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| 1 | Signaling pathways and targeted therapy for myocardial infarction显示文摘Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. | Qing Zhang Lu Wang Shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 11 |
| 2 | Fabrication of Nanoscale Step Height Structure Using Atomic Layer Deposition Combined with Wet Etching显示文摘The current techniques used for the fabrication of nanosteps are normally done by layer growth and then ion beam thinning. There are also extra films grown on the step surfaces in order to reduce the roughness. So the whole process is time consuming. In this paper, a nanoscale step height structure is fabricated by atomic layer deposition(ALD) and wet etching techniques. According to the traceable of the step height value, the fabrication process is controllable. Because ALD technology can grow a variety of materials, aluminum oxide(Al_2O_3) is used to fabricate the nanostep. There are three steps of Al_2O_3 in this structure including 8 nm, 18 nm and 44 nm. The thickness of Al_2O_3 film and the height of the step are measured by anellipsometer. The experimental results show that the thickness of Al_2O_3 film is consistent with the height of the step. The height of the step is measured by AFM. The measurement results show that the height is related to the number of cycles of ALD and the wet etching time. The bottom and the sidewall surface roughness are related to the wet etching time. The step height is calibrated by Physikalisch-Technische Bundesanstalt(PTB) and the results were 7.5±1.5 nm, 15.5±2.0 nm and 41.8±2.1 nm, respectively. This research provides a method for the fabrication of step height at nanoscale and the nanostep fabricated is potential used for standard references. | WANG Chenying YANG Shuming JING Weixuan REN Wei LIN Qijing ZHANG Yijun JIANG Zhuangde | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 3 |
| 3 | Fault Ride-through Hybrid Controller for MMC-HVDC Transmission System via Switching Control Units Based on Bang-bang Funnel Controller显示文摘This paper proposes a fault ride-through hybrid controller(FRTHC)for modular multi-level converter based high-voltage direct current(MMC-HVDC)transmission systems.The FRTHC comprises four loops of cascading switching control units(SCUs).Each SCU switches between a bang-bang funnel controller(BBFC)and proportional-integral(PI)control loop according to a state-dependent switching law.The BBFC can utilize the full control capability of each control loop using three-value control signals with the maximum available magnitude.A state-dependent switching law is designed for each SCU to guarantee its structural stability.Simulation studies are conducted to verify the superior fault ride-through capability of the MMC-HVDC transmission system controlled by FRTHC,in comparison to that controlled by a vector controller(VC)and a VC with DC voltage droop control(VDRC). | Yang Liu Zehui Lin Chenying Xu Lei Wang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，2： | 1 |
| 4 | Impact of allelopathic rice seedlings on rhizospheric microbial populations and their functional diversity显示文摘 | Lin Ruiyu Rong Hong Zhou Junjian Yu Cuiping Ye Chenying Chen Liangsheng Lin Wenxiong | 2007 | Acta Ecologica Sinica2007，，9： | 1 |
| 5 | Cloning and expression of JRIP a ribosome-inactivating protein from the seeds of Jatropha curcas显示文摘 | LIN J CHENY XUY | 2003 | Act Bot Sin2003，45，7： | 1 |
| 6 | Estimation of num- ber of people in crowded scenes using perspective trans- formation显示文摘 | LIN S F CHEN CHAO H X | 2001 | IEEE Transactions on Systems Man and Cybernetics Part A: Systems and Humans2001，31，6： | 1 |
| 7 | Boosting the Electrochemical Performance of Li-and Mn-Rich Cathodes by a Three-in-One Strategy显示文摘There are plenty of issues need to be solved before the practi-cal application of Li-and Mn-rich cathodes,including the detrimental voltage decay and mediocre rate capability,etc.Element doping can e ectively solve the above problems,but cause the loss of capacity.The introduction of appropriate defects can compensate the capacity loss;however,it will lead to structural mismatch and stress accumulation.Herein,a three-in-one method that combines cation–polyanion co-doping,defect construction,and stress engineering is pro-posed.The co-doped Na^(+)/SO_(4)^(2-)can stabilize the layer framework and enhance the capacity and voltage stability.The induced defects would activate more reac-tion sites and promote the electrochemical performance.Meanwhile,the unique alternately distributed defect bands and crystal bands structure can alleviate the stress accumulation caused by changes of cell parameters upon cycling.Consequently,the modified sample retains a capacity of 273 mAh g^(-1)with a high-capacity retention of 94.1%after 100 cycles at 0.2 C,and 152 mAh g^(-1)after 1000 cycles at 2 C,the corresponding voltage attenuation is less than 0.907 mV per cycle. | Wei He Fangjun Ye Jie Lin Qian Wang Qingshui Xie Fei Pei Chenying Zhang Pengfei Liu Xiuwan Li Laisen Wang Baihua Qu Dong-Liang Peng | 2021 | Nano-Micro Letters2021，13，12： | 1 |
| 8 | Nonlinear fuzzy H∞ guidance law with saturation ofactuators against maneu- vering targets 显示文摘 | CHEN B S CHENY Y LIN C L | 2002 | IEEE Transactions on Control Systems Technology2002，10，6： | 1 |
