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| 1 | Coordinated regulation of apical hook development by gibberellins and ethylene in etiolated Arabidopsis seedlings显示文摘当在土壤发芽时,当通过土壤耸出时,黑暗成年的 Arabidopsis 幼苗开发一个顶端的钩,它保护子叶和顶端的 meristematic 纸巾。几荷尔蒙被报导清楚地调制这个过程。以前的研究证明了乙烯和赤霉素(气体) 并列地调整钩发展,尽管内在的分子的机制大部分是未知的。当 paclobutrazol 镇压了时,这里,我们显示出提高的那 GA 3 ethylene-overexpression 和 EIN3-overexpression (EIN3ox ) 导致了钩弯曲,并且 della 异种展出了夸大的钩弯曲,它要求了发信号的未经触动的乙烯小径。基因学习表明那提高 GA 的钩开发依赖于无钩 1 (HLS1 ) ,调停的一个中央管理者多重发信号小径的输入在顶端的钩开发期间。我们进一步发现那 GA 3 导致(并且 DELLA 蛋白质镇压了) 在乙烯感觉迟钝的 3/EIN3-LIKE 的 HLS1 表示 1 (EIN3/EIL1 ) 依赖举止, EIN3/EIL1 由此激活 HLS1 抄写由对它的倡导者直接有约束力。另外, DELLA 蛋白质被发现与 EIN3/EIL1 的 DNA 有约束力的领域交往并且镇压 EIN3/EIL1-regulated HLS1 表示。有 naphthylphthalamic 酸的处理,一个极的植物生长素运输禁止者,镇压 EIN3ox 线的组成地夸大的钩弯曲和 della 异种,支持那植物生长素在钩开发乙烯和 GA 小径下游地工作。一起拿,我们的结果作为联系 DELLA 的抄写因素的一个新类识别 EIN3/EIL1 并且证明 GA 由经由 EIN3/EIL1 函数的 derepression 导致 HLS1 的表达式部分与乙烯在合作支持顶端的钩形成。 | Fengying An Xing Zhang Ziqiang Zhu Yusi Ji Wenrong He Zhiqiang Jiang Mingzhe Li Hongwei Guo | 2012 | Cell Research2012，22，5： | 34 |
| 2 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
| 3 | Spectral analysis and self-adjusting mechanism for oscillation phenomenon in hydrogen-oxygen continuously rotating detonation engine显示文摘The continuously rotating detonation engine(CRDE)is a new concept of engines for aircraft and spacecraft.Quasi-stable continuously rotating detonation(CRD)can be observed in an annular combustion chamber,but the sustaining,stabilizing and adjusting mechanisms are not yet clear.To learn more deeply into the CRDE,experimental studies have been carried out to investigate hydrogen-oxygen CRDE.Pressure histories are obtained during each shot,which show that stable CRD waves are generated in the combustor,when feeding pressures are higher than 0.5 MPa for fuel and oxidizer,respectively.Each shot can keep running as long as fresh gas feeding maintains.Close-up of the pressure history shows the repeatability of pressure peaks and indicates the detonation velocity in hydrogen–oxygen CRD,which proves the success of forming a stable CRD in the annular chamber.Spectrum of the pressure history matches the close-up analysis and confirms the CRD.It also shows multi-wave phenomenon and affirms the fact that in this case a single detonation wave is rotating in the annulus.Moreover,oscillation phenomenon is found in pressure peaks and a self-adjusting mechanism is proposed to explain the phenomenon. | Liu Yusi Wang Yuhui Li Yongsheng Li Yang Wang Jianping | 2015 | Chinese Journal of Aeronautics2015，28，3： | 14 |
| 4 | Human ACE2-Functionalized Gold“Virus-Trap”Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection显示文摘The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus.Here,we present a Human Angiotensin-converting-enzyme 2(ACE2)-functionalized gold“virus traps”nanostructure as an extremely sensitive SERS biosensor,to selectively capture and rapidly detect S-protein expressed coronavirus,such as the current SARS-CoV-2 in the contaminated water,down to the single-virus level.Such a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as“virus-traps”composed of oblique gold nanoneedles,and 109-fold enhancement of Raman signals originating from multi-component SERS effects.Furthermore,the identification standard of virus signals is established by machine-learning and identification techniques,resulting in an especially low detection limit of 80 copies mL^(−1) for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min,which is of great significance for achieving real-time monitoring and early warning of coronavirus.Moreover,here-developed method can be used to establish the identification standard for future unknown coronavirus,and immediately enable extremely sensitive and rapid detection of novel virus. | Yong Yang Yusi Peng Chenglong Lin Li Long Jingying Hu Jun He Hui Zeng Zhengren Huang Zhi-Yuan Li Masaki Tanemura Jianlin Shi John R.Lombardi Xiaoying Luo | 2021 | Nano-Micro Letters2021，13，7： | 6 |
