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| 1 | Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats显示文摘Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central nervous system disease, but its effect in subarachnoid hemorrhage(SAH) remains unclear. In this study, we showed that intraperitoneal administration of gastrodin(100 mg/kg per day) significantly attenuated the SAH-induced neurological deficit, brain edema, and increased blood-brain barrier permeability in rats. Meanwhile, gastrodin treatment significantly reduced the SAHinduced elevation of glutamate concentration in the cerebrospinal fluid and the intracellular Ca2+ overload.Moreover, gastrodin suppressed the SAH-induced microglial activation, astrocyte activation, and neuronal apoptosis. Mechanistically, gastrodin significantly reduced the oxidative stress and inflammatory response, up-regulated the expression of nuclear factor erythroid 2–related factor2, heme oxygenase-1, phospho-Akt and B-cell lymphoma2, and down-regulated the expression of BCL2-associated X protein and cleaved caspase-3. Our results suggested that the administration of gastrodin provides neuroprotection against early brain injury after experimental SAH. | Xinzhi Wang Shuyue Li Jinbang Ma Chuangang Wang Anzhong Chen Zhenxue Xin Jianjun Zhang | 2019 | Neuroscience Bulletin2019，35，3： | 15 |
| 2 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 3 | Hybrid rice yield response to potted-seedling machine transplanting and slow-release nitrogen fertilizer application combined with urea topdressing显示文摘Machine transplanting and the application of slow-release nitrogen(N) fertilizer(SRNF) have played vital roles in the modernization of rice production. We aimed to determine the effects of potted-seedling transplanting—a new machine-transplanting method—and SRNF on hybrid rice yields. A 2-year splitplot experiment(2016–2017) was conducted in Meishan, Sichuan province, China, using two machinetransplanting methods(potted-seedling and blanket-seedling) and three N treatments. Total green leaf area, high-effective leaf area and its rate at heading, net photosynthetic rate of flag leaves 7 days after heading, glutamate synthase(GOGAT) and glutamine synthase(GS) activity after heading, dry matter production, and N accumulation at heading and maturity increased under the potted-seedling method or 70% SRNF as a base + 30% urea application at the panicle initiation stage(SBUP). Stem diameter and number of small and of all vascular bundles at the neck–panicle node in potted-seedling plants increased as a result of increasing numbers of effective panicles, secondary branches, and spikelets. In pottedseedling plants, treatment with SBUP increased the number of large and total vascular bundles at the panicle–neck internode and the number of differentiated and surviving secondary branches and spikelets and decreased the number of ineffective tillers and degenerated secondary branches and spikelets. We conclude that the potted-seedling machine transplanting method and SRNF combined with urea topdressing can strengthen the source–sink relationship in rice, resulting in higher yields. | Tengfei Lyu Jie Shen Jun Ma Peng Ma Zhiyuan Yang Zou Dai Chuangang Zheng Min Li | 2021 | The Crop Journal2021，9，4： | 3 |
| 4 | Puerarin accelerates neural regeneration after sciatic nerve injury显示文摘Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin(8-(β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) were injected intraperitoneally into mouse models of sciatic nerve injury. Puerarin at the middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling, and reduced the atrophy of the triceps surae on the affected side and promoted the regeneration of nerve fibers of the damaged spinal cord at 8 weeks after injury. We conclude that puerarin exerts an ongoing role to activate growth-associated protein 43 in the corresponding segment of the spinal cord after sciatic nerve injury, thus contributing to neural regeneration after sciatic nerve injuries. | Minfei Wu Guanjie Zhao Xiaoyu Yang Chuangang Peng Jianwu Zhao Jun Liu Rui Li Zhongli Gao | 2014 | Neural Regeneration Research2014，9，6： | 3 |