| 9 | Constructing an Energy Function for Power Systems with DFIGWT Generation Based on a Synchronous-generator-mimicking Model显示文摘In this paper we construct an energy function for multi-machine power systems with doubly-fed induction generator-based wind turbine(DFIGWT)according to a synchronous-generator-mimicking(SGM)model of the DFIGWT.An SGM model is proposed to approximate the dynamics of a DFIGWT.Similar to the modelling of a synchronous generator(SG),the internal dynamics of a DFIGWT are also described with differential equations of newly constructed virtual rotor angle and internal electromotive force(EMF)in the SGM model.Moreover,the power flow of a DFIGWT is expressed by nonlinear functions of its virtual rotor angle and internal EMF.The SGM model bridges the gap between the irregular and complex modelling of DFIGWTs and the well-developed energy function construction techniques for SG models.Based on the SGM model,a numerical energy function is constructed for power systems with DFIGWT generation.Both theoretical analysis and numerical studies were undertaken to validate that the proposed energy function satisfies the necessary conditions for an energy function of a power system. | Yang Liu Chenying Xu Zehui Lin Kaishun Xiahou Q.H.Wu | 2022 | CSEE Journal of Power and Energy Systems2022，8，1： | 1 |
| 10 | The influence of intellectual capital on new product development performance - the manufacturing companies of Taiwan as an example显示文摘 | ChenY S Lin M J J ChangC H | 2006 | Total Quality Management & Business Excellence2006，17，10： | 1 |
| 11 | On an interpolation property of outerplanar graphs显示文摘 | Lih K W Lin Chenying Tong Lida | 2006 | Disctete Appl Math2006，154，1： | 1 |
| 12 | Flammulina velutipes polysaccharide-iron (Ⅲ) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters显示文摘Iron deficiency anemia(IDA)is a common nutritional problem, but traditional iron supplements cause many adverse reactions. Thus, the development of a novel iron supplement might be significant for the treatment of IDA. This study aimed to study the transport mechanism of Flammulina velutipes polysaccharide-iron complex(FVP1-Fe(Ⅲ))in Caco-2 cells and the therapeutic effect on IDA rats, as well as the influence on gut microbiota in vivo. These results showed that in vitro, the uptake of FVP1-Fe(Ⅲ)was mediated by sodium-dependent glucose transporter-1(SGLT1)and facilitated glucose transporter-2(GLUT2)and GLUT2 played a dominant function. The multidrug resistance-associated protein-2(MRP-2)was involved in the efflux of FVP1-Fe(Ⅲ)across the Caco-2 cells. In vivo, FVP1-Fe(Ⅲ)had a better restorative effect on blood parameters and iron status indicators in rats with IDA as compared with FeSO_4 and exerted this effect by downregulating the expression of hepcidin. FVP1-Fe(Ⅲ)could also regulate gut microbiota dysbiosis in iron deficiency rats by returning the relative abundance of gut microbiota to the normal level. Besides, as a dietary factor, vitamin C(vit C)could enhance the therapeutic effect of FVP1-Fe(Ⅲ). These present findings showed that FVP1-Fe(Ⅲ)could be exploited as a novel iron supplement to treat IDA. | Chenying Shi Chen Cheng Xiaotong Lin Yanfang Qian Yufeng Du Guitang Chen | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 13 | Fucoidan-based dual-targeting mesoporous polydopamine for enhanced MRI-guided chemo-photothermal therapy of HCC via P-selectin-mediated drug delivery显示文摘The development of novel theranostic agents with outstanding diagnostic and therapeutic performances is still strongly desired in the treatment of hepatocellular carcinoma(HCC).Here,a fucoidan-modified mesoporous polydopamine nanoparticle dual-loaded with gadolinium iron and doxorubicin(FMPDA/Gd^(3+)/DOX)was prepared as an effective theranostic agent for magnetic resonance imaging(MRI)-guided chemo-photothermal therapy of HCC.It was found that FMPDA/Gd^(3+)/DOX had a high photothermal conversion efficiency of 33.4%and excellent T1-MRI performance with a longitudinal relaxivity(r1)value of 14.966 m M^(-1)·s^(-1).Moreover,the results suggested that FMPDA/Gd^(3+)/DOX could effectively accumulate into the tumor foci by dual-targeting the tumor-infiltrated platelets and HCC cells,which resulted from the specific interaction between fucoidan and overexpressed p-selectin receptors.The excellent tumor-homing ability and MRI-guided chemo-photothermal therapy therefore endowed FMPDA/Gd^(3+)/DOX with a strongest ability to inhibit tumor growth than the respective single treatment modality.Overall,our study demonstrated that FMPDA/Gd^(3+)/DOX could be applied as a potential nanoplatform for safe and effective cancer theranostics. | Gaofeng Shu Lin Shen Jiayi Ding Junchao Yu Xiaoxiao Chen Xiaoju Guo Enqi Qiao Yaning Chen Chenying Lu Zhongwei Zhao Yongzhong Du Minjiang Chen Jiansong Ji | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，6： | 0 |
| 14 | Retrospective Analysis of the Duration of Hospitalization of Imported Patients Infected with SARS-CoV-2 in Guangzhou, 2021显示文摘The pandemic of coronavirus disease 2019 is“not over,”in fact,the“dynamic clearing”policy for SARS-CoV-2 control and prevention in China has been firmly enforced.This study aimed to analyze the clinical symptoms and dynamic viral RNA changes in 2021 at Guangzhou Eighth People’s Hospital.This study showed that 31.4%of the patients(695/2212)tested negative for viral RNA from admission to the final release from quarantine.Of all negative cases,86.5%(601/695)remained in the hospital for no more than 5 days and were asymptomatic or mild.Among the remaining 402 patients who stayed for no more than 5 days,76.4%(307/402)were viral RNA retest positive during the isolation stage.However,96.4%of the peak viral RNA(296/307)was over Ct=33 cycles during the isolation stage. | Zhiwei Xie Guofang Tang Lu Li Jingrong Shi Qingxin Gan Xiaowen Zheng Jingyan Tang Huimin Zeng Chuyu Zhang Sisi Cheni Jianping Cui Zishi Lin Lihua Lin Youxia Li Jinxin Liu Feng Li Fengyu Hui Xiaoping Tang Xilong Deng | 2023 | Infectious Diseases & Immunity2023，3，1： | 0 |
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