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| 1 | Increasing the use of biocompatible,glucose-free peritoneal dialysis solutions显示文摘A major concern inhibiting some clinicians from embracing peritoneal dialysis(PD) as the preferred first modality of dialysis is the effects of PD solutions on the peritoneal membrane. These anatomical and functional changes predispose to complications like peritonitis,encapsulating peritoneal sclerosis and ultrafiltration failure. In recent years, 'biocompatible' and glucosesparing PD regimens have been developed to minimize damage to the peritoneal membrane. Can the use of these more expensive solutions be justified on current evidence? In this review of the literature, we explore how we may individualize the prescription of biocompatible PD fluid. | Ahad Qayyum Elizabeth Ley Oei Klara Paudel Stanley L Fan | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | Real-time and generic queue time estimation based on mobile crowdsensing显示文摘 | Jiangtao WANG Yasha WANG Daqing ZHANG Leye WANG Chao CHEN Jae Woong LEE Yuanduo HE | 2017 | Frontiers of Computer Science2017，11，1： | 4 |
| 3 | 美国青少年药物滥用和精神障碍共患的流行病学研究进展显示文摘 | 陈科文 Ley A.Killeya-Jones | 2004 | 中国药物依赖性杂志2004，13，4： | 4 |
| 4 | Abscisic acid perception and signaling: structura mechanisms and applications显示文摘不利环境条件是对农业产量的威胁因此在生计,健康和经济上施加全球效果。Abscisic 酸(骆驼毛的织物) 是调整不能生活的压力忍耐的重要植物荷尔蒙,从而允许种应付环境压力。以前,试图开发发信号的内在的骆驼毛的织物被困难在真正的骆驼毛的织物受体的鉴定妨碍了的机制的完全的理解。骆驼毛的织物受体的 PYR/PYL/RCAR 家庭的发现因此在克服这些障碍的努力代表了一个主要里程碑;从那以后,许多结构、功能的研究提供了详细卓见进从骆驼毛的织物感觉到骆驼毛的织物应答的基因抄写的激活的过程。这理解骆驼毛的织物感觉的机制并且发信号在压力抵抗的庄稼的遗传工程以及在新合成骆驼毛的织物收缩筋的设计用作最近的、初步的开发的基础,它为应力公差的农业改进保持大诺言。 | Ley Moy NG Karsten MELCHER Bin Tean TEH H Eric XU | 2014 | Acta Pharmacologica Sinica2014，35，5： | 4 |
| 5 | Anacardic acid(6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling显示文摘Anacardic acid(AA)is a mixture of 2-hydroxy-6-alkylbenzoic acid homologs.It is widely regarded as a non-specific histone acetyltransferase inhibitor of p300.The effects and the mechanisms of AA in LNCaP cells(prostate cancer cells) remain unknown.To investigate the effect of AA on LNCaP cells,we had carried out several experiments and found that AA inhibits LNCaP cell proliferation,induces G1/S cell cycle arrest and apoptosis of LNCaP cell.The mechanisms via which AA acts on LNCaP cells may be due to the following aspects.First,AA can regulate p300 transcription and protein level except for its mechanisms regulating function of p300 through post-translational modification in LNCaP cells.Second,AA can activate p53 through increasing the phosphorylation of p53 on Ser15 in LNCaP cells.AA can selectively activate p21(target genes of p53).Third,AA can down-regulates androgen receptor(AR)through supressing p300.Our study suggests that AA has multiple anti-tumor activities in LNCaP cells and warrants further investigation. | Jing Tan Binghai Chen Leye He Yuxin Tang Zhiqiang Jiang Guangmin Yin Jinrong Wang Xianzhen Jiang | 2012 | Chinese Journal of Cancer Research2012，24，4： | 3 |
| 6 | 大学非英语专业英语口语测试的研究和实践显示文摘以语言测试理论为依据,运用定量分析法,对东莞理工学院2006和2007级非英语专业学生进行了大规模英语口语测试及问卷调查,证明了英语口语测试的必要性和可行性,并探讨了中外教师携手合作进行英语口语测试的新模式及其产生的反拨作用,试图为大规模英语口语测试的改革提供一种新思路。 | 王永 刘瑾 Alan Lotz Susan Ley | 2010 | 东莞理工学院学报2010，17，6： | 3 |
