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| 1 | Opportunities and challenges of the Sponge City construction related to urban water issues in China显示文摘Waterlogging is one of the major water issues in most cities of China and directly restricts their urbanization processes.The construction of Sponge City is an effective approach to solving the urban water issues,particularly for the waterlogging.In this study,both the urban issues emerged at the stage of rapid urbanization in China and the demands as well as problems of Sponge City construction related with the water issues were investigated,and the opportunities and challenges for the Sponge City construction in the future were also proposed.It was found that the current stormwater management focused on the construction of gray infrastructures(e.g.,drainage network and water tank) based on the fast discharge idea,which was costly and hard to catch up with the rapid expansion of city and its impervious surface,while green infrastructures(e.g.,river,lake and wetland)were ignored.Moreover,the current construction of Sponge City was still limited to low impacted development(LID) approach which was concentrated on source control measures without consideration of the critical functions of surrounding landscapes(i.e.,mountain,river,wetland,forest,farmland and lake),while application of the integrated urban water system approach and its supported technologies including municipal engineering,urban hydrology,environmental science,social science and ecoscape were relatively weak and needed to be improved.Besides,the lack of special Sponge City plan and demonstration area was also a considerable problem.In this paper,some perspectives on Good Sponge City Construction were proposed such as the point that idea of urban plan and construction should conform to the integral and systematic view of sustainable urban development.Therefore,both the basic theoretical research and the basic infrastructure construction such as monitoring system,drainage facility and demonstration area should be strengthened,meanwhile,the reformation and innovation in the urban water management system and the education system should also be urgently performed.The study was expected to provide a deeper thinking for the current Sponge City construction in China and to give some of suggestions for the future directions to urban plan and construction,as well as urban hydrology discipline. | XIA Jun ZHANG YongYong XIONG LiHua HE Shan WANG LongFeng YU ZhongBo | 2017 | Science China Earth Sciences2017，60，4： | 65 |
| 2 | African Swine Fever Virus MGF360-12L Inhibits Type Ⅰ Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway显示文摘African swine fever(ASF)is an infectious transboundary disease of domestic pigs and wild boar and spreading throughout Eurasia.There is no vaccine and treatment available.Complex immune escape strategies of African swine fever virus(ASFV)are crucial factors affecting immune prevention and vaccine development.MGF360 genes have been implicated in the modulation of the IFN-Ⅰresponse.The molecular mechanisms contributing to innate immunity are poorly understood.In this study,we demonstrated that ASFV MGF360-12 L(MGF360 families 12 L protein)significantly inhibited the mRNA transcription and promoter activity of IFN-βand NF-κB,accompanied by decreases of IRF3,STING,TBK1,ISG54,ISG56 and AP-1 m RNA transcription.Also,MGF360-12 L might suppress the nuclear localization of p50 and p65 mediated by classical nuclear localization signal(NLS).Additionally,MGF360-12 L could interact with KPNA2,KPNA3,and KPNA4,which interrupted the interaction between p65 and KPNA2,KPNA3,KPNA4.We further found that MGF360-12 L could interfere with the NF-κB nuclear translocation by competitively inhibiting the interaction between NF-κB and nuclear transport proteins.These findings suggested that MGF360-12 L could inhibit the IFN-Ⅰproduction by blocking the interaction of importinαand NF-κB signaling pathway,which might reveal a novel strategy for ASFV to escape the host innate immune response. | Yisha Zhuo Zeheng Guo Tongtong Ba Cheng Zhang Lihua He Cuiping Zeng Hanchuan Dai | 2021 | Virologica Sinica2021，36，2： | 21 |
