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| 1 | Application of Traditional Chinese Medicine injection in treatment of primary liver cancer:a review显示文摘OBJECTIVE:To investigate the application of Traditional Chinese Medicine Injections(TCMIs) for treatment of primary liver cancer(PLC).METHODS:A literature review was conducted using PubMed/Medline,Cochrane Library Controlled Clinical Trials Database,China National Knowledge Infrastructure(CNKI),China Scientific Journal Database(CSJD) and China Biology Medicine(CBM).Online websites including journal websites and databases of ongoing trials,as well as some Traditional Chinese Medicine journals that are not indexed in the electronic databases were also searched.RESULTS:The literature review showed that TCMIs as adjunctive medication for the treatment of PLC could regulate patient immunity,reduce bone marrow suppression,relieve clinical symptoms,and improve quality of life,as well as control disease progression and prolong survival time.CONCLUSION:Within the limitations of this review,we conclude that application of TCMIs as adjunctive medication may provide benefits for patients with PLC.Further large,high-quality trials are warranted. | Mouduo Li Cuixia Qiao Liping Qin Junyong Zhang Changquan Ling | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 22 |
| 2 | Progress in Global Gas Hydrate Development and Production as a New Energy Resource显示文摘Natural gas hydrates have been hailed as a new and promising unconventional alternative energy,especially as fossil fuels approach depletion,energy consumption soars,and fossil fuel prices rise,owing to their extensive distribution,abundance,and high fuel efficiency.Gas hydrate reservoirs are similar to a storage cupboard in the global carbon cycle,containing most of the world's methane and accounting for a third of Earth's mobile organic carbon.We investigated gas hydrate stability zone burial depths from the viewpoint of conditions associated with stable existence of gas hydrates,such as temperature,pressure,and heat flow,based on related data collected by the global drilling programs.Hydrate-related areas are estimated using various biological,geochemical and geophysical tools.Based on a series of previous investigations,we cover the history and status of gas hydrate exploration in the USA,Japan,South Korea,India,Germany,the polar areas,and China.Then,we review the current techniques for hydrate exploration in a global scale.Additionally,we briefly review existing techniques for recovering methane from gas hydrates,including thermal stimulation,depressurization,chemical injection,and CH4-CO2 exchange,as well as corresponding global field trials in Russia,Japan,United States,Canada and China.In particular,unlike diagenetic gas hydrates in coarse sandy sediments in Japan and gravel sediments in the United States and Canada,most gas hydrates in the northem South China Sea are non-diagenetic and exist in fine-grained sediments with a vein-like morphology.Therefore,especially in terms of the offshore production test in gas hydrate reservoirs in the Shenhu area in the north slope of the South China Sea,Chinese scientists have proposed two unprecedented techniques that have been verified during the field trials:solid fluidization and formation fluid extraction.Herein,we introduce the two production techniques,as well as the so-called'fbur-in-one'environmental monitoring system employed during the Shenhu production test.Methane is not currently commercially produced from gas hydrates anywhere in the world;therefore,the objective of field trials is to prove whether existing techniques could be applied as feasible and economic production methods for gas hydrates in deep-water sediments and permafrost zones.Before achieving commercial methane recovery from gas hydrates,it should be necessary to measure the geologic properties of gas hydrate reservoirs to optimize and improve existing production techniques.Herein,we propose horizontal wells,multilateral wells,and cluster wells improved by the vertical and in dividual wells applied during existing field trials.It is noteworthy that relatively pure gas hydrates occur in seafloor mounds,within near-surface sediments,and in gas migration conduits.Their extensive distribution,high saturation,and easy access mean that these types of gas hydrate may attract considerable attention from academia and industry in the future.Herein,we also review the occurrence and development of concentrated shallow hydrate accumulations and briefly introduce exploration and production techniques.In the closing section,we discuss future research needs,key issues,and major challenges related to gas hydrate exploration and production.We believe this review article provides insight on past,present,and future gas hydrate exploration and production to provide guidelines and stimulate new work into the field of gas hydrates. | LIU Liping SUN Zhilei ZHANG Lei WU Nengyou Yichao Qin JIANG Zuzhou GENG Wei CAO Hong ZHANG Xilin ZHAI Bin XU Cuiling SHEN Zhicong JIA Yonggang | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 13 |
