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| 1 | Ferroptosis:mechanisms and links with diseases显示文摘Ferroptosis is an iron-dependent cell death,which is different from apoptosis,necrosis,autophagy,and other forms of cell death.The process of feroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation of lipids,which can be prevented by iron chelators(e.g.deferiprone,deferoxamine)and small lipophilic antioxidants(e.g,ferrostatin,liproxstatin).This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association withseveral pathways,including iron,lipid,and cysteine metabolism.We have further discussed the contribution of ferroptosis to thepathogenesis of several diseases such as cancer,ischemia/reperfusion,and various neurodegenerative diseases(e.g.Alzheimersdisease and Parkinson's disease),and evaluated the therapeutic applications of ferroptosis inhibitors in clinics. | Hong-fa Yan Ting Zou Qing-zhang Tuo Shuo Xu Hua Li Abdel Ali Belaidi Peng Lei | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 2 | Relative humidity reconstruction for northwestern China's Altay Mountains using tree-ring δ^(18)O显示文摘Relative humidity is an important factor in water and water vapor feedback cycles.In this study,we established a 222-year annual tree-ring δ^(18)O chronology for Siberian larch(Larix sibirica Ldb.)from the Altay Mountains in northwestern China.Climate response analyses revealed that the relative humidity was the primary factor limiting tree-ring δ^(18)O fractionation.Based on our analysis,tree-ring δ^(18)O can be used to reconstruct the July–August relative humidity based on both a reasonable mechanism of tree-ring δ^(18)O fractionation and a statistically significant regression model.We used this model to reconstruct variations in the July–August relative humidity,and the model explained 47.4% of the total variation in the measured relative humidity data from 1961 to 2011.The relative humidity in the study area increased from 1900 to the 1990s and decreased thereafter.Two regime-shift dry periods were detected during the study period(one from 1817 to 1830 and the other from 2004 to 2011). | Guobao Xu Xiaohong Liu Dahe Qin Tuo Chen Wenzhi Wang Guoju Wu Weizhen Sun Wenling An Xiaomin Zeng | 2014 | Chinese Science Bulletin2014，59，2： | 14 |
| 3 | Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy显示文摘Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA: 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly(P<0.05), while the plasma level of albumin decreased significantly(P<0.05); The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group(P<0.01). Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased. | JIANG Wei LIU Tuo DONG Hui XU Yan LIU Li Qiu GUAN Guang Ju LIU Xiang Chun | 2015 | Biomedical and Environmental Sciences2015，28，3： | 13 |
| 4 | Effect of Root Architecture on Structural Stability and Erodibility of Topsoils during Concentrated Flow in Hilly Loess Plateau显示文摘Traditional vegetation techniques for the control of concentrated flow erosion are widely recognized, whereas only a few studies have experimentally investigated the impacts of belowground roots on the erodibility of topsoils in semi-arid areas. To quantify the effects of root architectures on soil erodibility and its relevant structural properties, simulated flow experiments were conducted at six-week intervals from 18 July to 20 October in 2012 in the hilly Loess Plateau. Five treatments were: 1) bare(control), 2) purple alfalfa(Medicago sativa), representing tap roots(T), 3) switchgrass(Panicum virgatum), representing fibrous roots(F), 4) purple alfalfa and switchgrass, representing both tap and fibrous roots(T + F), and 5) natural recovery(N). For each treatment, soil structural properties and root characteristics were measured at an interval of six weeks. Soil anti-scouribility was calculated. Results showed that grass planting slightly reduced soil bulk density, but increased soil aggregate content by 19.1%, 10.6%, 28.5%, and 41.2% in the treatments T, F, T + F, and N, respectively. Soil shear strength(cohesion and angle of internal friction(φ)) significantly increased after the grass was planted. As roots grew, soil cohesion increased by 115.2%–135.5%, while soil disintegration rate decreased by 39.0%–58.1% in the 21 th week compared with the recorded value in the 9th week. Meanwhile, root density and root surface area density increased by 64.0%–104.7% and 75.9%–157.1%, respectively. No significant differences in soil anti-scouribility were observed between the treatments of T and F or of T + F and N, but the treatments of T + F and N performed more effectively than T or F treatment alone in retarding concentrated flow. Soil aggregation and root surface-area density explained the observed soil anti-scouribility during concentrated flow well for the different treatments. This result proved that the restoration of natural vegetation might be the most appropriate strategy in soil reinforcement in the hilly Loess Plateau. | LI Qiang LIU Guobin ZHANG Zheng TUO Dengfeng XU Mingxiang | 2015 | Chinese Geographical Science2015，25，6： | 13 |
