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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes显示文摘在老鼠的产生的最近的突破胚胎的干细胞(rESCs ) 打开门到基因指向为人的疾病的学习创造模型的申请。另外,在里面从进三细菌层的衍生物的 rESCs 的 vitro 区别系统将为哺乳动物的开发,房间函数,织物修理,和药发现的调查用作一个强大的工具和资源。然而,这些使用被困难限制了在 vitro 区别。这研究的目的是建立一在里面从 rESCs 并且到的 vitro 区别系统调查 rESCs 是否能够形成区分终端的 cardiomyocytes。用最新确定的 rESCs,我们发现那胚胎植物或动物身体(EB ) 基于在没能为没有浆液的栽培 rESCs 工作的老鼠转换字符(mESC ) 区别使用的方法。我们然后由三个化学禁止者和喂调节媒介的联合开发了一个协议。在这个条件下面, rESCs 变成了 EB,宣传并且区分三胚胎的细菌层。而且,形成 rESC 的 EB 能区分进自发地在 plating 以后打败 cardiomyocytes。分子、结构、功能的性质的分析表明导出 rESC 的 cardiomyocytes 类似于从胎儿的老鼠心和 mESCs 导出的那些。在结论,我们成功地发展了一在里面为功能的 myocytes 通过被产生并且显示老鼠的显型的 rESCs 的 vitro 区别系统胎儿的 cardiomyocytes。这个唯一的细胞的系统将提供一条新途径学习早开发和心脏的功能,并且在测试的药理学和房间治疗用作一个重要工具。 | Nan Cao Jing Liao Zumei Liu Wenmin Zhu Jia Wang Lijun Liu Lili Yu Ping Xu Chun Cui Lei Xiao Huang-Tian Yang | 2011 | Cell Research2011，21，9： | 13 |
| 3 | Epitope peptides of influenza H3N2 virus neuraminidase gene designed by immunoinformatics显示文摘病毒表面蛋白质 neuraminidase (NA ) 是在流行性感冒的主要子类型特定的抗原类型 A 病毒。Neuraminidase 作为酶工作打破在红血球凝聚素之间的契约(哈) 并且到版本的 sialic 酸最新从感染的房间形成了病毒。在这研究,从 H3N2 子类型病毒的 NA 基因被定序, NA 蛋白质为 B 房间 epitopes 被屏蔽并且基于 immunoinformatics 估计了。把信息,三肽 ES8, RR9,和 WK7 基于这(盖住氨基酸残余 221228, 292300,和 383389,分别地) NA,蛋白质人工地被选择并且综合。这些肽被用来皮下地使新西兰兔子免疫提起 antisera。结果证明这三肽能够以一种特定、敏感的方式对 H3N2 病毒得到抗体,由连接酶的 immunosorbent 在 vitro 检测了试金。而且, hemadsorption 释放反的效果在 1:40 的冲淡发生在三 antisera 混合物。用数据库软件的排列证明在这三 epitope 肽的氨基酸残余在在这研究定序的所有 NA 在特定的地点被代替。我们建议这些 NA epitope 肽可能被使用与一起哈蛋白质同样疫苗的抗原。 | Lijun Liang Ping Huang Miaoheng Wen Hanzhong Ni Songnuan Tan Yonghui Zhang Qiuxia Chen | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 4 |
| 4 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 5 | Ecological Planning and Design of Waterfront in Xianghe County from the Perspective of Landscape Security Pattern显示文摘Waterfront is a precious resource in urban ecological construction,and also a key section for ecological protection,so ecological planning of urban waterfront has far-reaching influence on the whole region.This study explored ecological planning and design of waterfront from the perspective of landscape security pattern,analyzed current waterfront in Xianghe County and construction of landscape security pattern for waterfront,provided a basis for the ecological planning and design of landscape. | SHU Ping PAN Yunsheng WANG Lijun | 2013 | Journal of Landscape Research2013，5，6： | 3 |
| 6 | Study on battery state of charge correct algorithm of electric vehicle显示文摘State of Charge(SOC) is used to adjust the initialization SOC value so as to make electric vehicle simulation results close to real vehicle performance.This paper firstly analyses the battery SOC correct algorithm,then uses ADVISOR which is a electric vehicle simulation software to simulate a hybrid electric car with three different cases of no SOC correct,linear SOC correct and zero delta SOC correct,as well as makes the compare and analysis for those simulation results.In the end,an overall conclusion to SOC correct algorithm is given. | KAN Ping QIAN Lijun | 2012 | Computer Aided Drafting,Design and Manufacturing2012，22，2： | 2 |
