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| 1 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 2 | Longitudinal parameter identification of a small unmanned aerial vehicle based on modified particle swarm optimization显示文摘This paper describes a longitudinal parameter identification procedure for a small unmanned aerial vehicle(UAV)through modified particle swam optimization(PSO).The procedure is demonstrated using a small UAV equipped with only an micro-electro-mechanical systems(MEMS)inertial measuring element and a global positioning system(GPS)receiver to provide test information.A small UAV longitudinal parameter mathematical model is derived and the modified method is proposed based on PSO with selective particle regeneration(SRPSO).Once modified PSO is applied to the mathematical model,the simulation results show that the mathematical model is correct,and aerodynamic parameters and coefficients of the propeller can be identified accurately.Results are compared with those of PSO and SRPSO and the comparison shows that the proposed method is more robust and faster than the other methods for the longitudinal parameter identification of the small UAV.Some parameter identification results are affected slightly by noise,but the identification results are very good overall.Eventually,experimental validation is employed to test the proposed method,which demonstrates the usefulness of this method. | Jiang Tieying Li Jie Huang Kewei | 2015 | Chinese Journal of Aeronautics2015，28，3： | 10 |
| 3 | Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms显示文摘Background Alzheimer’s disease is a neurodegenerative disorder.Therapeutically,a transplantation of bone marrow mesenchymal stem cells(BMMSCs)can play a beneficial role in animal models of Alzheimer’s disease.However,the relevant mechanism remains to be fully elucidated.Main body Subsequent to the transplantation of BMMSCs,memory loss and cognitive impairment were significantly improved in animal models with Alzheimer’s disease(AD).Potential mechanisms involved neurogenesis,apoptosis,angiogenesis,inflammation,immunomodulation,etc.The above mechanisms might play different roles at certain stages.It was revealed that the transplantation of BMMSCs could alter some gene levels.Moreover,the differential expression of representative genes was responsible for neuropathological phenotypes in Alzheimer’s disease,which could be used to construct gene-specific patterns.Conclusions Multiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD models.Gene expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic effect.The transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer’s disease. | Chuan Qin Yalan Lu Kewei Wang Lin Bai Guiying Shi Yiying Huang Yongning Li | 2020 | Translational Neurodegeneration2020，9，2： | 9 |
| 4 | Chemically robust carbon nanotube-PTFE superhydrophobic thin films with enhanced ability of wear resistance显示文摘A chemically robust superhydrophobic nanocomposite thin film with enhanced wear resistance is prepared from a composite comprising polytetrafluoroethylene(PTFE) and carbon nanotubes.The superhydrophobic thin films with hierarchical structure are fabricated by spraying an environmentally friendly aqueous dispersion containing carbon nanotubes and PTFE resin on silicon wafer.Thin films with a contact angle of 154.1°± 2° and a sliding angle less than 2° remain superhydrophobic after abrading over 500 times under a pressure of 50 g/cm^2.The thin film is also extremely stable even under much stress conditions.To further the understanding of the enhancement of wear resistance,we investigated the formation of microsized structure and their effects.The growth of microbumps is caused by attracting solution droplet to the hydrophilic islands on hydrophobic surface. | Kewei Wang Pan Xiong Xiuping Xu Kan Wang YanLong Li Yufeng Zheng | 2017 | Progress in Natural Science:Materials International2017，27，3： | 4 |