| 5 | Structure,morphology,and microwave dielectric properties of SmAlO_(3) synthesized by stearic acid route显示文摘A rapid and facile approach was developed for the synthesis of ultrafine SmAlO_(3) powders through the combustion of stearic acid precursors.The obtained products were characterized by typical techniques including X-ray diffraction(XRD),Fourier Transform Infrared(FT-IR),thermogravimetric and differential thermal analysis(TG-DTA),scanning electron microscopy(SEM),and transmission electron microscopy(TEM)to analyze the phase composition and microstructure.The dielectric characteristics of SmAlO_(3) microwave ceramics,using the as-obtained products as original materials,were also studied.Compared with the conventional solid-state reaction method,the synthesis temperature was dramatically reduced to 750℃.The large-size sheet structure was composed of a number of micro/nano-scale crystallites,which were mostly irregular in shape due to the mutual growth and overlapping shapes of adjacent grains.The SmAlO_(3) ceramics with high density and uniform microstructure were obtained after sintering at 1500℃ for 4 h due to the favorable sintering activity of the as-synthesized powders.In addition,desired dielectric properties at microwave frequencies(dielectric constant ε_(r)=20.22,quality factor Q·f=74110 GHz,and a temperature coefficient of resonant frequency τ_(f)=-74.6 ppm/℃)were achieved. | Jiamao LI Chuimin ZHANG Hui LIU Tai QIU Chuangang FAN | 2020 | Journal of Advanced Ceramics2020，9，5： | 3 |
| 6 | p53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers显示文摘The DNA damage response helps to maintain genome integrity,suppress tumorigenesis,and mediate the effects of radiotherapy and chemotherapy.Our previous studies have shown that Smad1 is upregulated and activated by Atm in DNA damage response,which can further bind to p53 and promote p53 stabilization.Herewe report another aspect of the interplay between p53 and Smad1.Comparison of rectal tumor against paired paraneoplastic specimens and analysis of>500 colorectal tumors revealed that Smad1 was upregulated in tumor samples,which was attributable to p53 defects.Using MEFs as a model,we found that knockdown of the elevated Smad1 in p532/2 MEFs promoted cell proliferation,E1A/Ras-induced cell transformation,and tumorigenesis.Mechanistic studies suggest that elevated Smad1 and momentary activation inhibit cell proliferation by upregulating p57Kip2 and enhancing Atm–Chk2 activation.Surprisingly,elevated Smad1 appears to have a negative effect on chemotherapy,as colorectal tumors,primary cancer cells,and cell lines with Smad1 knockdown all showed an increase in chemosensitivity,which could be attributable to elevated p57Kip2.These findings underscore the significance of Smad1–p53 interaction in tumor suppression and reveal an unexpected role for Smad1 in chemoresistance of colorectal cancers. | Xinsen Ruan Qiao Zuo Hao Jia Jenny Chau Jinlin Lin Junping Ao Xuechun Xia Huijuan Liu Samy LHabib Chuangang Fu Baojie Li | 2015 | Journal of Molecular Cell Biology2015，7，2： | 2 |
| 7 | miR-128 and its target genes in tumorigenesis and metastasis显示文摘 | Molin Li Weiming Fu Lulu Wo Xiaohong Shu Fang Liu Chuangang Li | 2013 | Experimental Cell Research2013，，20： | 1 |
| 8 | Development of a novelchronic intermitten thypoxia chamber显示文摘 | Li Chuangang Lu Jiming Zhang Bingxi | 2012 | Sleep Breath2012，16，： | 1 |
| 9 | Luminescence of carbon nanotube bulbs显示文摘Carbon nanotube (CNT) bulbs made of decimeter-scale double-walled carbon nanotube (DWCNT) strands and films were fabricated and their luminescence properties, including the lighting efficiency, voltage-current relation and thermal stability were investigated. The results show that the DWCNT bulb has a comparable spectrum of visible light with tungsten bulb and its average efficiency is 40% higher than that of a tungsten filament at the same temperature (1400―2300 K). The nanotube filaments show both resistance and thermal stability over a large temperature region. No obvious damage was found for a nanotube bulb illuminating at 2300 K for more than 24 hours in vacuum. | LI ChuanGang WANG KunLin WEI JinQuan WEI BingQing ZHU HongWei WANG ZhiCheng LUO JianBin LIU WenJin ZHENG MingXin WU DeHai | 2007 | Chinese Science Bulletin2007，52，1： | 0 |
