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| 1 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 2 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 3 | Identification of HBsAg-specific antibodies from a mammalian cell displayed full-length human antibody library of healthy immunized donor显示文摘肝炎 B 免疫球蛋白(HBIG ) 在肝炎 B 的管理是重要的病毒(HBV ) 感染。试图作为 HBIG 的一种选择开发 recombinant monoclonal 抗体,我们报导 HBV 表面抗原(HBsAg ) 的成功的鉴定从在哺乳动物的房间上显示的一个全身的人的抗体图书馆的特定的抗体出现。把一个生来地使免疫的施主的外部血 mononuclear 房间的全部的 RNA 用作模板,抗体全部剧目被放大。联合四方法的结扎和 Flp 调停 recombinase 的集成(Flp 在里面) 系统,我们构造了每个房间在显示了一个种仅仅抗体分子的一个哺乳动物的基于房间的、充分人的、全身的抗体显示图书馆。由屏蔽使用激活荧光的房间排序的房间图书馆(FACS ) ,八个房间克隆显示那房间表面上的 HBsAg 特定的抗体被识别。抗体基因的 DNA 顺序分析揭示了三唯一的抗体。FACS 数据显示了那荧光灯表示(FSE ) 的力量,荧光灯绑定(FSB ) 的力量和相对有约束力的能力(RBA ) 都在他们之中是不同的。这些结果由使用我们的抗体表明了那哺乳动物的显示和屏蔽站台,我们能成功地从一个使免疫的全身的抗体图书馆识别抗原特定的抗体。因此,这个平台为治疗学的抗体的开发是很有用的。 | Chang-Zheng Li Zhong-Kun Liang Zhen-Rui Chen Hai-Bo Lou Ye Zhou Zhe-Huan Zhang Fei Yu Shuwen Liu Yuanping Zhou Shuguang Wu Wenling Zheng Wanlong Tan Shibo Jiang Chen Zhou | 2012 | Cellular & Molecular Immunology2012，9，2： | 7 |
| 4 | Preparation of alumina supported on carbon nano-tubes and its application in fluoride adsorption from an aqueous solution显示文摘A novel material, alumina supported on carbon nanotubes (Al2O3/CNT), was prepared from carbon nano-tubes and A1(NO3)3. X-ray diffraction (XRD) spectra demonstrate that alumina is amorphous, and scanning electron microscope (SEM) images show that CNT and alumina are homogeneously mixed. Furthermore, the fluoride adsorption behavior on the surface of Al2O3/CNT has been investigated and compared with other adsorbents. The results indicate that Al2O3/CNT has a high adsorption capacity, with a saturation adsorption capacity of 39.4 mg/g. It is also found that the adsorption capacity of Al2O3/CNT is 3.0-4.5 times that of γ-Al2O3 while almost equal to that of IRA-410 polymeric resin at 25°C . The adsorption isotherms of fluoride on Al2O3/CNT fit the Freundlich equation well, and optimal pH ranging from 5.0 to 9.0. | WANG Shuguang LI Yanhui ZHAO Dan XU Cailu LUAN Zhaokun LIANG Ji WU Dehai | 2002 | Chinese Science Bulletin2002，47，9： | 5 |
| 5 | Age, estimated glomerular filtration rate and ejection fraction score predicts contrast-induced acute kidney injury in patients with diabetes and chronic kidney disease: insight from the TRACK-D study显示文摘 | Li Jing Li Yi Wang Xiaozeng Yang Shuguang Gao Chuanyu Zhang Zheng Yang Chengming Jing Quanming Wang Shouli Ma Yingyan Wang Zulu Liang Yanchun Han Yaling | 2014 | Chinese Medical Journal2014，，12： | 3 |
| 6 | Research of blastocyte-like structure in chicken显示文摘The chicken embryo is a classic model used to investigate embryonic development, gene expression, and tissue differentiation, and is also an important research tool in studying the animal functional genomics. The whole blastoderms of fresh unincubated eggs from White Leg-horn chickens were collected with a paper ring, mechanically broken into small pieces and cul-tured in medium. Then the small pieces would develop into blastocyte-like structures (BLS), which could be facilitated by an addition of fetal bovine serum (FBS) to the primary culture and their diameter was nearly doubled from 12 to 24 h. The additional yolk had no positive effect on the development in the first 12 h but encouraged the BLSs attaching and inner cells differentiat-ing instead in 24 h. The inner cells of the BLS showing a high alkaline-phosphatase activity similar to those in mouse embryonic stem (ES) cells and also expressing a large amount of the specific stage embryonic antigen-1 (SSEA-1) on the surface, which was known to be the char-acteristic of non-differentiated mouse and avian ES cells, could finally differentiate into nerve-like cells, fibroblast cells and so on in the medium. Leukemia inhibitory factor (LIF) facilitated the cells’ proliferation and prevented differentiation in the suspended culture of the BLSs. So we drew the conclusion that the BLS obtained from broken blastoderm can be used to amplify avian ES cells so as to initiate a new method of producing transgenic chickens. | LI Jia1, PAN Qiuzhen1, LI Junying1, HAN Hongbing1, SUN Shufeng1, YANG Jun1, XU Shuguang, TIAN Liang, LIAN Zhengxing1,2, YANG Ning1,2 & LI Ning2,3 1. College of Animal Science and Technology, China Agricultural University, Beijing 100094, China 2. Laboratory of Animal Genetics and Breeding, Ministry of Agriculture, Beijing 100094, China 3. State Key Laboratory of Agrobiotechnology, Beijing 100094, China | 2005 | Science China(Life Sciences)2005，48，5： | 2 |