| 3 | Zircon U-Pb age of the Shacun gabbro body, Yuexi, Dabie orogen and its geological implications显示文摘The single grain zircon U-Pb age of the Shacun mafic-ultramafic intrusion, Yuexi, North Dabie is (128.1 ±2.0) Ma.This date indicates that the intrusion was implaced at Yanshanian when most Mesozoic granitoids were intruded. It was not the syn-collisional intrusion related to the subduction of the Yangtze Block and ultrahigh-pressure metamorphism at Indosinian. | GE Ningjie HOU Zhenhui LI Huimin CHEN Jiangfeng LIU Bin RUAN Jun QIN Liping | 2000 | Chinese Science Bulletin2000，45，1： | 12 |
| 4 | Biofunctionalization of metallic implants by calcium phosphate coatings显示文摘Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability.Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions.Calcium phosphates(CaPs)are the major inorganic component of bone tissues,and thus owning inherent biocompatibility and osseointegration properties.As such,they have been widely used in clinical orthopedics and dentistry.The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs.This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances,and then give insight into the representative biofunctions,i.e.osteointegration,corrosion resistance and biodegradation control,and antibacterial property,provided by CaP coatings for metallic implant materials. | Yingchao Su Irsalan Cockerill Yufeng Zheng Liping Tang Yi-Xian Qin Donghui Zhu | 2019 | Bioactive Materials2019，4，1： | 11 |
| 5 | Multi-scale Cyclone Activity in the Changjiang River–Huaihe River Valleys during Spring and Its Relationship with Rainfall Anomalies显示文摘Based on the recognition framework of the outermost closed contours of cyclones, an automated identification algorithm capable of identifying the multi-scale cyclones that occur during spring in the Changjiang River–Huaihe River valleys(CHV)were developed. We studied the characteristics of the multi-scale cyclone activity that affects CHV and its relationship with rainfall during spring since 1979. The results indicated that the automated identification algorithm for cyclones proposed in this paper could intuitively identify multi-scale cyclones that affect CHV. The algorithm allows for effectively describing the shape and coverage area of the closed contours around the periphery of cyclones. We found that, compared to the meso- and sub-synoptic scale cyclone activities, the synoptic-scale cyclone activity showed more intimate correlation with the overall activity intensity of multi-scale CHV cyclones during spring. However, the frequency of occurrence of sub-synoptic scale cyclones was the highest, and their effect on changes in CHV cyclone activity could not be ignored. Based on the area of impact and the depth of the cyclones, the sub-synoptic scale, synoptic scale and comprehensive cyclone intensity indices were further defined, which showed a positive correlation with rainfall in CHV during spring. Additionally, the comprehensive cyclone intensity index was a good indicator of strong rainfall events. | Yujing QIN Chuhan LU Liping LI | 2017 | Advances in Atmospheric Sciences2017，34，2： | 10 |
| 6 | Simultaneous regulation of cations and anions in an electrolyte for high-capacity, high-stability aqueous zinc–vanadium batteries显示文摘Safe,inexpensive aqueous zinc-ion batteries(AZIBs)are regarded as promising energy storage devices.However,they still face issues,including dissolution and collapse of the cathode as well as H_(2)evolution and the growth of Zn dendrites on the Zn anode.Herein,we simultaneously regulate the cations and anions in the electrolyte for high-capacity,high-stability aqueous zinc–vanadium(Zn–V)batteries based on a bimetallic cation-doped Na_(0.33)K_(0.1)V_(2)O_(5)·nH_(2)O cathode.We demonstrate that Na^(+) cations suppress cathode dissolution and restrain Zn dendrite growth