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| 1 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 2 | Argonaute protein as a linker to command center of physiological processes显示文摘MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by binding to target mRNAs with perfect or imperfect complementarity, recruiting an Argonaute (AGO) protein complex that usually results in degradation or translational repression of the target mRNA. AGO proteins function as the Slicer enzyme in miRNA and small interfering RNA (siRNA) pathways involved in human physiological and pathophysiological processes, such as antiviral responses and disease formation. Although the past decade has witnessed rapid advancement in studies of AGO protein functions, to further elucidate the molecular mechanism of AGO proteins in cellular function and biochemical process is really a challenging area for researchers. In order to understand the molecular causes underlying the pathological processes, we mainly focus on five fundamental problems of AGO proteins, including evolution, functional domain, subcellular location, post-translational modification and protein-protein interactions. Our discussion highlight their roles in early diagnosis, disease prevention, drug target identification, drug response, etc. | Kaifa Wei Lingjuan Wu Yanhui Chen Yina Lin Yanmei Wang Xiaoyao Liu Daoxin Xie | 2013 | Chinese Journal of Cancer Research2013，25，4： | 2 |
| 3 | Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis显示文摘In the sexually reproductive organisms, gametes are produced by meiosis following a limited mitotic amplification. However, the intrinsic program switching cells from mitotic to meiotic cycle is unclear.Alternative polyadenylation(APA) is a highly conserved means of gene regulation and is achieved by the RNA 30-processing machinery to generate diverse 30 UTR profiles. In Drosophila spermatogenesis, we observed distinct profiles of transcriptome-wide 30 UTR between mitotic and meiotic cells. In mutant germ cells stuck in mitosis, 30 UTRs of hundreds of genes were consistently shifted. Remarkably, altering the levels of multiple 30-processing factors disrupted germline's progression to meiosis, indicative of APA's active role in this transition. An RNA-binding protein(RBP) Tut could directly bind 30 UTRs of 30-processing factors whose expressions were repressed in the presence of Tut-containing complex. Further,we demonstrated that this RBP complex could execute the repression post-transcriptionally by recruiting CCR4/Twin of deadenylation complex. Thus, we propose that an RBP complex regulates the dynamic APA profile to promote the mitosis-to-meiosis transition. | Lingjuan Shan Chan Wu Di Chen Lei Hou Xin Li Lixia Wang Xiao Chu Yifeng Hou Zhaohui Wang | 2017 | Journal of Genetics and Genomics2017，44，2： | 1 |
| 4 | Enhancing the stability of metal-organic frameworks in humid air by incorporating water repellent functional groups显示文摘 | Wu Tianjiao Shen Lingjuan Luebbers Matthew Hu Chunhua Chen Qingmei Ni Zheng Masel Richard I | 2010 | Chemical Communications2010，46，： | 1 |
| 5 | Uniformly Dispersed and Controllable Ligand‐Free Silver‐Nanoparticle‐Decorated TiO<sub>2</sub> Nanotube Arrays with Enhanced Photoelectrochemical Behaviors显示文摘 | Haidong Bian Xia Shu Jianfang Zhang Bao Yuan Yan Wang Lingjuan Liu Guangqing Xu Zhong Chen Yucheng Wu | 2013 | Chem Asian J2013，，11： | 1 |
| 6 | Integrated circulating tumor DNA and T cell repertoire predict radiotherapeutic response and outcome in non-small cell lung cancer patients with brain metastasis显示文摘Dear editor,The scarcity of routinemetastatic biopsies or resection limits the finding of biomarkers of diagnosis and prognosis in patients with brain metastases.Derived from necrosis,apoptosis,and secretion of tumor cells,circulating tumor DNA(ctDNA)is widely distributed in various body fluids,including peripheral blood and cerebrospinal fluid(CSF),as an alternative biomarker for tumor-associated analysis[1].Fortunately,genomic alterations of blood ctDNA and CSF ctDNA have been proven as prognostic markers in non-small cell lung cancer(NSCLC)patients with brain metastasis[2,3]. | Ling Peng Yawen Bin Peng Ding Lingjuan Chen Hao Zeng Zelong Xu Liyan Ji Xuan Gao Pian Liu Ye Wang Sheng Zhang Zhongxing Liao Xuefeng Xia Ruiguang Zhang Fan Tong Xiaorong Dong | 2023 | Cancer Communications2023，43，5： | 0 |
| 7 | A Multi-Period Constrained Multi-Objective Evolutionary Algorithm with Orthogonal Learning for Solving the Complex Carbon Neutral Stock Portfolio Optimization Model显示文摘Financial market has systemic complexity and uncertainty.For investors,return and risk often coexist.How to rationally allocate funds into different assets and achieve excess returns with effectively controlling risk are main problems to be solved in the field of portfolio optimization(PO).At present,due to the influence of modeling and algorithm solving,the PO models established by many researchers are still mainly focused on single-stage single-objective models or single-stage multiobjective models.PO is actually considered as a multi-stage multi-objective optimization problem in real investment scenarios.It is more difficult than the previous single-stage PO model for meeting the realistic requirements.In this paper,the authors proposed a mean-improved stable tail adjusted return ratio-maximum drawdown rate(M-ISTARR-MD)PO model which effectively characterizes the real investment scenario.In order to solve the multi-stage multi-objective PO model with complex multi-constraints,the authors designed a multi-stage constrained multi-objective evolutionary algorithm with orthogonal learning(MSCMOEA-OL).Comparing with four well-known intelligence algorithms,the MSCMOEA-OL algorithm has competitive advantages in solving the M-ISTARR-MD model on the proposed constructed carbon neutral stock dataset.This paper provides a new way to construct and solve the complex PO model. | CHEN Yinnan YE Lingjuan LI Rui ZHAO Xinchao | 2023 | Journal of Systems Science & Complexity2023，36，2： | 0 |
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