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| 1 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | 显示文摘 | Ma Erming Luo Shoufu Li Pengxing | 1988 | Thin Solid Films1988，166，： | 1 |
| 3 | EFFECT OF REINFORCEMENT VOLUME FRACTION ON PRECIPITATION IN MATRIX OF SiC_p/AI COMPOSITE显示文摘The differential scanning calorimetric(DSC) and transmission electron microanalysis(TEM) techniques were used to study the kinetic process of precipitation in matrix ofcast SiCp/2024 composites.The results showed that precipitation reactions of GPzone and intermediate phase S’(Al2CuMg)in the composites were accelerated comparedwith SiC-free material,the peak temperatures of both reactions were decreased.Thereaction enthalpies of both the GP zone and intermediate phase S’ formation in thematrix were substantially decreased after the addition of SiC.TEM analysis found thatthe alloying element Mg segregated at the SiC/Al interfaces,and was depleted in thematrix near the interface.The precipitation-free zones(PFZ) and precipitation-sparsezones(PSZ) formed near the interfaces,as a results,the volume fraction of precipitatesin matrix was reduced. | LIN Junshan LI Pengxing WU Renjie Shanghai Jiao Tong University,Shanghai,China postdoctoral,Institute of Composite Materials,Shanghai Jiaotong University,Shanghai 200030,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，8： | 1 |
| 4 | A transmission electron microscopy study on the crystallization of amorphous Ni-P electroless deposited coatings显示文摘 | Ma Faming Luo Shoufu Li Pengxing | 1988 | Thin Solid Films1988，166，： | 1 |
| 5 | Adsorption of 1,2-dichlorobenzene from water to carbon nanotubes显示文摘 | PengX J Li Y H Luan Z K | | 0，，1： | 1 |
| 6 | EFFECTS OF THERMAL CYCLE ON MECHANICAL PROPERTIES OF SiC PARTICLES REINFORCED MoSi_2 COMPOSITE显示文摘EFFECTSOFTHERMALCYCLEONMECHANICALPROPERTIESOFSiCPARTICLESREINFORCEDMoSi_2COMPOSITE￥ZHENGLingyi;JINYanping;LIPengxing(TheState?.. | ZHENG Lingyi JIN Yanping LI Pengxing(The State Key Laboratory of Metal Matrix Composites Materials,Shanghai Jiao Tong University,Shanghai 200030,China) | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，2： | 0 |
| 7 | SARS-CoV-2-specific CD4^(+)T cells are associated with long-term persistence of neutralizing antibodies显示文摘Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing antibodies in infected or vaccinated people and how vaccines protect against other SARS-CoV-2 variants is critical for assessing public vaccination plans.Here,we measured different plasm antibody levels 2 and 12 months after disease onset,including anti-RBD,anti-N,total neutralizing antibodies,and two neutralizing-antibody clusters.We found that total neutralizing antibodies declined more slowly than total anti-RBD and anti-N IgG. | Zhongfang Wang Xiaoyun Yang Xinyue Mei Yumin Zhou Zhiqiang Tang Guichang Li Jiaying Zhong Mengqiu Yu Mingzhu Huang Xiaoling Su Bijia Lin Pengxing Cao Ji Yang Pixin Ran | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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