| 3 | Intercropping with Solanum nigrum and Solanum photeinocarpum from Two Ecoclimatic Regions Promotes Growth and Reduces Cadmium Uptake of Eggplant Seedlings显示文摘Soil contamination by heavy metals is a serious environmental problem worldwide, and reduction of heavy metal accumulation in vegetables grown on contaminated land is a matter of urgency. A pot experiment was conducted to study the effects of intercropping with the Cd hyperaccumulators Solanum nigrum and Solanum photeinocarpum from two ecoclimatic regions, Ya'an and Chengdu,Sichuan Province, China, on the growth and cadmium(Cd) uptake of eggplant(Solanum melongena L.). The biomass, photosynthetic pigment contents, and activities of antioxidant enzymes of eggplant were enhanced by intercropping. The biomass of eggplant was the highest after intercropping with S. photeinocarpum from Ya'an, but did not differ significantly from that after intercropping with S. nigrum from Chengdu. The shoot Cd content of eggplant was significantly reduced by intercropping with the hyperaccumulators,which ranked as follows: S. nigrum from Chengdu > S. nigrum from Ya'an > S. photeinocarpum from Chengdu > S. photeinocarpum from Ya'an, with the decreases being 19.60%, 14.36%, 9.66%, and 6.42%, respectively, as compared with the control. The lowest shoot Cd content and translocation factor of eggplant were attained after intercropping with S. nigrum from Chengdu. Therefore, it was feasible to intercrop eggplant with S. nigrum and S. photeinocarpum on Cd-contaminated soil. | TANG Yi HE Juan YU Xuena XIE Yongdong LIN Lijin SUN Guochao LI Huanxiu LIAO Mingan LIANG Dong XIA Hui WANG Xun ZHANG Jing LIU Zejing TU Lihua LIU Li | 2017 | Pedosphere2017，27，3： | 17 |
| 4 | Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries显示文摘Due to the limitations in autogenous nerve grafting or Schwann cell transplantation,large gap peripheral nerve injuries require a bridging strategy supported by nerve conduit.Cell based therapies provide a novel treatment for peripheral nerve injuries.In this study,we first experimented an optimal scaffold material synthesis protocol,from where we selected the 10%GFD formula(10%GelMA hydrogel,recombinant human basic fibroblast growth factor and dental pulp stem cells(DPSCs))to fill a cellulose/soy protein isolate composite membrane(CSM)tube to construct a third generation of nerve regeneration conduit,CSM-GFD.Then this CSM-GFD conduit was applied to repair a 15-mm long defect of sciatic nerve in a rat model.After 12 week post implant surgery,at histologic level,we found CSM-GFD conduit could regenerate nerve tissue like neuron and Schwann like nerve cells and myelinated nerve fibers.At physical level,CSM-GFD achieved functional recovery assessed by a sciatic functional index study.In both levels,CSM-GFD performed like what gold standard,the nerve autograft,could do.Further,we unveiled that almost all newly formed nerve tissue at defect site was originated from the direct differentiation of exogeneous DPSCs in CSM-GFD.In conclusion,we claimed that this third-generation nerve regeneration conduit,CSM-GFD,could be a promising tissue engineering approach to replace the conventional nerve autograft to treat the large gap defect in peripheral nerve injuries. | Lihua Luo Yan He Ling Jin Yanni Zhang Fernando P.Guastaldi Abdullkhaleg A.Albashari Fengting Hu Xiaoyan Wang Lei Wang Jian Xiao Lingli Li Jianming Wang Akon Higuchi Qingsong Ye | 2021 | Bioactive Materials2021，6，3： | 11 |
| 5 | Yolk-shell structured Co-C/Void/Co9S8 composites with a tunable cavity for ultrabroadband and efficient low- frequency microwave absorption显示文摘 | Xiaofang Liu Chengcheng Hao Lihua He Cheng Yang Yubin Chen Chengbao Jiang Ronghai Yu | 2018 | Nano Research2018，11，8： | 10 |
| 6 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 7 | Characteristics of fecal microbiota in non-alcoholic fatty liver disease patients显示文摘This study was designed to investigate the gut microbiota of patients with non-alcoholic fatty liver disease. The inclusive and exclusive criteria for NAFLD patients and healthy subjects were formulated, and detailed clinical data were collected. The genomic DNA of stool samples were extracted for 16 S r DNA sequencing, and the amplified V4-region was sequenced on the Illumina Miseq platform. Metastats analysis was performed to identify the differential taxa between the groups. Redundancy analysis was used to evaluate the association between gut microbial structure and clinical variables. Thirty NAFLD patients and37 healthy controls were involved. The 16 S r DNA sequencing showed that there was a dramatic variability of the fecal microbiota among all the individuals. Metastats analysis identified eight families and 12 genera with significant differences between the two groups. When some clinical parameters, such as waist-to-hip ratio(WHR) and homeostasis model assessment of insulin resistance(HOMA-IR), were enrolled in Redundancy analysis, the distribution of the two group of samples was obviously changed. The compositional shifts in fecal bacterial communities of NAFLD patients from the healthy controls were mainly at family or genus levels. According to our Redundancy analysis, insulin resistance and obesity might be closely related to both NAFLD phenotype and intestinal microecology. | Fan Li Gang Sun Zikai Wang Wenming Wu He Guo Lihua Peng Lili Wu Xu Guo Yunsheng Yang | 2018 | Science China(Life Sciences)2018，61，7： | 9 |
