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| 1 | Multiscale analysis of the contents of palmatine in the Nature populations of Phellodendron amurense in Northeast China显示文摘Palmatine is a valuable ingredient in Chinese medicine that is produced by Phellodendron amurense Rupr.The contents of palmatine content in root bark, trunk bark,perennial branch bark, annual branches, and leaves of the trees with different ages and geographies in Northeast China were measured by high-performance liquid chromatography.The contents of palmatine in the barks of root, trunk, and perennial branch were significantly higher than those in annual branches and leaves. The contents of palmatine in trunk bark and root bark from Lesser Khingan Mountains increased with age, which is significantly opposite to other three vegetation types. The contents of palmatine in perennial branch bark, annual bark and leaves had no significant regularity. Moreover, the contents of palmatine in samples of root bark, trunk bark, perennial branch bark and annual bark varied significantly with latitude. The nature populations of P. amurense growing at low latitude contained significantly more palmatine than those growing at high latitude. These results provide a scientific basis for the reasonable cultivation and efficient utilization of P. amurense. | Minglong Sun Lijiao Xu Yingli Peng Tong Liu Yuhong Zhang Zhiqiang Zhou | 2016 | Journal of Forestry Research2016，27，2： | 2 |
| 2 | HOXC4 up-regulates NF-κB signaling and promotes the cell proliferation to drive development of human hematopoiesis, especially CD43+ cells显示文摘The hematopoietic function of HOXC4 has not been extensively investigated.Our research indicated that induction of HOXC4 in co-culture system from D10 significantly promoted productions of most hematopoietic progenitor cells.CD34−CD43+cells could be clearly classified into CD34−CD43^(low) and CD34−CD43^(high) sub-populations at D14.The former cells had greater myelogenic potential,and their production was not significantly influenced by induction of HOXC4.By contrast,the latter cells had greater potential to differentiate into megakaryocytes and erythroid cells,and thus had properties of erythroid–megakaryocyte common progenitors,which abundance was increased by∼2-fold when HOXC4 was induced from D10.For CD34−CD43^(low),CD34+CD43+,and CD34−CD43^(high) sub-populations,CD43 level served as a natural index for the tendency to undergo hematopoiesis.Induction of HOXC4 from D10 caused more CD43+cells sustain in S-phase with up-regulation of NF-κB signaling,which could be counteracted by inhibition of NF-κB signaling.These observations suggested that promotion of hematopoiesis by HOXC4 is closely related to NF-κB signaling and a change in cell-cycle status,which containing potential of clinical applications. | Jiahui Zeng Wencui Sun Jing Chang Danying Yia Lijiao Zhu Yonggang Zhang Xu Pan Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxin Liu Bo Chen FengMa | 2020 | Blood Science2020，2，4： | 1 |
| 3 | Study on potential evapotranspiration and wet-dry condition in the seasonal frozen soil region of northern Tibetan Plateau显示文摘This study was based on the CEOP/CAMP-Tibet observed data at AWS (Automatic Weather Station) of MS3478 in the seasonal frozen soil region of northern Tibetan Plateau from March 2007 to February 2008.The variation characteristics of PE (potential evapotranspiration) were analyzed based on the Penman-Monteith method recommended by FAO (the Food and Agriculture Organization of the United Nations).The contributions of dynamic,thermal and water factors to PE were discussed,and the wet-dry condition of the plateau region was further studied.The results indicated that daily PE was between 0.52 mm and 6.46 mm for the whole year.Monthly PE was over 107 mm from May to September,but decreased to less than 41 mm from November to February.Annual PE was 1,037.8 mm.In the summer,thermal PE was significantly more than dynamic PE,but conversely in the winter.Annual variation of thermal PE was of sine wave pattern.In addition,drought and semi-drought climate lasted for a long time while semi-humid climate was short.The effect of water and dynamic factors on PE varied considerably with the seasons.Annual variation of thermal PE was of sine wave pattern. | HuiGen He ZeYong Hu XueYi Xun Jun Sun Li Hao LiJiao Xu Wen Peng | 2011 | Research in Cold and Arid Regions2011，3，2： | 1 |
