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| 1 | Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-KB pathway显示文摘 | Zong-chao LIU Zhen-long WANG Chen-yi HUANG Zhi-jiang FU Yong LIU Zhang-chao WEI Shi-gui LIU Chuan MA Jie-liang SHEN Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，6： | 29 |
| 2 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 3 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 4 | Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/ reperfusion injury显示文摘目的: 进一步描绘膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的角色在早、迟了(第二扇窗户) ischemic preconditioning (欧洲电脑生产厂商)- 并且 postconditioning (停靠港) 调停了对 ischemia/reperfusion (I/R ) 的 cardioprotection 损害。 | Sunny Yang XIANG Linda L YE Li-lu Marie DUAN Li-hui LIU Zhi-dong GE John A AUCHAMPACH Garrett J GROSS Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 9 |
| 5 | Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation显示文摘The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes.However, the effects of CHR’s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9 C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide(3 AB)and ABT888. Ectopic expression of PARP1 effectively blocked this CHR’s cardioprotection against DOX-induced cardiomyocyte injury in H9 C2 cells. Furthermore, pre-administration with both CHR and 3 AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague–Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy. | Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 6 | Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives显示文摘The novel severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and an ongoing severe pandemic.Curative drugs specific for COVID-19 are currently lacking.Chloroquine phosphate and its derivative hydroxychloroquine,which have been used in the treatment and prevention of malaria and autoimmune diseases for decades,were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients.Therefore,chloroquine phosphate was first used in the treatment of COVID-19 in China.Later,under a limited emergencyuse authorizati on from the FDA,hydroxychloro quine in combi nation with azithromyci n was used to treat COVID-19 patie nts in the USA,although the mechanisms of the anti-COVID-19 effects remain unclear.Preliminary outcomes from clinical trials in several countries have gen erated con troversial results.The desperatio n to control the pan demic overrode the con cerns regardi ng the serious adverse effects of chloro quine derivatives and combi nation drugs,i ncluding lethal arrhythmias and cardiomyopathy.The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease.While respiratory symptoms are the major clin ical man ifestati ons,cardiovascular abno rmalities,in eluding arrhythmias,myocarditis,heart failure,and ischemic stroke,have been reported in a significant number of COVID-19 patients.Patients with preexisting cardiovascular conditions(hypertension,arrhythmias,etc.)are at increased risk of severe COVID-19 and death.From pharmacological and cardiovascular perspectives,therefore,the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated,and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events. | Xiao-lei Zhang Zhuo-ming Li Jian-tao Ye Ji ng Lu Lingyu Linda Ye Chun-xiang Zhang Pei-qing Liu Dayue D Duan | 2020 | Acta Pharmacologica Sinica2020，41，11： | 3 |
| 7 | Epidemiological Characteristics of Plague in the Meriones unguiculatus Plague Focus--Inner Mongolia Autonomous Region,China,1950−2019显示文摘From 1950 to 2019,a total of 267 plague cases in humans were reported in the Inner Mongolia Autonomous Region with 133 deaths and 10,710 Yersinia pestis isolates;21 of these cases were reported from the Meriones unguiculatus(M.unguiculatus)plague focus with 6 deaths and 6,771 isolates.According to the plague situation in the Inner Mongolia Autonomous Region and the implementation of local preventive measures,the prevalence of plague in humans in the M.unguiculatus plague focus of the Inner Mongolia Autonomous Region could be divided into four stages.The first stage was the initial stage of plague prevention and control(1950–1959),with 0.80 cases annually and a case fatality rate of 37.50%.The second stage was the plague eradication stage(1960–1979),with 0.15 cases annually and a case fatality rate of 33.33%.The third stage was the plague