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| 1 | Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo显示文摘肺癌症是在整个世界的癌症相关的死亡的领先的原因。在最近的年里,肺的腺癌在频率超过了有鳞的房间癌并且是在许多国家的肺癌症的占优势的形式。流行病学的调查显示出在消费和死亡从许多癌症评估的大蒜(瞀或蒜之类 sativum ) 之间的一种反的关系。Diallyl trisulfide (DATS ) 是导出大蒜的混合物之一(是也知道:organosulfer 混合物,振荡) 。DATS 能导致 apoptosis 并且禁止许多癌症细胞线的生长。我们的学习证明 DATS 导致的 apoptotic 事件是通过导致了 Bax/Bcl-2 和 caspase-3, -8, 和 -9 的活动的比率的起来规定的 anti-apoptotic Bcl-2 的重要减少的线粒体依赖者 caspase 串联。最后, DATS 导致了 apoptosis 并且在一个集中依赖者和时间依赖者举止禁止了增长。由与 A549 异种皮移植建立女 BALB/c 裸体老鼠的一个动物模特儿,没有与控制组相比引起重量损失或任何另外的副作用,而且,我们在裸体老鼠发现 DATS 的那口头的 gavage A549 异种皮移植的显著地延迟的生长。在 vitro 并且在 vivo 的所有证据建议 DATS 能是理想的反癌症药。 | Wenjun Li Hui Tian Lin Li Shuhai Li Weiming Yue Zhitao Chen Lei Qi Wensi Hu Yingchao Zhu Bin Hao Cun Gao Libo Si Fei Gao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 2 | Novel resonant pressure sensor based on piezoresistive detection and symmetrical in-plane mode vibration显示文摘In this paper,a novel resonant pressure sensor is developed based on electrostatic excitation and piezoresistive detection.The measured pressure applied to the diaphragm will cause the resonant frequency shift of the resonator.The working mode stress–frequency theory of a double-ended tuning fork with an enhanced coupling beam is proposed,which is compatible with the simulation and experiment.A unique piezoresistive detection method based on small axially deformed beams with a resonant status is proposed,and other adjacent mode outputs are easily shielded.According to the structure design,high-vacuum wafer-level packaging with different doping in the anodic bonding interface is fabricated to ensure the high quality of the resonator.The pressure sensor chip is fabricated by dry/wet etching,high-temperature silicon bonding,ion implantation,and wafer-level anodic bonding.The results show that the fabricated sensor has a measuring sensitivity of~19 Hz/kPa and a nonlinearity of 0.02%full scale in the pressure range of 0–200 kPa at a full temperature range of−40 to 80°C.The sensor also shows a good quality factor>25,000,which demonstrates the good vacuum performance.Thus,the feasibility of the design is a commendable solution for high-accuracy pressure measurements. | Xiangguang Han Qi Mao Libo Zhao Xuejiao Li Li Wang Ping Yang Dejiang Lu Yonglu Wang Xin Yan Songli Wang Nan Zhu Zhuangde Jiang | 2020 | Microsystems & Nanoengineering2020，6，1： | 4 |
| 3 | The enhanced protective effects of salvianic acid A: A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier显示文摘Ischemic stroke is the leading cause of disability and death worldwide. Currently, the only proven treatment for ischemic stroke is restoring the cerebral blood supply. In addition, some of the tissue is damaged during the subsequent reperfusion because of the overproduction of reactive oxygen species (ROS). Furthermore, antioxidant therapies have shown promise in preclinical studies for the treatment of ischemia-reperfusion injury. However, their therapeutic efficacy has been limited because of their low bioavailability in brain. To resolve this issue, we synthesized ROS-responsive, fan-shaped dendrimer nanoparticles (NPs) and conjugated them with a blood-brain barrier (BBB)-targeting peptide, COG1410, and salvianic acid A (SA), which is an effective antioxidant in ischemic stroke. The BBB targeting peptide acts as a ligand of the nanocarrier system and penetrates the BBB through the endocytosis of the ligand receptor. The results showed that T-SA-NPs not only target and accumulate in the infarct area, they also reduce over 2 times of the infarct area and reverse the behavioral deficits in MCAO mice, which illustrates that these NPs have an effective therapeutic effect on the ischemic stroke. In addition, these NPs had no toxicity in any organs of the body. Importantly, the present study provides an alternative strategy for delivering antioxidants to the brain and achieving targeted therapy of ischemic stroke. | Yaru Li Xiaojie Zhang Zhifeng Qi Xueling Guo Xiaopeng Liu Wenjuan Shi Yang Liu Libo Du | 2020 | Nano Research2020，13，10： | 4 |