| 4 | Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials显示文摘Background: The HOX genes are master regulators of embryogenesis that are also involved inhematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles inhematopoiesis and leukemogenesis.Methods: We established HOXA9-inducible human embryonic stem cells (HOXA9/hESCs) with normalpluripotency and potential for hematopoiesis, which could be used to analyze gene function with highaccuracy. HOXA9/hESCs co-cultured with aorta–gonad–mesonephros-derived stromal cells (AGM-S3) wereinduced to overexpress HOXA9 with doxycycline (DOX) at various times after hematopoiesis started andthen subjected to flow cytometry.Results: Induction of HOXA9 from Day 4 (D4) or later notably promoted hematopoiesis and also increasedthe production of CD34+ cells and derived populations. The potential for myelogenesis was significantlyelevated while the potential for erythrogenesis was significantly reduced. At D14, a significant promotion ofS phase was observed in green fluorescent protein positive (GFP+) cells overexpressing HOXA9. NF-κBsignaling was also up-regulated at D14 following induction of HOXA9 on D4. All of these effects could becounteracted by addition of an NF-κB inhibitor or siRNA against NFKB1 along with DOX.Conclusions: Overexpression of HOXA9 starting at D4 or later during hematopoiesis significantly promotedhematopoiesis and the production of myeloid progenitors while reduced the production of erythroidprogenitors, indicating that HOXA9 plays a key role in hematopoiesis and differentiation of hematopoieticlineages. | Jiahui Zeng Danying Yi Wencui Sun Yuanlin Liu Jing Chang Lijiao Zhu Yonggang Zhang Xu Pan Yong Dong Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxin Liu Bo Chen Feng Ma | 2021 | Cell Regeneration2021，10，1： | 0 |
| 5 | Didymin attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress显示文摘Objective:This study was designed to investigate the protective effects of didymin(Did)on doxorubicin(DOX)-induced cardiotoxicity.Methods:After pretreatment with Did(2,4,8 mg/kg intraperitoneal i.p.)for 7 d,the male C57 mice were injected with single dose of DOX(20 mg/kg i.p.).The cardioprotective effect of Did was observed on the 7th day after DOX treatment.Results:DOX delayed body growth and caused cardiac tissue injury,oxidative stress,and mitochondrial dysfunction.Similar experiments in H9C2 cardiomyocytes showed that DOX reduced cell viability,increased generation of reactive oxygen species(ROS)and fragmentation of DNA,decreased mitochondrial membrane potential,and induced cardiomyocyte apoptosis.However,all of these adverse effects were suppressed by Did pretreatment.Did increased protein expression of glutamate-L-cysteine ligase catalytic subunit(GCL),heme oxygenase 1(HO-1),and nuclear factor erythroid 2-related factor 2(Nrf2).Besides,Did also induced activation of PI3K/AKT.Conclusion:These findings indicated Did prevented DOX-induced cardiac injury and apoptosis via activating PI3K/AKT/Nrf2 signaling pathway. | Rongchang Chen Guibo Sun Lijiao Xu Xu Zhang Wenying Zeng Xiaobo Sun | 2022 | Chinese Herbal Medicines2022，14，1： | 0 |
| 6 | Decoding m^(6)A mRNA methylation by reader proteins in liver diseases显示文摘N6-methyladenosine(m^(6)A)is a dynamic and reversible epigenetic regulation.As the most prevalent internal post-transcriptional modification in eukaryotic RNA,it participates in the regulation of gene expression through various mechanisms,such as mRNA splicing,nuclear export,localization,translation efficiency,mRNA stability,and structural transformation.The involvement of m^(6)A in the regulation of gene expression depends on the specific recognition of m^(6)A-modified RNA by reader proteins.In the pathogenesis and treatment of liver disease,studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by m^(6)A modification,in which abnormal expression of reader proteins determines the fate of these gene transcripts.In this review,we introduce m^(6)A readers,summarize the recognition and regulatory mechanisms of m^(6)A readers on mRNA,and focus on the biological functions and mechanisms of m^(6)A readers in liver cancer,viral hepatitis,non-alcoholic fatty liver disease(NAFLD),hepatic fibrosis(HF),acute liver injury(ALI),and other liver diseases.This information is expected to be of high value to researchers deciphering the links between m^(6)A readers and human liver diseases. | Lijiao Sun Xin Chen Sai Zhu Jianan Wang Shaoxi Diao Jinyu Liu Jinjin Xu Xiaofeng Li Yingyin Sun Cheng Huang Xiaoming Meng Xiongwen Lv Jun Li | 2024 | Genes & Diseases2024，11，2： | 0 |
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