| 5 | Geological significance of nickeliferous minerals in the Fule Pb–Zn deposit, Yunnan Province, China显示文摘The Fule Pb–Zn deposit is located in the Sichuan–Yunnan–Guizhou Province, and it is an important and giant low temperature metallogenic domain in China.In our research area, the Pb–Zn deposits are mainly hosted in the Permian Yangxin Formation and are composed of dolostone and limestone. The distance between the ore bodies and the Permian Emeishan basalt ranged from 50 to160 m. In this study, the nickel rich minerals, including vaesite, polydymite and millerite, were reported for the first time in the Fule deposit. These minerals occurred as xenomorphic mineral aggregate and were sporadically distributed in the sphalerite–galena–calcite vein, which is the main ore type in the deposit. Our study indicated that the paragenetic sequence of minerals in the Fule deposit is the following order: polydymite → vaesite→ millerite → sphalerite → galena → tetrahedrite(tennantite).The geological occurrence characteristics of those nickeliferous minerals suggested that the Permian Emeishan basalt is a possible barrier layer of Pb–Zn ore-forming fluid, and it is an important source for the Ni and part of the Cu in the deposit. The Sichuan–Yunnan–Guizhou Pb–Zn mineralization province is a world-class production base of Pb and Zn, in which the Permian Emeishan basalt and Pb–Zn deposits have uniformly spatial distribution, but the relationship of mineralization between them is still under debate. This report provides new evidence forunderstanding the relationship between Pb–Zn mineralization and Permian Emeishan basalt in the Sichuan–Yunnan–Guizhou Pb–Zn mineralization province. | Zhenli Li Lin Ye Yusi Hu Zhilong Huang | 2018 | Acta Geochimica2018，37，5： | 6 |
| 6 | Secondary organic aerosols in Jinan, an urban site in North China: Significant anthropogenic contributions to heavy pollution显示文摘Secondary organic aerosols(SOAs) are an important component of particulates, but whether biogenic SOAs(BSOAs) or anthropogenic SOAs(ASOAs) are the dominant contributors to haze pollution remains poorly characterized. In this study, particulate samples were collected from September 2014 to August 2015 at an urban site in Jinan, which is the capital of Shandong Province and a typical city in the North China Plain. The PM2.5 samples were analyzed for BSOA(isoprene(SOAI) and monoterpenes(SOAM)) and ASOA(aromatic(SOAA)) tracers. The concentrations of the SOAAtracer(1.1 ± 1.0 ng/m3) were lowest, and those of SOAItracers(41.8 ± 86.2 ng/m3) were highest, with the concentrations of SOAMtracers(19.4 ± 9.9 ng/m3) being intermediate. The SOAItracers were more abundant in the summer and less abundant in the winter. Both SOAIand SOAMincreased with increasing ozone level but decreased with increasing NOx level. Correlation analysis revealed a good correlation between 2,3-dihydroxy-4-oxopentanoic acid and levoglucosan levels in three seasons. These results suggested that biomass burning activities occurring in the NCP can enhance the emissions of aromatics and should be controlled, especially in the autumn and winter. SOA tracers were classified according to pollution degree, and the results showed that as pollution increases, the contributions of SOAAincrease. These results indicate that reducing anthropogenic emissions is necessary to prevent SOA pollution, especially during heavy pollution episodes. | Yusi Liu Xingru Li Guiqian Tang Lili Wang Bo Lv Xueqing Guo Yuesi Wang | 2019 | Journal of Environmental Sciences2019，31，6： | 6 |
| 7 | Charge‑Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS‑CoV‑2 S Protein Detection显示文摘The outbreak of coronavirus disease 2019 has seriously threatened human health.Rapidly and sensitively detecting SARSCoV-2 viruses can help control the spread of viruses.However,it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity.Therefore,it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity.Herein we report,for the first time,Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement,which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement.Their SERS sensitivity is optimized to 3.0×10^6 and 1.4×10^6 under the optimal resonance excitation wavelength of 532 nm.Additionally,remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein.Moreover,its detection limit is as low as 5×10^−9 M,which is beneficial to achieve real-time monitoring and early warning of novel coronavirus.This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology. | Yusi Peng Chenglong Lin Li Long Tanemura Masaki Mao Tang Lili Yang Jianjun Liu Zhengren Huang Zhiyuan Li Xiaoying Luo John RLombardi Yong Yang | 2021 | Nano-Micro Letters2021，13，3： | 3 |