| 4 | 3D bioprinting of a biomimetic meniscal scaffold for application in tissue engineering显示文摘Appropriate biomimetic scaffolds created via 3D bioprinting are promising methods for treating damaged menisci.However,given the unique anatomical structure and complex stress environment of the meniscus,many studies have adopted various techniques to take full advantage of different materials,such as the printing combined with infusion,or electrospining,to chase the biomimetic meniscus,which makes the process complicated to some extent.Some researchers have tried to tackle the challenges only by 3D biopringting,while its alternative materials and models have been constrained.In this study,based on a multilayer biomimetic strategy,we optimized the preparation of meniscus-derived bioink,gelatin methacrylate(GelMA)/meniscal extracellular matrix(MECM),to take printability and cytocompatibility into account together.Subsequently,a customized 3D bioprinting system featuring a dual nozzle+multitemperature printing was used to integrate the advantages of polycaprolactone(PCL)and meniscal fibrocartilage chondrocytes(MFCs)-laden GelMA/MECM bioink to complete the biomimetic meniscal scaffold,which had the best biomimetic features in terms of morphology and components.Furthermore,cell viability,mechanics,biodegradation and tissue formation in vivo were performed to ensure that the scaffold had sufficient feasibility and functionality,thereby providing a reliable basis for its application in tissue engineering. | Zhou Jian Tian Zhuang Tian Qinyu Peng Liqing Li Kun Luo Xujiang Wang Diaodiao Yang Zhen Jiang Shuangpeng Sui Xiang Huang Jingxiang Liu Shuyun Hao Libo Tang Peifu Yao Qi Guo Quanyi | 2021 | Bioactive Materials2021，6，6： | 3 |
| 5 | Down-regulation of MTA1 protein leads to the inhibition of migration, invasion, and angiogenesis of non-small-cell lung cancer cell line显示文摘联系转移的蛋白质 1 (MTA1 ) 高表示在许多人的好攻击的肿瘤被检测了并且在象侵略,转移,和 angiogenesis 那样的恶意的生物行为起重要作用。然而,在调整 non-small-cell 肺癌症(NSCLC ) 的恶意的行为的 MTA1 蛋白质的特定的角色和机制房间仍然保持不清楚。阐明 MTA1 蛋白质的详细函数,我们下面调整在由在 vitro 的 RNA 干扰(RNAi ) 的 NSCLC 房间线的 MTA1 蛋白质表达式,并且发现 MTA1 蛋白质的下面规定显著地禁止了 95D 房间的移植和侵略潜力。进一步的研究表明 MTA1 蛋白质的下面规定显著地减少了矩阵 metalloproteinase-9 的活动,它能是为 95D 房间移植和侵略的抑制负责的机制。另外,试管形成试金证明 MTA1-siRNA 95D 房间的调节媒介导致的完全的试管的数字比 95D 房间的显著地小。这些调查结果证明那 MTA1 蛋白质在调整 95D 房间的迁居,侵略,和 angiogenesis 潜力起重要作用,由 RNAi 建议那条 MTA1 蛋白质下面规定可能是一条新奇治疗学的途径禁止 NSCLC 的前进。 | Shuhai Li Hui Tian Weiming Yue Lin Li Cun Gao Libo Si Wenjun Li Wensi Hu Lei Qi Ming Lu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 2 |
| 6 | Virological and sero- logical study of human infection with swine influenza A H1N1 virus in China显示文摘 | Zu Rongqiang Dong Libo Qi Xian | 2013 | Virology2013，446，12： | 1 |
| 7 | Construction of hierarchically porous metal-organic framework particle by a facile MOF-template strategy显示文摘Increasing the mass diffusion efficiency is a major challenge in the realm of metal-organic frameworks(MOFs).Construction of hierarchically porous,typically microporous MOF adsorbents or catalysts is crucial for enhancing both mass transfer and molecular accessibility.Many strategies have been proposed for the synthesis of hierarchically porous MOFs(HP-MOFs),with some striking results.In this paper,we proposed a facile and versatile strategy,termed the MOF-Template strategy,for fabricating hierarchical pores in MOF particle.The highly controlled crystalline sizes and morphologies of the unstable Cu-MOFs Cu_(3)(BTC)_(2) and Cu(Qc)_(2) have been