on the anode via an electrostatic shield effect.We also illustrate that ClO_(4)^(-) anions participate in energy storage at the cathode and are reduced to Cl^(-),generating a protective layer on the Zn anode surface and providing a stable interface to decrease Zn dendrites and H_(2)evolution during long-term cycling.When Na^(+) and ClO_(4)^(-) are introduced into an aqueous ZnSO_(4) electrolyte,a Zn/Zn symmetric cell shows durable and reversible Zn stripping/plating for 1500 h at a current density of 1 mA cm^(-2) and with an area capacity of 1 mAh cm^(-2).Zn/Na_(0.33)K_(0.1)V_(2)O_(5)·nH_(2)O full batteries exhibit a high capacity of 600 mAh g^(-1)at 0.1 A g^(-1) and long-term cycling performance for 5000 cycles,with a capacity of 200 mAh g^(-1) at 20 Ag^(-1). | Ziqing Wang Miao Zhou Liping Qin Minghui Chen Zixian Chen Shan Guo Liangbing Wang Guozhao Fang Shuquan Liang | 2022 | eScience2022，2，2： | 8 |
| 7 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 8 | An imine-linked covalent organic framework as the host material for sulfur loading in lithium–sulfur batteries显示文摘Lithium–sulfur(Li–S) batteries have high theoretical specific capacity, providing new opportunities for the next generation of secondary battery. Covalent organic framework(COF) as a new porous crystalline material has been used as the host material in Li–S battery to improve the cell's cycling stability. In this paper, an imine-linked TAPB-PDA-COF was applied as the host material for sulfur loading(60%) in Li–S battery. The TAPB-PDA-COF has a beehive-like morphology with high thermal stability(up to 500 ℃).In the electrochemical experiment, the performance of the composite cathode with acetylene black(AB) and super-P(S-P) as the conductive additives was studied individually. The initial discharge capacity under 0.2 A/g current density was 991 mAh/g and 1357 mAh/g for TAPB-PDA-COF/S@A-B and TAPB-PDACOF/S@S-P, respectively. The better result of S-P based cathode than A-B could be due to the better conductivity of the S-P, as proved by the EIS results. When further increased the current density to 2 A/g,the S-P based composite cathode can still deliver a comparable initial discharge capacity of 630 and 274 mAh/g capacity remained after 940 cycles. This results will inspire researchers develop more suitable conductive additives together with the host materials for high performance Li–S battery. | Jianyi Wang Liping Si Qin Wei Xujia Hong Ligui Lin Xin Li Jingyi Chen Peibiao Wen Yuepeng Cai | 2019 | Journal of Energy Chemistry2019，28，1： | 7 |
| 9 | 分级凝胶电解质调控Zn^(2+)配位隧道助力无枝晶锌负极显示文摘本文采用离子交联的方法,制备了高离子限域和氢键增强的单宁酸改性海藻酸基复合凝胶电解质.其中,单宁酸中的酚羟基和海藻酸钠中的羧基可以分别与锌离子进行配位和螯合,有效降低Zn^(2+)溶剂化壳层周围结合水分子的活性,通过增强的离子限域效应抑制了副反应和枝晶的生成,实现了锌的均匀沉积.利用该凝胶电解质组装的Zn/NH_(4)V_(4)O_(10)全电池搁置5d后,在2 A g^(-1)下循环200圈的容量保持率高达97.25%.同时,由于单宁酸中的羰基和海藻酸钠、水分子中的羟基之间形成强分子间氢键相互作用,电池在0℃低温下的循环稳定性也得到明显提升.此外,单宁酸中的酚羟基也可与钒基离子螯合,抑制循环过程中钒的溶解,为抑制钒基正极溶解和提高钒基电池小电流密度下的循环稳定性提供了新的解决方案. | Bingyao Zhang Liping Qin Yun Fang Yizhao Chai Xuesong Xie Bingan Lu Shuquan Liang Jiang Zhou | 2022 | Science Bulletin2022，67，9： | 6 |
| 10 | Thermal comfort assessment in civil aircraft cabins显示文摘Aircraft passengers are more and demanding in terms of thermal comfort. But it is not yet easy for aircraft crew to control the environment control system(ECS) that satisfies the thermal comfort for most passengers due to a number of causes. This paper adopts a corrected predicted mean vote(PMV) model and an adaptive model to assess the thermal comfort conditions for 31 investigated flights and draws the conclusion that there does exist an uncomfortable thermal phenomenon in civil aircraft cabins, especially in some short-haul continental flights. It is necessary to develop an easy way to predict the thermal sensation of passengers and to direct the crew to control ECS. Due to the assessment consistency of the corrected PMV model and the adaptive model, the adaptive model of thermal neutrality temperature can be used as a method to predict the cabin optimal operative temperature. Because only the mean outdoor effective temperature ET* of a departure city is an input variable for the adaptive model, this method can be easily understood and implemented by the crew and can satisfy 80–90% of the thermal acceptability levels of passengers. | Pang Liping Qin Yue Liu Dong Liu Meng | 2014 | Chinese Journal of Aeronautics2014，27，2： | 5 |