| 7 | Lactobacillus plantarum KLDS1.0386 with antioxidant capacity ameliorates the lipopolysaccharide-induced acute liver injury in mice by NF-κB and Nrf2 pathway显示文摘The Lactobacillus is of great interest as a natural antioxidant to ameliorate liver injury for its antioxidant capacity.In a previous experiment,Lactobacillus plantarum KLDS 1.0386 was excellent in adhesion and anti-inflammation.This research assessed the antioxidant capacity of L.plantarum KLDS 1.0386 and how it ameliorates the LPS-induced acute liver injury.In vitro results showed that L.plantarum KLDS 1.0386 had potential antioxidant capacity with 27 genes,and it had better capacities in hydroxyl radicals scavenging and lipid antioxidant than the reference strain L.plantarum WCFS1 (P < 0.05).In vivo results,L.plantarum KLDS 1.0386 significantly reduced hepatic tissue injury,pro-inflammatory cytokines (TNF-α,IL-6),myeloperoxidase (MPO) activities and biochemical indicators of hepatotoxicity (ALT,AST,ALP) (P < 0.05),compared with the LPS-treated mice.Moreover,L.plantarum KLDS 1.0386 increased the relative abundance of the genera,including Lachnospiraceae_NK4A136_group,Muribaculaceae and Alistipes,which significantly increased the level of acetic acid and butyric acid (P < 0.05).The results also showed L.plantarum KLDS 1.0386 significantly adjusted the expression of HO-1,NQO1,CAT,NF-κB,TLR4 and IκB-α in the liver (P < 0.05).Overall,these results indicated that L.plantarum KLDS 1.0386 had great functionality in reducing LPS-induced acute liver injury. | Jiahuan Dong Lijun Ping Qinggang Xie Deyu Liu Li Zhao Smith Etareri Evivie Zhongjiang Wang Bailiang Li Guicheng Huo | 2022 | Food Bioscience2022，47，3： | 2 |
| 8 | Rapid screening detection of fluoroquinolone residues in milk based on turn-on fluorescence of terbium coordination polymer nanosheets显示文摘We report a facile, effective and rapid screening method for the determination of total fluoroquinolones(FQs) in milk using lanthanide coordination polymer nanomaterials as the sensing platform. The nonluminescent coordination polymer nanosheets(CPNSs) used in this work are composed of adenosine monophosphate(AMP) and terbium(Tb^(3+)) ions(AMP/Tb CPNSs). The as-prepared CPNSs were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy and fluorescence techniques. Tb^(3+) acts as the center ion of the coordination polymer, with AMP assembled through phosphate and amine groups. However, the reaction between FQs and AMP/Tb CPNSs noticeably turns on the fluorescence due to the strong coordination interaction between FQs and Tb^(3+). Under optimized conditions, the fluorescence intensity of AMP/Tb at 545 nm shows a linear relationship with FQ concentrations between 0.04 μmol/L and 5.0 μmol/L. The relative standard deviation(RSD) of the intraday precision is below 1%, and detection limits are as low as 0.01 μmol/L. The proposed method was successfully applied to the determination of FQs in milk samples. | Xin Xu Lixia Feng Jie Li Ping Yuan Jiangao Feng Lijun Wei Xianglei Cheng | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 9 | Expression of Redox Factor-1 in Early Injury Period after Liver Transplantation in Rat Model显示文摘这研究的目的是在老鼠模型在肝移植以后在早时期(24 h ) 观察在接枝的损害和氧化还原作用 factor-1 (Ref-1 ) 的表示之间的关系。150 只成年男威斯特老鼠随机包括肝被划分成三个组移植组,假冒的外科组和未经治疗的控制组。在肝移植以后,动物在不同时间点被牺牲,并且 Ref-1 的表示的变化和意义然后被 immunohistochemistry,血清学和组织病理学说探索。作为与假冒的外科组和未经治疗的控制组相比, Ref-1 蛋白质在的表示移植组在在肝移植以后的早时期是更强壮的。与病理分析,大量渗透的发炎房间在门静脉附近被发现。肝的纸巾是损害。然而,在假冒的外科的损害和未经治疗的控制组是比较地细微的。浆液中高音和著名计算机生产厂商层次在 6-12 h 到达了山峰,并且在 12 h 以后显著地减少了。这些数据建议在在移植以后的更早的时期的肝损害的度在 6 h 达到顶点然后减少。并且 Ref-1 蛋白质由肝的 ischemic 灌注损害导致了可能在修理损害起一个关键作用。 | Ping Zhang Xiaohong Du Zhipeng Sun Lijun Xu | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 10 | Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents显示文摘 | HU Hao JIANG Mingyan XIE Lijun HU Gang ZHANG Cuirong ZHANG Lixia ZHOU Shunguang ZHANG Meihui GONG Ping | 2015 | Chemical Research in Chinese Universities2015，31，5： | 1 |
