5篇
您的检索式：作者名="Lin Yechun"
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| 1 | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90显示文摘分子的女伴热吃惊蛋白质 90 的激活(Hsp90 ) 依赖于 ATP 绑定和水解作用,它发生在蛋白质的 N 终端域。这里,我们与 ATP 和 ATP 类似物在土著人并且在建筑群决定了人的 Hsp90 的 N 终端领域的三水晶结构,提供由 Hsp90 的 ATP 水解作用的催化机制的一个清楚的看法。另外, ATP 的绑定导致 N 终端领域是能被用来部分解释 Hsp90 的孤立的 N 终端领域为什么举办很弱的 ATP hydrolytic 活动的一个中间的状态。 | Jian Li Lihua Sun Chunyan Xu Feng Yu Huan Zhou Yanlong Zhao Jian Zhang Jianhua Cai Cheney Mao Lin Tang Yechun Xu Jianhua He | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 2 | Repetitive Control Design for Optimal Performance显示文摘 | Chert Wentao Lin Yechun | 2011 | Asian Journal of Control2011，13，6： | 1 |
| 3 | Repetitive Control Design for Optimal Performance 显示文摘 | Chen Weitao Lin Yechun | 2011 | Asian Journal of Control2011，13，6： | 1 |
| 4 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers显示文摘Nicotinamide adenine dinucleotide(NAD+)is a central metabolite in cellular processes.Depletion of NAD+has been demonstrated to be a prevalent theme in both prokaryotic and eukaryotic immune responses.Short prokaryotic Argonaute proteins(Agos)are associated with NADase domain-containing proteins(TIR-APAZ or SIR2-APAZ)encoded in the same operon.They confer immunity against mobile genetic elements,such as bacteriophages and plasmids,by inducing NAD+depletion upon recognition of target nucleic acids.However,the molecular mechanisms underlying the activation of such prokaryotic NADase/Ago immune systems remain unknown.Here,we report multiple cryo-EM structures of NADase/Ago complexes from two distinct systems(TIR-APAZ/Ago and SIR2-APAZ/Ago).Target DNA binding triggers tetramerization of the TIR-APAZ/Ago complex by a cooperative self-assembly mechanism,while the heterodimeric SIR2-APAZ/Ago complex does not assemble into higher-order oligomers upon target DNA binding.However,the NADase activities of these two systems are unleashed via a similar closed-to-open transition of the catalytic pocket,albeit by different mechanisms.Furthermore,a functionally conserved sensor loop is employed to inspect the guide RNA–target DNA base pairing and facilitate the conformational rearrangement of Ago proteins required for the activation of these two systems.Overall,our study reveals the mechanistic diversity and similarity of Ago protein-associated NADase systems in prokaryotic immune response. | Xinwei Wang Mu Wang Tuo Xu Ye Feng Qiang Shao Shuo Han Xiaojing Chu Yechun Xu Shuling Lin Qiang Zhao Beili Wu | 2023 | Cell Research2023，33，10： | 0 |
| 5 | An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction显示文摘The pathophysiology of preeclampsia(PE)remains unclear.PE spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide concern.We collected placental and umbilical artery samples from normotensive and PE pregnancies.Mineralocorticoid receptor(MR)and its alternative splicing variant(ASV)expression and their biological effects on PE were examined.An MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples(umbilical artery,~57.58%;placenta,~36.84%).The MR ASV expression was positively associated with blood pressure in both groups.The MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling pathways.The MR ASV can also impair the proliferation,migration,and tube formation ability of endothelial cells.These findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology,especially in endothelial dysfunction,and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases. | Mengxi Guo Chengliang Zhou Gufeng Xu Lin Tang Yechun Ruan Ying Yu Xianhua Lin Dandan Wu Hao Chen Priscilla Yu Luyang Jin Yinyu Wang Yimei Wu Kamran Ullah Tanzil Ur Rahman Xinmei Liu Jianzhong Sheng Hsiao-Chang Chan Hefeng Huang | 2020 | Science China(Life Sciences)2020，63，3： | 0 |
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