| 11 | Microbiome:from community metabolism to host diseases显示文摘Microorganisms live in almost every habitat on the earth from the poles to the equator,from forest to desert,from mountain to deep sea,from geysers to karst structures,as well as the body of almost all multicellular organisms from plants to animals.Essentially,species among the microbial populations interact in different ways,as predators and prey,or as symbionts in the form of communities,so adapt to | Nan Qin Xiuzhu Dong Liping Zhao | 2018 | Science China(Life Sciences)2018，61，7： | 5 |
| 12 | An Outbreak of Multidrug-Resistant Tuberculosis in a Secondary School --Hubei Province, 2019显示文摘What is already known about this topic?Multidrug-resistant tuberculosis(MDR-TB)is a type of tuberculosis with resistance to common treatments such as isoniazid and rifampicin.MDR-TB is a major global health challenge and needs to be controlled tightly through prevention measures,early diagnosis,and full treatment and management.What is added by this report?This outbreak was the first MDR-TB related public health emergency in Hubei Province.In total,five MDR-TB cases and nine clinically diagnosed cases were identified within one class in a secondary school.Students and teachers from other classes were monitored,but no other cases were found.What are the implications for public health practice?The implementation of TB prevention and control measures in schools is important to increase knowledge on TB and to raise awareness on protecting personal wellbeing.The Automatic Early Warning Information System alerted the local health department and allowed for a timely response to prevent further disease spread. | Mengxian Zhang Tang Wang Shuangyi Hou Jianjun Ye Liping Zhou Zhong Zhang Zhiqiang Deng Qin Da Guoming Li Shiyue Li | 2019 | China CDC weekly2019，1，5： | 5 |
| 13 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 14 | Measurement system for wind turbine acoustic noise assessment based on IEC standard and Qin's model显示文摘A novel measurement system specially used in noise emission assessment and verification of wind turbine generator systems is presented that complies with specifications given in IEC 61400-11 to ensure the process consistency and accuracy. Theory elements of the calculation formula used for the sound power level of wind turbine have been discussed for the first time, and detailed calculation procedure of tonality and audibility integrating narrowband analysis and psychoacoustics is described. With a microphone and two PXI cards inserted into a PC, this system is designed in Qin′s model using VMIDS development system. Benefiting from the virtual instrument architecture, it′s the first time that all assessment process have been integrated into an organic whole, which gives full advantages of its efficiency, price, and facility. Mass experiments show that its assessment results accord with the ones given by MEASNET member. | Sun Lei Qin Shuren Bo Lin Xu Liping Stephan Joeckel | 2008 | 仪器仪表学报2008，29，3： | 3 |
| 15 | ThERF1 regulates its target genes via binding to a novel cis-acting element in response to salt stress显示文摘Ethylene responsive factors(ERFs) are plantspeci fi c transcription factors that are involved in a variety of biological processes. We previously demonstrated that an ERF gene from Tamarix hispida, Th ERF1, encodes a protein binding to GCC-box and DRE motifs and negatively modulates abiotic stress tolerance. In the present study, microarray analysis was performed to study the genes regulated by Th ERF1 on a genomic scale. There were 154 and 307 genes(respectively representing 134 and 260 unique genes) signi fi cantly up- and downregulated by Th ERF1 under salt stress conditions,respectively. A novel motif, named TTG, was identi fi ed to be recognized by Th ERF1, which commonly presents in the promoters of Th ERF1-targeted genes. The TTG motif is also bound by other ERFs of a different subfamily from T. hispida and Arabidopsis, indicating that it is commonly recognized by ERF proteins. The binding af fi nities of ERFs to the TTG motif R e s e a r c h Aare signi fi cantly induced by salt stress. The TTG motif is more enriched than the GCC-box and DRE motifs in the promoters of Th ERF1-targeted genes. Taken together, these studies suggested that the TTG motif plays an important role in the gene expression regulated by ERFs in response to salt stress. | Liuqiang Wang Chao Wang Liping Qin Wenjin Liu Yucheng Wang | 2015 | Journal of Integrative Plant Biology2015，57，10： | 3 |
