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| 1 | Characterization of micro-arc ceramic coatings on Ti-2Al-2.5Zr alloy substrates显示文摘Titanium oxide coatings were synthesized on Ti-2Al-2.5Zr alloy substrates by micro-arc oxidation (MAO) tech-nique. The surface features of the coatings were studied by scanning electron microscopy. The micro-arc discharge channels of the Ti-2Al-2.5Zr alloy decrease while the discharge channel size increases clearly with an increase in treating time. With an increase of the coating thickness the porous layer thickness increases apparently. Phase composition of the surface layers of the coatings was evaluated by X-ray diffraction and X-ray photoelectron spectroscopy. The results of XRD and XPS analysis show that the MAO coating mainly consists of anatase and rutile TiO2. | HE Xiao WU Jihong SHEN Liru | 2007 | Rare Metals2007，26，5： | 2 |
| 2 | Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I: C) for enhanced tumoral photodynamic-immunotherapy显示文摘Red blood cell(RBC)-mimicking nanoparticles(NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs(M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of the positively charged aggregation-induced emission luminogen(AIEgen)(named P2-PPh3) and the negatively charged polyinosinic : polycytidylic acid(Poly(I : C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with additional photosensitizing ability for photodynamic therapy(PDT), while Poly(I : C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity, and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region as a result of an enhanced permeability and retention(EPR)effect, and the spleen because of the homing effect of the RBC-mimicking shell. Upon light irradiation,P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens(TA). The anti-tumor immunity is further enhanced by the presence of Poly(I : C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I : C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment. | Jun Dai Meng Wu Quan Wang Siyang Ding Xiaoqi Dong Liru Xue Qingqing Zhu Jian Zhou Fan Xia Shixuan Wang Yuning Hong | 2021 | National Science Review2021，8，6： | 1 |
| 3 | Genetic dissection of the powdery mildew resistance in wheat breeding line LS5082 using BSR-Seq显示文摘Powdery mildew of wheat is a destructive disease seriously threatening yield and quality worldwide.Comprehensive dissection of new resistance-related loci/genes is necessary to control this disease.LS5082 is a Chinese wheat breeding line with resistance to powdery mildew.Genetic analysis,using the populations of LS5082 and three susceptible parents(Shannong 29,Shimai 22 and Huixianhong),indicated that a single dominant gene,tentatively designated PmLS5082,conferred seedling resistance to different Blumeria graminis f.sp.tritici(Bgt)isolates.Bulked segregant RNA-Seq was carried out to map PmLS5082 and to profile differentially expressed genes associated with PmLS5082.PmLS5082 was mapped to a 0.7 cM genetic interval on chromosome arm 2BL,which was aligned to a 0.7 Mb physical interval of 710.3–711.0 Mb.PmLS5082 differs from the known powdery mildew(Pm)resistance genes on chromosome arm 2BL based on their origin,chromosome positions and/or resistance spectrum,suggesting PmLS5082 is most likely a new Pm gene/allele.Through clusters of orthologous groups and kyoto encyclopedia of genes and genomes analyses,differentially expressed genes(DEGs)associated with PmLS5082 were profiled.Six DEGs in the PmLS5082 interval were confirmed to be associated with PmLS5082 via qPCR analysis,using an additional set of wheat samples and time-course analysis postinoculation with Bgt isolate E09.Ten closely linked markers,including two kompetitive allele-specific PCR markers,were confirmed to be suitable for marker-assisted selection of PmLS5082 in different genetic backgrounds,thus can be used to detect PmLS5082 and pyramid it with other genes in breeding programs. | Liru Wu Tong Zhu Huagang He Xinyou Cao Haosheng Li Hongxing Xu Mengshu Jia Lipei Zhang Jiancheng Song Ghader Mirzaghaderi Cheng Liu Pengtao Ma | 2022 | The Crop Journal2022，10，4： | 1 |
| 4 | NIR-Ⅱ fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis显示文摘Ovarian cancer is a global problem,and is typically diagnosed in the middle or late stages,with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic methods.Dual-modal near-infrared Ⅱ(NIR-Ⅱ,1,000–1,700 nm)fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep penetration.Herein,we report a novel organic NIR-Ⅱ dye(H10)with excellent aggregation-induced-emission(AIE)characteristics(I/I0>1.6)utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole(ST)-based building block.Then,water-soluble and biocompatible H10@follicle-stimulating hormone(H10@FSH)dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were synthesized.Finally,for the first time,in vivo dual-mode NIR-Ⅱ fluorescent/photoacoustic(PA)imaging and image-guided surgery of patient-derived tumor xenograft(PDTX)and micro-metastatic abdominal ovarian cancer lesions were investigated.This novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients. | Siyu Lu Liru Xue Meng Yang Jingjing Wang Yang Li Yuxin Jiang Xuechuan Hong Mingfu Wu Yuling Xiao | 2022 | Nano Research2022，15，10： | 0 |