| 8 | Trace Elements in Sphalerite from the Dadongla Zn-Pb Deposit, Western Hunan-Eastern Guizhou Zn-Pb Metallogenic Belt, South China显示文摘The western Hunan-eastern Guizhou Zn-Pb metallogenic belt is one of the important Zn-Pb mineralization regions in China.The Dadongla deposit,located in the northeast of Guizhou Province,is one of the typical Zn-Pb deposits in the region and has estimated resources more than 12 million metric tons(Mt)with an average grade of 4.11 wt%Zn+Pb.Its orebodies are hosted in the lower Cambrian Aoxi Formation dolomite,occurring as bedded,para-bedded in shape,and in conformity with the wall rock.The ore mineral assemblage is simple,dominated by sphalerite with minor pyrite and galena,and the gangue minerals are composed of dolomite,calcite with minor bitumen and barite.In view of the lack of geological and geochemical researches,the genesis of Zn-Pb ore is still unclear.Laser ablation-inductively coupled plasma mass spectrometry(LA-ICPMS)spot and mapping analyses were used to obtain sphalerite trace element chemistry in the Dadongla Zn-Pb deposit in Guizhou,China,aiming to constrain its ore genesis.The results show that sphalerite is characterized by the enrichment of Cd,Fe,Ge and Hg,corresponding with that of typical MVT deposits.Four zones were identified in the sphalerite crystal from Dadongla from the center to margin according to the color bands.in which the zone in the center,representing the early ore-stage sphalerite,is characterized by enrichment of Cd relatively,while the zone forming at late ore-stage is enriched in Ge and Hg relatively.The finding was controlled by differential leached metals content in ore-forming fluid from its source rock.Notably,critical element Ge trends to be enriched at the late ore-stage and follows a substitution of 2 Zn^2+(?)Ge^4++□(vacancy).Moreover,the calculated ore-forming temperature ranges from 79.9℃to 177.6℃by the empirical formula,which is similar to that of typical Mississippi Valley-type(MVT)deposits.Compared with the features of trace elements in sphalerite from different types of deposits,together with the geology,the Dadongla deposit belongs to an MVT Zn-Pb deposit. | HU Yusi YE Lin WEI Chen LI Zhenli HUANG Zhilong WANG Haoyu | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 3 |
| 9 | Enhance the delivery of light energy ultra-deep into turbid medium by controlling multiple scattering photons to travel in open channels显示文摘Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media.In this paper,we present an innovative method to overcome this limitation and enhance the delivery of light energy ultradeep into turbid media with significant improvement in focusing.Our method is based on a wide-field reflection matrix optical coherence tomography(RM-OCT).The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization parameter in order to get more accurate reversal results deep inside the scattering sample.We propose a concept named model energy matrix,which provides a direct mapping of light energy distribution inside the scattering sample.To the best of our knowledge,it is the first time that a method to measure and quantify the distribution of beam intensity inside a scattering sample is demonstrated.By employing the inversion of RM to find the matched wavefront and shaping with a phase-only spatial light modulator,we succeeded in both focusing a beam deep(~9.6 times of scattering mean free path,SMFP)inside the sample and increasing the delivery of light energy by an order of magnitude at an ultra-deep(~14.4 SMFP)position.This technique provides a powerful tool to understand the propagation of photon in a scattering medium and opens a new way to focus light inside biological tissues. | Jing Cao Qiang Yang Yusi Miao Yan Li Saijun Qiu Zhikai Zhu Pinghe Wang Zhongping Chen | 2022 | Light(Science & Applications)2022，11，5： | 2 |
