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| 1 | Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury显示文摘Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of c-aminobutyric acid A receptors(GABA_ARs), which play a vital role in pain modulation in the lateral thalamus, a main gate where somatosensory information enters the cerebral cortex. Using high-performance liquid chromatography/tandem mass spectrometry,we found increased levels of neurosteroids(pregnenolone,progesterone, deoxycorticosterone, allopregnanolone, and tetrahydrodeoxycorticosterone) in the chronic stage of neuropathic pain(28 days after spared nerve injury) in rats.The expression of the translocator protein TSPO, the upstream steroidogenesis rate-limiting enzyme, increased at the same time. In vivo stereotaxic microinjection of neurosteroids or the TSPO activator AC-5216 into the lateral thalamus(AP-3.0 mm, ML ±3.0 mm, DV 6.0 mm)alleviated the mechanical allodynia in neuropathic pain,while the TSPO inhibitor PK 11195 exacerbated it. The analgesic effects of AC-5216 and neurosteroids were significantly attenuated by the GABA_AR antagonist bicuculline. These results suggested that elevated neurosteroids in the lateral thalamus play a protective role in the chronic stage of neuropathic pain. | Meng Zhang Jia Liu Meng-Meng Zhou Honghai Wu Yanning Hou Yun-Feng Li Yuxin Yin Lemin Zheng Feng-Yu Liu Ming Yi You Wan | 2016 | Neuroscience Bulletin2016，32，4： | 6 |
| 2 | A NEW DIGITAL MODULATION RECOGNITION METHOD USING FEATURES EXTRACTED FROM GAR MODEL PARAMETERS显示文摘Based on the features extracted from generalized autoregressive (GAR) model parameters of the received waveform, and the use of multilayer perceptron(MLP) neural network classifier, a new digital modulation recognition method is proposed in this paper. Because of the better noise suppression ability of the GAR model and the powerful pattern classification capacity of the MLP neural network classifier, the new method can significantly improve the recognition performance in lower SNR with better robustness. To assess the performance of the new method, computer simulations are also performed. | Lu Mingquan Xiao Xianci Li Lemin (University of Electronic Science and Technology of China, Chengdu 610054) | 1999 | Journal of Electronics(China)1999，16，3： | 3 |
| 3 | Angiogenesis in hepatocellular carcinoma:mechanisms and anti-angiogenic therapies显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-associated death worldwide.Angiogenesis,the process of formation of new blood vessels,is required for cancer cells to obtain nutrients and oxygen.HCC is a typical hypervascular solid tumor with an aberrant vascular network and angiogenesis that contribute to its growth,progression,invasion,and metastasis.Current anti-angiogenic therapies target mainly tyrosine kinases,vascular endothelial growth factor receptor(VEGFR),and plateletderived growth factor receptor(PDGFR),and are considered effective strategies for HCC,particularly advanced HCC.However,because the survival benefits conferred by these anti-angiogenic therapies are modest,new anti-angiogenic targets must be identified.Several recent studies have determined the underlying molecular mechanisms,including pro-angiogenic factors secreted by HCC cells,the tumor microenvironment,and cancer stem cells.In this review,we summarize the roles of pro-angiogenic factors;the involvement of endothelial cells,hepatic stellate cells,tumor-associated macrophages,and tumor-associated neutrophils present in the tumor microenvironment;and the regulatory influence of cancer stem cells on angiogenesis in HCC.Furthermore,we discuss some of the clinically approved anti-angiogenic therapies and potential novel therapeutic targets for angiogenesis in HCC.A better understanding of the mechanisms underlying angiogenesis may lead to the development of more optimized anti-angiogenic treatment modalities for HCC. | Changyu Yao Shilun Wu Jian Kong Yiwen Sun Yannan Bai Ruhang Zhu Zhuxin Li Wenbing Sun Lemin Zheng | 2023 | Cancer Biology & Medicine2023，20，1： | 3 |