| 5 | Moisture‑Electric–Moisture‑Sensitive Heterostructure Triggered Proton Hopping for Quality‑Enhancing Moist‑Electric Generator显示文摘Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal expression.However,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information representation.Here,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any attenuation.Our research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design. | Ya’nan Yang Jiaqi Wang Zhe Wang Changxiang Shao Yuyang Han Ying Wang Xiaoting Liu Xiaotong Sun Liru Wang Yuanyuan Li Qiang Guo Wenpeng Wu Nan Chen Liangti Qu | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 6 | A SIMULTANEOUS MULTI-PROBE DETECTION LABEL-FREE OPTICAL-RESOLUTION PHOTOACOUSTIC MICROSCOPY TECHNIQUE BASED ON MICROCAVITY TRANSDUCER显示文摘We demonstrate the feasibility of simultancous multi-probe detection for an optcal-resolution photoacoustic microscopy(OR-PAM)system.OR-P AM has elicited the attention of biomedical imaging researchers because of its optical absorption contrast and high spatial resolution with great imaging depth.OR-PAM allows label-free and noninvasive imaging by maximizing the optical absorption of endogenous biomolecules.However,given the inadequate absoption of some biomolcules,detection sensitivity at the same incident intensity requires improvement.In this study,a modulated continuous wave with power density less than 3mW/cm^(2)(1/4 of the ANSI safety limit)excited the weak photoacoustic(PA)signals of biological cells.A microcavity traneducer is developed based on the bulk modulus of gas five orders of magnitude lower than that of solid;air pressure variation is inversely proportional to cavity volume at the same temperature increase.Considering that a PA wave expands in various directions,detecting PA signals from different positions and adding them together can increase detection sensitivity and signal-to-noise ratio.Therefore,we employ four detectors to acquire tiny PA signals simul-taneously.Experimental results show that the developed OR-PAM system allows the label-free imaging of cells with weak optical absorption. | YONGBO WU ZHILIE TANG YAN CHI LIRU WU | 2013 | Journal of Innovative Optical Health Sciences2013，6，3： | 0 |
| 7 | Wind-Thermal Environmental Characteristic of Multi-Variable Passive Enhanced Natural Ventilation System for High and Large Space Building显示文摘Natural ventilation effects in high and large space buildings of tropical areas greatlya ffect the air conditioning energy consumption.Aiming at nearly zero energy building design,thisp aper mainly contributes to provide theoretical basis and reference for thermal comfortable air conditioning system design of high and large space buildings.Taking a theatre in Hainan as study object,a newly composite enhanced natural ventilation system is proposed by integrating theu nderground tunnel-based earth to air heat exchange system and the solar chimney.Ventilationq uantity,air velocity and air temperature field,human vertical temperature gradient differenceu nder24simulation working conditions are considered and analyzed by using ANSYS Fluent.Fort he underground tunnel,results show that Group Two with double underground tunnels and side airs upply location shows its advantages in cooling effects and air supply uniformity.Then for the solar chimney,results show that the solar radiation intensity contributes to larger difference int ransmission power and leads to different cooling effects.On the whole,the system under workingc ondition No.7with120m long,side air supply,double underground tunnel and20m high,1mw ide,0.6°absorber plate angle solar chimney shows its priority in better comprehensive performance. | Lin Liu Haoran Huang Chenghe Wu Liru Liu Jing Tian | 2023 | Journal of Harbin Institute of Technology(New Series)2023，30，5： | 0 |
| 8 | Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling显示文摘Mutation of the MAPK7 gene was related to human scoliosis.Mapk7 regulated the development of limb bones and skulls in mice.However,the role of MAPK7 in vertebral development is still unclear.In this study,we constructed Col2a1-cre;Mapk7 f/f transgenic mouse model to delete Mapk7 in cartilage,which displayed kyphosis and osteopenia.Mechanistically,Mapk7 loss decreased MEF2C expression and thus activated PTEN to oppose PI3K/AKT signaling in vertebral growth plate chondrocytes,which impaired chondrocyte hypertrophy and attenuated vertebral ossification.In vivo,systemic pharmacological activation of AKT rescued impaired chondrocyte hypertrophy and alleviated mouse vertebral defects caused by Mapk7 deficiency.Our study firstly clarified the mechanism by which MAPK7 was involved in vertebral development,which might contribute to understanding the pathology of spinal deformity and provide a basis for the treatment of developmental disorders of the spine. | Chengzhi Wu Hengyu Liu Dongmei Zhong Xiaoming Yang Zhiheng Liao Yuyu Chen Shun Zhang Deying Su Baolin Zhang Chuan Li Liru Tian Caixia Xu Peiqiang Su | 2024 | Genes & Diseases2024，11，2： | 0 |
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