| 5 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 6 | Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver显示文摘Organic anion transporters(OATs)and organic anion transporter polypeptides(OATPs)are classified within two SLC superfamilies,namely,the SLC22A superfamily and the SLCO superfamily(formerly the SLC21A family),respectively.They are expressed in many tissues,such as the liver and kidney,and mediate the absorption and excretion of many endogenous and exogenous substances,including various drugs.Most are composed of 12 transmembrane polypeptide chains with the C-terminus and the N-terminus located in the cell cytoplasm.OATs and OATPs are abundantly expressed in the liver,where they mainly promote the uptake of various endogenous substrates such as bile acids and various exogenous drugs such as antifibrotic and anticancer drugs.However,differences in the locations of glycosylation sites,phosphorylation sites,and amino acids in the OAT and OATP structures lead to different substrates being transported to the liver,which ultimately results in their different roles in the liver.To date,few articles have addressed these aspects of OAT and OATP structures,and we study further the similarities and differences in their structures,tissue distribution,substrates,and roles in liver diseases. | Ting-Ting Li Jia-Xing An Jing-Yu Xu Bi-Guang Tuo | 2019 | World Journal of Clinical Cases2019，7，23： | 12 |
| 7 | Unfolding analysis of LaBr3:Ce gamma spectrum with a detector response matrix constructing algorithm based on energy resolution calibration显示文摘With respect to the gamma spectrum, the energy resolution improves with increase in energy. The counts of full energy peak change with energy, and this approximately complies with the Gaussian distribution. This study mainly examines a method to deconvolve the LaBr_3:Ce gamma spectrum with a detector response matrix constructing algorithm based on energy resolution calibration.In the algorithm, the full width at half maximum(FWHM)of full energy peak was calculated by the cubic spline interpolation algorithm and calibrated by a square root of a quadratic function that changes with the energy. Additionally, the detector response matrix was constructed to deconvolve the gamma spectrum. Furthermore, an improved SNIP algorithm was proposed to eliminate the background. In the experiment, several independent peaks of ^(152)Eu,^(137)Cs, and ^(60)Co sources were detected by a LaBr_3:Ce scintillator that were selected to calibrate the energy resolution. The Boosted Gold algorithm was applied to deconvolve the gamma spectrum. The results showed that the peak position difference between the experiment and the deconvolution was within ± 2 channels and the relative error of peak area was approximately within 0.96–6.74%. Finally, a ^(133) Ba spectrum was deconvolved to verify the efficiency and accuracy of the algorithm in unfolding the overlapped peaks. | Rui Shi Xian-Guo Tuo Huai-Liang Li Yang-Yang Xu Fan-Rong Shi Jian-Bo Yang Yong Luo | 2018 | Nuclear Science and Techniques2018，29，1： | 11 |
| 8 | Preparation of ternary Cr_2 O_3-SiC-TiO_2 composites for the photocatalytic production of hydrogen显示文摘Novel ternary Cr 2 O 3 -SiC-TiO 2 composites were synthesized by implanting Cr 3+ into SiC-TiO 2 via sol-gel and impregnation approaches. The results from X-ray diffraction, scanning electron microscopy and trans- mission electron microscopy show that the Cr 3+ species were doped onto the surface of the SiC-TiO 2 carrier. The diffuse reflectance ultraviolet-visible absorption spectra revealed that the absorption edges of the ternary Cr 2 O 3 -SiC-TiO 2 composites were gradually shifted red with increasing chromium content. The luminescence intensities of the composites decreased with increasing doped Cr 3+ content due to the reduction in the number of recombination sites of electron-hole pairs. The ternary Cr 2 O 3 -SiC-TiO 2 com- posites showed high hydrogen-producing activities, which probably results from the formation of donor levels of the Cr 3+ species in the forbidden band of the SiC semiconductor. | Yaojun Zhang Yong Xu Tuo Li Yachao Wang | 2012 | Particuology2012，10，1： | 8 |