| 7 | Effect of surface free energy of acetylene black powder on air electrode performance显示文摘The effects of acetylene black powder surface free energy on air electrode electrochemical performance and lifetime were studied. The acetylene black was immersed in 30% H2O2 at room temperature and the changes of functional groups and surface free energy were investigated by X-ray Photoelectron Spectroscopy (XPS) and powder contact angle (CA). The air electrode performance was characterized by the potential polarization curves and the lifetime was measured by constant-current discharge. It shows that, its surface free energy is the lowest when the acetylene black is immersed in H2O2 for 240 h. The polarization potential of the air electrode prepared by the pretreated acetylene black is 0.25 V(vs. Hg/HgO), 0.21 V lower than the air electrode with untreated acetylene black when the working current density is 100 mA·cm-1. And its lifetime is over 800 h at 80 mA·cm-1. The pretreatment of acetylene black for proper time by H2O2 is favorable for the stability of the tri-phase reaction interface of air electrode and improvement of its performance. | OU Xiuqin LIU Shuguang LIANG Guangchuan LI Ying ZHI Xiaoke HAN Bin | 2006 | Rare Metals2006，25，z1： | 1 |
| 8 | On erg- odic sum capacity of fading cognitive multiple-access and broadcast channels 显示文摘 | Zhang Rui Cui Shuguang Liang Yingchang | 2009 | IEEE Transaction on Information Theory2009，55，11： | 1 |
| 9 | On Erg- odic Sum Capacity of Fading Cognitive Multiple-Access and Broadcast Channels 显示文摘 | ZHANG Rui CUI Shuguang LIANG Yingchang | 2009 | 1EEE Transactions on Informa- tion Theory2009，55，11： | 1 |
| 10 | Abnormal Resting Brain Activity in Patients With Functional Dyspepsia Is Related to Symptom Severity显示文摘 | Fang Zeng Wei Qin Fanrong Liang Jixin Liu Yong Tang Xuguang Liu Kai Yuan Shuguang Yu Wenzhong Song Mailan Liu Lei Lan Xin Gao Yijun Liu Jie Tian | 2011 | Gastroenterology2011，，2： | 1 |
| 11 | Dynamic Re- sousece Alloceation in Cognitive Radio Networks 显示文摘 | ZHANG Rui LIANG Yingchang CUI Shuguang | 2010 | IEEE Signal Processing Magazine2010，27，3： | 1 |
| 12 | Immobi lized 1,1,3,3-tetramethylguanidine ionic liquids as the cata lyst for synthesizing propylene glycol methyl ether显示文摘 | Liang Shuguang Zhou Yinxi Liu Huizhen | 2010 | Catal Lett2010，140，： | 1 |
| 13 | 显示文摘 | Liang Guangchuan Liu Shuguang Li Changlong | 2007 | J Rare Earths2007，，： | 1 |
| 14 | Highly efficient synthesis of cyclic carbonates from CO2 and epoxides over cellulose/KI显示文摘 | Liang Shuguang Liu Huizhen Jiang Tao | | 0，，07： | 1 |
| 15 | On ergod-ic sum capacity of fading cognitive multiple-access andbroadcast channels 显示文摘 | Zhang Rui Cui Shuguang Liang Yingchang | 2009 | IEEE Transactions on Informa-tion Theory2009，55，11： | 1 |
| 16 | Dynamic Resource Allocation in Cognitive Radio Networks: A Convex Optimization Perspective 显示文摘 | ZHANG Rui LIANG Yingchang CUI Shuguang | 2010 | IEEE Signal Processing Magazine2010，27，3： | 1 |
| 17 | Values of blink reflex and electroneurography in diagnosis of facial paralysis显示文摘BACKGROUND: The electrophysiological test was mainly achieved by the reaction of nerve fiber to electrical stimulus, usually expressed by the amplitude and latency. Blink reflex and electroneurography (ENOG) are widely applied in facial paralysis, the amplitude would step down, and the latency would prolong when the facial nerve was injured. OBJECTIVE: To compare the value of blink reflex and ENOG in the diagnosis of facial paralysis (Bell's palsy). DESIGN: A controlled trial. SETTINGS: Affiliated Hospital, Chengdu University