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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 3 | Shooting and bouncing rays: calculating the RCS of an arbitrarily shaped cavity 显示文摘 | Ling H Chou Pt C Lee S W | 1989 | IEEE Transactions on Antennas and Propagation1989，37，2： | 1 |
| 4 | Contrasting geochemical and Sm- Nd isotopic compositions of Archean metasediments from the Kongling high-grade terrain of the Yangtze craton: Evidence for cra- tonic evolution and redistribution of REE during crustal anatexis显示文摘 | Gao S Ling W L Qiu Y M | 1999 | Geochimica et Cosmochimica Acta1999，63，1314： | 1 |
| 5 | Antibody-based inhibition of DKKI suppresses tumor-induced bone resorption and multiple myeloma growth in vivo显示文摘 | YACCOBY S LING W ZHAN F | 2007 | Blood2007，109，5： | 1 |
| 6 | A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China显示文摘 | You-lin Qiao John W Sellors Paul S Eder Yan-ping Bao Jeanette M Lim Fang-hui Zhao Bernhard Weigl Wen-hua Zhang Roger B Peck Ling Li Feng Chen Qing-jing Pan Attila T Lorincz | 2008 | Lancet Oncology2008，，10： | 1 |
| 7 | A Simple Printed Ultrawideband Antenna with a Quasi-Transmission Line Section 显示文摘 | Ling C W Chung S | 2009 | IEEE Trans Antennas Propag2009，57，10： | 1 |
| 8 | Recognition of Grenvillian volcanic suite in the Shennongjia region and its tectonic significance for the South China Craton 显示文摘 | Qiu X F Ling W L Liu X M Kusky T Berkana W ZhangY H Gao Y J Lu S S Kuang H Liu C X | 2011 | Precambrian Research2011，191，： | 1 |
| 9 | Determination of DNA by Use of the Molecular 'Light Switch' Complex of Ru(bipy)2(dppz)^2+ 显示文摘 | Ling L S He Z K Song G W | 2000 | Mikrochhn Acta2000，134，12： | 1 |
| 10 | Contrasting Geo- chemical and Sm-Nd Isotopic Compositions of Archean Metasediments from the Kongling High-grade Terrain of the Yangtze Craton: Evidence for Cratonic Evolution and Redistribution of REE During Crustal Anatexis 显示文摘 | GAO S LING W L QIU Y M | 1999 | Geochimiea et Cosmochimica Acta1999，63，1314： | 1 |
| 11 | Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple Myelom a growth in vivo显示文摘 | Yaccoby S Ling W Zhan F | 2007 | Blood2007，109，5： | 1 |
| 12 | Project scheduling for collaborative product development using DSM显示文摘 | Chen C H Ling S F Chen W | 2002 | International Journal of Project Management2002，21，： | 1 |
| 13 | Parametric investigation of laser diode bonding using euteetie AuSn solder 显示文摘 | TEO J W R LIA G Y LING M S | 2007 | Thin Solid Films2007，515，： | 1 |
| 14 | Crucial role of corneal lymphangiogenesis for allograft rejection in alkali-burned cornea bed显示文摘 | Ling S Qi C Li W | | 0，，： | 1 |
| 15 | Just noticeable distortion model and its applications in video coding 显示文摘 | Yang X K Ling W S Lu Z K | 2005 | Signal Processing: Image Communication2005，20，7： | 1 |
| 16 | Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China显示文摘 | Ling X Bi S Yang W et a1 | 2009 | J Infect Dis2009，，200： | 1 |
| 17 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 18 | A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification:findings from the National Institute on Drug Abuse Clinical Trials Network显示文摘 | Ling W Amass L Shoptaw S | 2005 | Addiction2005，100，8： | 1 |
| 19 | Shooting and bouncing rays: Calculating the RCS of an arbitrarily shaped cavity 显示文摘 | LING H CHOU R C LEE S W | 1989 | IEEE Trans on Antennas Propogation1989，，2： | 1 |
| 20 | Room occupancies:Cruise lines out-do the hotels显示文摘 | Toh R S Rivers M J Ling T W | | 0，，01： | 1 |
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