| 9 | Interactions between wind and water erosion change sediment yield and particle distribution under simulated conditions显示文摘Wind and water erosion are among the most important causes of soil loss, and understanding their interactions is important for estimating soil quality and environmental impacts in regions where both types of erosion occur. We used a wind tunnel and simulated rainfall to study sediment yield, particle-size distribution and the fractal dimension of the sediment particles under wind and water erosion. The experiment was conducted with wind erosion firstly and water erosion thereafter, under three wind speeds(0, 11 and 14 m/s) and three rainfall intensities(60, 80 and 100 mm/h). The results showed that the sediment yield was positively correlated with wind speed and rainfall intensity(P<0.01). Wind erosion exacerbated water erosion and increased sediment yield by 7.25%–38.97% relative to the absence of wind erosion. Wind erosion changed the sediment particle distribution by influencing the micro-topography of the sloping land surface. The clay, silt and sand contents of eroded sediment were also positively correlated with wind speed and rainfall intensity(P<0.01). Wind erosion increased clay and silt contents by 0.35%–19.60% and 5.80%–21.10%, respectively, and decreased sand content by 2.40%–8.33%, relative to the absence of wind erosion. The effect of wind erosion on sediment particles became weaker with increasing rainfall intensities, which was consistent with the variation in sediment yield. However, particle-size distribution was not closely correlated with sediment yield(P>0.05). The fractal dimension of the sediment particles was significantly different under different intensities of water erosion(P<0.05), but no significant difference was found under wind and water erosion. The findings reported in this study implicated that both water and wind erosion should be controlled to reduce their intensifying effects, and the controlling of wind erosion could significantly reduce water erosion in this wind-water erosion crisscross region. | TUO Dengfeng XU Mingxiang ZHAO Yunge GAO Liqian | 2015 | Journal of Arid Land2015，7，5： | 8 |
| 10 | Application of pole-zero cancellation circuit in nuclear signal filtering and shaping algorithm显示文摘In radiation measurement and digital nuclear spectrum systems,traditional nuclear signal processing circuits in nuclear electronics have been gradually replaced by digital algorithm modules with the application of highperformance programmable hardware logic devices(such as FPGA or DSP).Referring to the digital realization method of inverse RC integral circuit systems,the function of the pole-zero cancellation(PZC)circuit was analyzed,a new modified cascade equivalent model of PZC was established,and the time-domain digital PZC(DPZC)recursive algorithm was derived in detail in this study.Two parameters kIand k_(D)are included in the new algorithm,where kIshould match the exponential decay time constant of the input signal to realize the pole-zero compensation,while the decay time constant of the output signal can be changed with the adjustable parameter k_(D)(which is larger than the decay time constant of the input signal).Based on the new DPZC algorithm module,two trapezoidal(triangular)shaping filters were designed and implemented.The amplitude–frequency characteristics of the output signal of the proposed trapezoidal shaping algorithm and the convolution trapezoidal shaping algorithm were compared,with fixed peaking time.The results show that the trapezoidal shaping algorithm based on DPZC can better suppress high-frequency noise.Finally,based on the Na I(Tl)scintillator(u75 mm×75 mm)detector and^(137)Cs source,the effect of the k_(D)value on the energy resolution of the DPZC trapezoidal(triangular)shaping algorithm was studied.The experimental results show that,with an increase in k_(D),the energy resolution of the system improved and reached the maximum when k_(D)was greater than 10,and the optimal energy resolution of the system was 7.72%. | Huai-Ping Wang Jian-Bin Zhou Xiao-Ping Ouyang Xian-Guo Tuo Xu Hong Yi Liu Jie Yu You-Xian Jin | 2021 | Nuclear Science and Techniques2021，32，8： | 7 |
| 11 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 12 | Unfolding neutron spectra from water-pumping-injection multilayered concentric sphere neutron spectrometer using self-adaptive differential evolution algorithm显示文摘A self-adaptive differential evolution neutron spectrum unfolding algorithm(SDENUA)is established in this study to unfold the neutron spectra obtained from a water-pumping-injection multilayered concentric sphere neutron spectrometer(WMNS).Specifically,the neutron fluence bounds are estimated to accelerate the algorithm convergence,and the minimum error between the optimal solution and input neutron counts with relative uncertainties is limited to 10^(-6)to avoid unnecessary calculations.Furthermore,the crossover probability and scaling factor are self-adaptively controlled.FLUKA Monte Carlo is used to simulate the readings of the WMNS under(1)a spectrum of Cf-252 and(2)its spectrum after being moderated,(3)a spectrum used for boron neutron capture therapy,and(4)a reactor spectrum.Subsequently,the measured neutron counts are unfolded using the SDENUA.The uncertainties of the measured neutron count and the response matrix are considered in the SDENUA,which does not require complex parameter tuning or an a priori default spectrum.The results indicate that the solutions of the SDENUA agree better with the IAEA spectra than those of MAXED and GRAVEL in UMG 3.1,and the errors of the final results calculated using the SDENUA are less than 12%.The established SDENUA can be used to unfold spectra from the WMNS. | Rui Li Jian-Bo Yang Xian-Guo Tuo Jie Xu Rui Shi | 2021 | Nuclear Science and Techniques2021，32，3： | 4 |