| 11 | Heat transfer characteristics of carbon steel spirally fluted tube for high pressure preheaters显示文摘 | Wang Lijun Sun Dawen Liang Ping | 2000 | Energy Conversion & Management2000，41，10： | 1 |
| 12 | Evaluation of strategy for analyzing mouse liver plasma membrane proteome显示文摘Plasma membrane (PM) proteome is one of the major subproteomes present in the cell,and is very important in liver function. In the present work, C57 mouse liver PM was purified by density-gradient centrifugation. The purified PM was verified by electron microscope analysis and Western blotting. The results showed that the PM was enriched by more than 20-fold and the contamination of mitochondria was reduced by 2-fold compared with the homogenization fraction. Proteins were separated by 2DE and 1DE, trypsin-digested and submitted to ESI-Q-TOF and MALDI-TOF-TOF mass spectrometry or directly digested in solution and analyzed by LC-ESI ion trap mass spectrometry. In all, 547 non-redundant mouse liver PM proteins were identified, of which 34% contributed to plasma membrane or plasma membrane-related proteins. This study optimized and evaluated the HLPP plasma membrane proteome analysis method and made a systematic analysis on PM proteome. | CHEN Ping ZHANG LiJun LI XuanWen WANG XiE CAO Rui LIU Zhen XIONG JiXian PENG Xia WEI YingJuan YING XingFeng WANG XianChun LIANG SongPing | 2007 | Science China(Life Sciences)2007，50，6： | 1 |
| 13 | Effects of Sub-chronic Intoxication of 1,8-cineole on Blood Biochemical Indexes of Mice显示文摘[Objective] Effects of sub-chronic intoxication of 1,8-cineole on body weights,routine blood indexes and biochemical indexes of mice were investigated. [Method] One hundred and sixty mice with body weights of 15- 17 g were randomly divided into four groups( forty mice per group). Mice were injected to1,8- cineole with doses of 192. 45,64. 15 and 21. 38 mg / kg body weight( test groups) and the water solution of tween-80 with a volume fraction of 0. 5%( control group) respectively. Each mouse was administered orally at the dose of 0. 2 m L per 10 g body weight once a day consecutively for 90 d. The body weight,routine blood indexes and serum biochemical indexes of mice were determined on the 30 thd,60thd,90 thd and the 30 thd after stopping the administration of 1,8-cineole.[Result]The effects of 1,8-cineole on the body weight,routine blood indexes and serum biochemical indexes of mice with the doses of 64. 15 and 21. 38 mg/kg body weight had no statistically significant difference compared with the control group( P > 0. 05). 1,8-cineole with the dose of 192. 45 mg / kg body weight exhibited different influences on routine blood indexes and serum biochemical indexes of mice after the oral administration of 1,8-cineole for 60 d and 90 d,and statistically significant differences in many blood biochemical indexes were observed( P < 0. 