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| 1 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Fixation of biological tissues with a naturally occurring crosslinking agent:Fixation rate and effects of pH,temperature,and initial fixative concentration显示文摘 | Sung HW Chang Y Liang IL | 2000 | J Biomed Mater Res2000，52，： | 1 |
| 3 | Stability of a biological tissue fixedwitha naturally occurring crosslinking agent (genipin)显示文摘 | Sung HW Liang IL Chen CN | 2001 | J Biomed Mater Res2001，55，： | 1 |
| 4 | Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin)显示文摘 | Sung HW Liang IL Chen CN | 2001 | Journal of Biomedical Materials Research Part A2001，55，： | 1 |
| 5 | Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin) 显示文摘 | Sung HW Liang IL Chen CN | 2001 | Journal of the Biomedical Materials Research2001，55，4： | 1 |
| 6 | Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease显示文摘 | Lu IL Mahindroo N Liang PH | 2006 | J Med Chem2006，49，17： | 1 |
| 7 | Significance of cardiactroponin I and creatine kitlase release after coronary intervention 显示文摘 | Wu CJ Liang ~IL Chiou KR | 2001 | Zhonghua Yi Xue Za Zhi!i Taipei)2001，64，6： | 1 |
| 8 | Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin)显示文摘 | Sung HW Liang IL Chen CN Huang RN Liang HF | 2001 | Journal of biomedical materials research2001，55，： | 1 |
| 9 | Purification and characterization of two antifungal chitinases extracellu- lady produced by Bacillus amyloliquefaciens V656 in a shrimp and crab shell powder medium显示文摘 | SL Wang IL Shih TW Liang Wang | 2002 | J Agric Food Chem2002，50，8： | 1 |
| 10 | Wavelet Estimation in Heteroscedastic Model Under Censored Samples显示文摘认为 heteroscedastic 回归模型 Y i = g ( x i )是+蟽 i e i , 1 鈮? i 鈮? n ,这里( x i , u i )被修理是未知的设计点, g 和 f 功能定义在上[ 0 , 1 ], e i 是独立的有平均数零的随机的错误。假定那 Y i 随机被审查,审查分发功能被知道或未知,我们讨论率强壮一致地为 g 和 f 的小浪评估者的集中分别地。另外,为 g 的小浪评估者的 asymptotic 规度被调查。关键词审查了样品 - heteroscedastic 回归模型 - 小浪评估者 - 强壮的 unform 集中率 - asymptotic 规度先生(2000 ) 题目分类 62G05 这个工作被中国(10571136 ) 和 Wonkwang 大学资助的国家自然科学基础在 2007 | Han Ying LIANG Jong IL BAEK | 2007 | Acta Mathematica Sinica,English Series2007，23，12： | 1 |
| 11 | Engineering of hollow polymeric nanosphere-supported imidazolium-based ionic liquids with enhanced antimicrobial activities显示文摘The design of stable,efficient and processable bactericidal materials represents a significant challenge for combating multidrugresistant bacteria in a variety of engineering fields.Herein,we report a facile strategy for the preparation of hollow polymeric nanosphere(HPN)-supported imidazolium-based ionic liquids(denoted as HPN-ILs)with superior antimicrobial activities.HPNILs were tailored by moderate Friedel−Crafts polymerization followed by the sequential covalent bonding of imidazole and bromoalkene.The resultant HPN-ILs have uniform hollow spherical morphology,an adequate surface area,and excellent physicochemical stability.Furthermore,they are highly active against both Gram-positive and Gram-negative bacteria and exhibit typical time/dosage-dependent antibacterial activities.The rational combination of porous HPNs and antibacterial ILs to generate an all-in-one entity may open new avenues for the design and fabrication of efficient bacteriostatic agents.Moreover,HPN-ILs have good biocompatibility and can also be loaded onto diverse matrices,and thus could extend their practical bactericidal application in the potential biomedical-active field. | Yu Zhang Shuwei Li Yixin Xu Xinyun Shi Mingxin Zhang Yingning Huang Ying Liang Yaqiong Chen Wanli Ji Jung Rae Kim Wenliang Song Deng-Guang Yu Il Kim | 2022 | Nano Research2022，15，6： | 1 |
| 12 | Does the Loss of ARID1A (BAF- 250a) Expression in Endometrial Clear Cell Carcinomas Have Any Clinicopathologic Significance? A Pilot Assessment 显示文摘 | Fadare O Renshaw IL Liang SX | 2012 | J Cancer2012，3，： | 1 |
| 13 | Detoxification of aflatoxin B1by enzymes isolated from Arnii Ilariella tabescans显示文摘 | LIU DL YAO DS LIANG IL | 1998 | Food and Chemical Toxicology1998，36，： | 1 |
| 14 | a-catulin drives metastasis by activating ILK and driving an ~y~3 integrin signaling axis 显示文摘 | Liang CH Chiu SY Hsu IL | 2012 | Cancer Res2012，73，1： | 1 |
| 15 | Stability of a biological tissue fixed with a naturally occurring crosslinking agent ( genip- in) 显示文摘 | Sung 14W Liang IL Chen CN | 2001 | J Biomed Mater Res2001，55，4： | 1 |
| 16 | Stabhty of a biological tissue fixed with a natural occurring crosslinking agent 显示文摘 | Sung HW Liang IL Chen CN | 2001 | Journal of Biomedical Baterials Research2001，55，： | 1 |
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