| 16 | Management characteristics and prognosis after stroke in China:findings from a large nationwide stroke registry显示文摘Background and purpose There is limited nationwide evidence about the standard management characteristics of stroke types and prognosis in China.This study aimed to assess clinical characteristics,in-hospital and after-discharge management characteristics and prognosis for stroke types in China.Methods A nationwide registry recruited 14244 imaging-confirmed first-ever incident strokes from 132 hospitals across 31 provinces of China during 2007-2008,recording presenting characteristics,diagnostic procedures and in-hospital treatment.After hospital discharge,patients were followed up for 6 months.Conventional statistical methods were used to examine the patterns of management and prognosis.Results Overall,68.7%,26.9%and 4.4%were ischaemic stroke(IS),intracerebral haemorrhage(ICH),and subarachnoid haemorrhage(SAH),respectively.Only 20%were managed in a dedicated stroke unit.Among IS,1.3%received thrombolysis within 3 hours after symptom onset,whereas the proportions of receiving in-hospital antiplatelet therapy,neuroprotective agents and traditional Chinese medicines(TCM)were 88.4%,69.7%and 70.6%,respectively.For ICH,63.3%and 36.3%received neuroprotective agents and TCM in hospital,respectively.At discharge,70.7%and 38.0%of the patients with IS were given antiplatelet and statin therapies,respectively,decreasing to 64.8%and 23.9%,respectively,at 6 months.In-hospital mortality was 3.2%,9.3%and 10.1%for IS,ICH and SAH,respectively,with a further 8.6%,18.2%and 22.0%,respectively,died by 6 month.Meanwhile,in-hospital recurrence rate was 2.6%,1.9%and 7.2%for IS,ICH and SAH,respectively,with a further 8.0%,5.1%and 7.5%,respectively,recurred by 6 month.Conclusions In China,the mortality rate of stroke is lower than that reported from west populations,though most strokes are not managed in specialised stroke unit.There is widespread use of some unproven therapies but limited proven treatments,especially after discharge,leading to unnecessary recurrent risks. | Haiqiang Qin Yiping Chen Gaifen Liu Iain Turnbull Runhua Zhang Zixiao Li Yilong Wang Liping Liu Xingquan Zhao Zhengming Chen Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 3 |
| 17 | ThERF1 from Tamarix hispida confers decreased tolerance to oxidative and drought stresses and is regulated by a WRKY protein显示文摘The ethylene-responsive factor family is one of the largest families of plant-specific transcription factors that are involved in plant development and stress responses. Previously, we demonstrated that the gene Th ERF1,encoding a novel ethylene-responsive factor from Tamarix hispida, negatively modulates abiotic stress tolerance. In the present study, Arabidopsis plants overexpressing Th ERF1 had decreased oxidative tolerance and increased transpirational water loss rate compared with wild-type plants, leading to sensitivity to abiotic stress. Real-time RT-PCR showed that the upstream regulator of Th ERF1,Th WRKY2, is involved in responses to different abiotic stresses. Furthermore, both Th WRKY2 and Th ERF1 shared similar expression patterns in the stems and leaves of T.hispida when exposed to salinity, drought and abscisic acid. Chromatin immunoprecipitation assays further confirmed that Th WRKY2 can directly bind to the promoter of Th ERF1 and regulate its expression. This study revealed the regulatory mechanism of Th ERF1 expression in response to abiotic stresses in T. hispida. | Liuqiang Wang Chao Wang Liping Qin Ping Hu Yucheng Wang | 2016 | Journal of Forestry Research2016，27，4： | 2 |
| 18 | Absence of hexavalent chromium in marine carbonates:implications for chromium isotopes as paleoenvironment proxy显示文摘The oxygenation of Earth’s atmosphere is widely regarded to have played an important role in early-life evolution.Chromium(Cr)isotopes recorded in sedimentary rocks have been used to constrain the atmospheric oxygen level(AOL)over geological times based on the fact that a positive Cr isotopic signature is linked to the presence of Cr(Ⅵ)as a result of oxidative continental weathering.However,there is no direct evidence of the presence of Cr(Ⅵ)in sedimentary rocks yet.Carbonates are most widely distributed over geological times and were thought to have incorporated Cr(Ⅵ)directly from seawater.Here,we present results of Cr valence states in carbonates which show Cr(Ⅲ)is the dominant species in all samples spanning a wide range of geological times.These findings indicate that Cr(Ⅵ)in seawater was reduced either before or after carbonate precipitation,which might have caused Cr isotopic fractionation between seawater and carbonates,or marine carbonates preferentially uptake Cr(Ⅲ)from seawater.As Cr(Ⅲ)can come from non-redox Cr cycling,which also can cause isotopic fractionation,we suggest that positively fractionated Cr isotopic values do not necessarily correspond to the rise in AOL. | Ziyao Fang Liping Qin Wei Liu Tao Yao Xiaoyan Chen Shiqiang Wei | 2021 | National Science Review2021，8，3： | 2 |
