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| 1 | The theory of compression–shear coupled composite wave propagation in rock显示文摘The wave velocity analysis of rock medium is the main method used to explore the internal compositions in the crust and research seismic.In this paper,a compression–shear coupled nonlinear elastic constitutive relation is established,which is consistent with the mechanical properties of rock and mineral medium under high pressure.On this basis,numerical solutions of the wave equation and plane wave analytical solutions for the primary and secondary wave velocities are obtained.As is indicated by the comparison with the linear elastic constitutive theory,the results reflect the compression–shear coupling characteristics of the rock,including the stress path effect and the compression–shear coupling wave effect.With different parameter values,the velocity of the secondary wave changes from lower than that of the elastic shear wave,to higher than that of the elastic shear wave.The research results are expected to provide meaningful explanations for the physical mechanisms of the supershear wave and sub-Rayleigh wave,and guidance for the detection of rock and soil composition and the observation of seismic waves. | Jianhua Lu Songlin Xu Chunhe Miao Yushan Xie Liangzhu Yuan Hao Ma Meiduo Chen Pengfei Wang | 2022 | Deep Underground Science and Engineering2022，1，1： | 1 |
| 2 | Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy显示文摘Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma(HCC) via transarterial chemoembolization(TACE). However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion(LPE) stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase(LOX). The obtained LOX-loaded CaCO_(3)&hemin-stabilized LPE(LHCa-LPE) showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids(PUFAs), a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC. | Chunjie Wang Lei Zhang Zhijuan Yang Dongxu Zhao Zheng Deng Jialu Xu Yumin Wu Yu Hao Ziliang Dong Liangzhu Feng Zhuang Liu | 2024 | National Science Review2024，11，1： | 0 |
| 3 | Study on fl ame retardant ABS显示文摘Flame-retardant ABS resin was prepared by adding fl ame retardant,toughening agent and dispersing silicone oil with acrylonitrile-butadiene-styrene resin(ABS,grade 0215 A)as raw material.The results showed that in the ABS resin,fl ame retardant with tetrabromobisphenol A and antimony trioxide as the composite system(the mass ratio of 2:1)was added.When the bromine content of the system was more than 10%,the flame retardant ABS meets the requirements of UL 94 V-0.The best toughening agent for flame retardant ABS resin is ABS graft powder.When the amount of fl ame retardant ABS is 9%~19%(mass fraction)Strength of 150-200 J/m;in the same formula and operating conditions,brominated alkylene oxide as fl ame retardant prepared fl ame retardant ABS resin,the weather resistance is better than tetrabromobisphenol A as fl ame retardant The Composite expansion fl ame retardant and coated red phosphorus is an eff ective halogen-free fl ame retardant. | Xiaonan Lin Wenmin Feng Liangzhu Xu | 2017 | Materials Science(Materials Review)2017，1，1： | 0 |
| 4 | CircR-ZC3HC1 mediates MiR-384-5p/SIRT1 axis to promote neuronal autophagy and relieves ischemic stroke显示文摘Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including autophagy.This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms.Methods:Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected.Hippocampal neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro model.The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope.Cell apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2 were assessed byflow cytometry and western blotting.The binding relationships among circR-ZC3HC1,miR-384-5p,and SIRT1 were predicted and verified.Results:Low expression of circR-ZC3HC1 was found in blood samples of IS patients and OGD-treated neurons.Overexpressed circR-ZC3HC1 or inhibited miR-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-MA treatment.Mechanistically,circR-ZC3HC1 targeted miR-384-5p to mediate SIRT1 expression.miR-384-5p overexpression or SIRT1 knockdown in the presence of circR-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced apoptosis.Conclusion:Collectively,circR-ZC3HC1 promoted neuronal autophagy to attenuate IS via miR-384-5p/SIRT1 axis. | MIN SHEN XIAOMAN XU GUANGLING SUN LIANGZHU WANG TAO YING HANG SU WEI WANG QINGHUA CAO ZHEZHE SUN | 2024 | BIOCELL2024，48，3： | 0 |
| 5 | Wide grain 4,encoding an alpha-tubulin,regulates grain size by affecting cell expansion in rice显示文摘Rice is one of the three most important food crops in the world.Increasing rice yield is an effective way to ensure food security.Grain size is a key factor affecting rice yield;however,the genetic and molecular mechanisms regulating grain size have not been fully investigated.In this study,we identified a rice mutant,wide grain 4-D(wg4-D),that exhibited a significant increase in grain width and a decrease in grain length.Histological analysis demonstrated that WG4 affects cell expansion thereby regulating grain size.MutMap-based gene mapping and complementary transgenic experiments revealed that WG4 encodes an alpha-tubulin,OsTubA1.A SNP mutation in WG4 affected the arrangement of cortical microtubules and caused a wide-grain phenotype.WG4 is located in nuclei and cytoplasm and expressed in various tissues.Our results provide insights into the function of tubulin in rice and identifies novel targets the regulation of grain size in crop breeding. | Yi Liu Lianan Guo Guoli Qu Yang Xiang Xu Zhao Hua Yuan Ting Li Liangzhu Kang Shiwen Tang Bin Tu Bingtian Ma Yuping Wang Shigui Li Weilan Chen Peng Qin | 2023 | The Crop Journal2023，11，6： | 0 |
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