on MOFs with ultra-high contents and precise controllability.By incorporation of a chemotherapeutic drug into the Fe-DNA shell,the systems allow to integrate chemotherapy and gene therapy with photodynamic therapy for combinational tumor treatment.Moreover,the hybrid nanostructures enable light-triggered production of cytotoxic singlet oxygen,which further boosts the endosomal escape of the system for an enhanced gene silencing efficacy and thus improved therapeutic outcome.This work highlights a robust approach for the construction of coordination-based drug delivery systems to combat tumor. | Xueyan Feng Bei Liu Zehao Zhou Wei Li Jian Zhao Lele Li Yuliang Zhao | 2023 | Nano Research2023，16，11： | 0 |
| 17 | FY-4 Satellite Enters Thermal Control Modification Stage显示文摘The solar array deployment test for FY-4 has been completed at the satellite assembly center of the Shanghai Institute of Satellite Equipment,SAST,marking the FY-4 satellite enters the thermal con- | FANG Yizhu ZHAO Lele | 2015 | Aerospace China2015，16，2： | 0 |
| 18 | New insights into the dispersion history and adaptive evolution of taxon Aegilops tauschii in China显示文摘Aegilops tauschii,the wild progenitor of wheat D-genome and a valuable germplasm for wheat improvement,has a wide natural distribution from eastern Turkey to China.However,the phylogenetic relationship and dispersion history of Ae.tauschii in China has not been scientifically clarified.In this study,we genotyped 208 accessions(with 104 in China)using dd RAD sequencing and 55K SNP array,and classified the population into six sublineages.Three possible spreading routes or events were identified,resulting in specific distribution patterns,with four sublineages found in Xinjiang,one in Qinghai,two in Shaanxi and one in Henan.We also established the correlation of SNP-based,karyotypebased and spike-morphology-based techniques to demonstrate the internal classification of Ae.tauschii,and developed consensus dataset with 1245 putative accessions by merging data previously published.Our analysis suggested that eight inter-lineage accessions could be assigned to the putative Lineage 3and these accessions would help to conserve the genetic diversity of the species.By developing the consensus phylogenetic relationships of Ae.tauschii,our work validated the hypothesis on the dispersal history of Ae.tauschii in China,and contributed to the efficient and comprehensive germplasm-mining of the species. | Hao Li Fang Nie Lele Zhu Menghua Mu Ruixiao Fan Jingyao Li Aaqib Shaheen Yifan Liu Can Li Wenjuan Liu Huihui Liang Xinpeng Zhao Shenglong Bai Guanghui Guo Zheng Li Yiheng Hu Yuannian Jiao Jonathan Adams Assaf Distelfeld Guiling Sun Suoping Li Yun Zhou Chun-Peng Song | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 19 | Dataset of Comparative Observations for Land Surface Processes over the Semi-Arid Alpine Grassland against Alpine Lakes in the Source Region of the Yellow River显示文摘Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot. However, the characteristics of the lake-atmosphere interaction over the high-altitude lakes are still unclear, which inhibits model development and the accurate simulation of lake climate effects. The source region of the Yellow River(SRYR) has the largest outflow lake and freshwater lake on the TP and is one of the most densely distributed lakes on the TP. Since 2011,three observation sites have been set up in the Ngoring Lake basin in the SRYR to monitor the lake-atmosphere interaction and the differences among water-heat exchanges over the land and lake surfaces. This study presents an eight-year(2012–19), half-hourly, observation-based dataset related to lake–atmosphere interactions composed of three sites. The three sites represent the lake surface, the lakeside, and the land. The observations contain the basic meteorological elements,surface radiation, eddy covariance system, soil temperature, and moisture(for land). Information related to the sites and instruments, the continuity and completeness of data, and the differences among the observational results at different sites are described in this study. These data have been used in the previous study to reveal a few energy and water exchange characteristics of TP lakes and to validate and improve the lake and land surface model. The dataset is available at National Cryosphere Desert Data Center and Science Data Bank. | Xianhong MENG Shihua LYU Zhaoguo LI Yinhuan AO Lijuan WEN Lunyu SHANG Shaoying WANG Mingshan DENG Shaobo ZHANG Lin ZHAO Hao CHEN Di MA Suosuo LI Lele SHU Yingying AN Hanlin NIU | 2023 | Advances in Atmospheric Sciences2023，40，6： | 0 |
| 20 | Metal oxide ion gated transistors based sensors显示文摘Metal oxide ion-gated transistors(MOIGTs)have garnered significant attention within the sensing domain due to their potential for achieving heightened sensitivity while consuming minimal energy across diverse scenarios.By harnessing the advantageous combination of metal oxides'high carrier mobility and facile surface customization,coupled with the potent signal amplification capabilities of ion-gated transistors,MOIGTs offer a promising avenue for discerning biomolecules,overseeing chemical reactions,p H levels,as well as facilitating gas or light determination.Over the past few decades,the MOIGT field has made remarkable strides in refining device physics,enhancing material properties,showcasing robust sensing capabilities,and broadening its application spectrum.These advancements have simultaneously unveiled new challenges and opportunities,necessitating interdisciplinary expertise to fully unlock the commercial potential of MOIGTs.In this comprehensive review,we offer a snapshot of this swiftly evolving technology,delve into its current applications,and provide insightful recommendations for future directions in the coming decade. | LI Yang YAO Yu WANG LeLe WANG LiWei PANG YunCong LUO ZhongZhong ARUNPRABAHARAN Subramanian LIU ShuJuan ZHAO Qiang | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
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