|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reannotation of the cultivated strawberry genome and establishment of a strawberry genome database显示文摘Cultivated strawberry(Fragaria×ananassa)is an important fruit crop species whose fruits are enjoyed by many worldwide.An octoploid of hybrid origin,the complex genome of this species was recently sequenced,serving as a key reference genome for cultivated strawberry and related species of the Rosaceae family.The current annotation of the F.ananassa genome mainly relies on ab initio predictions and,to a lesser extent,transcriptome data.Here,we present the structure and functional reannotation of the F.ananassa genome based on one PacBio full-length RNA library and ninety-two Illumina RNA-Seq libraries.This improved annotation of the F.ananassa genome,v1.0.a2,comprises a total of 108,447 gene models,with 97.85%complete BUSCOs.The models of 19,174 genes were modified,360 new genes were identified,and 11,044 genes were found to have alternatively spliced isoforms.Additionally,we constructed a strawberry genome database(SGD)for strawberry gene homolog searching and annotation downloading.Finally,the transcriptome of the receptacles and achenes of F.ananassa at four developmental stages were reanalyzed and qualified,and the expression profiles of all the genes in this annotation are also provided.Together,this study provides an updated annotation of the F.ananassa genome,which will facilitate genomic analyses across the Rosaceae family and gene functional studies in cultivated strawberry. | Tianjia Liu Muzi Li Zhongchi Liu Xiaoyan Ai Yongping Li | 2021 | Horticulture Research2021，8，1： | 2 |
| 2 | Isolation of yellow catfish β-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein显示文摘 | Jiachun Ge Zhangji Dong Jingyun Li Zhiqiang Xu Wei Song Jie Bao Dong Liang Junbo Li Kui Li Wenshuang Jia Muzi Zhao Yongxiang Cai Jiaxin Yang Jianlin Pan Qingshun Zhao | 2012 | Transgenic Research2012，，5： | 1 |
| 3 | PARAMETRIC AND NON-PARAMETRIC COMBINATION MODEL TO ENHANCE OVERALL PERFORMANCE ON DEFAULT PREDICTION显示文摘The probability of default(PD) is the key element in the New Basel Capital Accord and the most essential factor to financial institutions' risk management.To obtain good PD estimation,practitioners and academics have put forward numerous default prediction models.However,how to use multiple models to enhance overall performance on default prediction remains untouched.In this paper,a parametric and non-parametric combination model is proposed.Firstly,binary logistic regression model(BLRM),support vector machine(SVM),and decision tree(DT) are used respectively to establish models with relatively stable and high performance.Secondly,in order to make further improvement to the overall performance,a combination model using the method of multiple discriminant analysis(MDA) is constructed.In this way,the coverage rate of the combination model is greatly improved,and the risk of miscarriage is effectively reduced.Lastly,the results of the combination model are analyzed by using the K-means clustering,and the clustering distribution is consistent with a normal distribution.The results show that the combination model based on parametric and non-parametric can effectively enhance the overall performance on default prediction. | LI Jun PAN Liang CHEN Muzi YANG Xiaoguang | 2014 | Journal of Systems Science & Complexity2014，27，5： | 1 |
| 4 | Investigation of the structure and catalytic performance of highly dispersed Nibased catalysts for the growth of carbon nanostructures显示文摘 | Li Muzi Fan Guoli Qin Hua | 2012 | Iad Eng Chem Res2012，51，11： | 1 |
| 5 | A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer显示文摘 | Yuxin Chen Muzi Zhao Saiqun Wang Jie Chen Yun Wang Qinhong Cao Wenbin Zhou Jin Liu Zhiyang Xu Guoqing Tong Jianmin Li | 2009 | Journal of Cancer Research and Clinical Oncology2009，，9： | 1 |
| 6 | The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP 1 activity via RhoA显示文摘Osteosarcoma is the most common malignant bone tumour,and the metastasis of osteosarcoma is an important cause of death.Evidence has shown that the mevalonate pathway is highly activated and is expected to be a new target for tumour therapy.In this study,we investigated the effect of mevalonate signalling on osteosarcoma metastasis and its molecular mechanism.First,we found that the key rate-limiting enzyme of mevalonate signalling,3-hydroxy-3-methylglutaryl-CoA reductase(HMGCR),was highly expressed in osteosarcoma cells,and inhibition of HMGCR with simvastatin significantly inhibited the motility of 143B cells.Next,we found that YAP1 activity was