| 8 | Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium显示文摘Biocompatible and biodegradable magnesium(Mg)based metals have attracted great interest for use in orthopedic implants and devices.Based on our previous study that Mg with and without micro-arc oxidation(MAO)coating showed obvious cytotoxic effect on tumor cells due to the increase of pH value during the degradation of Mg,this study further evaluated the cytotoxic effect of Mg and MAO coated Mg on osteosarcoma(MG-63)cells by analyzing the cell adhesion,morphology and number through observation of scanning electron microscope,as well as live/dead staining,lactate dehydrogenase(LDH)activity and 4,6-diamidino-2-phenylindole(DAPI)assay.The results indicated that,compared to titanium,Mg could strongly inhibit the cell adherence,morphology and number of MG-63 on the surface of the naked Mg,whereas the MAO coated Mg showed relative weak cytotoxic effect on MG-63 cells,expecting that magnesium based metals with suitable coating can be designed to be applied as tumor prosthesis in the clinical practice. | Mei Li Ling Ren LiHua Li Peng He GuoBo Lan Yu Zhang Ke Yang | 2014 | Journal of Materials Science & Technology2014，30，9： | 7 |
| 9 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 10 | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90显示文摘分子的女伴热吃惊蛋白质 90 的激活(Hsp90 ) 依赖于 ATP 绑定和水解作用,它发生在蛋白质的 N 终端域。这里,我们与 ATP 和 ATP 类似物在土著人并且在建筑群决定了人的 Hsp90 的 N 终端领域的三水晶结构,提供由 Hsp90 的 ATP 水解作用的催化机制的一个清楚的看法。另外, ATP 的绑定导致 N 终端领域是能被用来部分解释 Hsp90 的孤立的 N 终端领域为什么举办很弱的 ATP hydrolytic 活动的一个中间的状态。 | Jian Li Lihua Sun Chunyan Xu Feng Yu Huan Zhou Yanlong Zhao Jian Zhang Jianhua Cai Cheney Mao Lin Tang Yechun Xu Jianhua He | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 11 | Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing,membrane fusion,and viral infectivity显示文摘Dear Editor,By the end of June 2020,the pandemic of coronavirus diseases 2019(COVID-19)had resulted in more than 10 million individuals,all over the world,being infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).1 The high contagiousness of SARS-CoV-2 virus was largely attributed to the relatively unique sequence composition in its spike(S)glycoprotein,which is in charge of the host entry by interacting with its cellular receptor angiotensin-converting enzyme 2(ACE2).2,3 The S glycoprotein can be processed into an N terminal S1 fragment that is responsible for receptor binding,and a C terminal S2 fragment that functions to promote membrane fusion.4 SARS-CoV-2 is a type of single-stranded positive-sense ribonucleic acid(RNA)virus,and an increasing number of mutations were identified across the SARS-CoV-2 genome,including the region encoding S glycoprotein.Nevertheless,the functional implications of these mutations remain largely unknown,we here reported the mutation analysis of S gene and a functional exploration of the dominant D614G mutation. | Xiaoyi Jiang Zhengrong Zhang Chenxi Wang Hongguang Ren Lihua Gao Haoran Peng Zubiao Niu He Ren Hongyan Huang Qiang Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 12 | Dependence of creep age formability on initial temper of an Al-Zn-Mg-Cu alloy显示文摘The initial temper of the material may directly affect the whole creep age forming(CAF)process. In terms of creep deformation and stress relaxation, using the constant-stress creep aging and constant-strain stress relaxation aging tests, the relationship between initial temper and CAF formability is investigated for an Al-Zn-Mg-Cu alloy at 165 °C for 18 h. Three tempers are selected as the initial tempers in CAF, viz., solution, retrogression and re-solution. The CAF formability of this alloy with initial temper of retrogression is the best, and the creep strain of the retrogression tempered specimen after creep aging of 18 h is about 1.21 and 1.34 times than that of the solution and the re-solution tempered specimens, respectively. The calculated stress exponents of this alloy with three initial tempers range from 7.3 to 