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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Paraffin/SiC as a Novel Composite Phase-Change Material for a Lithium-Ion Battery Thermal Management System显示文摘A lithium-ion battery thermal management system has always been a hot spot in the battery industry. In this study, a novel high-thermal-conductivity composite phase-change material(CPCM) made by paraffin wax and silicon was adopted to facilitate heat transfer. Moreover, high resistance or even insulation of CPCM is capable of preventing short circuits between the cells. The heat transfer mechanism of CPCMs was determined under a scanning electron microscope. A thermogravimetric analyzer was employed to determine the thermal stability. A diff erential scanning calorimeter was used to explore the thermophysical properties of the composite samples. By comparing the results of the experiment, it was reported that under the silicon carbide content of 5%, the parameters were better than others. The phase-change enthalpy of CPCM was 199.4 J/g, the leakage rate of liquid was 4.6%, and the melting point was 53.6℃. To verify the practicality of CPCM, a three-dimensional layered battery pack model was built in the COMSOL Multiphysics software. By simulating the thermal runaway inside the battery packs of various materials, it was reported that the addition of CPCM significantly narrowed the temperature range of the battery pack from 300–370 to 303–304 K. Therefore, CPCM can eff ectively increase the rate of heat transfer to prevent the chain of thermal runaway reactions. It also enables the battery pack to run at a stable temperature. | Wei Kang Yiqiang Zhao Xueheng Jia Lin Hao Leping Dang Hongyuan Wei | 2021 | Transactions of Tianjin University2021，27，1： | 2 |
| 3 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 4 | Unsupervised Anomaly Detection Based on an Evolutionary Artificial Immune Network 显示文摘 | Liu Fang Lin Leping | 2005 | LNCS 34492005，6，12： | 1 |
| 5 | Ternary PtSmCo NPs electrocatalysts with enhanced oxygen reduction reaction显示文摘PtSmCo ternary metal nanoparticles(NPs)were synthesized as electrocatalysts for oxygen reduction reaction(ORR).Firstly,SmCo NPs were prepared by potentiostatic electrodeposition in ionic liquids(ILs),and the average particle diameter of SmCo NPs corresponds to about 238 nm(-0.65 V),72 nm(-0.75 V)and 45 nm(-0.85 V),respectively.Secondly,displacement and reductions of SmCo NPs occur in the K2 PtCl4 and L-ascorbic acid sodium with about 3 nm of Pt NPs which grow on the surface of SmCo NPs to form PtSmCo ternary metal NPs.Studies of cycle voltammetry(CV)and line sweep voltammetry(LSV)indicate that the electrocatalytic property for ORR generates a decreasing order of commercial Pt/C>PtSmCo0.85>PtSmCo0.75>PtSmCo0.65.Accelerated durability testing(ADT)after 10000 cycles shows that PtSmCo0.85 NPs electrocatalyst decreases by-40%in electrochemical active surface areas(ECSA),the half-wave potential(E1/2)only negatively shifts by 14 mV and decreases by^13.6%in mass activity(MA).When compared with JM Pt/C,where it decreases by^49%in ECSA,E1/2 is negatively shifted by 40 mV and decreased by^50%in MA.Therefore,PtSmCo0.85 NPs electrocatalyst is more stable than JM Pt/C. | Qinghua Gong Leping Wang Ni Yang Lin Tian Gang Xie Bing Li | 2020 | Journal of Rare Earths2020，38，12： | 1 |
| 6 | AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development显示文摘 | Sellitto Caterina Li Leping Gao Junyuan Robinson Michael L Lin Richard Z Mathias Richard T White Thomas W | 2013 | Journal of Clinical Investigation2013，，12： | 1 |
| 7 | Control synthesis of linear distributed parameter switched systems显示文摘The control synthesis for switched systems is extended to distributed parameter switched systems in Hilbert space. Based on semigroup and operator theory, by means of multiple Lyapunov method incorporated average dwell time approach, sufficient conditions are derived in terms of linear operator inequalities framework for distributed parameter switched systems. Being applied to one dimensional heat propagation switched systems, these linear operator inequalities are reduced to linear matrix inequalities subsequently. In particular, the state feedback gain matrices and the switching law are designed, and the state decay estimate is explicitly given whose decay coefficient completely depends on the system's parameter and the boundary condition. Finally, two numerical examples are given to illustrate the proposed method. | Leping Bao Shumin Fei Lin Chai | 2015 | Journal of Systems Engineering and Electronics2015，26，3： | 0 |
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