significantly upregulated in osteosarcoma cells and that YAP1 knockdown inhibited the motility of 143B cells.We also found that the mevalonate pathway regulated the motility of 143B cells by modulating YAP1 phosphorylation and cellular localization.Moreover,we found that the activity of YAP1 was regulated by the mevalonate pathway by modulating the cell membrane localization of RhoA.Finally,we demonstrated that inhibition of the mevalonate pathway notably reduced the lung metastasis of 143B cells,as reflected by the decreased incidence and number of metastatic nodules and the increased survival time of the nude mice.Taken together,our findings suggest that the mevalonate pathway can promote the metastasis of osteosarcoma by activating YAP1 via RhoA.Inhibition of the mevalonate pathway may be a promising therapeutic strategy for osteosarcoma metastasis. | Xing Du Yunsheng Ou Muzi Zhang Kai Li Wei Huang Dianming Jiang | 2022 | Genes & Diseases2022，9，3： | 1 |
| 7 | Zwitterionic polymers:Addressing the barriers for drug delivery显示文摘Nanocarriers play an important role in drug delivery for disease treatment.However,nanocarriers face a series of physiological barriers after administration such as blood clearance,nonspecific tissue/cell localization,poor cellular uptake,and endosome trapping.These physiological barriers seriously reduce the accumulation of drugs in target action site,which results in poor therapeutic efficiency.Although polyethylene glycol(PEG)can increase the blood circulation time of nanocarriers,its application is limited due to the“PEG dilemma”.Zwitterionic polymers have been emerging as an appealing alternative to PEG owing to their excellent performance in resisting nonspecific protein adsorption.Importantly,the diverse structures bring functional versatility to zwitterionic polymers beyond nonfouling.This review focuses on the structures and characters of zwitterionic polymers,and will discuss and summarize the application of zwitterionic polymers for drug delivery.We will highlight the strategies of zwitterionic polymers to address the physiological barriers during drug delivery.Finally,we will give some suggestions that can be utilized for the development of zwitterionic polymers for drug delivery.This review will also provide an outlook for this field.Our aim is to provide a comprehensive and systemic review on the application of zwitterionic polymers for drug delivery and promote the development of zwitterionic polymers. | Muzi Li Wen Zhang Jiaxin Li Yinghe Qi Chen Peng Nan Wang Huili Fan Yan Li | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 8 | Rosaceae fruit transcriptome database(ROFT)-a useful genomic resource for comparing fruits of apple,peach,strawberry,and raspberry显示文摘Rosaceae is a large plant family consisting of many economically important fruit crops including peach,apple,pear,strawberry,raspberry,plum,and others.Investigations into their growth and development will promote both basic understanding and progress toward increasing fruit yield and quality.With the ever-increasing high-throughput sequencing data of Rosaceae,comparative studies are hindered by inconsistency of sample collection with regard to tissue,stage,growth conditions,and by vastly different handling of the data.Therefore,databases that enable easy access and effective utilization of directly comparable transcript data are highly desirable.Here,we describe a database for comparative analysis,ROsaceae Fruit Transcriptome database(ROFT),based on RNA-seq data generated from the same laboratory using similarly dissected and staged fruit tissues of four important Rosaceae fruit crops:apple,peach,strawberry,and red raspberry.Hence,the database is unique in allowing easy and robust comparisons among fruit gene expression across the four species.ROFT enables researchers to query orthologous genes and their expression patterns during different fruit developmental stages in the four species,identify tissue-specific and tissue-/stage-specific genes,visualize and compare ortholog expression in different fruit types,explore consensus co-expression networks,and download different data types.The database provides users access to vast amounts of RNA-seq data across the four economically important fruits,enables investigations of fruit type specification and evolution,and facilitates the selection of genes with critical roles in fruit development for further studies. | Muzi Li Stephen M.Mount Zhongchi Liu | 2023 | Horticulture Research2023，10，12： | 0 |
