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| 1 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats显示文摘Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification in vitro. This study aimed to examine the effect of Radix Achyranthis Bidentatae on advanced glycation end products and on learning and memory capabilities in ovariectomized rats. Ovariectomized rats were treated with Radix Achyranthis Bidentatae alcohol extracts (containing 1.5 g/kg crude drug) or 0.1% aminoguanidine for 12 weeks and behavioral testing was performed with the Y-electrical maze. This test revealed that Radix Achyranthis Bidentatae and aminoguanidine could improve the learning and memory capabilities of ovariectomized rats. Results of competitive enzyme-linked immunosorbent assay showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine reduced the accumulation of advanced glycation end products in the frontal cortex of ovariectomized rats, while increasing content in the blood and urine. Biochemical tests showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine decreased superoxide dismutase activity in the serum and frontal cortex, and increased serum levels of glutathione peroxidase in ovariectomized rats. In addition, there was no apparent effect on malondialdehyde levels. These experimental findings indicate that Radix Achyranthis Bidentatae inhibits production of advanced glycation end products and its accumulation in brain tissue, and improves learning and memory capabilities in ovariectomized rats. These effects may be associated with an anti-oxidative action of the extract. | Yuefen Wang Ya Xu Yanshu Pan Weihong Li Wei Zhang Yang Liu Jing Jia Pengtao Li | 2013 | Neural Regeneration Research2013，8，18： | 4 |
| 3 | CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus显示文摘Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However,the mechanism by which CypA regulates M1 ubiquitination remains unknown. In this study, we reported that E3 ubiquitin ligase AIP4 promoted K48-linked ubiquitination of M1 at K102 and K104, and accelerated ubiquitin–proteasome-mediated degradation of M1. The recombinant IAV with mutant M1 (K102 R/K104 R) could not be rescued, suggesting that the ubiquitination of M1 at K102/K104 was essential for IAV replication. Furthermore, CypA inhibited AIP4-mediated M1 ubiquitination by impairing the interaction between AIP4 and M1. More importantly, both the mutations of M1 (K102 R/K104 R) and CypA inhibited the nuclear export of M1, indicating that CypA regulates the cellular localization of M1 via inhibition of AIP4-mediated M1 ubiquitination at K102 and K104, which results in the reduced replication of IAV.Collectively, our findings reveal a novel ubiquitination-based mechanism by which CypA regulates the replication of IAV. | Madina Mahesutihan Weinan Zheng Liang Cui Yun Li Pengtao Jiao Wenxian Yang Wei Liu Jing Li Wenhui Fan Limin Yang Wenjun Liu Lei Sun | 2018 | Virologica Sinica2018，33，5： | 3 |
| 4 | Efficient white light emitting diodes based on Cu-doped ZnInS/ZnS core/shell quantum dots显示文摘 | Xi Yuan Jie Hua Ruosheng Zeng Dehua Zhu Wenyu Ji Pengtao Jing Xiangdong Meng Jialong Zhao Haibo Li | 2014 | Nanotechnology2014，，43： | 2 |
| 5 | Plasmonic Ag@Oxide Nanoprisms for Enhanced Performance of Organic Solar Cells显示文摘 | Peng Du Pengtao Jing Di Li Yinghui Cao Zhenyu Liu Zaicheng Sun | 2015 | Small2015，，20： | 1 |
| 6 | Solving logistics transportation based on genetic simulated annealing algorithm 显示文摘 | WANG Pengtao LIU Yanliang WU Jing | 2008 | Journal of Computational Information Systems2008，4，2： | 1 |