| 10 | Plasmon-enhanced light-matter interactions and applications显示文摘Surface plasmons are coherent and collective electron oscillations confined at the dielectric–metal interface.Benefitting from the inherent subwavelength nature of spatial profile,surface plasmons can greatly accumulate the optical field and energy on the nanoscale and dramatically enhance various light–matter interactions.The properties of surface plasmons are strongly related to materials and structures,so that metals,semiconductors and two-dimensional materials with various morphologies and structures can have alternating plasmonic wavelengths ranging from ultraviolet,visible,near infrared to far infrared.Because the electric field can be enhanced by orders of magnitude within plasmonic structures,various light–matter interaction processes including fluorescence,Raman scattering,heat generation,photoacoustic effects,photocatalysis,nonlinear optical conversion,and solar energy conversion,can be significantly enhanced and these have been confirmed by both theoretical,computational and experimental studies.In this review,we present a concise introduction and discussion of various plasmon-enhanced light–matter interaction processes.We discuss the physical and chemical principles,influencing factors,computational and theoretical methods,and practical applications of these plasmon-enhanced processes and phenomena,with a hope to deliver guidelines for constructing future high-performance plasmonic devices and technologies. | Huakang Yu Yusi Peng Yong Yang Zhi-Yuan Li | 2019 | npj Computational Materials2019，，1： | 2 |
| 11 | Time-Domain Dual Component Computation Diversity Based on Generalized Hybrid Carrier显示文摘In this paper,the concept of computation diversity is proposed by employing generalized hybrid carrier(GHC)system.The signal is backed up by transform-domain computation to enhance the anti-fading capability.Theoretical analysis is presented to demonstrate the superiority of the proposed method.Numerical simulations in doubly-selective fading channels are provided to verify the results.The bit error rate(BER)performance is guaranteed with a small computational complexity increment.The proposed method not only extends the new diversity dimension,but also improves the diversity gain of the system without occupying additional wireless resources.Moreover,the proposed method shows good adaptability with single carrier modulation and improves diversity performance.As the simulation results shown,time-domain dual component computation diversity(TDC-CD)has 1d B BER gain and 0.1diversity gain at high signal-to-noise ratio,and single carrier system with TDC-CD achieves 2d B BER gain at 10~(-4). | Yuqing Feng Xuejun Sha Yong Li Xiaojie Fang Yusi Zhang | 2021 | China Communications2021，18，10： | 2 |
| 12 | Growth asymmetry precedes differential auxin response during apical hook initiation in Arabidopsis显示文摘The development of a hook-like structure at the apical part of the soil-emerging organs has fascinated botanists for centuries,but how it is initiated remains unclear.Here,we demonstrate with highthroughput infrared imaging and 2-D clinostat treatment that,when gravity-induced root bending is absent,apical hook formation still takes place.In such scenarios,hook formation begins with a de novo growth asymmetry at the apical part of a straightly elongating hypocotyl.Remarkably,suchde novo asymmetric growth,but not the following hook enlargement,precedes the establishment of a detectable auxin response asymmetry,and is largely independent of auxin biosynthesis,transport and signaling.Moreover,we found that functional cortical microtubule array is essential for the following enlargement of hook curvature.When microtubule array was disrupted by oryzalin,the polar localization of PIN proteins and the formation of an auxin maximum became impaired at the to-be-hook region.Taken together,we propose a more comprehensive model for apical hook initiation,in which the microtubuledependent polar localization of PINs may mediate the instruction of growth asymmetry that is either stochastically taking place,induced by gravitropic response,or both,to generate a significant auxin gradient that drives the full development of the apical hook. | Yang Peng Dan Zhang Yuping Qiu Zhina Xiao Yusi Ji Wenyang Li Yiji Xia Yichuan Wang Hongwei Guo | 2022 | Journal of Integrative Plant Biology2022，64，1： | 1 |