| 13 | Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system显示文摘The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets.Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying.In this study,the technique of differential spectra was employed,which made it possible to monitor the dissolution testing in situ.The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid(4.0),and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets. | Yan Wang Ping-Ping Xu Xin-Xia Li Kun Nie Ming-Fu Tuo Bin Kong Jian Chen | 2012 | Journal of Pharmaceutical Analysis2012，2，5： | 4 |
| 14 | Novel Even Beam Splitters Based on Subwavelength Binary Simple Periodic Rectangular Structure显示文摘In this paper, a novel method of a subwavelength binary simple periodic rectangular structure is presented to realize even beam splitting by combining the rigorous couple-wave analysis with the genetic algorithm. Several even splitters in the terahertz region were designed and one of the silicon-based beam splitters designed to separate one incident beam into four emergent beams has total efficiency up to 92.23 %. Zero-order diffraction efficiency was reduced to less than 0.192 % and the error of uniformity decreased to 6.51 9 10-6. These results break the limitation of even beam splitting based on the traditional scalar theory. In addition, the effects of the incident angle, wavelength, as well as the polarizing angle on the diffraction efficiency and uniformity were also investigated. | Haixuan Huang Shuangchen Ruan Tuo Yang Ping Xu | 2015 | Nano-Micro Letters2015，7，2： | 3 |
| 15 | Gene cloning and induced expression pattern of IRF4 and IRF10 in the Asian swamp eel(Monopterus albus)显示文摘The Asian swamp eel(Monopterus albus) is one of the most economically important freshwater fish in East Asia,but data on the immune genes of M.albus are scarce compared to other commercially important fish.A better understanding of the eel's immune responses may help in developing strategies for disease management,potentially improving yields and mitigating losses.In mammals,interferon regulatory factors(IRFs) play a vital role in both the innate and adaptive immune system; though among teleosts IRF4 and IRF10 have seldom been studied.In this study,we characterized IRF4 and IRF10 from M.albus(maIRF4 and maIRF10) and found that maIRF4 cDNA consists of 1 716 nucleotides encoding a 451 amino acid(aa) protein,while maIRF10 consists of 1 744 nucleotides including an open reading frame(ORF) of 1 236 nt encoding 411 aa.The maIRF10 gene was constitutively expressed at high levels in a variety of tissues,while maIRF4 showed a very limited expression pattern.Expression of maIRF4 and maIRF10 in head kidney,and spleen tissues was significantly up-regulated from 12 h to 48 h post-stimulation with polyinosinic: polycytidylic acid(poly I:C),lipopolysaccharide(LPS) and a common pathogenic bacteria Aeromonas hydrophila.These results suggest that IRF4 and IRF10 play roles in immune responses to both viral and bacterial infections in M.albus. | Qiao-Qing XU Dai-Qin YANG Rui TUO Jing WAN Ming-Xian CHANG Pin NIE | 2014 | Zoological Research2014，35，5： | 3 |
| 16 | Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion显示文摘Ischemic stroke represents a significant danger to human beings,especially the elderly.Interventions are only available to remove the clot,and the mechanism of neuronal death during ischemic stroke is still in debate.Ferroptosis is increasingly appreciated as a mechanism of cell death after ischemia in various organs. | Qing-zhang Tuo Yu Liu Zheng Xiang Hong-Fa Yan Ting Zou Yang Shu Xu-long Ding Jin-jun Zou Shuo Xu Fei Tang Yan-qiu Gong Xiao-lan Li Yu-jie Guo Zhao-yue Zheng Ai-ping Deng Zhang-zhong Yang Wen-jing Li Shu-ting Zhang Scott Ayton Ashley I.Bush Heng Xu Lunzhi Dai Biao Dong Peng Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 17 | Ecological Environment Conservation and Restoration and Sustainable Development of Minqin Oasis显示文摘Minqin oasis in the lower reaches of the Shiyang River is a main natural barrier for the Wuwei Basin. Due to the combined influence of human activities and natural factors in the past half a century, water quality in the lower reaches of the Shiyang River decreased and ecological environment deteriorated, which influenced sustainable development of this area and surrounding area seriously. This paper analyzed current situation and reasons of the deteriorated