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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 4 | Synthesis of bis(amine anhydride)s for novel high Tgs and organosoluble poly(amine imide) s by palladium-catalyzed amination of 4-chlorophthalide anhydride 显示文摘 | Li W M Li S H Zhang Q Y | 2007 | Macromolecules2007，40，： | 10 |
| 5 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 6 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 7 | PEG-IFN序贯核苷类似物治疗HBeAg阳性慢性乙型肝炎患者的效果评价显示文摘【据Hepatology International 2021年2月报道】题:PEG-IFN序贯核苷类似物治疗HBe Ag阳性慢性乙型肝炎患者的效果评价(作者Xu W等)目前慢性乙型肝炎抗病毒治疗策略优化主要有3种可能方案:(1)PEG-IFN和核苷类似物起始联合治疗;(2)核苷类似物序贯PEG-IFN治疗;(3)PEG-IFN序贯核苷类似物治疗。方案(1)和方案(2)目前已有较多研究评估,然而方案(3)的疗效尚缺乏临床研究评价。该研究旨在评估PEG-IFN序贯核苷类似物治疗HBe Ag阳性慢性乙型肝炎患者的疗效。 | 李强 XU W LI Q HUANG C | 2021 | 临床肝胆病杂志2021，37，4： | 5 |
| 8 | 鼠软骨纳米压痕系数:创伤后骨关节炎发病和进展的敏感指标显示文摘创伤后骨性关节炎(post-traumatic osteoarthritis,PTOA)是由损伤引起的关节软骨及其他滑膜组织的不可逆破坏,年轻人常见,而软骨表面直接损伤、关节骨折、韧带及半月板损伤造成的负荷失稳均可导致PTOA。目前,PTOA的分子病因学机制及功能性症状并不明确。因此,对于预测性生物标记物的探索以及有效治疗手段的发展均处于早期研究阶段。本研究的目的在于展示PTOA模型鼠关节软骨的纳米机械性能,并证实其充当OA发病、好转及进展的敏感标记物的潜在可能。 | Doyran B Tong W Li Q 胡玮 夏远军 | 2017 | 中国骨科临床与基础研究杂志2017，9，4： | 5 |
| 9 | The genetic heterozygosity and fitness of tetraploid embryos and embryonic stem cells are crucial parameters influencing survival of mice derived from embryonic stem cells by tetraploid embryo aggregation显示文摘 | Li X Wei W Yong J Jia Q Yu Y Di K | 2006 | 中国生物学文摘2006，20，7： | 3 |
| 10 | Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells显示文摘 | Zhang,W Ge,W Li,CH You,SG Liao,LM Han,Q Deng,WM Zhao,RCH | 2005 | 中国生物学文摘2005，19，3： | 3 |
| 11 | Influence of Fe Addition on Products of Self-Propagating High-Temperature Synthesis Reaction in 3Ti-Si-2C System显示文摘Influence of Fe addition on products of self-propagating high-temperature synthesis (SHS) reaction in 3Ti-Si-2C system was investigated in the present study. Without Fe addition, Ti5Si3 and TiC are the dominant phases along with a small amount of Ti3SiC2 phase and unreacted C left in the final products. As Fe content ranges from 10% to 30%, the products consist of TiC, Ti5Si3, Fe2Ti and unreacted C, but no trace of Ti3SiC2 phase is detected. Furthermore, the amounts of both Fe2Ti and C phases increase with Fe content increasing. Addition of Fe has a great effect on the reaction route and significantly restrains the formation of Ti3SiC2 during the combustion synthesis process, and therefore, the SHS is not an effective fabrication technique to synthesize the ternary Ti3SiC2 ceramic in either 3Ti-Si-2C or Fe-3Ti-Si-2C system. Besides, without Fe addition, Ti5Si3 presents as the coarse irregular appearance with an obviously sintered morphology. In contrast, the shape of Ti5Si3 exhibits more and more spherical (cobblestone-like) and the surface becomes increasingly smooth, because the amount of liquids formed during the SHS reaction increases with the increase of Fe content. On the other hand, with Fe content increasing from 0 to 30 wt.%, the particulate size of TiC decreases from more than 5 μm to 1 μm or less, mainly due to the fact that the combustion temperature decreases with the increase of Fe content in the preforms. | Guan Q L Wang H Y Li S L Si W P Jiang Q C | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 12 | Brittle elastoplastic damage constitutive model for jointed rockmass and computation concerning bolt-reinforcement显示文摘 | Zhu W Zhang Q Li S Lee C F | 2003 | International Journal of Damage Mechanics2003，12，： | 2 |
| 13 | 甜菜碱对肥育猪生长激素脉冲释放和血清代谢的影响显示文摘用添加含量为0和0.125%甜菜碱的日粮饲喂肥育猪,试验对杂交肥育猪日粮中甜菜碱对猪的生长性能、生长激素(GH)脉冲释放及血清代谢的影响进行研究。每试验组3个重复,每个重复8头猪(4头去势公猪,4头母猪),试验在饲喂后3h内每15min采集一次血液样本,测定生长激素脉冲释放。结果表明:添加甜菜碱组平均日增重增加5.45%(P〈0.05),而平均日采食量和饲料转化率则不受影响。 | Huang Q C Xu Z R Han X Y Li W F | 2007 | 饲料博览(技术版)2007，，7： | 2 |
| 14 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 15 | 显示文摘 | Sun Y P Li X Q Zhang W X | 2007 | Colloids and Surfaces Physicochemieal and Engineering Aspects2007，308，13： | 1 |
| 16 | A novel functionally graded material in the Ti-Si-C system显示文摘 | LUO Y G PAN W LI S Q WANG R G LI J Q | 2003 | Mater Sci Eng A2003，345，： | 1 |
| 17 | Nano-Stuctured PtFe/C as Cathode Catalyst in Direct Methanol Fuel Cell显示文摘 | Li W Z Zhou W J Li H Q | 2004 | Electrochim Acta2004，49，： | 1 |
| 18 | Two triterpenoids and other constituents from Petasites tricholobus显示文摘 | XIE W D ZHANG Q LI P L | 2005 | Phytochemistry2005，66，： | 1 |
| 19 | A survey and comparison of Petri net based deadlock prevention policies for flexible manufacturing systems显示文摘 | LI Z W ZHOU M C WU N Q | 2008 | IEEE Trans on Syst Man Cybern C Appl Reviews2008，38，2： | 1 |
| 20 | Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity显示文摘 | Li R Wang W Q Zhang H | 2007 | Am J Physiol Endocrinol Metab2007，293，6： | 1 |
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