| 4 | Biotinylated dextran amine anterograde tracing of the canine corticospinal tract显示文摘In this study, biotinylated dextran amine (BDA) was microinjected into the left cortical motor area of the canine brain. Fluorescence microscopy results showed that a large amount of BDA-labeled pyramidal cells were visible in the left cortical motor area after injection. In the left medulla oblongata, the BDA-labeled corticospinal tract was evenly distributed, with green fluorescence that had a clear boundary with the surrounding tissue. The BDA-positive corticospinal tract entered into the right lateral funiculus of the spinal cord and descended into the posterior part of the right lateral funiculus, close to the posterior horn, from cervical to sacral segments. There was a small amount of green fluorescence in the sacral segment. The distribution of BDA labeling in the canine central nervous system was consistent with the course of the corticospinal tract. Fluorescence labeling for BDA gradually diminished with time after injection. Our findings indicate that the BDA anterograde tracing technique can be used to visualize the localization and trajectory of the corticospinal tract in the canine central nervous system. | Xiao Han Guangming Lv Huiqun Wu Dafeng Ji Zhou Sun Yaofu Li Lemin Tang | 2012 | Neural Regeneration Research2012，7，11： | 2 |
| 5 | Traffic-Aware VDC Embedding in Data Center: A Case Study of FatTree显示文摘Virtualization is a common technology for resource sharing in data center.To make efficient use of data center resources,the key challenge is to map customer demands(modeled as virtual data center,VDC) to the physical data center effectively.In this paper,we focus on this problem.Distinct with previous works,our study of VDC embedding problem is under the assumption that switch resource is the bottleneck of data center networks(DCNs).To this end,we not only propose relative cost to evaluate embedding strategy,decouple embedding problem into VM placement with marginal resource assignment and virtual link mapping with decided source-destination based on the property of fat-tree,but also design the traffic aware embedding algorithm(TAE) and first fit virtual link mapping(FFLM) to map virtual data center requests to a physical data center.Simulation results show that TAE+FFLM could increase acceptance rate and reduce network cost(about 49%in the case) at the same time.The traffic aware embedding algorithm reduces the load of core-link traffic and brings the optimization opportunity for data center network energy conservation. | LUO Shouxi YU Hongfang LI Lemin LIAO Dan SUN Gang | 2014 | China Communications2014，11，7： | 2 |
| 6 | Pervasive QpS routing in next gener- ation networks 显示文摘 | Wang Yu Li Lemin Xu Du | 2008 | Computer Communications2008，，： | 1 |
| 7 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 8 | A Distributed Flow Rate Control Algorithm for Networked Agent System with Multiple Coding Rates to Optimize Multimedia Data Transmission 显示文摘 | ZENG Shuai LI Lemin LIAO Dan | 2013 | Mathematical Problems in Engineering2013，，2013： | 1 |
| 9 | Supporting IP on the ATM networks: An overview显示文摘 | Ke Huang Lemin Li | 1998 | Computer Communications1998，21，2： | 1 |
| 10 | The Beijing four-component density functional program package (BDF) and its application to EuO, EuS, YbO and YbS显示文摘 | Wenjian Liu Gongyi Hong Dadi Dai Lemin Li Michael Dolg | 1997 | Theoretical Chemistry Accounts1997，，2： | 1 |
| 11 | The Beijing four-component density functional program package (BDF) and its application to EuO, EuS, YbO and YbS显示文摘 | Wenjian Liu Gongyi Hong Dadi Dai Lemin Li Michael Dolg | 1997 | Theoretical Chemistry Accounts1997，，2： | 1 |
| 12 | Dynamic Grooming Algorithms for Survivable WDM Mesh Networks显示文摘 | Wen Haibo Li Lemin He Rongxi | 2003 | Photonic Network Communications2003，6，3： | 1 |
| 13 | Dynamic Rou- ting and Assignment of Wavelength Algorithms in Muhifiber Wavelength Division Multiplexing Network 显示文摘 | Xu Shizhong Li Lemin Wang Sheng | 2000 | IEEE Journal on selected areas in communica- tions2000，18，10： | 1 |
| 14 | Shared sub-path protection algorithm in traffic-grooming WDM mesh networks显示文摘 | He Rongxi Wen Haibo Li Lemin | 2004 | Photonic Network Communications2004，8，3： | 1 |
| 15 | Signal extraction and power spectrumestimation using wavelet transform scalespace filtering and bayes shrinkage显示文摘 | Zheng Yuanjin Tay David B H Li Lemin | 2000 | Signal Processing2000，80，： | 1 |
| 16 | A new shared-path protection algorithm under shared risk link group constraints for survivable WDM mesh networks显示文摘 | Lei Guo Hongfang Yu Lemin Li | 2004 | Optics Communications2004，，4： | 1 |
| 17 | 显示文摘 | Yang Xueling Zhu Li Yang Lemin | 2011 | Trans Nonfer- rous Met Soc China2011，21，： | 1 |
| 18 | Dynamic routing and assignment of wavelength algorithms in multifiber wavelength division multiplexing networks 显示文摘 | Xu S Li Lemin Wang S | 2000 | IEEE JSAC2000，18，10： | 1 |
| 19 | Signal extraction and power spectrum estimation using wavelet transform scale space filtering and Bays shrinkage显示文摘 | ZHENG Yuanjin DAVID B H LI Lemin | 2000 | Signal Processing2000，80，： | 1 |
| 20 | Signal extraction and power spectrum estimation using wavelet transform scale space filtering and Bays shrinkage显示文摘 | ZHENG Yuanjin DAVID B H LI Lemin | 2000 | Signal Processing2000，80，： | 1 |
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