ecological environment in the lower reaches of the Shiyang River, and proposed that water environment regulation was the primary task in the eco-environment control of Minqin area, specifically,(a) By using existing policies, accelerating the construction of water-saving agriculture in the middle reaches of the Shiyang River, water quantity in the lower reaches would be guanranted, water shortage for agricultural production and ecological use in Minqin oasis would be relieved;(b) Unreasonable human activities such as overexploitation of underground water should be controlled strictly;(c) Water conservancy project should be developed vigorously to ensure rate of flow. It was expected that the above schemes would contribute to the benign circulation of ecological environment in Minqin oasis. | WANG Lide YAO Tuo XU Feng HAN Fugui GUO Chunxiu WANG Fangling Li Faming | 2016 | Journal of Landscape Research2016，8，1： | 2 |
| 18 | Transcriptomics-based identification and characterization of 11 CYP450 genes of Panax ginseng responsive to MeJA显示文摘Cytochromes P450 (CYP450s),a superfamily of mono-oxygenases,are essential to generate highly functionalized secondary metabolites in plants and contribute to the diversification of specialized triterpenoid biosynthesis in eudicots.However,screening and identifying the exact CYP450 genes in ginsenoside biosynthesis is extremely challenging due to existence of large quantities of members in CYP450 superfamily.Therefore,to screen the CYP450 genes involved in ginsenoside bio- synthesis,transcriptome dataset of Panax ginseng was created in our previous work using the technique of the next-generation sequencing.On the basis of bioinformatics analysis,16 putative CYP450 genes with significant differential expression were screened from the dataset and submit- ted to GenBank,in which 11 of them have been cloned.Methyl jasmonate (MeJA)was used as an elicitor to analyze the expression profiles of candidate CYP450 genes by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR).The results of qRT-PCR analysis revealed that the expression of some CYP450 genes were strongly induced by MeJA and showed different transcription levels at different treatment time points.Homology analysis indicated that each putative CYP450 protein of P.ginseng has a conserved domain consisting of E-E-R-F-P-R-G. The CYP450 genes were screened and cloned here to enrich the resources of CYP450 genes,and the results of bioinformatics analysis provided a foundation to further identify the function of CYP450s involved in ginsenoside biosynthesis.Furthermore,this study facilitated the construction of microbial cell factories for increasing the production of ginsenosides by means of metabolic engineering. | Xu Zeng Tiao Luo Jijia Li Gui Li Donghua Zhou Tuo Liu Xian Zou Aparna Pandey Zhiyong Luo | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 2 |
| 19 | Hierarchical Dispatch Method for Integrated Heat and Power Systems Based on a Feasible Region of Boundary Variables显示文摘Fully utilizing the flexibility provided by a district heating system(DHS)can promote wind power accommodation for an electric power system(EPS).However,for privacy or communication reasons,existing power and heat dispatch methods are not suitable for practical application.In this paper,a general math formulation of the hierarchical dispatch method is proposed to coordinate EPS and DHS operators based on the feasible region of boundary variables(FRBV),and a method based on the simplicial approximation approach is proposed to obtain a conservative FRBV approximation of a DHS.A simulation based on a real 41-node DHS is constructed to determine the factors that may impact the boundaries of the FRBV,and then the performance of the simplicial approximation approach is displayed by visualizing the approximation process for the FRBV,and finally three dispatch methods are compared to show the advantages of the proposed hierarchical dispatch method. | Tuo Jiang Yong Min Weichun Ge Lei Chen Qun Chen Fei Xu Huanhuan Luo Guiping Zhou | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 2 |
| 20 | Simulation study on the boron-coated GEM neutron beam monitor显示文摘A Monte Carlo method of the 3D GEM simulation is introduced.The physical process of the neutron detection is described with the Geant4 code and the Garfield code.The results of the optimized electric-fields,the emitted ions spectrum,the electrons transverse diffusion and the signal width are presented.Moreover,the preliminary result with a CF-252 neutron source is reported.These are useful in designing detector structures and to provide an optimized option for the development of the boron-coated GEM neutron beam monitor. | WANG YanFeng SUN ZhiJia ZHOU JianRong YANG GuiAn XU Hong WANG Tuo CHEN YuanBo | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 2 |
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