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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Testosterone enhances apoptosis-related damage in human vascular endothelial cells显示文摘 | Ling S Dai A Williams M R | 2002 | Endocrinology2002，143，3： | 1 |
| 3 | Production, purification and characterization of anintracellar aflatoxin - detoxifizyme from Armillariella tabescens (E- 20) 显示文摘 | Liu D L Yao D S Ling R | 2001 | Food and Chemical Toxicology2001，39，： | 1 |
| 4 | A novel combined vaccine candidate containing epitopes of HCV NS3,core and E1 proteins induces multi-specific immune responses in BALB/c mice显示文摘 | Zeng R H Li G X Ling S G | 2009 | Antivir Res2009，84，： | 1 |
| 5 | Some cautionary notes on the use of principal components regression显示文摘 | Hadi A S Ling R F | 1998 | The American Statistician1998，52，： | 1 |
| 6 | Molecular diagnosis of clear cell sarcoma: Detection of EWS-ATF1 and MITF transcripts and histopathological and ultrastruetural analysis of 12 ea- ses 显示文摘 | LING C R TSCHEMYAVSKY S J WOODRUFF J M | 2002 | J MolDiagn2002，4，1： | 1 |
| 7 | Parametric investigation of laser diode bonding using euteetie AuSn solder 显示文摘 | TEO J W R LIA G Y LING M S | 2007 | Thin Solid Films2007，515，： | 1 |
| 8 | Performance of photocatalytic reactors using immobilized TiO2 film for the degradation of phenol and methylene blue dye present in water stream 显示文摘 | Ling C M Mohamed A R Bhatia S | 2004 | Chemosphere2004，57，7： | 1 |
| 9 | Face stability analysis of shallow shield tunnels in dry sandy ground using the discrete element method显示文摘 | CHEN R P TANG L J LING D S | 2011 | Computers and Geotechnics2011，38，： | 1 |
| 10 | Perfomanee of photocatalytic reactors using immobilized TiO2 film for the degradation of phenol and methylene blue dye present in water stream 显示文摘 | Ling C M Mohamed A R Bhatia S | 2004 | Chemosphere2004，57，7： | 1 |
| 11 | Sensitivity to topoisomerase inhibitors and cisplatin is associated with epidermal growth factor receptor expression in human cervical squamous carcinoma ME180 sublines 显示文摘 | LING Y H DONATO N J PEREZ S R | 2001 | Cancer Chemother Pharmaco12001，47，6： | 1 |
| 12 | Shooting and bouncing rays: Calculating the RCS of an arbitrarily shaped cavity 显示文摘 | LING H CHOU R C LEE S W | 1989 | IEEE Trans on Antennas Propogation1989，，2： | 1 |
| 13 | Room occupancies:Cruise lines out-do the hotels显示文摘 | Toh R S Rivers M J Ling T W | | 0，，01： | 1 |
| 14 | Dy- namic capabilities and performance:Strategy, struc- ture and environment 显示文摘 | Wilden R Gudergan S P Nielsen B B Lings I | 2013 | Long Range Planning2013，46，12： | 1 |
| 15 | Shear-Induced Molecular Orientation and Crystallization in Isotactic:Polypropylene:Effects of the Deformation Rate and Strain显示文摘 | Somani R H Ling Yang Hsiao B S | 2005 | Macromolecules2005，38，： | 1 |
| 16 | Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion显示文摘 | Ling C Del Guerra S Lupi R | 2008 | Diabetologia2008，51，4： | 1 |
| 17 | Study on im- munosensor based on gold nanoparticles/chitosan and MnO2 nanoparticles composite membrane-Prussian blue modified gold electrode显示文摘 | Ling S J Yuan R ChaiYQ etal | 2009 | Bioprocess Biosyst Eng2009，3，32： | 1 |
| 18 | Neoproterozoic tectonic evolution of the northwestern Yangtze Craton, South China: Implications for a- malgamation and breakup of the Rodinia supereontinent 显示文摘 | Ling W Gao S Zhang B R | 2003 | Precamb Res2003，122，： | 1 |
| 19 | Impackted cancellous allografts and cement for revision total hip arthroplasty with bone显示文摘 | Gie G A linder L Ling R S | 2002 | Clin Orthop Relat Res2002，75，1： | 1 |
| 20 | Review of gold extraction from ores 显示文摘 | La Brooy S R Linge H G Walker G S | 1994 | Minerals Engineering1994，7，10： | 1 |
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