surveillance stage(1980-1999),with 0.25 cases annually and a case fatality rate of 20.00%.The fourth stage is the comprehensive prevention and control stage under the emergency system(2000-2019),with 0.25 cases annually and a case fatality rate of 20.00%.The surveillance of rodent density(1981-2019)and studies on plague-related factors among M.unguiculatus have shown that the higher the M.unguiculatus density,the higher the nocturnal rodent capture rate(r=0.670,p<0.05)and the higher the indirect hemagglutination assay(IHA)positive rate of M.unguiculatus(r=0.344,p<0.05);the higher the percentage of hosts infected,the lower the M.unguiculatus density(r=-0.361,p<0.05)and the lower the IHA positive rate of M.unguiculatus(r=-0.337,p<0.05);the higher the percentage of nests infected with fleas,the lower the IHA positive rate of M.unguiculatus(r=-0.348,p<0.05).Together,these results suggest that it is necessary to simultaneously monitor the pathogens,serology,and vector index of M.unguiculatus to accurately reflect the plague prevalence among local animals.Although bubonic plague is the main plague type of the M.unguiculatus plague focus,severe pneumonic plague or septic plague may be secondary when the bubonic plague is misdiagnosed or not treated in time.In addition,the plague in animals is relatively virulent in the M.unguiculatus plague focus,and the risk of spreading to humans is higher.For plague in the Inner Mongolia Autonomous Region,comprehensive control efforts should be aimed at the M.unguiculatus focus,covering host animals,vector insects,and humans. | Boxi Liu Dayu Zhang Yuhuang Chen Zhaokai He Jun Liu Dongyue Lyu Weiwei Wu Ran Duan Shuai Qin Junrong Liang Huaiqi Jing Xin Wang | 2020 | China CDC weekly2020，2，49： | 3 |
| 8 | Preparation of isotropic Sm_2Fe_(17)N_x magnetic powders and their bonded magnets显示文摘The isotropic Sm2Fe17Nx magnetic powders were prepared by Hydrogenation-Disproportion-Desorption-Recombination (HDDR) process. The phase and microstructure evolutionary process of Sm-Fe alloy during the solidification, homogenization, HDDR and nitration processes were investigated by means of XRD, SEM, EDX and AFM. The results show that the homogeneous Sm2Fe17 alloy was successfully obtained and the impurity phases and residual stress were well removed by heated at 1050 ℃ for 24 h. When heated at 800 ℃ for 1h in H2 of 0.1 MPa, the alloy turns into SmHx and α-Fe with plenty of nanocrystals. After vacuumized at 800 ℃ for 2 h the alloy recombines into Sm2Fe17 with a crystal grain size of about 85 nm. The lattice constant of the alloy increases and the expanding of the crystal cell reaches 6.28% after nitrified at 500 ℃ for 5 h. The magnetic property of isotropic bonded Sm2Fe17Nx magnets is Br=0.6704 T, Hcj=1015 kA·m-1, (BH)max=73.7 kJ·m-3 with a density of 6.04 g·cm-3. | YE Jinwen LIU Ying LI Meng SONG Dayu GAO Shengji TU Mingjing | 2006 | Rare Metals2006，25，z1： | 2 |
| 9 | Incidence and Risk Factors of the Upper-Limb Musculoskeletal Disorders Among Occupational Groups in Key Industries—China,2018–2021显示文摘What is already known about this topic?The burden of illness and economic losses due to upper-limb work-related musculoskeletal disorders(UL-WMSDs)is high;thus,they have become a major global public health problem.At present,the epidemiological characteristics of UL-WMSDs in China's occupational population are still unknown.What is added by this report?The incidence of UL-WMSDs among key occupational groups in China is 22.5%,with distinct occupational characteristics.What are the implications for public health practice?This study has primarily determined the occurrence and potential risk factors of UL-WMSDs in key industries in China and provided data support for recommending prevention and control of the occurrence of such diseases in key industries in China,and in facilitating the addition into the China’s List of Legal Occupational Diseases. | Ning Jia Meibian Zhang Huadong Zhang Ruijie Ling Yimin Liu Gang Li Yan Yin Hua Shao Hengdong Zhang Bing Qiu Dongxia Li Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Xinglin Fang Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Jun Qi Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2022 | China CDC weekly2022，4，50： | 1 |
