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| 1 | Long-term persistence of polychlorinated dibenzo- p -dioxins and dibenzofurans in air, soil and sediment around an abandoned pentachlorophenol factory in China显示文摘 | Cheng Li Minghui Zheng Bing Zhang Lirong Gao Lidan Liu Xin Zhou Xiaodong Ma Ke Xiao | 2011 | Environmental Pollution2011，，： | 1 |
| 2 | Genome-wide identification and analysis of late embryogenesis abundant (LEA) genes in Prunus mume显示文摘 | Dongliang Du Qixiang Zhang Tangren Cheng Huitang Pan Weiru Yang Lidan Sun | 2013 | Molecular Biology Reports2013，，2： | 1 |
| 3 | Long-term persistence of polychlorinated dibenzo- p -dioxins and dibenzofurans in air, soil and sediment around an abandoned pentachlorophenol factory in China显示文摘 | Cheng Li Minghui Zheng Bing Zhang Lirong Gao Lidan Liu Xin Zhou Xiaodong Ma Ke Xiao | 2011 | Environmental Pollution2011，，： | 1 |
| 4 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 5 | The genomics of ornamental plants: current status and opportunities显示文摘With the rapid development of sequencing technologies,followed by the reduction of sequencing cost,numerous ornamental plants have been sequenced,resulting in their genomic studies shifting from gene cloning and marker development to whole genome profiling.A profound understanding of genome structure and function at the whole genome level can not only help to modify ornamental traits,such as fragrance,color and flower shape,through genetic engineering,but also infer the genetic relationship and evolutionary history of ornamental plants via comparative genomics analysis.In this paper,we review the current situation of sequencing strategies and the application of genomics to study the origin and evolution of ornamental plants.We highlight challenges of ornamental plant genomic research.The use of cutting-edge technologies,such as genomics,gene editing and molecular design polymerization breeding,can facilitate our understanding of genetic regulation mechanisms and the germplasm innovation of important traits in ornamental plants.The results can be expected to significantly increase the breeding efficiency of ornamental plants. | Mingyu Li Zhenying Wen Juan Meng Tangren Cheng Qixiang Zhang Lidan Sun | 2022 | Ornamental Plant Research2022，2，1： | 0 |
| 6 | How to accurately extract large-scale urban land?Establishment of an improved fully convolutional neural network model显示文摘Realizing accurate perception of urban boundary changes is conducive to the formulation of regional development planning and researches of urban sustainable development.In this paper,an improved fully convolution neural network was provided for perceiving large-scale urban change,by modifying network structure and updating network strategy to extract richer feature information,and to meet the requirement of urban construction land extraction under the background of large-scale low-resolution image.This paper takes the Yangtze River Economic Belt of China as an empirical object to verify the practicability of the network,the results show the extraction results of the improved fully convolutional neural network model reached a precision of kappa coefficient of 0.88,which is better than traditional fully convolutional neural networks,it performs well in the construction land extraction at the scale of small and medium-sized cities. | Boling YIN Dongjie GUAN Yuxiang ZHANG He XIAO Lidan CHENG Jiameng CAO Xiangyuan SU | 2022 | Frontiers of Earth Science2022，16，4： | 0 |
| 7 | Identification of the PmWEEP locus controlling weeping traits in Prunus mume through an integrated genome-wide association study and quantitative trait locus mapping显示文摘Weeping Prunus mume(mei)has long been cultivated in East Asia for its specific ornamental value.However,little is known about the regulatory mechanism of the weeping trait in mei,which limits molecular breeding for the improvement of weeping-type cultivars.Here,we quantified the weeping trait in mei using nested phenotyping of 214 accessions and 342 F 1 hybrids.Two major associated loci were identified from the genome-wide association study(GWAS),which was conducted using 3,014,409 single nucleotide polymorphisms(SNPs)derived from resequencing,and 8 QTLs and 55 epistatic loci were identified from QTL mapping using 7,545 specific lengths amplified fragment(SLAF)markers.Notably,an overlapping PmWEEP major QTL was fine mapped within a 0.29 Mb region on chromosome 7(Pa7),and a core SNP locus closely associated with the weeping trait was screened and validated.Furthermore,a total of 22 genes in the PmWEEP QTL region were expressed in weeping or upright mei based on RNA-seq analysis.Among them,only a novel gene(Pm024213)containing a thioredoxin(Trx)domain was found to be close to the core SNP and specifically expressed in buds and branches of weeping mei.Co-expression analysis of Pm024213 showed that most of the related genes were involved in auxin and lignin biosynthesis.These findings provide insights into the regulatory mechanism of the weeping trait and effective molecular markers for molecular-assisted breeding in Prunus mume. | Xiaokang Zhuo Tangchun Zheng Suzhen Li Zhiyong Zhang Man Zhang Yichi Zhang Sagheer Ahmad Lidan Sun Jia Wang Tangren Cheng Qixiang Zhang | 2021 | Horticulture Research2021，8，1： | 0 |
