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| 1 | O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),emerged in late 2019 and has since caused a pandemic.Although there have been extensive studies worldwide,our understanding of this newly emerged pathogen is far from sufficient.The pathogenesis of the SARS-CoV-2 infection is not fully understood,although a“two-stage”hypothesis was proposed in our previous study. | Wenmin Tian Delin Li Nan Zhang Guijie Bai Kai Yuan Haixia Xiao Feng Gao Yang Chen Catherine C.L.Wong George Fu Gao | 2021 | Cell Research2021，31，10： | 9 |
| 2 | Construction of an artificial intelligence system in dermatology: effectiveness and consideration of Chinese Skin Image Database (CSID)显示文摘After more than 60 years of development,artificial intelligence(AI)has been widely used in various fields.Especially in recent years,with the development of deep learning,AI has made many remarkable achievements in the medical field.Dermatology,as a clinical discipline with morphology as its main feature,is particularly suitable for the development of AI.The rapid development of skin imaging technology has helped dermatologists to assist in the diagnosis of diseases and has greatly improved the accuracy of diagnosis.Skin imaging data have natural big data attributes,which is important for AI research.The establishment of the Chinese Skin Image Database(CSID)has solved many problems such as isolated data islands and inconsistent data quality.Based on the CSID,many pioneering achievements have been made in the research and development of AI-assisted decision-making software,the establishment of expert organizations,personnel training,scientific research,and so on.At present,there are still many problems with AI in the field of dermatology,such as clinical validation,medical device licensing,interdisciplinary,and standard formulation,which urgently need to be solved by joint efforts of all parties. | Chengxu Li Wenmin Fei Yang Han Xiaoli Ning Ziyi Wang Keke Li Ke Xue Jingkai Xu Ruixing Yu Rusong Meng Feng Xu Weimin Ma Yong Cui | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 3 | Resistance index and browning mechanism of apple peel under high temperature stress显示文摘Apples are one of the most important economic crops worldwide.Because of global warming and an aggravation of environmental,abnormally high temperatures occur frequently in fruit-growing season and seriously affect normal fruit growth and reduce fruit quality and yield.We took five-year-old Ruixue’(Qinfu 1×Pink Lady;CNA20151469.1) fruits as test materials,and the ambient temperature during fruit development was monitored.The results showed that during the fruit-growing season,especially during the rapid growth stage (July to August),the maximum daily temperature exceeded 30℃ and lasted for more than 40 days.To determine the effects of high temperature stress on the apple fruit resistance,we treated expanding,veraison,and maturity-period fruits at different temperatures.It was found that the fruits of the expanding period showed strong resistance to high temperature stress,whereas during veraison and maturity,fruit resistance to high temperature stress decreased,and the fruit peel browning phenotype appeared.Meanwhile,the content of malonaldehyde (MDA),hydrogen peroxide (H_(2)O_(2)),and superoxide anion (O._(2)^(-)) in the peel gradually increased with increasing temperature.The content of total phenols,flavanol,and flavonoids in the peel decreased substantially at 45℃.Moreover,it was found that polyphenol oxidase gene (MdPPO1) was most sensitive to high temperature stress in apple.Furthermore,transient and stable MdPPO1 overexpression significantly promoted peel browning.The transgenic materials were more sensitive to high temperatures,and browning was more severe compared to non-genetically modified organism (WT).Stable MdPPO1 knockout calli obtained via clustered regularly interspersed short palindromic repeats (CRISPR/Cas9) gene knockout technology reduced the browning phenotype,and the resultant fruits were not sensitive to the effects of high temperature stress.Thus,MdPPO1 expression may be a key factor of high temperature-related changes observed in the browning phenotype that provides a scientific theoretical basis for the selection of high temperature-resistant varieties and apple cultivation and management in the future. | Hui Wang Shuhui Zhang Zidun Wang Dongmei Li Leiyu Yan Yifeng Feng Xiaojie Liu Rongxin Chen Wenmin Fan Lulong Sun Zhengyang Zhao | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 4 | Study on fl ame retardant ABS显示文摘Flame-retardant ABS resin was prepared by adding fl ame retardant,toughening agent and dispersing silicone oil with acrylonitrile-butadiene-styrene resin(ABS,grade 0215 A)as raw material.The results showed that in the ABS resin,fl ame retardant with tetrabromobisphenol A and antimony trioxide as the composite system(the mass ratio of 2:1)was added.When the bromine content of the system was more than 10%,the flame retardant ABS meets the requirements of UL 94 V-0.The best toughening agent for flame retardant ABS resin is ABS graft powder.When the amount of fl ame retardant ABS is 9%~19%(mass fraction)Strength of 150-200 J/m;in the same formula and operating conditions,brominated alkylene oxide as fl ame retardant prepared fl ame retardant ABS resin,the weather resistance is better than tetrabromobisphenol A as fl ame retardant The Composite expansion fl ame retardant and coated red phosphorus is an eff ective halogen-free fl ame retardant. | Xiaonan Lin Wenmin Feng Liangzhu Xu | 2017 | Materials Science(Materials Review)2017，1，1： | 0 |
| 5 | Synthesis of 2-trifluoromethylquinolines through rhodium-catalysed redox-neutral[3+3]annulation between anilines and CF_(3)-ynones using traceless directing groups显示文摘Rhodium-catalysed regioselective redox-neutral[3+3]-cycloaddition of anilines with CF_(3)-ynones was achieved via a traceless directing group strategy.A variety of substituted 2-trifluromethylquinoline compounds were obtained in good to excellent yields,which exhibited favorable blue emission properties. | Haichao Huang Hailong Wang Chao Gong Zhenjing Zhuang Wenmin Feng Si-Hai Wu Lianhui Wang | 2022 | Organic Chemistry Frontiers2022，9，2： | 0 |
| 6 | Modulated Quasi-plane Tunneling Current显示文摘A new tutmeling junction can be formed by an insulator layer inserting into a quantum well, and in the quantum well, a quasi-plane tunneling current can be formed by applying a tunneling voltage. If a P-N junction is grown on the quantum well, the tunneling current can be modulated by a P-N junction-bias voltage. The modulated quasi-plane tunneling current is not only related to the bias voltage, but also to the depth of the quantum well. It is analyzed that the P-N junction-bias voltage how to affect the tunneling current and a method of measuring the depth of the quantum well is presented. | Peng Feng Wenmin Dai (China Center of Advanced Science & Technology (World Laboratory ) P.O. Box 8730, Beijing 100080, China)(Applied Science School, University of Science and Technology Beijing, Beijing 100083, China) | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，1： | 0 |
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