| 10 | H'-ATPase- defective variants of Lactobacillus delbrueckii subsp, bttlgaricus contribute to inhibition of postacidification of yogurt during chilled storage显示文摘 | WANG Xinhui REN Hongyang LIU Dayu | 2013 | Journal of Food Science2013，78，2： | 1 |
| 11 | Astudy on the effect of natural enemies cotton Aphis gossypii Glover in Turupan cotton fields in Xinjiang 显示文摘 | Liu Caizhen Zhang Dayu Su Suiquan | 2001 | Journal of East China Normal University(NaturalScience)2001，，2： | 1 |
| 12 | Effects ofinoculating Lactobacillus sakei starter cultures on the microbiologicalquality and nitrite depletion of Chinese fermented sausages显示文摘 | WANG Xinhui REN Hongyang LIU Dayu | 2013 | FoodControl2013，32，2： | 1 |
| 13 | H^+-ATPase- defective variants of Lactobacillusdelbrueckii subsp, bulgaricus contribute to inhibition of postacidification of yogurt during chilled storage显示文摘 | WANG Xinhui REN Hongyang LIU Dayu | 2013 | Journal of Food Science2013，78，： | 1 |
| 14 | Isatachophoresis preconcentration integrated micro fluidic chip for highly sensitive genotyping of the hepatitis B virus显示文摘 | Dayu Liu Ming Shi Huaiqing Huang | 2006 | J Chromatography B2006，844，1： | 1 |
| 15 | Simplified transient isotachophoresis/capillary gel electrophoresis method for highly sensitive analysis of polymerase chain reaction samples on a microchip with laserinduced fluorescence detection显示文摘 | Liu Dayu Ou Ziyou Xu Mingfei | 2008 | Journal of Chromatography A2008，1214，12： | 1 |
| 16 | Analysis of multiplex PCR fragments with PMMA microchip显示文摘 | Liu Dayu Zhou Xiaomian Zhong Runtao | 2006 | Talanta2006，68，3： | 1 |
| 17 | Onchip coupling of freesolution transient ITP and CGE for highly efficient separation of dsDNA with variable sample loading amounts 显示文摘 | Liu Dayu Chen Bin Wang Lihui | 2009 | Electrophoresis2009，30，24： | 1 |
| 18 | Polymorphism analysis and evaluation of 19 STR loci in the Han population of Southern China显示文摘 | Dayue Tong Yong Chen Xueling Ou Weihong Chen Sujuan Liu Yinming Zhang Hongyu Sun | 2013 | Annals of Human Biology2013，，2： | 1 |
| 19 | Determination of SARS-coronavirus by microfluidic chip system显示文摘 | Xiaomian Zhou Dayu Liu | 2004 | Electrophoresis2004，25，： | 1 |
| 20 | Astragaloside IV derivative HHQ16 ameliorates infarctioninduced hypertrophy and heart failure through degradation of lncRNA4012/9456显示文摘Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction(MI)heart failure(HF).Here,we report a novel small molecule HHQ16,an optimized derivative of astragaloside IV,which effectively reversed infarction-induced myocardial remodeling and improved cardiac function by directly acting on the cardiomyocyte to reverse hypertrophy.The effect of HHQ16 was associated with a strong inhibition of a newly discovered Egr2-affliated transcript Inc9456 in the heart.While minimally expressed in normal mouse heart,Inc9456 was dramatically upregulated in the heart subjected to left anterior descending coronary artery ligation(LADL)and in cardiomyocytes subjected to hypertrophic stimulation.The critical role of Inc9456 in cardiomyocyte hypertrophy was confirmed by specific overexpression and knockout in vitro.A physical interaction between Inc9456 and G3BP2 increased NF-kB nuclear translocation,triggering hypertrophy-related cascades.HHQ16 physically bound to Inc9456 with a high-affinity and induced its degradation.Cardiomyocyte-specific Inc9456 overexpression induced,but knockout prevented LADL-induced,cardiac hypertrophy and dysfunction.HHQ16 reversed the effect of Inc9456 overexpression while lost its protective role when Inc9456 was deleted,further confirming Inc9456 as the bona fide target of HHQ16.We further identified the human ortholog of Inc9456,also an Egr2-affliated transcript,Inc4012.Similarly,Inc4012 was significantly upregulated in hypertrophied failing hearts of patients with dilated cardiomyopathy.HHQ16 also specifically bound to Inc4012 and caused its degradation and antagonized its hypertrophic effects.Targeted degradation of pathological increased Inc4012/lnc9456 by small molecules might serve as a novel promising strategy to regress infarction-induced cardiac hypertrophy and HF. | Jingjing Wan Zhen Zhang hennan Wu Saisai Tianbei Zang Ge Jin Qingyan Sun Pin Wang Xin Luan Yili Yang Xuelin Zhan Lingyu Linda Ye Dayue Darrel Duan Xia Liu Weidong Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
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