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| 1 | METTL3-mediated N^6-methyladenosine mRNA modification enhances long-term memory consolidation显示文摘 | Zeyu Zhang Meng Wang Dongfang Xie Zenghui Huang Lisha Zhang Ying Yang Dongxue Ma Wenguang Li Qi Zhou Yun-Gui Yang Xiu-Jie Wang | 2018 | Cell Research2018，28，11： | 29 |
| 2 | Polyaniline-modified cetyltrimethylammonium bromide- graphene oxide-sulfur nanocomposites with enhanced performance for lithium-sulfur batteries显示文摘 | Yongcai Qiu Wanfei Li Guizhu Li Yuan Hou Lisha Zhou Hongfei Li Meinan Liu Fangmin Ye Xiaowei Yang Yuegang Zhang | 2014 | Nano Research2014，7，9： | 11 |
| 3 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 4 | MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling显示文摘发信号的 BMP 怎么集成到并且使动摇人的 pluripotent 干细胞(hPSCs ) 的 pluripotency 电路开始区别进单个细菌层是一个长期的难题。这里,我们报导肌肉片断 homeobox 2 (MSX2 ) , msh 家庭的一个 homeobox 抄写因素, BMP 发信号的直接目标基因和 hPSC 到 mesendoderm 的区别的一个主人调停人。MSX2 的强制表示足够废除 pluripotency 并且导致 hPSCs 的指导 mesendoderm 区别,当 MSX2 弄空损害 mesendoderm 正式就职时。MSX2 是在 hPSCs 的 BMP 小径的直接目标基因,并且能被 Wnt 信号 synergistically 在 mesendoderm 正式就职期间经由 LEF1 激活。而且, MSX2 使动摇通过到 SOX2 倡导者和 SOX2 抄写的压抑的直接绑定的 pluripotency 电路,当 MSX2 通过节的倡导者的直接绑定和激活由 SOX2 的同时的抑制和节的表示的正式就职控制 mesendoderm 系承诺时。有趣地, SOX2 能支持 MSX2 蛋白质的降级,建议在在干细胞命运的控制的二个指定系的因素之间的相互的对抗。一起,我们的调查结果揭示使动摇的关键新机制在 hPSCs 的 pluripotency 和指导系承诺。 | Qingqing Wu Leisheng Zhang Pei Su Xiaohua Lei Xin Liu Hongtao Wang Lisha Lu Yang Bai Tao Xiong Dong Li Zhengmao Zhu Enkui Duan Erlie Jiang Sizhou Feng Mingzhe Hang Yuanfu Xu Fei Wang Jiaxi Zhou | 2015 | Cell Research2015，25，12： | 8 |
| 5 | Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation显示文摘Dear Editor,Lipid droplets(LDs)are dynamic lipid-storage organelles of storage depots and sources of essential substrates for myriad cellular processes and protect cells from lipotoxicity(Ohsaki et al.,2006).Disrupted LD and fat storage homeostasis has been linked to metabolic diseases such as atherosclerosis,obesity,and type II diabetes(Levin et al.,2001).Structurally,the core of neutral lipids in LDs is surroun ded by a phospholipid mono layer and coated with specific proteins(Storey et al.,2011).Perilipin family of proteins are the predominant LD-associated proteins. | Jianxi Zhu Mingyang Xu Yi Liu Lisha Zhuang Kejun Ying Feng Liu Dan Liu Wenbin Ma Zhou Songyang | 2019 | Protein & Cell2019，10，5： | 7 |
| 6 | Failure probability estimation of overhead transmission lines considering spatial and temporal variation in severe weather显示文摘Estimation for weather-related failure probability of overhead transmission lines is essential in the reliability assessment of a power system.This paper analyzes the outage and weather data of 110 kV overhead transmission lines in the Guangxi Zhuang Autonomous Region of China during 2011–2014.The result reveals obvious uneven distributions of outage events for time and space due to the spatial and temporal variation of severe weather.Based on the results, an estimation method is proposed in this paper.Split and aggregation is used to smooth the outage and weather data.The poisson model is adopted in our method to investigate the statistic characteristics of transmission line outage events.Regression analysis is applied to obtain the correlation between the weather intensity and history failure rate.Furthermore the method proposed is validated against the empirical outage data. | Shuai YANG Wenjun ZHOU Shiyang ZHU Le WANG Lisha YE Xuezhi XIA Han LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 5 |
