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| 1 | Altered regional homogeneity in post-traumatic stress disorder: a resting-state functional magnetic resonance imaging study显示文摘Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD. | Yan Yin Changfeng Jin Lisa T. Eyler Hua Jin Xiaolei Hu Lian Duan Huirong Zheng Bo Feng Xuanyin Huang Baoci Shan Qiyong Gong Lingjiang Li | 2012 | Neuroscience Bulletin2012，28，5： | 9 |
| 2 | Environmental and biological monitoring of exposures to PAHs and ETS in the general population显示文摘 | Noel J. Aquilina Juana Mari Delgado-Saborit Claire Meddings Stephen Baker Roy M. Harrison Peyton Jacob Margaret Wilson Lisa Yu Minjiang Duan Neal L. Benowitz | 2010 | Environment International2010，，7： | 1 |
| 3 | HIV vaccine acceptability among communities at risk: The impact of vaccine characteristics显示文摘 | Peter A. Newman Naihua Duan Sung-Jae Lee Ellen T. Rudy Danielle S. Seiden Lisa Kakinami William E. Cunningham | | Vaccine0，，： | 1 |
| 4 | 显示文摘 | Duane T Birnbaum Jacqueline D Kosrnala Lisa BrannonPeppas | 2000 | Journal of Nanoparticle Research2000，2，： | 1 |
| 5 | Molecular weight distribution changes during degradation and release of PLGA nanoparlicles ontaining epirubicin HC1 journal of biomaterials science显示文摘 | Duane T Birnbaum Lisa Brannon-Peppas | 2003 | Polymer Edition January2003，1，14： | 1 |
| 6 | Differences in HIV vaccine acceptability between genders显示文摘 | Lisa Kakinami Peter A. Newman Sung-Jae Lee Naihua Duan | 2008 | AIDS Care2008，，5： | 1 |
| 7 | HIV vaccine acceptability among communities at risk: The impact of vaccine characteristics显示文摘 | Peter A. Newman Naihua Duan Sung-Jae Lee Ellen T. Rudy Danielle S. Seiden Lisa Kakinami William E. Cunningham | 2005 | Vaccine2005，，12： | 1 |
| 8 | Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau显示文摘The gut microbiome shows changes under a plateau environment,while the disbalance of intestinal microbiota plays an important role in the pathogenesis of irritable bowel syndrome(IBS);however,the relationship between the two remains unexplored.In this work,we followed up a healthy cohort for up to a year before and after living in a plateau environment and performed 16S ribosomal RNA(rRNA)sequencing analysis of their fecal samples.Through evaluating the participants’clinical symptoms,combined with an IBS questionnaire,we screened the IBS sub-population in our cohort.The sequencing results showed that a high-altitude environment could lead to changes in the diversity and composition of gut flora.In addition,we found that the longer the time volunteers spent in the plateau environment,the more similar their gut microbiota composition and abundance became compared to those before entering the plateau,and IBS symptoms were significantly alleviated.Therefore,we speculated that the plateau may be a special environment that induces IBS.The taxonomic units g_Alistipes,g_Oscillospira,and s_Ruminococcus_torques,which had been proved to play important roles in IBS pathogenesis,were also abundant in the IBS cohort at high altitudes.Overall,the disbalance of gut microbiota induced by the plateau environment contributed to the high frequency of IBS and the psychosocial abnormalities associated with IBS.Our results prompt further research to elucidate the relevant mechanism. | Xingguang ZHANG Wei XU Weilong ZHONG Wencheng ZHANG Cheng YANG Lisa DUAN Haiyan NIU Yanmei DONG Taotao LIU Shihai XIA Bangmao WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，9： | 0 |
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