| 8 | BULKED SEGREGANT RNA SEQUENCING(BSR-SEQ)IDENTIFIES A NOVEL ALLELE ASSOCIATED WITH WEEPING TRAITS IN PRUNUS MUME显示文摘Weeping species are used both as ornamental plants and for breeding dwarf plant types.However,exploration of casual genes controlling weeping traits is rather limited.Here,we identified individuals with contrasting phenotypes from an Fx bi-parental mapping population of Prunus mume which was developed from a cross between the upright cultivar/Liuban,and the weeping cultivar'Fentai Chuizhi'.Bulked segregant RNA sequencing was used and five QTLs on chromosome 7 were identified.The Pm024074(PmilGT72B3)allele,belonging to the UDP-glycosyltransferase superfamily containing the coniferyl-alcohol glucosyltransferase domain,was identified in a genomic region overlapping with a previously identified QTL;and had a synonymous transition of T66(upright)to C(weeping)in the coding sequence and a 470-bp deletion in the promoter region.Pm024074 had exceptionally high expression in buds and stems of weeping P.mume.Weighted correlation network analysis indicates that genes neighboring Pm024074 were significantly associated with plant architecture.In addition,a reliable single nucleotide polymorphism marker was developed based on the variation in the Pm024074 gene,providing precise marker-assisted breeding for weeping traits.This study provides insights into the genetic mechanism governing the weeping trait in P.mume,and indicates potential applications for the manipulation of tree architecture. | Xiaokang ZHUO Tangchun ZHENG Zhiyong ZHANG Suzhen LI Yichi ZHANG Lidan SUN Weiru YANG Jia WANG Tangren CHENG Qixiang ZHANG | 2021 | Frontiers of Agricultural Science and Engineering2021，8，2： | 0 |
| 9 | Mapping the genetic architecture of developmental modularity in ornamental plants显示文摘Developmental modularity,i.e.,coherent organization and function of developmentally related traits,is an emergent property of organismic development and evolution.However,knowledge about how modular variation and evolution are driven genetically is still limited.Here,using ornamental plants as an example,we propose a computational framework to map,visualize and annotate the genetic architecture of trait modularity by integrating modularity theory into system mapping,a statistical model for multifaceted genetic mapping of complex traits.A developmental module can be viewed as an ecosystem,in which the constituting components compete for space and resources or cooperate symbiotically to organize its function and behavior.This interactive process is quantified by mathematical models and evolutionarily interpreted by game theory.The proposed framework can test whether and how genes regulate the coordination of different but interconnected traits through their competition or cooperation to downstream developmental modularity. | Zhenying Wen Libo Jiang Mingyu Li Ang Dong Meixia Ye Juan Meng Ping Li Tangren Cheng Qixiang Zhang Lidan Sun | 2021 | Ornamental Plant Research2021，1，1： | 0 |
| 10 | Laser capture microdissection for biomedical research: towards high-throughput, multi-omics, and single-cell resolution显示文摘Spatial omics technologies have become powerful methods to provide valuable insights into cells and tissues within a complex context,significantly enhancing our understanding of the intricate and multifaceted biological system.With an increasing focus on spatial heterogeneity,there is a growing need for unbiased,spatially resolved omics technologies.Laser capture microdissection(LCM)is a cutting-edge method for acquiring spatial information that can quickly collect regions of interest(ROIs)from heterogeneous tissues,with resolutions ranging from single cells to cell populations.Thus,LCM has been widely used for studying the cellular and molecular mechanisms of diseases.This review focuses on the differences among four types of commonly used LCM technologies and their applications in omics and disease research.Key attributes of application cases are also highlighted,such as throughput and spatial resolution.In addition,we comprehensively discuss the existing challenges and the great potential of LCM in biomedical research,disease diagnosis,and targeted therapy from the perspective of high-throughput,multi-omics,and single-cell resolution. | Wenbo Guo Yining Hu Jingyang Qian Lidan Zhu Junyun Cheng Jie Liao Xiaohui Fan | 2023 | Journal of Genetics and Genomics2023，50，9： | 0 |
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