| 7 | Neuroprotective effects of total saponins from Rubus parvifolius L. on cerebral ischemia/reperfusion injury in rats显示文摘This study examines the neuroprotective effects and mechanisms of action of total saponins from Rubus parvifolius L. (TSRP) on focal cerebral ischemia and reperfusion injury in rats. Focal cerebral ischemia and reperfusion injury was performed in rats using the suture method. The results indicate that intragastric injection of TSRP, at 5, 10 and 20 mg/kg, could decrease neurological impairment, reduce cerebral infarct volume, diminish pathological changes, and significantly inhibit the apoptosis of neurons surrounding the ischemic area. In addition, TSRP upregulated the expression of the anti-apoptotic factor Bcl-2, at the protein and mRNA levels, and it downregulated the expression of the pro-apoptotic factor Bax, at the protein and mRNA levels. These findings indicate that TSRP protects against cerebral ischemia/reperfusion injury, and that it may do so by regulating the expression of Bcl-2 and Bax. | Jisheng Wang Fang Zhang Li Tang Liqiong Sun Xiaolin Song] Lisha Cao Zongyin Qiu Chenglin Zhou | 2012 | Neural Regeneration Research2012，7，3： | 5 |
| 8 | Laser-based micro/nanofabrication in one, two and three dimensions显示文摘有各种各样的尺寸的功能的材料和结构的先进 micro/nanofabrication 在现代 nanoscience 和技术代表一个关键研究话题并且为象 nanoelectronics, nanophotonics 和 micro/nanoelectromechanical 系统那样的众多的出现技术变得极其重要。这评论系统地探索在制作挑战性经由常规途径被制作的各种各样的尺寸的 nanomaterials 和 micro/nanostructures 处理途径的非常规的材料。研究努力为生长和制造集中于基于激光的技术一个维(1D ) ,二维(2D ) 并且三维(3D ) nanomaterials 和 micro/nanostructures。下列研究话题被论及,包括:1 ) 为碳 nanotubes (CNT ) 的 1D nanomaterial 的高度有效的生长和集成的帮助激光的化学蒸汽免职(CVD ) , 2 ) 在周围的条件下面的 graphene 带子的直接写的激光(LDW ) ,并且 3 ) 经由添加剂和减少性的过程的 3D micro/nanostructures 的 LDW。与常规制造方法作比较,基于激光的方法在先进功能的材料和结构的 micro/nanofabrication 展出几个唯一的优点。为 1D CNT 生长,帮助激光的 CVD 进程能由于高度强烈的精力交货和导致激光的光近地的效果认识到两快速的材料合成和生长地点的紧密的控制和 CNT 的取向。为 2D graphene 合成和 patterning,房间温度并且露天绝缘的表面上的大规模 graphene 模式的制造被一个 LDW 过程成功地认识到。为 3D micro/nanofabrication,二光子的聚合(TPP ) 和减少性的多光子脱离(MPA ) 处理的添加剂的联合启用为常规制造方法挑战性的任意的复杂 3D micro/nanostructures 的制造。就基于激光的技术的众多的唯一的优点而言,基于激光的 micro/nanofabrication 被期望在先进功能的 micro/nano-devices 的制造起一个越来越重要的作用。 | Wei XIONG Yunshen ZHOU Wenjia HOU Lijia JIANG Masoud MAHJOURI-SAMANI Jongbok PARK Xiangnan HE Yang GAO Lisha FAN Tommaso BALDACCHINI Jean-Francois SILVAIN Yongfeng LU | 2015 | Frontiers of Optoelectronics2015，8，4： | 4 |
| 9 | The distribution of chlorophyll a in the tropical eastern Indian Ocean in austral summer显示文摘To study the effect of hydrographic factors on the spatial distributions of chlorophyll a (Chl a), an investigation was carried out in the tropical eastern Indian Ocean (80 -100 E along 7 S, and 7 -18 S along 80 E) in December 2010. The fluorescent method was used to obtain total Chl a and size-fractioned Chl a at the 26 stations. The results show that surface Chl a concentration averaged at (0.168 ± 0.095) mg/m 3 s.d. (range: 0.034-0.475 mg/m 3 ), concentrations appeared to be higher in the west for longitudinal variations, and higher in the north for latitudinal variations. Furthermore, the surface Chl a concentration was lower (0.034-0.066 mg/m 3 ) in the region to the south of 16 S. There was a strong subsurface Chl a maximum layer at all stations and the depth of the Chl a maximum increased towards to the east and south along with the respective nitracline. The spatial variation of Chl a was significant: correlation and regression analysis suggests that it was primarily affected by PO 3 4 , N(NO 3 -N+NO 2 -N) and temperature. Size-fractionated Chl a concentration clearly showed that the study area was a typical oligotrophic open ocean, in which picophytoplankton dominated, accounting for approximately 67.8% of total Chl a, followed by nanophytoplankton (24.5%) and microphytoplankton (7.6%). The two larger fractions were sensitive to the limitation of P, while picophytoplankton was primarily affected by temperature. | HONG Lisha WANG Chunsheng ZHOU Yadong CHEN Mianrun LIU Hongbin LIN Zhongyang SONG Xunshu | 2012 | Acta Oceanologica Sinica2012，31，5： | 3 |