| 9 | Properties of multi‑GNSS uncalibrated phase delays with considering satellite systems,receiver types,and network scales显示文摘The Wide-Lane(WL)and Narrow-Lane(NL)Uncalibrated Phase Delays(UPDs)are the prerequisites in the traditional Precise Point Positioning(PPP)Ambiguity Resolution(AR).As the generation mechanism of various biases becomes more complex,we systematically studied the impact factors of four satellite systems WL and NL UPDs from the perspective of parameter estimation.Approximately 100 stations in a global network are used to generate the UPDs.The results of different satellite systems show that the estimation method,update frequency,and solution mode need to be treated differently.Two regional networks with different receiver types,JAVAD,and Trimble,are also adopted.The results indicate that the receiver-dependent bias has an influence on UPD estimation.Also,the hardware delays can inhibit the satellite-side UPDs if these receiver-specific errors are not fully deployed or even misused.Furthermore,the temporal stability and residual distribution of NL UPDs are significantly enhanced by utilizing a regional network,with the improvements by over 68%and 40%,respectively.It demonstrates that different network scales exhibit the different implication of unmodeled errors,and the unmodeled errors cannot be ignored and must be handled in UPD estimation. | Ping Zeng Zhetao Zhang Yuanlan Wen Xiufeng He Lina He Muzi Li Wu Chen | 2023 | Satellite Navigation2023，4，3： | 0 |
| 10 | Investigation of the Severity of Modular Construction Adoption Barriers with Large-Scale Group Decision Making in an Organization from Internal and External Stakeholder Perspectives显示文摘Modular construction as an innovativemethod aids the construction industry in transforming to off-site construction production with high efficiency and environmental friendliness.Despite the obvious advantages,the uptake of modular construction is not booming as expected.However,previous studies have investigated and summarized the barriers to the adoption ofmodular construction.In this research,a Large-ScaleGroupDecisionMaking(LSGDM)-based analysis is first made of the severity of barriers to modular construction adoption from the perspective of construction stakeholders.In addition,the Technology-Organization-Environment(TOE)framework is utilized to identify the barriers based on three contexts(technology,organization,and environment).The Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)and LSGDM models are both implemented for the first time to analyze the severity of the barriers to modular adoption based on questionnaire results from internal and external stakeholders in an organization.Finally,in this research,in-depth insights into the severity of barriers are gained,providing a reference for construction organizations to manage modular adoption. | Muzi Li | 2023 | Computer Modeling in Engineering & Sciences2023，137，12： | 0 |
| 11 | ISSR Analysis of Chlorophytum Treated by Three Kinds of Chemical Mutagen显示文摘Chlorophytum leaves were treated with three kinds of chemical mutagen,EMS,DES and NaN 3 with different concentration to obtain the variation materials with excellent properties. The results showed that the genetic similarity coefficient of variation plants with EMS treatment was between 0.648 and 0.868,with NaN 3 treatment was between 0.598 and 0.859,and with DES treatment was between 0.668 and 0.904,of which the mutagenic effects with 0.8℅ EMS,250 mg L -1 NaN 3 and 0.3% DES on chloro- phytum were the best. ISSR molecular marker technique was used to analyze their genetic diversities. Total 392 polymorphic bands were obtained through 18 ISSR primers. Polymorphic ratio was 72.4%,which showed that DNA mutation took place in various degrees. | WU Lijun LI Muzi YANG Xue YANG Tao WANG Jingang | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，4： | 0 |
| 12 | Combined Echocardiography and Lung Ultrasound for Extubation Outcome Prediction in Children after Cardiac Surgery显示文摘Background:Children are at risk of extubation failure after congenital heart disease surgery.Such cases should be identified to avoid possible adverse consequences of failed extubation.This study aimed to identify ultrasound predictors of successful extubation in children who underwent cardiac surgery.Methods:Children aged 3 months to 6 years who underwent cardiac surgery(if they were intubated for>6 h and underwent a spontaneous breathing trial)were included in this study.Results:We included 83 children who underwent surgery for congenital heart disease.Transthoracic echocardiography and lung ultrasound were performed immediately before spontaneous breathing trials.Upon spontaneous breathing trial completion,respiratory parameters,including