of Traditional Chinese Medicine; West China Hospital of Sichuan University; Mianyang Hospital of Traditional Chinese Medicine; Sichuan People's Hospital. PARTICIPANTS: The patients who had finished the tests of blink reflex (n =207) and ENOG (n =205) were selected from the Affiliated Hospital, Chengdu University of Traditional Chinese Medicine; West China Hospital of Sichuan University; Mianyang Hospital of Traditional Chinese Medicine; Sichuan People's Hospital from September 2001 to July 2003. After treatment for 4 weeks, the patients finished tests of blink reflex (n =207) and ENOG (n =205) were randomly divided into primary treatment group (n =68, 69), acupuncture group (n =71, 66) and comprehensive treatment group (n =68, 70), respectively. Approval was obtained from the ethic committee of hospital. METHODS: Patients in the primary treatment group and acupuncture group were treated with western medicine, acupuncture and moxibustion alone respectively, and those in the comprehensive treatment group were treated with acupuncture and moxibustion based on western medicine. The whole period of treatment was 4 weeks. The tests of blink reflex and ENOG were carried out using Japanese light and electricity MEB-2200 electromyogram/induced potential instrument for once before and after treatment respectively. The normal value of the latency period of wave R1 was within 13 ms, and the difference was 1-1.2 ms between the left and right sides. MAIN OUTCOME MEASURES: The latency of wave R1 of blink reflect and the latency and wave amplitude of ENOG on the affected and healthy sides before and after treatment were observed. RESULTS: Totally 207 and 205 patients received tests of blink reflex and ENOG, but 17 and 16 cases respectively did not finish the second measurement, finally 190 and 189 cases were involved in the analysis of results. The latencies of wave R1 on the affected side after treatment were significantly longer than those before treatment (t =-6.253, P < 0.01); The latencies of wave R1 on the normal side were in the normal range before and after treatment; The latencies of wave R1 before treatment on the affected side was significantly longer than that on the normal side (t =-5.896, P < 0.01), but there were no significant differences between the affected and normal sides after treatment (P > 0.05). It was indicated that the latencies of wave R1 on the affected side had restored normally, and the blink reflex was improved obviously after treatment. The latency of ENOG on the affected side before treatment was significantly prolonged as compared with that on the normal side (t =2.247, P < 0.01); After treatment, the difference between the affected and normal side became smaller, but remarkable significance still existed (t =10.810, P < 0.01). In spite of the obvious improvement of affected side before and after treatment, there were still significant differences (t =-8.110, P < 0.05). The wave amplitude on the affected side was decreased after treatment, which was not significantly different from that before treatment (P >0.05). CONCLUSION: After treatment of facial paralysis, blink reflect was greatly improved, there was an obvious hysteresis in the latency of ENOG. Therefore, blink reflect was better than ENOG in the early diagnosis, while ENOG was suitable for evaluating the prognosis. The ENOG examination was better than blink reflex at middle and late period. | Ying Li Fanrong Liang Shuguang Yu Zhong Zheng | 2007 | Neural Regeneration Research2007，2，12： | 0 |
| 18 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 19 | Study of Preparation and Characteristics of Pyridoxalated Polyhemoglobin显示文摘StudyofPreparationandCharacteristicsofPyridoxalated PolyhemoglobinLiangShuguang;TongMingrong;PanJilunandYuYaoting(Institutefo... | Liang Shuguang Tong Mingrong Pan Jilun and Yu Yaoting (Institute for Melcular Biology, Nankai University, 300071 Tianjin) | 1994 | Chinese Journal of Reactive Polymers1994，3，1： | 0 |
| 20 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
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