05). However,the differences in routine blood indexes and serum biochemical indexes were not statistically significant between the test groups and the control group at the 30 thd after stopping the administration of 1,8-cineole( P > 0. 05).[Conclusion]1,8-cineole had sub-chronic oral toxicity to mice. The no observed adverse effect level( NOAEL) of 1,8-cineole was 64. 15 mg/kg body weight and the lowest observed adverse effect level( LOAEL) of 1,8-cineole was 192. 45 mg / kg body weight. Effects of 1,8-cineole on blood biochemical indexes of mice were in short term and reversible. | Du Yonghua Wang Chuan Zhou Lijun Zhang Ping Wei Qin Yin Zhongqiong Jiang Qinjiu Jiang Jihong | 2015 | Animal Husbandry and Feed Science2015，7，3： | 1 |
| 14 | Molecular distillation for recovering tocopherol and fatty acid methyl esters from rapeseed oil deodoriser distillate显示文摘 | JIANG Shaotong SHAO Ping PAN Lijun | 2006 | Biosyst Eng2006，93，4： | 1 |
| 15 | Downlink per- formance analysis of MIMO relaying networks 显示文摘 | Wang Ping Zu Lijun Liu Fuqiang | 2012 | Wireless Personal Communications2012，62，3： | 1 |
| 16 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 17 | Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents显示文摘 | MA Junjie HU Gang XIE Lijun CHEN Lei XU Boxuan GONG Ping | 2015 | Chemical Research in Chinese Universities2015，31，6： | 1 |
| 18 | Germ cell transplantation in infertility mouse显示文摘This work investigated the spermatogenesis in an infertility BALB/c-nu mouse model by reinfusing germline stem cells into seminiferous tubules. Donor germ cells were isolated from male FVB/NJ-GFP transgenic mice. Seminiferous tubule microinjection was applied to achieve intratubular germ cell transfer. The germ cells were injected into exposed testes of the infertility mice. We used green fluo-rescence and DNA analysis of donor cells from GFP transgenic mice as genetic marker. The natural mating and Southern blot methods were applied to analyze the effect of sperm cell transplantation and the sperm function after seminiferous tubule microinjection. The spermatogenesis was morphologi-cally observed from the seminiferous tubules in 41/60 (68.33%) of the injected recipient mice using allogeneic donor cells. In the colonized testes, matured spermatozoa were seen in the lumen of the seminiferous tubules. In this research, BALB/c-nu infertility mouse model, the recipient animal, was used to avoid immunological rejection of donor cells, and germ cell transplantation was applied to overcome infertility caused by busulfan treatment. These results demonstrate that this technique of germ cell transplantation is of great use. Germ cell transplantation could be potentially valuable to oncological patients. | XIE XiaYang TENG Yong MA LiangHong LIU LiJun WANG Xiang SONG YingChing XU Ping | 2008 | Chinese Science Bulletin2008，53，1： | 1 |
| 19 | Molecular distil- lation for recovering tocopherol and fatty acid methyl esters from rapeseed oil deodoriser distillate 显示文摘 | Jiang Shaotong Shao Ping Pan Lijun | 2006 | Biosyst Eng2006，93，4： | 1 |
| 20 | Responses to air temperature and soil moisture of growth of four dominant species on sand dunes of central Inner Mongolia显示文摘 | Yuanrun Zheng Glyn M. Rimmington Zhixiao Xie Lei Zhang Ping An Guangsheng Zhou Xiangjun Li Yunjiang Yu Lijun Chen Hideyuki Shimizu | 2008 | Journal of Plant Research2008，，5： | 1 |
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