| 5 | Mechanism of protective film formation during CO_2 corrosion of X65 pipeline steel显示文摘Electrochemical techniques, X-ray diffraction (XRD), and scanning electron microscopy (SEM) were applied to study the corrosion behaviors of X65 steel in static solution with carbon dioxide (CO2) at 65°C. The results show that iron carbonate (FeCO3) deposits on the steel surface as a corrosion product scale. This iron carbonate scale acts as a barrier to CO2 corrosion, and can reduce the general corrosion rate. The protection ability of the scale is closely related to the scale morphological characteristics. | Tong Li Yonggjin Yang Kewei Gao Minxu Lu | 2008 | Journal of University of Science and Technology Beijing2008，15，6： | 2 |
| 6 | Advanced noble-metal-free bifunctional electrocatalysts for metal-air batteries显示文摘The sluggish reaction kinetics at the oxygen cathode is one of the important issues hindering the commercialization of the metal-air batteries.Although the noble metal can be used as the high-efficiency electrocatalyst to solve the problems to some extent,the high cost and scarcity of these noble-metal catalysts have limited their application in electrocatalysis.In this review,we discussed the mecha-nisms of the ORR and OER,and proposed the principles for the bifunctional electrocatalysts firstly,and then the state-of-the-art bifunctional catalysts,including carbon-based materials and transition-metal-based materials.On the basis of that,the self-supporting 3D noble-metal-free bifunctional ORR/OER catalysts were also discussed.Finally,the perspectives for the bifunctional electrocatalysts were discussed. | Wenhao Tang Boya Li Kewei Teng Xiaodong Wang Ruiping Liu Mengwei Wu Lei Zhang Pengfei Ren Junqing Zhang Ming Feng | 2022 | Journal of Materiomics2022，8，2： | 2 |
| 7 | Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration显示文摘Oncostatin M (OSM ) 是 interleukin-6 家庭的 cytokine 并且在发炎期间起重要作用。然而,它在 myoblast 区别的角色和肌肉新生仍然保持未经勘探。我们这里证明 OSM potently 主要由激活 JAK1/STAT1/STAT3 小径禁止了 myoblast 区别。OSM downregulated myocyte 提高有约束力的因素 2A (MEF2A ) , upregulated Id1 和 Id2 的表示,并且禁止了 MyoD 和 MEF2 的 transcriptional 活动。另外, OSM 也提高了 STAT3 和 OSM 受体的表示,它组成了一个积极反馈环进一步放大导致 OSM 的发信号。而且,我们发现身体上与 MEF2 联系并且镇压的那 STAT1 它的 transcriptional 活动,它能说明 MEF2 的调停 OSM 的压抑。尽管在在 vivo 的正常肌肉无法发现, OSM 很快在肌肉损害上然后即时被导致就在 myoblasts 的多数前的 downregulated 区分。没有影响 myoblast 增长,在肌肉的 OSM 的延长表示损害了新生进程,建议 OSM 工作阻止增殖的 myoblasts 在肌肉新生的早阶段期间的早熟的区别。 | Fang Xiao Haixia Wang Xinrong Fu Yanfeng Li Kewei Ma Luguo Sun Xiang Gao Zhenguo Wu | 2011 | Cell Research2011，21，2： | 2 |
| 8 | Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-1ysine and its anti-nociceptive effects on inflammatory pain in rodents显示文摘 | Bo-chuan TENG Yan SONG Fan ZHANG Tian-yang MA Jin-Iong QI Hai-lin ZHANG Gang LI KeWei WANG | 2016 | Acta Pharmacologica Sinica2016，37，8： | 2 |
| 9 | The relationship between fracture toughness of CO 2 corrosion scale and corrosion rate of X65 pipeline steel under supercritical CO 2 condition显示文摘 | Yucheng Zhang Xiaolu Pang Shaopeng Qu Xin Li Kewei Gao | 2011 | International Journal of Greenhouse Gas Control2011，，6： | 2 |
| 10 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 11 | Granular analyzing of weapon SoS demand description显示文摘The systematism of weapon combat is the typical characteristic of a modern battlefield.The process of combat is complex and the demand description of weapon system of systems(SoS)is difficult.Granular analyzing is an important method for solving the complex problem in the world.Granular thinking is introduced into the demand description of weapon SoS.Granular computing and granular combination based on a relation of compatibility is proposed.Based on the level of degree and degree of detail,the granular resolution of weapon SoS is defined and an example is illustrated at the end. | Zhao Qingsong Yang Kewei Chen Yingwu Li Mengjun | 2009 | Journal of Systems Engineering and Electronics2009，20，3： | 2 |
| 12 | The composite of nitrided steel H13 and TiN coatings by plasma duplex treatment and the effect of pre-nitriding显示文摘 | MA Shengli LI Yanhuai XU Kewei | 2001 | Surface and Coatings Technology2001，137，： | 1 |