| 10 | Fabrication of Baking-Free Bricks Using Gold Tailings and Cemented Materials with Low Alkalinity显示文摘The purpose of this paper was using gold mine tailings and cemented materials with low alkalinity to fabricate baking-free bricks.The obtained baking-free brick samples were evaluated by unconfined compressive strength(UCS),water absorption percentage,freezing-thawing cycle,and drying-wetting cycle.The microstructures of the baking-free brick samples were analyzed using X-ray diffraction(XRD)and scanning electron microscope(SEM)techniques.The baking-free brick specimens cured for 28 days with the addition of 10%mixing water consumption and 1:6 cement/tailing ratio tended to obtain favorable comprehensive properties such as a high compressive strength of 15.15 MPa,a low water absorption percentage of 11.8%,excellent freezing-thawing resistance with a 8.9%UCS loss rate after 15 freezing-thawing cycles and good drying-wetting resistance with a 11%UCS loss rate after 10 drying-wetting cycles.The XRD and SEM test results verified that different kinds of hydrate products including C-S-H and C-S-A-H gels,and ettringite were produced during hydration process,which were responsible for good physical,mechanical properties,and durability of the obtained baking-free bricks.Therefore,the experimental results showed that it was practical and reasonable to utilize the homemade cementitious materials in our laboratory to stabilize the gold tailings for production of baking-free bricks,which still met the requirements of major regional construction standards in some countries. | Jiamao Li Tao Si Lin Li Chuangang Fan Zhaofang He Yuandi Qian | 2022 | Journal of Renewable Materials2022，10，11： | 0 |
| 11 | Comparative study of LiNiO_2, LiNi_(0.8)Co_(0. 2)O_2 and LiNi_(0.75)Al_(0.25)O_2 for lithium-ion batteries显示文摘The comparative study of LiNi0.8Co0.2O2 and LiNi0.75Al0.25O2 was carried out by X-ray diffraction (XRD) and electrochemical methods. The results show that Co and Al doping suppress the phase transition during charge-discharge. The experiments indicate that LiNi0.75Al0.25O2 has the better cycle-ability and over-charge resistance comparing with LiNi0.8Co0.2O2. The interfacial behavior was studied by use of electrochemical impedance spectroscopy (EIS). The results show that LiNi0.75Al0.25O2 has a slightly larger polarization character than LiNi0.8Co0.2O2. | Chuangang Lin, Weihua Qiu, Zhimin Li, Jialing Hong, Huanyu Hu, and Zhongqin LuLaboratory on Solid State Ionics, University of Science and Technology Beijing, Beijing 100083, China | 2002 | Journal of University of Science and Technology Beijing2002，9，6： | 0 |
| 12 | Utilization of Low-Alkalinity Cementitious Materials in Cemented Paste Backfill of Gold Mine Tailings显示文摘The purpose of this paper was to explore the possility of using low alkalinity cementitious materials as binders,in which ground blast furnace slag and fly ash acted as a partial replacement of ordinary Portland cement,and CaSO_(4),Na_(2)SO_(4),and CaO were used as a sulfate activator and alkali activated additives,to solidify gold mine tail-ings for preparation of a green,inexpensive cemented paste backill(CPB).For this target,the effects of cement/tailings ratio,superplasticizer dosage,solid content,tailings fineness on the mechanical properties of the CPB were inves tigated.Additionally,the hydration mechanism of the CPB was analyzed based on X-ray diffraction and scanning electron microscopy results.The results showed that the fuidity of the CPB slurry could be improved by adding polycarboxylic acid superplasticizer.The unconfined compressive strength(UCS)of the CPB specimens was increased with the increase of cement/tailings ratio and solid content.Under the same experi-mental conditions,the 28 d UCS of the CPB specimens was 3.8-4.9 times higher than that of ordinary Portland cement.The softening coefficient of the CPB specimens was increased with the increasing cement/tailings ratio,ranging from 0.83 to 0.92.The shrinkage rate of the CPB specimens was decreased from 0.70%to 0.54%with the increase of cement/tailings ratio from 1:12 to 1:4 The UCS of the full tailings CPB was the highest,followed by the fine tailings CPB specimens,and the UCS of the coarse tailings CPB specimens was the lowest.The low alka-linity binder was proved to be a promising material to improve the engineering performances of the CPB.The optimal mixing ratio is 1:6 cement/tailings ratio,0.15 wt% superplastizer dosage,and 70 wt%solid content.Pre-pared by this mixing ratio,the UCS values of the CPB after 3,7,and 28 d curing ages reached 1.85,5.87,and 9.16 MPa,respectively,which were suitable as CPB for the Zhaoyuan gold mine in terms of strength requirements. | Jiamao Li Chuimin Zhang Lin Li Chuangang Fan Zhaofang He Yuandi Qian | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
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