| 19 | Pattern characteristics in patients with primary liver cancer in different clinical stages显示文摘OBJECTIVE: To explore the characteristics of primary liver cancer in terms of Traditional Chinese Medicine(TCM) by analyzing the variations of the patterns along with the clinical stages.METHODS: The patients who were hospitalized in the Changhai Hospital of Traditional Chinese Medicine dated from March 1999 to December 2008 were included in this retrospective study. The patients were grouped according to their cancer stages, and their patterns were judged and quantified according to the 'Standard diagnosis and quantitative criteria of the common patterns in primary liv-er cancer' formulated by the Changhai Hospital of Traditional Chinese Medicine. Statistics methods included ANOVA and nonparametric test, among others.RESULTS: The data of the 398 newly diagnosed patients showed that Qi Stagnation, Blood Stasis, and Dampness patterns were more frequent than the other basic patterns with relatively high scores; patterns of Liver Qi Stagnation, Liver Blood Stasis, and Dampness Heat were more than the other complex patterns and scored relatively high. Scores of Dampness and Liver Qi Stagnation patterns varied among the groups at different stages and the differences were statistically significant(PDampness= 0.002,PLiver Qi Stagnation= 0.020). The highest scores of Dampness pattern and Liver Qi Stagnation pattern corresponded with Stage Ⅲb, and Stage equency wⅢ a, respectively. Dampness pattern fras higher(P =0.001) in the Stage Ⅲb group than in other groups.CONCLUSION: Pattern characteristics in patients with primary liver cancer of different clinical stages might manifest in the variations of the Dampness pattern along the process of the disease and the major pathogenic factor of primary liver cancer might be Dampness. | Qin Liping Meng Jing Lang Qingbo Liu Long Li Bai | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 2 |
| 20 | CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription显示文摘Toll-like receptors (TLRs) play critical roles in innate immunity and inflammation. The molecular mechanisms by which TLR signaling is fine-tuned remain to be completely elucidated. Cullin 4B (CUL4B), which assembles the CUL4B-RING E3 ligase complex (CRL4B), has been shown to regulate diverse developmental and physiological processes by catalyzing monoubiquitination for histone modification or polyubiquitination for proteasomal degradation. Here, we identified the role of CUL4B as an intrinsic negative regulator of the TLR-triggered inflammatory response. Deletion of CUL4B in macrophages increased the production of proinflammatory cytokines and decreased anti-inflammatory cytokine IL-10 production in response to pathogens that activate TLR3, TLR4, or TLR2. Myeloid cell-specific Cul4b knockout mice were more susceptible to septic shock when challenged with lipopolysaccharide, polyinosinic-polycytidylic acid or Salmonella typhimurium infection. We further demonstrated that enhanced TLR-induced inflammatory responses in the absence of CUL4B were mediated by increased GSK3β activity. Suppression of GSK3β activity efficiently blocked the TLR-triggered increase in proinflammatory cytokine production and attenuated TLR-triggered death in Cul4b mutant mice. Mechanistically, CUL4B was found to negatively regulate TLR-triggered signaling by epigenetically repressing the transcription of Pten, thus maintaining the anti-inflammatory PI3K-AKT-GSK3β pathway. The upregulation of PTEN caused by CUL4B deletion led to uncontrolled GSK3β activity and excessive inflammatory immune responses. Thus, our findings indicate that CUL4B functions to restrict TLR-triggered inflammatory responses through regulating the AKT-GSK3β pathway. | Yu Song Peishan Li Liping Qin Zhiliang Xu Baichun Jiang Chunhong Ma Changshun Shao Yaoqin Gong | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
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