| 10 | Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation显示文摘Interspecies chimera through blastocyst complementation could be an alternative approach to create human organs in animals by using human pluripotent stem cells.A mismatch of the major histocompatibility complex of vascular endothelial cells between the human and host animal will cause graft rejection in the transplanted organs.Therefore,to achieve a transplantable organ in animals without rejection,creation of vascular endothelial cells derived from humans within the organ is necessary.In this study,to explore whether donor xeno-pluripotent stem cells can compensate for blood vasculature in host animals,we generated rat-mouse chimeras by injection of rat embryonic stem cells(rESCs)into mouse blastocysts with deficiency of Flk-1 protein,which is associated with endothelial and hematopoietic cell development.We found that rESCs could differentiate into vascular endothelial and hematopoietic cells in the rat-mouse chimeras.The whole yolk sac(YS)of Flk-1^EGFP/ECFP rat-mouse chimera was full of rat blood vasculature.Rat genes related to vascular endothelial cells,arteries,and veins,blood vessels formation process,as well as hematopoietic cells,were highly expressed in the YS.Our results suggested that rat vascular endothelial cells could undergo proliferation,migration,and self-assembly to form blood vasculature and that hematopoietic cells could differentiate into B cells,T cells,and myeloid cells in rat-mouse chimeras,which was able to rescue early embryonic lethality caused by Flk-1 deficiency in mouse. | Xiaomin Wang Hui Shi Juanjuan Zhou Qingjian Zou Quanjun Zhang Shixue Gou Pengfei Chen Lisha Mou Nana Fan Yangyang Suo Zhen Ouyang Chengdan Lai Quanmei Yan Liangxue Lai | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 11 | NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis显示文摘Lung cancer,which is exacerbated by environmental pollution and tobacco use,has become the most common cause of cancer-related deaths worldwide,with a five-year overall survival rate of only 19%(Siegel et al.,2020;Yang et al.,2020;Yu and Li,2020).Nearly 85%of lung cancers are non-small cell lung cancers,of which lung adenocarcinoma is the most common subtype accounting for 50%of non-small cell lung cancer cases.At present,radiotherapy is the primary therapeutic modality for lung cancer at different stages,with significant prolongation of survival time(Hirsch et al.,2017;Bai et al.,2019;Shi et al.,2020). | Lisha ZHOU Changsheng DONG Zhuoming XU Xinran WANG Luyi ZHANG Siyuan CHEN Jiahao CHEN Yingying ZHU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 2 |