exploited in their utilization as sacrificial agents by uniformly dispersing them during the shaping process of ZIF-8.Through a facile treatment with alkaline solution,tunable mesopores and macropores could be easily introduced in the shaped ZIF-8 spheres.This strategy could effectively improve the adsorption kinetics and separation productivity of MOF materials while maintaining high mechanical stability,offering promising prospects for industrial application. | Tianhao Lan Qi Wang Chunyu Lu Jianhui Li Jinlong Li Yang Chen Libo Li Jiangfeng Yang Jinping Li | 2023 | Particuology2023，，3： | 1 |
| 8 | Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells显示文摘 | Shujun Zhang Jiping Qi Libo Sun Binglin Cheng Shangha Pan Min Zhou Xueying Sun | 2009 | Molecular Biology Reports2009，，4： | 1 |
| 9 | In-Fiber Thermally Diffused Coupler and Fiber Bragg Grating Inscribed in Twin-Core Fiber for Sensitivity-Enhanced Vector Bending Sensing显示文摘A vector bending fiber sensor based on core-by-core inscribed fiber Bragg gratings in a twin-core fiber has been proposed and experimentally demonstrated.An in-fiber integrated vector bending sensor is realized by using the thermal diffusion technique to fabricate the coupler.The characteristics of the coupler fabricated by thermal diffusion are simulated and experimented.By inscribing fiber Bragg gratings with different reflection wavelengths in the two cores of a symmetrical twin-core fiber,the curvature sensitivity can be enhanced by tracking the wavelength difference between the fiber Bragg gratings of the two cores.The measured bending sensitivity of the fiber Bragg grating ranges from–161.6 pm/m^(−1) to+165.5 pm/m^(−1).The differential sensitivity of the two cores is twice that of a conventional single grating,and the temperature-induced crosstalk is also reduced.The bending sensor proposed in this paper has the advantages of high integration,enhancing the sensitivity and two-dimensional orientation recognizability,and reducing temperature crosstalk,which can be a promising candidate for structural health monitoring or wearable artificial electronics applications. | Lingzhi MENG Hongye WANG Qi XIA Tingting YUAN Xiaotong ZHANG Libo YUAN | 2023 | Photonic Sensors2023，13，3： | 0 |
| 10 | Antarctic krill antioxidant peptides show inferior IgE-binding ability and RBL-2H3 cell degranulation显示文摘Enzymatic hydrolysis,isolation,and purification might make a great deal of difference in antioxidant activity and antigenicity of peptide components.This study aimed to isolate and purify antioxidant peptide components from Antarctic krill and evaluate their allergenicity of them.Electron paramagnetic resonance(EPR)spectroscopy results indicated 3-10 kDa Antarctic krill hydrolysates(AKHs)had higher DPPH and·OH radical scavenging rates.And the second component(N2-2)purified 3-10 kDa hydrolysate showed better ability to scavenge DPPH and·OH radicals(P<0.05),which were(47.43±2.18)%and(34.33±1.25)%,respectively.Additionally,indirect-ELISA results revealed that N2-1 had a weaker ability to bind specific IgE and that N2-2 had a lower binding capability to specific IgG1(P<0.05).And N2-2 had a higher EC50 value of(5.29±0.95)ng/mL(P<0.05)in cell degranulation assay,which was about 13.80 times that of Antarctic krill.Therefore,N2-2 might be the potential source of the antioxidant peptides with lower allergenicity. | Jie Ding Chunyan Zhu Pengfei Jiang Libo Qi Na Sun Songyi Lin | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 11 | Focal Mechanism Solution of the 2011 M_S4.8 Anqing Earthquake Determined from the CAP Method显示文摘In this article, we have inverted local broadband waveform data to determine the focal mechanism of the 2011 MS4.8 Anqing earthquake. Our results show that the best double couple solution of the MS4.8 