| 13 | Vertical Profiles of Volatile Organic Compounds in Suburban Shanghai显示文摘As Volatile Organic Compounds(VOCs)are one of the precursors of ozone,their distribution and variable concentrations are highly related to local ozone pollution control.In this study,we obtained vertical profiles of VOCs in Shanghai’s Jinshan district on 8 September and 9 September in 2016 to investigate their distribution and impact on local atmospheric oxidation in the near surface layer.Vertical samples were collected from heights between 50 m and 400 m by summa canisters using an unmanned aerial vehicle(UAV).Concentrations of VOCs(VOCs refers to the 52 species measured in this study)varied minimally below 200 m,and decreased by 21.2%from 100 m to 400 m.The concentrations of VOCs above 200 m decreased significantly in comparison to those below 200 m.The proportions of alkanes and aromatics increased from 55.2%and 30.5%to 57.3%and 33.0%,respectively.Additionally,the proportion of alkenes decreased from 13.2%to 8.4%.Toluene and m/p-xylene were the key species in the formation of SOA and ozone.Principal component analysis(PCA)revealed that the VOCs measured in this study mainly originated from industrial emissions. | Yuhan LIU Hongli WANG Shengao JING Ming ZHOU Shenrong LOU Kun QU Wanyi QIU Qian WANG Shule LI Yaqin GAO Yusi LIU Xiaobing LI Zhong-Ren PENG Junhui CHEN Keding LU | 2021 | Advances in Atmospheric Sciences2021，38，7： | 1 |
| 14 | Genesis of fahlore in the Tianbaoshan lead–zinc deposit, Sichuan Province, China: a scanning electron microscopy–energy dispersive spectroscopy study显示文摘The Tianbaoshan deposit, located in the southwestern part of the Yangtze Block, is a representative Pb–Zn deposit in the Sichuan–Yunnan–Guizhou Pb–Zn metallogenic province. The Pb–Zn orebodies are hosted in the upper Sinian Dengying Formation dolostone. The predominant minerals are sphalerite, galena, pyrite, chalcopyrite, quartz, and calcite with minor arsenopyrite,fahlore, and dolomite. The deposit is characterized by relatively strong Cu mineralization. However, the relationship between Pb–Zn and Cu mineralization is unknown. We analyzed the mineralogy and composition of fahlore, chalcopyrite, arsenopyrite, sphalerite, and galena using scanning electron microscopy–energy dispersive spectroscopy, with the aim of providing new evidence for the genesis of the Pb–Zn–(Cu) ore. The results show that the Cu ore in the deposit is dominated by chalcopyrite and fahlore, both of which formed before or during the Pb–Zn ore-forming stage. The fahlore showed dramatic compositional variation and was characterized by negative correlations between Ag and Cu, and between As and Sb,suggesting substitution of Ag for Cu, and that As and Sb substitute in the same site in the fahlore lattice. Based on backscattered electron images and composition, the fahlorewas divided into two types. Type I fahlore crystallized early and is characterized by enrichment of Cu and depletion in Ag and Sb. Type II fahlore formed after Type I, and is rich in Ag and poor in Cu and As. Moreover,galena and fahlore are the host minerals of Ag. The variation of valence state with As host mineral—from fahlore to arsenopyrite—indicates the metallogenic environment changed from relatively oxidizing to reducing with a high p H. In the light of Gibbs energies of reciprocal reactions and isotherms for cation exchange, the composition of the fahlore implies its ore-forming temperature was lower than220 °C, corresponding with typical Mississippi Valley-type(MVT) deposits. Based on the geologic character and geochemical data of this deposit, we suggest that the Tianbaoshan deposit belongs to the MVT deposit category. | Yusi Hu Lin Ye Zhenli Li Zhilong Huang Jiawei Zhang | 2018 | Acta Geochimica2018，37，6： | 1 |