arterial blood gas analysis and frequency-to-tidal volume ratio,were similarly recorded.For outcome assessment,all children were followed up for 48 h after extubation.We successfully extubated 57 children(68.7%).These children were significantly older and weighed more but had shorter aortic cross-clamp and cardiopulmonary bypass times.Children who could not be weaned or extubated had prolonged total mechanical ventilation and pediatric intensive care unit stay.In the multivariate regression analysis,a lung ultrasound score≥12 and ejection fraction≥40%immediately before spontaneous breathing trials were the only independent predictors of successful extubation.When combined,the lung ultrasound score and an ejection fraction≥40%showed a better diagnostic performance than every other isolated variable(lung ultrasound,N-terminal-pro-B-type natriuretic peptide,and frequency-to-tidal volume ratio).Conclusions:The combination of lung ultrasound and transthoracic echocardiography immediately before the spontaneous breathing trial effectively predicts extubation outcomes in children after cardiac surgery. | Muzi Li Hong Meng Liang Zhang Yuzi Zhou Chao Liang Zhiling Luo Hao Wang | 2022 | Congenital Heart Disease2022，17，3： | 0 |
| 13 | Study on the Role of Vitamin D in Systemic Lupus Erythematosus显示文摘Vitamin D is a hormone precursor with multiple biological effects.It binds to vitamin D receptors on target cells.It is an important participant in the metabolism of calcium and phosphorus in vivo.It is closely related to cell cycle,cell proliferation,differentiation,apoptosis,signal transduction and immune regulation.Its role in the treatment of infection,tumor and even immune diseases has been gradually recognized and studied.Patients with systemic lupus erythematosus generally have decreased levels of active vitamin D,and low levels of vitamin D are associated with disease occurrence,disease activity and complications.In the past ten years,a large number of studies have been carried out on it globally to explore the role of vitamin D in the occurrence and development of systemic lupus erythematosus.This paper summarizes its recent research progress. | Jiadian Wang Muzi Cui Siyi Wang Xiao Xue Kerong Ren ZhiLu Li Saijia Li Pingping Yan | 2021 | Journal of Advances in Medicine Science2021，4，1： | 0 |
| 14 | Identification and characterization of stearoyl-CoA desaturase in Toxoplasma gondii显示文摘Few information of the function of stearoyl-coenzyme A (CoA) desaturase (SCD) in apicomplaxan parasite has been obtained. In this study, we retrieved a putative fatty acyl-CoA desaturase (TGGT1_238950) by a protein alignment with Plasmodium falciparum SCD in ToxoDB. A typical △9-desaturase domain was revealed in this protein. The putative desaturase was tagged with HA endogenously in Toxoplasma gondii, and the endoplasmic reticulum localization of the putative desaturase was revealed, which was consistent with the fatty acid desaturases in other organisms. Therefore, the TGGT1_238950 was designated T gondii SCD. Based on CRISPR/Cas9 gene editing tech no logy, SCD conditional kno ckout muta nts in the T gondii TATi strai n were obtai ned. The growth in vitro and pathogenicity in mice of the mutants suggested that SCD might be dispensable for tachyzoite growth and proliferation. The SCD-overexpressing line was constructed to further explore SCD function.The portion of palmitoleic acid and oleic acid were increased in SCD-overexpressi ng parasites,compared with the RH pare ntal strai n, indicati ng that T.gondii in deed is compete nt for unsaturated fatty acid synthesis.The SCD-overexpressing tachyzoites propagated slower than the parental strain,with a decreased invasion capability and weaker pathogenicity in mice. The TglF2α phosphorylation and the expression changes of several genes demonstrated that ER stress was triggered in the SCD-overexpressing parasites,which were more apt toward autophagy and apoptosis. The function of unsaturated fatty acid synthesis of TgSCD was consistent with our hypothesis.On the other hand,SCD might also be involved in tachyzoite autophagy and apoptosis. | Pan Hao Xia Cui Jing Liu Muzi Li Yong Fu Qun Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 0 |