event is 16°, 74° and 120° for strike, dip and rake angles of one nodal plane respectively, and 131°, 33°, 30° for the other nodal plane. The estimated focal depth is about 3km. Both strikes of the two nodal planes differ significantly to the strike of Susong-Zongyang fault, along which seismic activity has been at a low level since the Late Quaternary. This implies that this earthquake may not have occurred on the Susong-Zongyang fault, and we infer that a buried fault with strike of NNE may be the seismogenic structure of this event. | Hong Dequan Wang Xingzhou Han Libo Qi Hao Zhang Bing | 2012 | Earthquake Research in China2012，26，2： | 0 |
| 12 | Measurement of interacting quantum phases:A band mapping scheme显示文摘Band mapping is widely used in various scenarios of cold atom physics to measure the quasi-momentum distribution and band population.However,conventional methods fail in strongly interacting systems.Here we propose and experimentally realize a novel scheme of band mapping that can accurately measure the quasi-momentum of interacting manybody systems.Through an anisotropic control in turning down the threedimensional optical lattice,we can eliminate the effect of interactions on the band mapping process.Then,based on a precise measurement of the quasi-momentum distribution,we introduce the incoherent fraction as a physical quantity that can quantify the degree of incoherence of quantum many-body states.This method enables precise measurement of processes such as the superfluid to Mott insulator phase transition.Additionally,by analyzing the spatial correlation derived from the quasi-momentum of superfluid-Mott insulator phase transitions,we obtain results consistent with the incoherent fraction.Our scheme broadens the scope of band mapping and provides a method for studying quantum many-body problems. | Qi Huang Zijie Zhu Yifei Wang Libo Liang Qinpei Zheng Xuzong Chen | 2023 | Frontiers of physics2023，18，5： | 0 |
| 13 | Noninvasive fluid bubble detection based on capacitive micromachined ultrasonic transducers显示文摘Ultrasonic fluid bubble detection is important in industrial controls,aerospace systems and clinical medicine because it can prevent fatal mechanical failures and threats to life.However,current ultrasonic technologies for bubble detection are based on conventional bulk PZT-based transducers,which suffer from large size,high power consumption and poor integration with ICs and thus are unable to implement real-time and long-term monitoring in tight physical spaces,such as in extracorporeal membrane oxygenation(ECMO)systems and dialysis machines or hydraulic systems in aircraft.This work highlights the prospect of capacitive micromachined ultrasonic transducers(CMUTs)in the aforementioned application situations based on the mechanism of received voltage variation caused by bubble-induced acoustic energy attenuation.The corresponding theories are established and well validated using finite element simulations.The fluid bubbles inside a pipe with a diameter as small as 8 mm are successfully measured using our fabricated CMUT chips with a resonant frequency of 1.1 MHz.The received voltage variation increases significantly with increasing bubble radii in the range of 0.5–2.5 mm.Further studies show that other factors,such as bubble positions,flow velocities,fluid medium types,pipe thicknesses and diameters,have negligible effects on fluid bubble measurement,demonstrating the feasibility and robustness of the CMUT-based ultrasonic bubble detection technique. | Jiawei Yuan Zhikang Li Qi Ma Jie Li Zixuan Li Yihe Zhao Shaohui Qin Xuan Shi Libo Zhao Ping Yang Guoxi Luo Xiaozhang Wang Kwok Siong Teh Zhuangde Jiang | 2023 | Microsystems & Nanoengineering2023，9，1： | 0 |
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