| 15 | Anti-tumor drug delivery of pH-sensitive poly(ethylene glycol)-poly( L -histidine-)-poly( L -lactide) nanoparticles显示文摘 | Rong Liu Dong Li Bin He Xianghui Xu Mingming Sheng Yusi Lai Gang Wang Zhongwei Gu | 2011 | Journal of Controlled Release2011，，1： | 1 |
| 16 | Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women显示文摘Growth differentiation factor 11(GDF11) is an important circulating factor that regulates aging.However,the role of GDF11 in bone metabolism remains unclear.The present study was undertaken to investigate the relationship between serum GDF11 level,bone mass,and bone turnover markers in postmenopausal Chinese women.Serum GDF11 level,bone turnover biochemical markers,and bone mineral density(BMD) were determined in 169 postmenopausal Chinese women(47–78 years old).GDF11 serum levels increased with aging.There were negative correlations between GDF11 and BMD at the various skeletal sites.After adjusting for age and body mass index(BMI),the correlations remained statistically significant.In the multiple linear stepwise regression analysis,age or years since menopause,BMI,GDF11,and estradiol were independent predictors of BMD.A significant negative correlation between GDF11 and bone alkaline phosphatase(BAP) was identified and remained significant after adjusting for age and BMI.No significant correlation was noted between cross-linked N-telopeptides of type I collagen(NTX) and GDF11.In conclusion,GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation,BAP,in postmenopausal Chinese women.GDF11 potentially exerts a negative effect on bone mass by regulating bone formation. | Yusi Chen Qi Guo Min Zhang Shumin Song Tonggui Quan Tiepeng Zhao Hongliang Li Lijuan Guo Tiejian Jiang Guangwei Wang | 2016 | Bone Research2016，4，1： | 1 |
| 17 | Study on the electrochemical behavior of Mg and Al ions in LiCl-KCl melt and preparation of Mg-Al alloy显示文摘The electrochemical behavior of Mg^(2+)and Al^(3+)in LiCl-KCl(mass 4:1)melt at 973 K was studied on a Mo electrode systematically by cyclic voltammetry,square wave voltammetry and chronopotentiometry.The results showed that the reductions of Mg^(2+)and Al^(3+)were reversible processes controlled by the rate of the mass transfer.When Mg^(2+)and Al^(3+)coexisted in LiCl-KCl melt,they had no significant effect on the reduction potential of each other.The equilibrium potentials of Mg^(2+)/Mg and Al^(3+)/Al were obtained by open circuit potential method.Their apparent standard potentials were also calculated in this system and the values were-2.52 V vs Cl_(2)/Cl^(−),-1.66 V vs Cl_(2)/Cl^(−),respectively.Correspondingly,the apparent Gibbs free energies of Mg^(2+)/Mg and Al^(3+)/Al were-485.71 kJ/mol^(-1),-480.78 kJ/mol^(-1).Finally,potentiostatic electrolysis was performed on a Mo electrode in LiCl-KCl-MgCl_(2)-AlCl_(3)(the mass ratio of MgCl_(2) to AlCl_(3) was 10:1)melt at different potentials.The components of the deposits were characterized by scanning electron microscope and energy dispersive spectroscopy.The study revealed that the content of Al in the deposit decreased as the overpotential increased and Al tended to segregate at the grain boundaries. | Shaolong Li Yusi Che Chenyao Li Yongchun Shu Jilin He Bin Yang Jianxun Song | 2022 | Journal of Magnesium and Alloys2022，10，3： | 1 |
| 18 | HLA-E-restricted Hantaan virus-specific CD8^(+)T cell responses enhance the control of infection in hemorrhagic fever with renal syndrome显示文摘Infection with the Hantaan virus(HTNV)may result in severe hemorrhagic fever with renal syndrome(HFRS).The functions of HLA-E-restricted CD8^(+)T lymphocytes in virus control and vaccine development have recently received increased attention.The purpose of this research is to discover HLA-E-restricted CD8^(+)T cell epitopes on HTNV as well as the features of these epitope-specific CD8^(+)T cells in HFRS patients.To anticipate HLA-Erestricted HTNV epitopes,the NetMHCpan servers were utilized.The K562/HLA-E cell binding test and the enzyme-linked immunospot assay were used to confirm