| 15 | Color Elements and Creative Design of Xiuzhou Folk Painting显示文摘Xiuzhou folk painting,also known as the Xiuzhou modern folk painting,is a significant carrier of the folk culture in the south of Yangtze River in China.Abundant in forms and themes,the painting unfolds the customs and practices in the region with its conspicuous appearance,rich colors,full composition and simple style,providing important research value for the study of the region's humanities and culture.With the case study of Xu Zhenzhai,this paper aims to study the color application in Xiuzhou folk painting,facilitate creative design of its packaging and endow it with more practical significance and cultural value of intangible cultural heritage so as to facilitate the protection and inheritance of traditional local culture in the region. | Muzi Li | 2021 | 管理科学与研究(中英文版)2021，10，1： | 0 |
| 16 | Shear behavior and off-fault damage of saw-cut smooth and tension-induced rough joints in granite显示文摘The damage of rock joints or fractures upon shear includes the surface damage occurring at the contact asperities and the damage beneath the shear surface within the host rock.The latter is commonly known as off-fault damage and has been much less investigated than the surface damage.The main contribution of this study is to compare the results of direct shear tests conducted on saw-cut planar joints and tension-induced rough granite joints under normal stresses ranging from 1 MPa to 50 MPa.The shear-induced off-fault damages are quantified and compared with the optical microscope observation.Our results clearly show that the planar joints slip stably under all the normal stresses except under 50 MPa,where some local fractures and regular stick-slip occur towards the end of the test.Both post-peak stress drop and stick-slip occur for all the rough joints.The residual shear strength envelopes for the rough joints and the peak shear strength envelope for the planar joints almost overlap.The root mean square(RMS)of asperity height for the rough joints decreases while it increases for the planar joint after shear,and a larger normal stress usually leads to a more significant decrease or increase in RMS.Besides,the extent of off-fault damage(or damage zone)increases with normal stress for both planar and rough joints,and it is restricted to a very thin layer with limited micro-cracks beneath the planar joint surface.In comparison,the thickness of the damage zone for the rough joints is about an order of magnitude larger than that of the planar joints,and the coalesced micro-cracks are generally inclined to the shear direction with acute angles.The findings obtained in this study contribute to a better understanding on the frictional behavior and damage characteristics of rock joints or fractures with different roughness. | Fanzhen Meng Feili Wang Louis Ngai Yuen Wong Jie Song Muzi Li Chuanqing Zhang Liming Zhang | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，4： | 0 |
| 17 | Nutrients Deficiency and Excess Phenomena of Cut Rose and Their Physiological Significances显示文摘On the basis of a brief introduction of essential major elements and trace elements for cut rose,the physiological effect and deficiency and excess phenomena of major elements including nitrogen,phosphorus,potassium,magnesium,calcium,sulfur and trace elements including zinc,molybdenum,boron,iron,manganese,copper were mainly described; the main factors influencing nutrients absorption of cut rose were summarized,in order to provide a reference for the reasonable fertilization of cut rose. | Jin Xingzi Li Ming Jin Muzi Yang Jin | 2014 | Plant Diseases and Pests2014，5，4： | 0 |
| 18 | Machine learning for membrane design and discovery显示文摘Membrane technologies are becoming increasingly versatile and helpful today for sustainable development.Machine Learning(ML),an essential branch of artificial intelligence(AI),has substantially impacted the research and development norm of new materials for energy and environment.This review provides an overview and perspectives on ML methodologies and their applications in membrane design and dis-covery.A brief overview of membrane technologies isfirst provided with the current bottlenecks and potential solutions.Through an appli-cations-based perspective of AI-aided membrane design and discovery,we further show how ML strategies are applied to the membrane discovery cycle(including membrane material design,membrane application,membrane process design,and knowledge extraction),in various membrane systems,ranging from gas,liquid,and fuel cell separation membranes.Furthermore,the best practices of integrating ML methods and specific application targets in membrane design and discovery are presented with an ideal paradigm proposed.The challenges to be addressed and prospects of AI applications in membrane discovery are also highlighted in the end. | Haoyu Yin Muzi Xu Zhiyao Luo Xiaotian Bi Jiali Li Sui Zhang Xiaonan Wang | 2024 | Green Energy & Environment2024，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员