9.5, indicating that the CAF of this alloy is mainly controlled by the dislocation creep. The various formability for three initial tempers are attributed to different inhibitions of the transgranular precipitates on the dislocation movement. For the retrogression temper, the initial fine and uniformly distributed precipitates are seriously coarsened after6 h of CAF, which minimally inhibit the dislocation movement. While, for the re-solution temper,the fine precipitates are re-precipitated in the matrix of the alloy, which observably hinder the dislocation movement and lead to the worst formability. | Lei Chao Yang He Li Heng Shi Nian Fu Jin Zhan Lihua | 2016 | Chinese Journal of Aeronautics2016，29，5： | 5 |
| 13 | Dramatic transition between electric and magnetic rotations in ^(106)Ag显示文摘The lifetimes for the states of magnetic dipole band in106Ag have been measured using the Doppler-shift attenuation method via the reaction of100Mo(11B,5n)106Ag at a beam energy of 60 MeV.The reduced transition strengths of the magnetic dipole band,the B(M1)/B(E2)ratios together with the signature of the level energy as a function of angular momentum for the positive parity states of106Ag show that a drastic change of excitation mode,that is,from electric rotation to magnetic rotation,occurs within one unit of spin at around Iπ=12+.Theoretical calculations based on the triaxial projected shell model consistently reproduce the experimental data and provide an explanation on the nature of observed phenomena such that the dynamical drift of the rotational axis suddenly from the principal axis to the tilted one,along the positive parity bands of106Ag. | ZHENG Yun ZHU LiHua CHEN YongShou WU XiaoGuang HE ChuangYe HAO Xin LIU Ying WANG ZhiMin LI XueQin LI GuangSheng GAO ZaoChun SUN HuiBin | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，9： | 4 |
| 14 | Microstructure and Mechanical Properties of Aer Met 100 Ultra-high Strength Steel Joints by Laser Welding显示文摘Aer Met100 ultra-high strength steel plates with a thickness of 2 mm were welded using a CO2 laser welding system. The influences of the welding process parameters on the morphology and microstructure of the welding joints were investigated, and the mechanical property of the welding joints was analyzed. The experimental results showed that the fusion zone of welding joint mainly consisted of columnar grains and a fine dendrite substructure grew epitaxially from the matrix. With the other conditions remaining unchanged, a finer weld microstructure was along with the scanning speed increase. The solidification microstructure gradually transformed from cellular crystal into dendrite crystal and the spaces of dendrite secondary arms rose from the fusion line to the center of the fusion zone. In the fusion zone of the weld, the rapid cooling caused the formation of martensite, which led the microhardness of the fusion zone higher than that of the matrix and the heat affected zone. The tensile strength of the welding joints was tested as 1 700 MPa, which was about 87% of the matrix. However, the tensile strength of the welding joints without defects existed was tested as 1832 MPa, which was about 94% of the matrix. | 刘奋成 YU Xiaobin HUANG Chunping HE Lihua CHEN Yuhua BU Wende | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，4： | 4 |
| 15 | Development of BCPDA-Eu^3+-BAS Labeled Hepatitis B Surface Antibodies显示文摘 | TAN Wenjia SUN Zhixia XUAN Lili LI Junling XIE Wenbing HE Chengyan PAN Lihua | 2018 | Chemical Research in Chinese Universities2018，34，1： | 4 |
| 16 | Development of a rapid and sensitivity magnetic chemiluminescence immunoassay for DNA methyltransferase 1 in human serum显示文摘DNA methyltransferase 1(DNMT1)is a useful biomarker for lung cancer in early clinical diagnosis.A rapid magnetic chemiluminescence immunoassay(MCLIA)for DNMT1 in human serum has been developed.Horseradish peroxidase(HRP)-second-Ab was used to labeled polyclonal antibodies of anti-DNMT1.DNMT1 in sample integrates with specific immunomagnetic beads and can constitute a supersandwiched immunoreaction.In magnetic field,nonspecific materials can be separated.After luminescent substrate luminol-H2O2-BIP was added,the relative light unit(RLU)of HRP was detected and was discovered to be directly proportional to the content of DNMT1 in sample.The correlative variables involved in the MCLIA value were optimized and the methodological evaluation was carried out.After optimization,in the range of0.5–128 ng/mL,the linear regression equation was y=0.5014 x+1.769(x was logCDNMT1,y was relative luminescence units(RLU)/RLU0),and the limit of detection was 0.01 ng/mL.The RSD of intra-and interassays were 15.8%–16.9%and 14.3%–18.1%,respectively.The recovery was from 70.0%to 106.2%.Furthermore,paralleled with purchasable enzyme-linked immunosorbent assay(ELISA)kits,MCLEIA had lower detection limit,wider linear range and shorter detection time.Therefore,the MCLEIA established in this study could be used for the sensitive detection of DNMT1 in serum sample. | Sitian He Leiliang He Beibei Liu Songcheng Yu Li'e Liu Yongmei Tian Jia Wang Lihua Ding Yilin Wang Lingbo Qu Fei Yu Yongjun Wu | 2019 | Chinese Chemical Letters2019，30，5： | 4 |