epitope binding to HLA-E.The number and features of HLA-E-restricted epitope-specific CD8^(+)T lymphocytes in HFRS patients were investigated using tetramer staining,intracellular cytokine labeling,proliferation,and cytotoxicity assays.Six HTNV-derived HLA-Erestricted CD8^(+)T cell epitopes were found in this study.In mild/moderate HFRS patients,the frequency of HLA-E-restricted epitope-specific CD8^(+)T cells was greater than in severe/critical patients.CD38+HLA-DR+HLA-E-restricted CD8^(+)T cells were identified.Meanwhile,CD45RA^(+)CCR7^(-)effector memory-re-expressing CD45RA T cells with early and intermediate maturation and differentiation characteristics predominated.Notably,CD8^(+)T cells from milder HFRS patients produced more interferon-γ,interleukin-2,and granzyme B,had a stronger proliferative potential,and were inversely linked with the amount of plasma HTNV virus load.Furthermore,HLA-E-restricted epitope-specific CD8^(+)T cells demonstrated improved cytotoxic activity in vitro during the acute stage of HFRS.Taken together,the findings demonstrate the protective effects of HLA-E-restricted CD8^(+)T cells during HTNV infection,suggesting that HLA-E-targeted vaccines against HTNV might be developed for HLA-diverse populations. | Kang Tang Yusi Zhang Xinyu Li Chunmei Zhang Xiaozhou Jia Haifeng Hu Lihua Chen Ran Zhuang Yun Zhang Boquan Jin Ying Ma | 2023 | Biosafety and Health2023，5，5： | 0 |
| 19 | Visualized SERS Imaging of Single Molecule by Ag/ Black Phosphorus Nanosheets显示文摘Single-molecule detection and imaging are of great value in chemical analysis,biomarker identification and other trace detection fields.However,the localization and visualization of single molecule are still quite a challenge.Here,we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets(Ag/BP-NS)synthesized by a unique photoreduction method as a surfaceenhanced Raman scattering(SERS)sensor.Such a SERS substrate features the lowest detection limit of 10^(–20) mol L^(−1) for R6G,which is due to the three synergistic resonance enhancement of molecular resonance,photoinduced charge transfer resonance and electromagnetic resonance.We propose a polarization-mapping strategy to realize the detection and visualization of single molecule.In addition,combined with machine learning,Ag/BP-NS substrates are capable of recognition of different tumor exosomes,which is meaningful for monitoring and early warning of the cancer.This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. | Chenglong Lin Shunshun Liang Yusi Peng Li Long Yanyan Li Zhengren Huang Nguyen Viet Long Xiaoying Luo Jianjun Liu Zhiyuan Li Yong Yang | 2022 | Nano-Micro Letters2022，14，5： | 0 |
| 20 | Impact of LHC probes of SUSY and recent measurement of(g-2)_μon Z_(3)-NMSSM显示文摘It is well known that excessively heavy supersymmetric particles(sparticles)are disfavored to explain the(g−2)_(μ) anomaly,but some people overlook that moderately light sparticles are also disfavored by the LHC probes of supersymmetry.We take the Next-to-Minimal Supersymmetric Standard Model as an example to emphasize the latter point.It is found that,if the theory is required to explain the anomaly at 2σlevel and meanwhile keep consistent with the LHC results,the following lower bounds may be set:tanβ&20,|M_(1)|&275 GeV,M_(2)&300 GeV,μ&460 GeV,m_(μL)&310 GeV,and m_(μR)&350 GeV,where M_(1)and M_(2)denote gaugino masses,μrepresents the Higgsino mass,and m_(μL)and m_(μR)are the mass of Smuons with L and R denot-ing their dominant chiral component.This observation has significant impacts on dark matter(DM)physics,e.g.,the popular Z-and Higgs-funnel regions have been excluded,and the Bino-dominated neutralino DM has to co-annihilate with the Wino-dominated electroweakinos(in most cases)and/or Smuons(in few cases)to obtain the correct density.It is also inferred that these conclusions keep valid for the Minimal Supersymmetric Standard Model since the underlying physics for the bounds are the same. | Junjie Cao Fei Li Jingwei Lian Yusi Pan Di Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，9： | 0 |
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