| 7 | 根据基础降压用药分析恩格列净在2型糖尿病合并高血压患者中的降压作用显示文摘在EMPA—REG血压试验中,与安慰剂比较,恩格列净(empagliflozin)10或25mg/d可降低2型糖尿病合并高血压患者的糖化血红蛋白、血压及体质量水平。 | Mancia G Cannon CP Tikkanen I Zeller C Ley L Woerle HJ Broedl UC Johansen OE 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 8 | The Origin and Evolution of Mutations in Acute Myeloid Leukemia显示文摘 | John S. Welch Timothy J. Ley Daniel C. Link Christopher A. Miller David E. Larson Daniel C. Koboldt Lukas D. Wartman Tamara L. Lamprecht Fulu Liu Jun Xia Cyriac Kandoth Robert S. Fulton Michael D. McLellan David J. Dooling John W. Wallis Ken Chen Christop | 2012 | Cell2012，，2： | 3 |
| 9 | Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy显示文摘 | Omry Koren Julia K. Goodrich Tyler C. Cullender Aymé Spor Kirsi Laitinen Helene Kling B?ckhed Antonio Gonzalez Jeffrey J. Werner Largus T. Angenent Rob Knight Fredrik B?ckhed Erika Isolauri Seppo Salminen Ruth E. Ley | 2012 | Cell2012，，3： | 2 |
| 10 | Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine显示文摘 | Ruth E. Ley Daniel A. Peterson Jeffrey I. Gordon | 2006 | Cell2006，，4： | 2 |
| 11 | Alternative Explanations for Inner-City Gentrification: A Canadian Assessment显示文摘 | David Ley | 1986 | Annals of the Association of American Geographers1986，，4： | 2 |
| 12 | Immune and Inflammatory Mechanisms of Atherosclerosis *显示文摘 | Elena Galkina Klaus Ley | 2009 | Annual Review of Immunology2009，，： | 2 |
| 13 | Clinical Significance of IL-2, IL-10, and TNF-α in Prostatic Secretion of Patients With Chronic Prostatitis显示文摘 | Leye He Yong Wang Zhi Long Chonghe Jiang | 2010 | Urology2010，，3： | 2 |
| 14 | 菠萝蛋白酶治疗心血管疾病的系统综述(英文)显示文摘背景:在2004年,全球估计有1710万人死于心血管疾病。根据美国心脏病协会的数据,心脏病与中风是2型糖尿病患者的首要致死及致残因素。寻找更多的安全有效的心血管疾病治疗方案对于该疾病的预防和治疗十分必要,营养补充品是可行方案之一。目的:探讨菠萝蛋白酶(一种食品补充品)对心血管疾病的预防和治疗作用。检索策略:2009年9月至2010年3月进行电子与手工检索。检索的数据库包括Ovid MEDLINE;All EBMReviews-Cochrane Database of Systematic Reviews(Cochrane DSR)、American College of Physicians(ACP)Journal Club、Database of Abstracts of Reviews of Effects(DARE)、Cochrane Central Register ofControlled Trials(CCTR)、Cochrane Methodology Register(CMR)、Health Technology Assessment(HTA)和National Health Service Economic Evaluation Database(NHSEED);Allied and ComplementaryMedicine(AMED)、British Nursing Index and Archive、EMBASE、Health Management InformationConsortium(HMIC)、ScienceDirect和Electronic Thesis Online Services(ETHOS)。检索语言限定为英文。纳入标准:有关菠萝蛋白酶用于预防或治疗心脑血管疾病的随机对照试验、人体研究、动物研究与实验性研究。资料提取与分析:3位作者分别对检索到的文章进行文献质量评估并提取文献资料。所收集的资料包括实验种类、用药剂量、治疗周期、测量指标、研究结果、菠萝蛋白酶的特征、结果的意义与研究结论。结果:在搜索到的223篇文章中,只有6篇文章符合纳入标准。包括3项动物实验和3项人体试验。菠萝蛋白酶可用来治疗急性血栓性静脉炎,因为它可减少血液中的纤维蛋白原含量,降低血小板聚集度,有保护心脏的作用,并能够改善动脉壁的结构,避免由凝血酶所诱发的血小板聚集,减少血栓的形成。结论:迄今为止,没有菠萝蛋白酶用于心血管疾病治疗的高质量的人体研究。在1948年至2010年间所发表的有关菠萝蛋白酶与心血管疾病的研究的数量极为有限。在未来的心血管疾病研究中这可能是一个值得探索的领域。 | Chit Moy Ley Amalia Tsiami 倪青 Nicola Robinson | 2011 | 中西医结合学报2011，9，7： | 2 |
| 15 | Modern synthetic methods for copper-mediated C(aql)-O,C(aryl)-N,and C(aryl)-S bond formation显示文摘 | LEY S V THOMAS A W | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 16 | Host-bacterial mutualism in the human intestine 显示文摘 | FREDRIK BACKHED LEY R E SONNENBURG J L | 2005 | Science2005，307，5717： | 1 |
| 17 | Differential expression of granzymes A and B in human eytotoxie lymphocyte subsets and T regulatory cells 显示文摘 | Grossman WJ Verbsky JW Tollefsen BL Kemper C Atkinson JP Ley TJ | 2004 | Blood2004，104，9： | 1 |
| 18 | Monocyte-endothelial cell interactions in the development of atherosclerosis显示文摘 | Mestas J Ley K | 2008 | Trends Cardiovasc Med2008，18，6： | 1 |
| 19 | An obesity-associated gut microbiome with increased capacity for energy harvest 显示文摘 | Turnbaugh PJ Ley RE Mahowald MA | 2006 | Nature2006，444，： | 1 |
| 20 | Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells 显示文摘 | Wesselschmidt RL Shresta S Russell JH Ley TJ | 1994 | Cell1994，76，： | 1 |
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