| 17 | Prion protein and cancers显示文摘正常细胞的 prion 蛋白质, PrP C 是一高度在所有哺乳动物保存了并且广泛地表示了房间表面 glycoprotein。PrP 的表示是 prion 疾病的枢轴的 inthe 致病;然而, PrP C 遗体不完全地理解。在房间模型,基于研究功能的过多被归因于 PrP C 。在这份报纸,我们考察了潜在的角色那 PrP 在房间生理学的 C 戏并且集中了于它对 tumorigenesis 的贡献。 | Xiaowen Yang Yan Zhang Lihua Zhang Tianlin He Jie Zhang Chaoyang Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 3 |
| 18 | Highly Selective Fluorescent Recognition towards Th4+ Based on Coumarin-derivatized Crescent Aromatic Oligoamide显示文摘intramolecularly 结合氢的新月状的芳香的 oligoamide 1 适用二香豆素残余被综合。从在金属离子 complexation 之上的紫外力、荧光灯的系列的结果证明用作形状坚持的脊梁的部分的二 fluorophores 在另外的 lanthanide 和 uranyl 离子上为 Th4+ 的识别向分子提供了高选择和敏感。A 48 褶层荧光灯在紧张的改进在增加 Th4+ 之上在 505 nm 被观察,当另外的金属阳离子没能导致如此的一个重要变化时。为 Th4+ 的视觉察觉被颜色变化完成。1 形成的建筑群和 Th4+ 的 stoichiometry 被发现是有稳定性常数的 1:1 (2. | Rongzhao Gao Jinchuan Hu Ke Zhang Youzhou He Peng Liu Shunzhong Luo Yanqiu Yang Liang Yang Wen Feng Lihua Yuan | 2013 | Chinese Journal of Chemistry2013，31，5： | 2 |
| 19 | Influence of process parameters and aging treatment on the microstructure and mechanical properties of Al Si8Mg3 alloy fabricated by selective laser melting显示文摘Many studies have investigated the selective laser melting(SLM)of AlSi10Mg and AlSi7Mg alloys,but there are still lack of researches focused on Al-Si-Mg alloys specifically tailored for SLM.In this work,a novel high Mg-content AlSi8Mg3 alloy was specifically designed for SLM.The results showed that this new alloy exhibited excellent SLM processability with a lowest porosity of 0.07%.Massive lattice distortion led to a high Vickers hardness in samples fabricated at a high laser power due to the precipitation of Mg_(2)Si nanoparticles from theα-Al matrix induced by high-intensity intrinsic heat treatment during SLM.The maximum microhardness and compressive yield strength of the alloy reached HV(211±4)and(526±12)MPa,respectively.After aging treatment at 150℃,the maximum microhardness and compressive yield strength of the samples were further improved to HV(221±4)and(577±5)MPa,respectively.These values are higher than those of most known aluminum alloys fabricated by SLM.This paper provides a new idea for optimizing the mechanical properties of Al-Si-Mg alloys fabricated using SLM. | Yaoxiang Geng Hao Tang Junhua Xu Yu Hou Yuxin Wang Zhen He Zhijie Zhang Hongbo Ju Lihua Yu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 2 |
| 20 | E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease,and the pathogenesis of SLE has not been fully elucidated.The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins;however,the potential role of FBXW7 in autoimmune diseases is unclear.In the present study,we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2,6,10,14-tetramethylpentadecane(TMPD).Myeloid cell-specific FBXW7-deficient(Lysm+FBXW7f/f)C57BL/6 mice showed decreased immune complex accumulation,glomerulonephritis,glomerular mesangial cell proliferation,and basemembrane thickness in the kidney.Lysm+FBXW7f/f mice produced fewer anti-Sm/RNP and anti-ANA autoantibodies and showed a decreased MHC II expression in B cells.In Lysm+FBXW7f/f mice,we observed that cell apoptosis was reduced and that fewer CD11b+Ly6Chi inflammatory monocytes were recruited to the peritoneal cavity.Consistently,diffuse pulmonary hemorrhage(DPH)was also decreased in Lysm+FBXW7f/f mice.Mechanistically,we clarified that FBXW7 promoted TMPD-induced cell apoptosis by catalyzing MCL1 degradation through K48-linked ubiquitination.Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice,which may provide novel ideas and theoretical support for understanding the pathogenesis of SLE. | Zhenlu Chong Chunjing Bao Jia He Tianxiao Chen Lijia Zhong Gaopeng Li Huanle Li Lutong Fang Yinjing Song Guoxiang Fu Xuyan Yang Lihua Lai Yang Liu Qingqing Wang | 2018 | Cellular & Molecular Immunology2018，15，12： | 2 |
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