| 7 | The involvement of a P38-like MAP kinase in ABA-induced and H2O2-mediated stomatal closure in Vicia faba L.显示文摘 | Jing Jiang Pengtao Wang Guoyong An Pengcheng Wang Chun-Peng Song | 2008 | Plant Cell Reports2008，，2： | 1 |
| 8 | SnO/SnO_(2) heterojunction:an alternative candidate for sensing NO_(2) with fast response at room temperature显示文摘The SnO_(2)-based family is a traditional but important gas-sensitive material.However,the requirement for high working temperature limits its practical application.Much work has been done to explore ways to improve its gas-sensing performance at room temperature(RT).For this report,SnO_(2),SnO,and SnO/SnO_(2) heterojunction was successfully synthesized by a facile hydrothermal combined with subsequent calcination.Pure SnO_(2) requires a high operating temperature(145℃),while SnO/SnO_(2) heterojunction exhibits an excellent performance for sensing NO_(2) at RT.Moreover,SnO/SnO_(2) exhibits a fast response,of 32 s,to 50 ppm NO_(2) at RT(27℃),which is much faster than that of SnO(139 s).The superior sensing properties of SnO/SnO_(2) heterojunction are attributed to the unique hierarchical structures,large number of adsorption sites,and enhanced electron transport.Our results show that SnO/SnO_(2) heterojunction can be used as a promising high-performance NO_(2) sensitive material at RT. | Pengtao WANG Wanyin GE Xiaohua JIA Jingtao HUANG Xinmeng ZHANG Jing LU | 2022 | Frontiers of Materials Science2022，16，3： | 0 |
| 9 | Ultrathin nanoporous metal-semiconductor heterojunction photoanodes for visible light hydrogen evolution显示文摘Plasmonic 金属半导体 nano 异质接面(NHJ ) 与他们的优异 photocatalytic 表演,为太阳能的有效利用提供机会。然而,科学意义和技术挑战为新产生留在合适的金属半导体 NHJ photoelectrodes 的发展灵活 optoelectronic 设备,它经常要求复杂处理。此处,我们报导综合三维(3D ) NHJ photoelectrodes 由保角地,涂层镉硫化物(CdS ) nanolayers 经由一个灵巧的电极淀积方法拍摄到 ultrathin nanoporous 黄金(NPG ) 上。NPG 的局部性的表面电浆子回声(LSPR ) 提高电子洞对产生和分离。而且,直接接触接口和 NHJ 的高传导性的框架结构增加 photogenerated 搬运人分离和运输。因此, NHJ 展览显然相对在任何一个黄金(Au ) 上扔的 CdS 提高了光电流密度和氢进化率在在可见光的照耀下面的 0 V 对 SCE (浸透的甘汞电极) 的陪衬或做氟的符号的锡氧化物(FTO ) 。而且,他们表明令人惊讶地稳定的 photoelectrochemical 氢进化(PEC -- 他) 在连续照耀的 104 s 上的活动。 | Weiqing Zhang Yunfeng Zhao Kai He Jun Luo Guoliang Li Ruirui Liu Siyu Liu Zhen Cao Pengtao Jing Yi Ding | 2018 | Nano Research2018，11，4： | 0 |
| 10 | Ln-substituted polytungstates as efficient hetergeneous catalysts for Knoevenagel condensation reaction显示文摘Three isomorphic polytungstates,CsgK_(18)H_(10){[Sm_(2)(H_(2)O)_(4)W_(4)O_(10)(AsW_(9)0_(33))3]_(2)(N(CH_(2)PO_(3))_(2))}:46.5H_(2)O(1),CS_(10)K_(9)H_(18){[Eu_(2)(H_(2)O)_(4)W_(4)O_(10)(AsW_(9)0_(33))_(3)]_(2)(N(CH_(2)PO_(3))_(2))}.41.5H_(2)O(2),Cs_(10)K_(9)H_(18){[Gd_(2)(H_(2)O)_(4)W_(4)O_(10)(AsW_(9)O_(33))_(3)]_(2)(N(CH_(2)PO_(3))_(2))}:46H_(2)O(_(3)),have been successfully synthesized and characterized by routine methods,and demonstrated excellent catalytic activities in Knoevenagel condensation reaction as heterogeneous catalysts.Notably,catalyst 1 achieved higher reaction activity than catalysts 2 and 3,where a satisfactory reaction yield(95%)and high TON value(6380)could be obtained at moderate reaction condition.In addition,in the scale-up experiment,with the help of catalyst 1,7.8g benzaldehyde and 5.7g ethyl cyanoacetate could transform into corresponding condensation product with a satisfactory yield(83%)and impressive TON value(13.883). | Baijie Xu Ruikun Zhao Zhen Jing Xinyi Ma Hui Zhao Pengtao Ma Jingping Wang Jingyang Niu | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
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