| 13 | Weapon system portfolio selection based on structural robustness显示文摘The system portfolio selection is a fundamental frontier issue in the development planning and demonstration of weapon equipment.The scientific and reasonable development of the weapon system portfolio is of great significance for optimizing the design of equipment architecture,realizing effective resource allocation,and increasing the campaign effectiveness of integrated joint operations.From the perspective of system-ofsystems,this paper proposes a unified framework called structure-oriented weapon system portfolio selection(SWSPS)to solve the weapon system portfolio selection problem based on structural invulnerability.First,the types of equipment and the relationship between the equipment are sorted out based on the operation loop theory,and a heterogeneous combat network model of the weapon equipment system is established by abstracting the equipment and their relationships into different types of nodes and edges respectively.Then,based on the combat network model,the operation loop comprehensive evaluation index(OLCEI)is introduced to quantitatively describe the structural robustness of the combat network.Next,a weapon system combination selection model is established with the goal of maximizing the operation loop comprehensive evaluation index within the constraints of capability requirements and budget limitations.Finally,our proposed SWSPS is demonstrated through a case study of an armored infantry battalion.The results show that our proposed SWSPS can achieve excellent performance in solving the weapon system portfolio selection problem,which yields many meaningful insights and guidance to the future equipment development planning. | JIANG Jiuyao LI Jichao YANG Kewei | 2020 | Journal of Systems Engineering and Electronics2020，31，6： | 1 |
| 14 | A multidetector CT angiography study of variations in the circle of Willis in a Chinese population显示文摘 | Qi Li Jialun Li Fajin Lv Kewei Li Tianyou Luo Peng Xie | 2010 | Journal of Clinical Neuroscience2010，，3： | 1 |
| 15 | Obtaining Constitutive Relationship for Rate-Dependent Rock in SHPB Tests显示文摘 | Zilong Zhou Xibing Li Zhouyuan Ye Kewei Liu | 2010 | Rock Mechanics and Rock Engineering2010，，6： | 1 |
| 16 | Enrichment-induced exercise to quantify the effect of different housing conditions: A tool to standardize enriched environment protocols显示文摘 | Hongyu Xie Yi Wu Jie Jia Gang Liu Qi Zhang Kewei Yu Zhenzhen Guo Li Shen Ruiping Hu | 2013 | Behavioural Brain Research2013，，： | 1 |
| 17 | A possible assignment for the ground scalar meson nonet显示文摘 | Li Demin Wei Kewei Yu Hong | 2005 | Eur Phys J A2005，25，： | 1 |
| 18 | Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model显示文摘 | Kewei Yu Yi Wu Qi Zhang Hongyu Xie Gang Liu Zhenzhen Guo Fang Li Jie Jia Shenyi Kuang Ruiping Hu | 2014 | Journal of the Neurological Sciences2014，，： | 1 |
| 19 | Three-dimensional molecular dynamics simulation of hydrogen-enhanced dislocation emission and crack propagation显示文摘A three-dimensional molecular dynamics simulation using the embedded atom method (EAM) potentials shows that for both pure Ni and Ni+H, dislocations are firstly emitted during loading and the crack propagates after enough disloca tions are emitted. In the case of hydrogen embrittlement, local plastic deformat ion is a precondition for crack propagation. For the crack along the (1 11) slip pla ne, one atom fraction in percent of hydrogen can decrease the critical stress in tensity for dislocation emission KIe from 0.42 to 0.36 MPam 1/2, and that for crack propagation KIp from 0.80 to 0.76 MPam1/2. Therefore, hydrogen enhances dislocation emission and crack pro pagation. | LI Zhongji, CHU Wuyang, LI Jinxu, GAO Kewei and QIAO Lijie(Department of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 1 |
| 20 | A possible assign- ment for the ground scalar meson nonet 显示文摘 | Li Detain Wei Kewei Yu Hong | 2005 | Eur Phys J A2005，25，： | 1 |
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