| 12 | The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity显示文摘The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well characterized.In particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is elusive.Here,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 levels.Alternatively,these patients mounted potent virus-specific TH1 and CD8+T cell responses.In sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these patients.These results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines. | Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang Jianfang Tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 13 | Industry Linkage and Low-carbon Development--Based on Logistics Industry & Manufacturing Industry显示文摘Key project of ' manufacturing industry and logistics industry linkage'was proposed in the Logistics Adjustment and Revitalization Plan by the state council in 2009. However the consumption and pollution generated by manufacturing industry and logistics industry linkage in China are also large at present. How to conduct manufacturing industry and logistics industry linkage by the low-carbon manner is one of most important issues under current low-carbon economy background. In this paper,the issue is studied and analyzed by constructing system dynamics model,which could propose suggestions for low-carbon linkage development of manufacturing industry and logistics industry. | Lei Ming Yang Huiqin Xiao Xian Ye Lisha Zhou Jilei | 2017 | Meteorological and Environmental Research2017，8，5： | 2 |
| 14 | Antioxidant activity of sulfated polysaccharide conjugates from abalone (Haliotisdiscus hannai Ino)显示文摘 | ZHU Beiwei WANG Lisha ZHOU Dayong | | 0，，： | 1 |
| 15 | 显示文摘 | Zhang Lisha Wang Wenzhong Zhou Lin etla | 2007 | Small2007，3，9： | 1 |
| 16 | Ultrasonic- assisted Synthesis of Visible-Light-Induced Bi2MO6 (M = W, Mo) Photocatalysts 显示文摘 | Zhou Lin Wang Wenzhong Zhang Lisha | 2007 | J Mol Catal A: Chem2007，268，12： | 1 |
| 17 | Ultrasonic-assisted synthesis of visible-light-induced Bi 2 MO 6 (M显示文摘 | Lin Zhou Wenzhong Wang Lisha Zhang | 2006 | Journal of Molecular Catalysis A Chemical2006，，1： | 1 |
| 18 | Nano Fe_(2)O_(3)embedded in montmorillonite with citric acid enhanced photocatalytic activity of nanoparticles towards diethyl phthalate显示文摘Nano-Fe_(2)O_(3)embedded in montmorillonite particles(Fe-Mt)were prepared to degrade diethyl phthalate(DEP)with citric acid(CA)under xenon light irradiation.Compared to pristine montmorillonite(Na-Mt),the embedding process increased 14.5-fold of iron content and 1.8-fold of specific surface area.The synthesized Fe-Mt have more oxygen vacancies than Fe_(2)O_(3)nanoparticles(nFe_(2)O_(3)),which could induce more reactive oxygen species(ROSs)generation in the presence of CA under xenon lamp irradiation.Fe-Mt with CA enhanced photo-assisted degradation of DEP 2.5 times as compared to nFe_(2)O_(3)with CA.Quenching experiments,electron paramagnetic resonance(EPR)spectroscopy and identification of products confirmed that surface-bound·OH was the main radical to degrade DEP.Common anions(i.e.,NO_(3)-,CO_(3)^(2-),Cl^-)and humic acid could compete·OH with DEP and cause slower degradation of DEP.The removal efficiency of DEP was more than 56%with Fe-Mt after three recycles,and the dissolved Fe concentration from Fe-Mt was below 75μmol/L,indicating Fe-Mt had a good stability as a catalyst.Fe-Mt together with CA appeared to be a promising strategy to remove organic pollutants in surface water,or topsoil under solar irradiation. | Zhaoyue Sun Lisha Feng Guodong Fang Longgang Chu Dongmei Zhou Juan Gao | 2021 | Journal of Environmental Sciences2021，33，3： | 1 |
| 19 | Ultrasonic-assistedsynthesis of visible-light-induced Bi2MO6(M=W,Mo)photocatalysts显示文摘 | ZHOU Lin WANG Wenzhong ZHANG Lisha | 2007 | J Mol Catal A:Chem2007，268，19： | 1 |
| 20 | Antioxiadant activity of sulphated polysaccharide conjugates from abalone(Haliotis discus hannai Ino)显示文摘 | Zhu Beiwei Wang Lisha Zhou Dayong | | 0，，227： | 1 |
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