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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Multiple - input Multiple- output Measurements and Modeling in Manhattan显示文摘 | Chizhik D Ling J Wolniansky P | 2003 | IEEE Journal on Selected Areas in Communications2003，21，3： | 1 |
| 3 | Polymer memories: Bistable electrical switching and device performance显示文摘 | Ling Qidan Liaw D J Teo E Y H | 2007 | Polymer2007，48，18： | 1 |
| 4 | Polymer electronic memories: Materials, devices and mechanisms显示文摘 | Ling Qidan Liaw D J Zhu Chunxiang | 2008 | Prog Polym Sci2008，33，10： | 1 |
| 5 | Study on biogas production by mesophilic fermentation with conyza canadensis显示文摘 | ZHANG L J LING W D ZHANG W D | 2013 | Advanced Materials Research2013，788，： | 1 |
| 6 | Multiple input multiple output measurements and modeling in Manhattan 显示文摘 | Chizhik D Ling J Wolniansky P W | 2003 | Selected Areas in Communications2003，21，3： | 1 |
| 7 | The Neural Mechanism Underlying the Female Advantage in Identifyin Negative Emotions: An Event-related Potential Study 显示文摘 | YUAN J J LING C D | 2008 | Neuroimage2008，，40： | 1 |
| 8 | Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines显示文摘 | LING Y H JIANG J D HOLLAND J F | 2002 | Mol Pharmacol2002，62，3： | 1 |
| 9 | Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence selective DNA- binding antitumor agent, hedamycin: evidence of survivin down- regulation associated with drug sensitivity 显示文摘 | WU J LING X PAN D | 2005 | J Biol Chem2005，280，10： | 1 |
| 10 | Green leaf volatiles enhance sex attractant p-heromone of the tobacco budworm,Heliothis virescens显示文摘 | Dickens J C Smith J N Ling D M | 1993 | Chemoecology1993，4，： | 1 |
| 11 | Dense phase conveying of fine coal at high total pressure显示文摘 | Oeldart D Ling S J | 1990 | Powder Technology1990，62，3： | 1 |
| 12 | Studies on flaovr volatiles of some sweet corn products显示文摘 | Buttery R G Stern D J Ling L C | 1982 | Journal of Agricultural and Food Chemistry1982，30，： | 1 |
| 13 | Optimization of enantioselectiveproduction of chiral epichlorohydrin catalyzed by a novel epoxidehydrolase from domestic duck liver by response surface methodology显示文摘 | Ling X Q Lu D Q Wang J | 2009 | African Journal of Biotechnology2009，8，20： | 1 |
| 14 | ,et al Polymer memories:Bistable electrical switching and device performance显示文摘 | Ling Q D Liaw D J Teo E Y H | 2007 | Polymer2007，48，18： | 1 |
| 15 | Detection of free k chains in human serum and urine using pairs of monoclonal antibodies reacting with Cepitopes not available on whole immunoglobulins显示文摘 | Ling NR Lowe J Hardie D | 1983 | Clin Exp Immunol1983，52，： | 1 |
| 16 | Face stability analysis of shallow shield tunnels in dry sandy ground using the discrete element method显示文摘 | CHEN R P TANG L J LING D S | 2011 | Computers and Geotechnics2011，38，： | 1 |
| 17 | RFLP analysis of SLA haplotypes in Swiss Large White and American Hampshire pigs using SLA class Ⅰand class Ⅱ probes显示文摘 | Gautischi C Ling M S Beever J E Mclaren D G Lewin H A Schook L B | 1991 | Animal Biotechnology1991，2，： | 1 |
| 18 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 19 | Dense phase conveying of fine coal at high total pressure显示文摘 | Geldart D Ling S J | 1990 | Powder Technology1990，62，： | 1 |
| 20 | Different origins of adakites from the Dabie mountains and the Lower Yangtze River Belt, Eastern China: Geochemical constraints显示文摘 | LING M X WANG F Y DING X ZHOU J B SUN W D | 2011 | International Geology Review2011，53，： | 1 |
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